Francis Ssali
ID: UNCST-2021-R012134
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A5409: A Phase 2 Randomized, Adaptive, Dose-Ranging, Open-Label Trial of Novel Regimens for the Treatment of Pulmonary Tuberculosis (RAD-TB)
REFNo: HS4036ES
1.2 Primary Objectives
1.2.1 To compare MGIT liquid culture TTP slope over the first 6 weeks of treatment for each experimental treatment arm to the SOC arm.
1.2.2 To compare new Grade 3 or higher adverse events (AEs) (safety) over the first 8 weeks of treatment for each experimental treatment arm to the SOC arm.
1.3 Secondary Objectives
1.3.1 To compare time to stable culture conversion by MGIT liquid culture by week 8 for each experimental treatment arm to the SOC arm.
1.3.2 To compare MGIT liquid culture TTP slope over the first 8 weeks of treatment for each experimental treatment arm to the SOC arm.
1.3.3 To compare new Grade 3 or higher AEs (safety) over 26 weeks of treatment for each experimental treatment arm to the SOC arm.
1.3.4 To compare discontinuations of anti-TB drugs for any reason prior to 8 and 26 weeks of treatment for each experimental treatment arm to the SOC arm.
1.3.5 To determine the dose- and exposure-response relationships between experimental drug estimated pharmacokinetic (PK) parameters with safety and efficacy.
1.3.6 To compare a composite of efficacy and safety outcomes using a risk-benefit approach for each experimental treatment arm to the SOC arm.
1.3.7 To compare MGIT liquid culture TTP slope over the first 6 weeks of treatment for Arms 3A-3B and Arms 4A-4B compared to Arm 2.
1.3.8 To compare durable cure by 52 weeks after treatment initiation in each experimental treatment arm to the SOC arm.
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Uganda |
2024-12-23 12:34:14 |
2027-12-23 |
Medical and Health Sciences |
Clinical Trial |
Non-degree Award |
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Hakimu Sseviiri
ID: UNCST-2024-R004881
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Formalizing and Elevating Workforce Visibility for Marginalized Sanitation Workers in Kampala, Uganda: Unravelling the intended and Unintended Consequences.
REFNo: SS2816ES
4. To co-design multi-stakeholder pathways towards effective formalization, integration and recognition of sanitation workers. ,3. To analyze the multi-dimensional intended and unintended impacts of formalizing and increasing the visibility of the workforce for the most marginalized workers. ,2. To identify and characterize actors involved in the formalization and visibility raising processes in Kampala city. ,1.To determine the different sanitation workers’ formalization and visibility raising initiatives overtime. ,To unravel the intended and unintended consequences of sanitation workers formalization and visibility enrichment in Kampala city, Uganda. ,
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Uganda |
2024-12-23 12:29:36 |
2027-12-23 |
Social Science and Humanities |
Non-Clinical Trial |
Non-degree Award |
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George Alaneme Uwadiegwu
ID: UNCST-2024-R003261
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ARTIFICIAL INTELLIGENCE PREDICTIVE MODELLING OF MECHANICAL AND RHEOLOGICAL PROPERTIES OF GEOPOLYMER-CONCRETE MADE FROM BLENDED BAGASSE AND BANANA-PEEL-ASH
REFNo: SIR365ES
i. To characterize Bagasse ash (BA) and Banana peel ash (BPA) as a geopolymer precursor
ii. To ascertain the optimal combination of the concrete mixture incorporating Bagasse ash (BA) and Banana peel ash (BPA) to replace ordinary Portland cement.
iii. To determine the mechanical and rheological properties of Bagasse ash (BA) and Banana peel ash (BPA) and blended geopolymer concrete matrix.
iv. To develop soft computing predictive models of ANN, GEP and ANFIS to explore the relationships between the Alkalis-activated binder blend and the rheological and mechanical strength response.
v. To compare and validate the models developed in (iv).
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Nigeria |
2024-12-23 12:28:18 |
2027-12-23 |
Engineering and Technology |
Non-Clinical Trial |
Degree Award |
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Sarah Wambete Namee
ID: UNCST-2024-R003551
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Effectiveness Of A Health Belief Model (HBM)-Based Educational Intervention On Tuberculosis (TB) Treatment Adherence Among Tb Patients In Two Hospitals In Kampala, Uganda: A Randomized Control Trial
REFNo: HS4558ES
To assess the effectiveness of a Health Belief Model (HBM)-based educational intervention on TB treatment Adherence level among TB patients in two hospitals in Kampala, Uganda.
1.To assess the level of TB knowledge among TB patients in two hospitals in Kampala, Uganda.
2.To assess the health beliefs of TB patients towards tuberculosis in two hospitals in Kampala, Uganda
3.To assess the quality of life of TB patients in two hospitals in Kampala, Uganda.
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Uganda |
2024-12-23 12:26:18 |
2027-12-23 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
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Christine Piloya Ruth
ID: UNCST-2024-R003592
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Patriarchy and Women Engagement in Environmental Conservation in Northern Uganda: A Case of Gulu District
REFNo: SS2986ES
4. To propose a framework or a model for effective engagement of women in environmental conservation in patriarchal societies.,3. To establish the effectiveness of the strategies used by stakeholders in fostering women’s engagement in environmental conservation within a patriarchal setting in Gulu district.,2. To investigate the extent to which the distinguishing features of patriarchy affect women’s engagement in environmental conservation in Gulu district.,1. To examine in context, the socio-cultural roles performed by women in environmental conservation within the patriarchal structure in Gulu district. ,To examine the extent to which patriarchy affects women\'s engagement in environmental conservation in Gulu district.,
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Uganda |
2024-12-23 12:24:42 |
2027-12-23 |
Social Science and Humanities |
Non-Clinical Trial |
Degree Award |
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Henry Mugerwa
ID: UNCST-2019-R000420
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A Phase 1b, Age De-Escalation/Dose Escalation Trial to Evaluate Safety, Tolerability, and Pharmacokinetics of MAM01 in an African Population of Adults and Children in a Setting of Perennial Malaria Transmission
REFNo: HS5298ES
Primary Objective.
To assess the safety and tolerability of MAM01.
Secondary Objectives.
To assess the safety of MAM01.
To characterize the PK of MAM01 following SC, IV, and IM administration of MAM01.
To assess the formation of anti-drug antibodies (ADAs) to MAM01.
Exploratory Objectives.
To assess the protective efficacy of a single dose of MAM01 over 182 days against Pf infection, as detected by blood smear microscopy compared to a placebo.
To assess the protective efficacy of a single dose of MAM01 over 182 days against Pf infection, as detected by blood smear microscopy compared to placebo.
To assess the protection of MAM01 against events of malaria illness (first/only and all episodes).
To correlate MAM01 concentration with Pf infection risk.
To assess the complexity of Pf infection following administration of MAM01 or placebo.
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Uganda |
2024-12-23 12:23:27 |
2027-12-23 |
Medical and Health Sciences |
Clinical Trial |
Non-degree Award |
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Eleanor Namusoke Magongo
ID: UNCST-2021-R013199
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Outcome Evaluation of the Young People and Adolescent Peer Support (YAPS) program Implementation in Uganda
REFNo: HS4809ES
1. To assess fidelity of the YAPS program implementation by different stakeholders (MoH, Implementing Partners, Districts, Facilities, and YAPS personnel)
2. To establish the effect of the YAPS program on the clinical cascade for Adolescents and Young People Living with HIV.
3. To explore perspectives of YAPS and other stakeholders on the effectiveness of the YAPS program.
4. To estimate the incremental costs of implementing the YAPS model at the different levels of implementation (National, District and health facility)
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Uganda |
2024-12-23 12:17:40 |
2027-12-23 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
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DANLADI MAKERI
ID: UNCST-2024-R005300
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Characterization of Staphylococcus aureus Isolated from Foot Ulcers of Diabetic Patients Attending Kampala International University Teaching Hospital, Bushenyi District, Uganda
REFNo: HS4836ES
v. To determine the molecular phylogeny of Staphylococcus aureus isolated from foot ulcers of Diabetic patients attending Kampala International University Teaching Hospital Bushenyi district, Uganda,iv. To determine the antibiogram profile of Staphylococcus aureus isolated from foot ulcers of Diabetic patients attending Kampala International University Teaching Hospital Bushenyi district, Uganda,iii. To assess the phenotypic distribution of Staphylococcus aureus in foot ulcers of Diabetic patients attending Kampala International University Teaching Hospital Bushenyi district, Uganda.,ii. To determine factors associated with diabetic foot infections among Diabetic patients with foot ulcers attending Kampala International University Teaching Hospital Bushenyi district, Uganda ,i. To determine the prevalence of diabetic foot infection among Diabetic patients with foot ulcers attending Kampala International University Teaching Hospital Bushenyi district, Uganda,To characterize Staphylococcus aureus isolated from foot ulcers of Diabetic patients attending Kampala International University Teaching Hospital Bushenyi district, Uganda ,
|
Nigeria |
2024-12-23 12:15:59 |
2027-12-23 |
Medical and Health Sciences |
Non-Clinical Trial |
Degree Award |
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Francis Omujal
ID: UNCST-2019-R000428
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DOCUMENTATION OF BATWA INDIGENOUS PEOPLE AND LOCAL COMMUNITIES’ KNOWLEDGE FOR BIO-PROSPECTING FOR THERAPEUTICS PRODUCTS
REFNo: NS658ES
c) To identify priority natural medicinal resources that can be used by BIP for development of therapeutic products for specific diseases ,b) To assess the availability status of medicinal resources used for TMK by the BIP,a) To document the traditional medicine practices of the BIP,To document TMK of the Batwa indigenous people for the development of therapeutic products.,
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Uganda |
2024-12-23 12:14:59 |
2027-12-23 |
Natural Sciences |
Non-Clinical Trial |
Non-degree Award |
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Edgar Mulogo Mugema
ID: UNCST-2023-R008170
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Epidemiology of pediatric severe malaria in the Kasese District of western Uganda
REFNo: HS5367ES
Study Objectives
The overarching goal of this proposed project is to describe the epidemiology of severe malaria among children in the Kasese District of western Uganda. Our scientific objective is to determine if the demographic, clinical, and laboratory characteristics of children admitted to a more urban level IV health center are different from our previous findings at a rural level III health center. To test this hypothesis, we propose to:
AIM 1: Describe the demographic characteristics of children admitted to SPHC with a diagnosis of malaria. We will conduct a prospective, observational study, enrolling children admitted to the IPD. Participating caregivers will complete a questionnaire documenting basic demographic factors as well as information about the household (e.g., location, LLIN access and use). We hypothesize that most children will be (i) <12 years of age, (ii) from areas within 20km of SPHC, and (iii) have previously sought care at lower-level facilities.
AIM 2: Document the clinical and laboratory characteristics of children admitted to SPHC with a diagnosis of malaria: We will elicit a history of illness from the caregiver and record relevant information including vital signs, results of laboratory testing (e.g., malaria RDT, hemoglobin, etc.), along with treatments administered during the hospitalization. We hypothesize that nearly all children will receive ≥24 hours of intravenous artesunate, but there may be substantial variation in dosing.
AIM 3: Estimate measures of severe malaria incidence and associated morbidity and mortality among children presenting to SPHC with malaria. We will record the results of laboratory testing for malaria in the OPD to determine the malaria positivity rate and incidence of SM (i.e., proportion with a positive RDT who are admitted). Among those who are admitted, we will document disposition (e.g., discharge, transfer, death) and complete follow up at 14, 30, 45, and 60 days post-discharge. We hypothesize that mortality will be greatest among children referred from lower-level facilities and those with delayed presentations
|
Uganda |
2024-12-23 12:12:56 |
2027-12-23 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
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