Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Ernest Mwebaze
ID: UNCST-2024-R015880
 EmpowerHerAI: Advancing Gender Equality and Responsible AI in Sub-Saharan Africa through Gender and Responsible AI Network (GRAIN)
REFNo: SIR456ES

General Objective
The general objective of the research study is to develop and evaluate low-resource multilingual AI language models by addressing issues of gender fairness, bias, and trustworthiness, and promoting inclusive and culturally contextualized AI tools for African languages.

Specific Objectives
1. Conduct a comprehensive review of existing datasets and training processes to identify potential gender gaps in relation to fairness, bias, and trustworthiness issues in low-resource multilingual language models.
2. Curate and collect parallel datasets for selected African languages to improve the development of low-resource multilingual language technologies.
3. Develop a robust and generalizable framework for creating AI language tools that address gender fairness, safety, and trustworthiness in non-English, low-resource multilingual models.
4. Develop a framework for incorporating human feedback and preferences into evaluating multilingual machine translation, speech recognition, and synthesis models, addressing the unique gender challenges presented by low-resource settings.

 Uganda 2024-12-23 11:15:21 2027-12-23 Engineering and Technology Non-Clinical Trial Non-degree Award
KADAI LAWAN ALHAJI
ID: UNCST-2024-R015583
 Analysis of Antimicrobial Metabolites of Aspergillus fumigatus, Isolated from Kitagata Hot Spring Utilizing Metabolomic and Molecular Docking Techniques
REFNo: NS891ES

Objectives
1 To ascertain physicochemical characteristics of Kitagata hot springs.
2 To isolate and identify thermophilic Aspergillus fumigatus from water sample of Kitagata hot spring.
3 To produce, extract and fractionate metabolites of thermophilic Aspergillus fumigatus to be isolated.
4 To determine the efficacy of antimicrobial value of extracted metabolites from the study organisms.
5 To simulate and predict the interaction between two structures of the metabolites

 Nigeria 2024-12-23 11:14:18 2027-12-23 Natural Sciences Non-Clinical Trial Degree Award
Edgar Mulogo Mugema
ID: UNCST-2023-R008170
 Improving business continuity for health services following extreme weather events (RESilience in HeAlth Post-Extreme weather events-RESHAPE Study)
REFNo: HS5370ES

Overall Objective

The primary objective of the proposed study is to develop and deploy the tools that will help healthcare services to better prepare for EWEs, cope better when affected by such events, and recover more effectively afterwards.


Specific Aims
Aim 1: Describe the healthcare systems in the Kasese District, and its served communities and how both have been affected by and responded to EWEs to provide a foundation for locally relevant insights into processes and adaptations, and their influence on health outcomes

Aim 2: Develop, with local partners, through business continuity planning, resilience engineering and participatory research methods, protocols for EWE preparedness, response and recovery, and guidance on good practices, knowledge exchange, and interventions development as a process for enhancing resilient healthcare delivery

Uganda 2024-12-23 11:10:15 2027-12-23 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Bamidele Olaiya Charles
ID: UNCST-2024-R003262
 OPTIMIZATION OF MECHANICAL AND THERMAL PROPERTIES OF SANDCRETE-BRICKS INCORPORATING SAWDUST AND BANANA-LEAF ASH USING GENETIC ALGORITHM AND ARTIFICIAL-NEURAL-NETWORK
REFNo: SIR366ES

i. To characterize the Sawdust Ash (SDA) and Banana Leaf Ash (BLA)
ii. To examine the effects of varying percentages of sawdust and banana-leaf ashes on the mechanical (compressive strength, flexural strength) and thermal properties of sandcrete bricks.
iii. To develop an optimization approach using a combination of Genetic Algorithm (GA) and Artificial Neural Network (ANN) to determine the optimal mix proportions for sandcrete bricks with improved mechanical and thermal properties.
iv. To evaluate the mineralogical and microstructural properties of the sandcrete bricks made with the SDA and BLA.
v. To provide insights into the sustainable and energy-efficient production of sandcrete bricks incorporating sawdust and banana-leaf ash

 Nigeria 2024-12-23 11:08:48 2027-12-23 Engineering and Technology Non-Clinical Trial Degree Award
Gertrude Nakigozi
ID: UNCST-2023-R007979
 CLIMATE SHOCK PILOT STUDY
REFNo: NS890ES

Validate the climate shock survey for Lake Victoria basin/ South western Uganda and examine determinants of climate variability impact, and conduct a comparison on the effects of Climate variability by community and occupation Climate variability
 Uganda 2024-12-23 11:07:21 2027-12-23 Natural Sciences Non-Clinical Trial Non-degree Award
Julia Harrison
ID: UNCST-2024-R004345
 Neonatal and Pediatric HIV and Sepsis on a Pediatric Surgery Ward in Uganda: A Prospective Study Standardizing HIV Testing and Sepsis Resuscitation and Treatment Algorithm to Guide Clinical Care
REFNo: HS5416ES

Main Objective 1. The general objective of this project is to determine the prevalence of sepsis, the underlying etiologies leading to sepsis, and the prevalence of HIV among patients with sepsis on the pediatric surgery ward at Mulago hospital. Additionally, our objective is to implement the 2020 surviving sepsis campaign guidelines on the pediatric surgery ward at Mulago Hospital. Specific Objectives 1. We will identify the etiologies leading to sepsis on the pediatric surgery ward at Mulago Hospital by examining the underlying pathologies in patients diagnosed with sepsis over a period of 7 months 2. We will determine the prevalence of HIV among patients with sepsis on the pediatric surgery ward at Mulago Hospital by testing patients with sepsis for HIV over a period of 7 months 3. We will implement the 2020 Surviving Sepsis Campaign Guidelines on the pediatric surgery ward at Mulago Hospital over a period of 1 month 4. We will determine the prevalence of sepsis on the pediatric surgery ward at Mulago Hospital by tracking patients diagnosed with sepsis over a period of 7 months
 USA 2024-12-23 11:05:56 2027-12-23 Medical and Health Sciences Non-Clinical Trial Non-degree Award
SIYA AGGREY
ID: UNCST-2019-R001737
 WATER HYACINTH’S EXTENT ON FRESHWATER SITES WITHIN QUEEN ELIZABETH NATIONAL PARK, UGANDA; IMPLICATIONS ON WATER QUALITY AND WILDLIFE HEALTH
REFNo: NS894ES

i) To assess the spatial extent and distribution of Water hyacinth (Pontederia crassipes) in Lake Edward, Lake George and the Kazinga Channel
ii) To examine the determinants of Water hyacinth (Pontederia crassipes) distribution within Lake Edward, Lake George and the Kazinga Channel
iii) To assess impact of Water hyacinth (Pontederia crassipes) on water quality within Lake Edward, Lake George and the Kazinga Channel
iv) To analyze policies that would support management of Water hyacinth (Pontederia crassipes) invasion within Lake Edward, Lake George and the Kazinga Channel.

 Uganda 2024-12-23 11:03:12 2027-12-23 Natural Sciences Non-Clinical Trial Non-degree Award
Solomon Kibudde
ID: UNCST-2021-R013747
 PHASE II RANDOMIZED NON-INFERIORITY TRIAL OF HYPOFRACTIONATED RADIOTHERAPY FOR LOCALLY ADVANCED CERVICAL CANCER IN UGANDA.
REFNo: HS5348ES

1) To compare the incidence of grade 3+ gastrointestinal and genitourinary toxicity at 1 year post-treatment with hypofractionated radiotherapy (40 Gy in 16 fractions) and conventional fractionated radiotherapy (45 Gy in 25 fractions) in women with cervical cancer in Uganda.
2) To evaluate and compare local control and cervical cancer-specific survival rates at 1 year after hypofractionated radiotherapy (40 Gy in 16 fractions) versus conventional radiotherapy (45 Gy in 25 fractions).
3) To determine the association between stage-adjusted mean squamous cell carcinoma antigen (SCC-Ag) at 1-month post-treatment with the Progression-free survival at 1- year post-treatment with hypofractionated radiotherapy (40 Gy in 16 fractions) or conventionally fractionated radiotherapy (45 Gy in 25 fractions).
4) To compare the costs of healthcare to patients with cervical cancer treated with hypofractionated radiotherapy (40 Gy in 16 fractions) versus conventional fractionated radiotherapy (45 Gy in 25 fractions).
5) To evaluate patient-reported outcomes and quality of life in patients with cervical cancer treated with hypofractionated radiotherapy (40 Gy in 16 fractions) versus conventional fractionated radiotherapy (45 Gy in 25 fractions).

 Uganda 2024-12-23 11:01:22 2027-12-23 Medical and Health Sciences Clinical Trial Degree Award
Pauline Byakika-Kibwika
ID: UNCST-2019-R001206
 Investigation of mpox transmission, disease sequel, and molecular epidemiology in Uganda (Mpoxep)
REFNo: HS5387ES

Primary Objectives
1. To characterize the socio-demographic, clinical, immunological, and virologic epidemiology of Mpox cases in Uganda.
2. To describe the natural history and asymptomatic transmission dynamics of Mpox among contacts.
3. To assess risk factors for clinical hospitalization, ICU admission, and fatal Mpox outcomes.
4. To investigate long-term sequelae among Mpox survivors.

Secondary Objectives
1. To determine the incidence and prevalence of Mpox among high-risk populations (long-distance truck drivers, commercial sex workers, refugees, and PLHA).
2. To assess infection risk and asymptomatic transmission using serology among contacts.
3. To identify risk factors for infection among ‘de novo’ cases with no documented epidemiological link.
4. To explore socio-anthropological factors influencing Mpox transmission, prevention, and care-seeking behavior.
5. To identify potential animal reservoirs of MPXV in Uganda.
6. To describe histopathologic features of Mpox skin lesions and localization of MPXV in different body organs and tissues.

 Uganda 2024-12-23 10:56:56 2027-12-23 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Wycliff Odude
ID: UNCST-2024-R002431
 Small-scale field evaluation of the efficacy, residual activity and acceptability of Sovrenta® 15WP against Malaria Vectors in Adjumani district, West Nile, Uganda.
REFNo: HS5300ES

1. To determine the susceptibility levels of both wild-type and Kisumu strain malaria vectors to Sovrenta® 15WP insecticide in Adjumani District, West Nile, Uganda.
2. To determine the comparative residual activity of Sovrenta® 15WP and Actellic 300CS insecticides on common wall-type surfaces in Adjumani, West Nile, Uganda over 10 months.
3. To generate specific information related to the acceptability of Sovrenta® 15WP insecticide as a new product by the community in Adjumani, West Nile, Uganda.
4. To assess the ease of use of the Sovrenta by the spray operators under field conditions in Adjumani District, West Nile, Uganda.

Uganda 2024-12-10 16:05:33 2027-12-10 Medical and Health Sciences Non-Clinical Trial Non-degree Award
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