Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Kevin Arbuckle
ID:
Using community engagement to improve snakebite prevention measures in rural Uganda
REFNo: HS2326ES

The project aims to improve awareness and implementation of prevention measures against snakebite envenoming in rural communities in Uganda. In doing so our ultimate aim is to reduce the burden of snakebite envenoming in these high risk areas, using our local connections and community-integration approach to ensure the project continues to deliver this aim long after the end of the funding period.

We will achieve our aim via the following specific objectives:-
- Gain an understanding of current community knowledge and attitudes surrounding snakes and snakebite via interviews and surveys.
- Use the information from the first objective to prepare appropriate materials for co-creation workshops with the local community to promote awareness of local snakes and snakebite risk, implementation of prevention strategies, and discussion of appropriate responses in the event of a bite, all with attention given to targeted and specific solutions to local challenges and context.
- Donation of appropriate resources to assist local communities in reducing the risk of snakebite, such as appropriate footwear to prevent accidental bites on exposed feet and handling equipment to enable trained members of the community to move snakes away from high-risk locations such as school premises and homes (see final objective).
- Implement a 'train-the-trainer' programme to train the co-applicant in safe removal of snakes from premises and to enable him to take advantage of his teacher-training to pass these skills onto other willing members of the community. This will ultimately lead to a sustained network of members of the local community who can maintain risk reduction in the longer term.
UK 2023-02-06 16:42:29 2026-02-06 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Noella Okalany Akwi Regina
ID: UNCST-2022-R011085
Congenital Cytomegalovirus Infection in Eastern Uganda
REFNo: HS2668ES

To determine the short-term neurodevelopmental outcomes and hearing impairment associated with congenital cytomegalovirus among infants in Eastern Uganda.,To determine the incidence of, and risk factors for postnatally acquired cytomegalovirus among infants in Eastern Uganda.,To describe the factors associated with congenital cytomegalovirus infection in neonates in Eastern Uganda.,To determine the prevalence of congenital cytomegalovirus infection among neonates in Eastern Uganda,To investigate the burden of congenital cytomegalovirus and its outcomes among infants in Eastern Uganda.,
Uganda 2023-02-06 16:21:08 2026-02-06 Medical and Health Sciences Clinical Trial Degree Award
Adeodata Rukyalekere Kekitiinwa
ID: UNCST-2019-R000799
IMPAACT 2028: Long-Term Clinical, Immunologic, and Virologic Profiles of Children who Received Early Treatment for HIV; DAIDS Study ID #38693
REFNo: HS2417ES

To characterize the long-term clinical, immunologic, and Virologic profiles of children who received early treatment for perinatally-acquired HIV
Uganda 2023-02-06 16:17:13 2026-02-06 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Kathy Burgoine
ID: UNCST-2022-R011521
Impact of prophylactic Continuous Positive Airway Pressure in the Delivery Room (DR-CPAP) on neonates <1500g in a low-resource setting: A feasibility trial
REFNo: HS2605ES

- To determine the acceptability of DR-CPAP to healthcare workers in a low-resource setting - To determine the post-intervention acceptability of using a two-stage consent process in neonatal emergencies in the delivery room in this setting - To evaluate the feasibility of a third-party allocation process for randomisation by determining the time to randomization - To evaluate feasibility of initiating DR-CPAP in a low-resource setting in infants with birthweight 800-1500g within 15 minutes of delivery - To determine the safety of initiating DR-CPAP in a low-resource setting - To estimate the sample size to be used for future evaluation in the full trial - To assess the feasibility of secondary outcome measures to be used in the full trial
UK 2023-02-02 12:18:23 2026-02-02 Medical and Health Sciences Clinical Trial Non-degree Award
Rachel Kawuma Mary Kagawa
ID: UNCST-2022-R009107
Understanding digitally driven risk networks to inform user-centric target product profiles (TPP) for next-generation HIV vaccines (DigiTaPP Study)
REFNo: SS1519ES

Objective 1: To understand HIV prevention product development pipeline and potential vaccine attributes through scientific consultations with vaccine experts and product developers
Sub-objectives:
1. To understand current status of HIV vaccine development pipeline and potential HIV vaccine candidates along with potential product attributes;
2. To explore how communities are being involved in the development process, especially whether the preferences of potential end-users are being considered in TPP development.

Objective 2: To understand the nature and characteristics of HIV risk networks (or sexual networks of target populations at risk for HIV), across digital and physical spaces to inform strategies for engaging all potential end-users
Sub-objectives:
1. To identify the nature and types of physical and virtual platforms used by relevant target populations, explore their stated reasons for using them, and their interconnections;
2. To explore the differences in risk behaviours, current prevention practices and preference for prevention products (including vaccines) among the end-users from physical and digital networks.

Objective 3: To understand preferences of potential end-users (from digital and physical networks) through elicitation research towards informing HIV vaccine target product profile
Sub-objectives:
1. To understand end-users’ preferences for product characteristics and delivery sites;
2. To understand perceived benefit, perceived burden and self-efficacy that may influence product attribute preferences and delivery options;
3. To understand interpersonal and social influences that may influence product attribute preferences and delivery options.
Uganda 2023-02-02 11:58:48 2026-02-02 Social Science and Humanities Non-Clinical Trial Non-degree Award
Peter Kisaakye
ID:
Measuring the incidence of abortion and the quality of postabortion care in refugee settings in Uganda
REFNo: SS1589ES

1. To measure the incidence of abortion in refugee settings in Uganda
2. To determine the severity of abortion-related complications in refugee settings in Uganda
3. To assess the capacity of the health system to offer post-abortion care to people living in refugee settings in Uganda

Uganda 2023-02-01 12:38:01 2026-02-01 Social Science and Humanities Non-Clinical Trial Non-degree Award
JANE  AMUGE
ID:
Implementing the Cooperative Resilience Measurement Index (CRMI) for Cooperatives in Uganda
REFNo: SS1592ES

1. Build the capacity of the cooperatives to establish prioritisation and ownership of the resilience investment.
2. Interrogate the value proposition of the CMRI to enhance cooperative sustainable resilience and competitiveness in Uganda.
3. To test the value proposition of the Coop Profiler to ensure adoption of the CMRI amongst cooperatives in Uganda
4. Publish a paper on the resilience capacity of agribusiness cooperatives in Uganda with policy recommendations

Uganda 2023-02-01 12:17:53 2026-02-01 Social Science and Humanities Non-Clinical Trial Non-degree Award
Margaret Lubwama
ID: UNCST-2019-R000636
Gastrointestinal colonization with drug resistant bacteria in Ugandan patients with cancer and HIV
REFNo: HS2437ES

The overall purpose of the study is to determine the prevalence of ESBL and CRE gastrointestinal colonization in patients with newly diagnosed cancer at the time of chemotherapy initiation and determine how colonization changes over the first month after chemotherapy is initiated. The aims of the study are; 1. To define the association between HIV status and prevalence of gastrointestinal colonization with multidrug resistant organisms (MDROs) among patients with cancer in Uganda. 2. To assess the factors associated with incident MDRO colonization in the first 30-days after initiation of chemotherapy. 3. To investigate whether gastrointestinal colonization with an MDRO is associated with an increased risk of developing a bacterial bloodstream infection with that organism.
Uganda 2023-01-31 12:02:29 2026-01-31 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Annet Mbabazi
ID:
A mixed-methods study exploring the effect of workplace environment on the well-being of academic staff at Makerere university.
REFNo: SS1548ES

i. To assess the effectiveness of the perceived work climate on the well-being of academic staff at Makerere University.
ii. To explore the perception of supervisory relationships on the well-being of academic staff at Makerere University.
iii. To investigate the effect of peer group interaction on the well-being of academic staff at Makerere University.


Uganda 2023-01-30 15:16:32 2026-01-30 Social Science and Humanities Non-Clinical Trial Degree Award
CHRISTINE ATUHAIRWE KIM
ID:
Predictors of HIV viral suppression, survival, and health-related quality of life (HR-QoL) among the Older infected persons in Uganda
REFNo: SS1396ES

1)To examine factors associated with virological failure among older infected persons on ART in Uganda.
2)To examine factors associated with survival among older infected persons on ART in Uganda.
3)To establish lifestyle factors associated with the Health-Related Quality of Life among older infected persons who have been on ART for at least 5 years in Uganda.

Uganda 2023-01-30 15:07:26 2026-01-30 Social Science and Humanities Non-Clinical Trial Degree Award
Shelley Jones
ID:
Child Rights Education in Diverse Global Contexts and Times of Crises - A decolonizing, participatory action research project with educators, children, and community members in Canada and Uganda
REFNo: SS1326ES

Our objective is to investigate ways to understand and leverage a contextualized approach to child rights education (in accordance with Article 29(d) of the United Nations Convention on the Rights of the Child (UNCRC) and 11(2) of the African Charter for the Rights and Welfare of Children (the Charter) in three diverse global contexts. We ask, what processes support educators in different contexts achieve impactful child rights education that empowers children to learn about and exercise their rights, particularly during times/situations of crises? Sub-questions include: 1) How can children’s voices and experiences be centered to inform our understanding of effective child rights education?; 2) How can parents and community members work with educators and children to promote and uphold children’s rights?; 3) How can child rights education best contribute to identifying and advocating for measures to ensure the well-being of all children is prioritized, especially during crises?
Canada 2023-01-30 14:58:26 2026-01-30 Social Science and Humanities Non-Clinical Trial Non-degree Award
Lauben Muhangane
ID:
MODELLING CATCHMENT LAND USE/ LAND COVER CHANGE AND ITS IMPACT ON THE FLOW OF RIVER RWIZI, SOUTH- WESTERN UGANDA
REFNo: NS436ES

To contribute to the evaluation of sustainable management options in order to improve the flow and quality of river Rwizi in the future,4. To determine the land management options most likely to improve the water flow of river Rwizi.,3. To model land use / land cover change of the catchment by 2040,2. To examine the trend in river flow over the past thirty years in ten year intervals ,1. To determine land use / land cover change rate and trend of the Rwizi catchment districts over the past thirty years in ten year intervals.,
Uganda 2023-01-30 14:40:05 2026-01-30 Natural Sciences Non-Clinical Trial Degree Award
Jasper Nidoi
ID: UNCST-2021-R012079
Improving TB case detection using a GeNder sensitive TB screening InTErvention in urban public health facilities in Uganda (IGNITE)
REFNo: HS2648ES

General objective The overall objective of this study is to codesign and evaluate a health facility-based TB screening intervention designed to increase active TB case detection by improving access to TB screening and care services, particularly among men, over a one-year study period. Specific 1) To codesign a health facility-based TB screening intervention targeting men 2) To evaluate the acceptability, appropriateness and feasibility of a health facility-based TB screening intervention targeting men 3) To evaluate the effectiveness of a health facility-based TB screening intervention targeting men in increasing the number of TB cases identified and initiated on treatment by sex over a one-year study period 4) To evaluate the cost-effectiveness of a health facility-based TB screening intervention targeting men
Uganda 2023-01-25 9:48:04 2026-01-25 Medical and Health Sciences Non-Clinical Trial Degree Award
Emmanuel Sendaula
ID: UNCST-2020-R014767
Pan-African Utilization of Lay Assessment Systems (PAULAS) Pilot Project
REFNo: HS2630ES

The self-reported Check-Up instrument will be used to collect data across the following domains: functional status, cognition, mood, communication, disease diagnoses, mental health, well-being, loneliness, and social engagement.,Collect health, well-being, and quality of life information on older people in central Uganda using the InterRAI Check-Up instrument. ,Assess the validity and reliability of the InterRAI Check-Up instrument in community-dwelling older adults in central Uganda.,
Uganda 2023-01-25 9:45:06 2026-01-25 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Jude Ssenyonjo
ID:
Elicitation research for primary HIV prevention among female sex workers in Uganda.
REFNo: HS2635ES

The study objective is to identify individual and provider-level barriers and facilitators to primary HIV prevention among female sex workers (FSWs) in an urban setting.,
Uganda 2023-01-25 9:42:47 2026-01-25 Medical and Health Sciences Non-Clinical Trial Degree Award
Arthur  Mpimbaza
ID: UNCST-2022-R008866
Evaluating malaria case management at public and private health facilities in the Busoga, Lango, Acholi, West Nile and Karamoja sub-regions, Uganda
REFNo: HS2585ES

General objective
The general objective of this study is to assess the capacity of the health services delivery system to provide malaria case management services in five high burden sub-regions in Uganda.
1.3.2 Specific objectives
1. To determine the readiness of public and private health facilities to provide malaria case management services to patients in five high burden sub-regions in Uganda.
2. To determine the readiness of drug shop to provide malaria case management services to patients in five high burden sub-regions in Uganda.
3. To assess healthcare worker competencies in malaria case management standards at public health facilities in five high burden sub-regions in Uganda.
4. To assess drug shop vendor competencies in malaria case management standards in five high burden sub-regions in Uganda

Uganda 2023-01-25 9:39:44 2026-01-25 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Paul  Kutyabami
ID: UNCST-2020-R015029
Ethics of Data Sharing in Uganda: Ethical Perspectives of Sharing Data among Researchers and Research Participants in Health Research
REFNo: HS2634ES

General Objective: The purpose is to explore ethical perspectives facilitators and barriers associated with willingness to share data in health research among researchers and research participants in low-resource settings
The Specific objectives of the study are:
1. To critically evaluate the ethical perspectives about data sharing in health research among researchers in Uganda
2. To critically evaluate research participants’ ethical concerns about researchers sharing participants’ personal data with third parties in Uganda
3. To assess facilitators and barriers associated with willingness to share data among researchers involved in health research in Uganda
4. To assess facilitators and barriers associated with research participants’ willingness to have personal data shared with third parties in health research in Uganda

Uganda 2023-01-23 12:15:28 2026-01-23 Medical and Health Sciences Non-Clinical Trial Degree Award
Felix Jurua
ID: UNCST-2022-R009182
A Retrospective evaluation of the National HIV rapid testing proficiency testing scheme in Uganda. Observations from 5 years of implementation
REFNo: HS2591ES

i. To evaluate the accuracy of HIV testers participating in the National HIV rapid testing proficiency scheme in Uganda over a 5-year period
ii. To compare the accuracy between laboratory professionals and non-laboratory professionals in the National HIV rapid testing proficiency scheme in Uganda over a 5-year period
iii. To evaluate the accuracy of HIV testers by testing point (i.e. lab and non-lab testing points) at facility level, which are enrolled in the National HIV rapid testing proficiency scheme in Uganda over a 5-year period
iv. To determine factors associated with accuracy among HIV testers participating in HIV RT participating in the National HIV RT EQA scheme in Uganda
Uganda 2023-01-20 15:36:15 2026-01-20 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Marjorie  Basemera Doreen
ID:
LEVEL OF MODERN CONTRACEPTIVES UPTAKE AND IDENTIFY THE FACTORS ASSOCIATED WITH UPTAKE OF MODERN CONTRACEPTIVES AMONG ADOLESCENT GIRLS LIVING IN SLUM SETTLEMENTS IN MAKINDYE
REFNo: SS1549ES

4. To identify the need factors to uptake of modern contraceptives among adolescents living in the slum settlements of Makindye division,3. To identify the enabling factors to uptake of modern contraceptives among adolescents living in the slum settlements of Makindye division,2. To identify the predisposing factors to uptake modern contraceptives of modern contraceptives among adolescents living in the slum settlements of Makindye division,1. To establish the proportion of female adolescents 15-19 years using modern contraceptives in the slum settlements of Makindye division,To assess the level of modern contraceptives uptake and identify the factors associated with uptake of modern contraceptives among adolescent girls living in slum settlements in Makindye division,
Uganda 2023-01-20 15:34:07 2026-01-20 Social Science and Humanities Non-Clinical Trial Degree Award
GIDEON  KURIGAMBA KWIKIRIZA
ID:
Retrospective assessment of road injuries and fatalities in Mulago National Referral Hospital and China-Uganda Friendship Naguru Hospital, Kampala
REFNo: SS1579ES

To re-estimate the number of road crash serious injuries and fatalities reported by the police.,To describe the type of injuries for road crash causalities who were admitted or died.,To link hospital road injury and fatality cases with reported police data on serious injuries and deaths for the same period.,To conduct a retrospective assessment of serious injuries and fatalities due to road traffic crashes.,
Uganda 2023-01-20 15:29:34 2026-01-20 Social Science and Humanities Non-Clinical Trial Non-degree Award
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