Jedediah Silver
ID: UNCST-2023-R007939
|
The Effects of Cassava Drying Technology on Commercialization and Consumption Smoothing
REFNo: SS1700ES
The main goals of the pilot RCT are to ascertain the technical efficiency of the machines, the viability of the model where agents operate the machines and charge a fee for drying, and to observe how harvest and sales timing, consumption and cropping decisions change when farmers gain access to drying technology. In addition, we will explore additional mechanisms including varying the contract structure, and getting a sense of which channels are most salient to focus on (e.g. how likely we would be to detect effects on intertemporal smoothing beyond addressing the barriers to adoption to a seemingly profitable technology).
|
USA |
2023-04-20 21:05:53 |
2026-04-20 |
Social Science and Humanities |
Non-Clinical Trial |
Non-degree Award |
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Beatrice Onyango Ekesa
ID:
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Bio-efficacy of Pro-Vitamin A-rich banana to improve vitamin A status among children in Uganda living in an area with a high burden of inflammation
REFNo: HS2721ES
3. Establish the stability of retinol isotopes on DSS at room temperature in the determination of TBS of vitamin A.,2. Assess the effect of inflammation and nutritional status on vitamin A absorption and TBS assessment among school-aged Ugandan children.,1. Determine the bio-efficacy of carotenoids in Pro-Vitamin A rich bananas in improving TBS in children aged 6-14years.,This study will determine the bio-efficacy of carotenoids in Pro-Vitamin A-rich banana-based diets and their potential in improving the vitamin A body stores by the RID technique among school-going children aged 6-14years living in Tororo district, an area with a high burden of inflammation.,
|
Kenya |
2023-04-19 12:44:24 |
2026-04-19 |
Medical and Health Sciences |
Clinical Trial |
Non-degree Award |
|
Bernard Muhangi Wakabi
ID:
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Managerial competences and performance of Microfinance Institutions in Uganda
REFNo: SS1693ES
iii. To establish the moderating effect of stakeholder management on the relationship between managerial competencies and financial performance of MFIs in Uganda.,ii. To examine the mediating effect of competitive advantage in the relationship between managerial competencies and financial performance of MFIs in Uganda.,i. To examine the relationship between managerial competencies and financial performance of MFIs in Uganda.,The study will examine the relationship between managerial competencies and financial performance while examining the mediating effect of competitive advantage and stakeholder management's moderating effect in the relationship between managerial competencies and financial performance of MFIs in Uganda.,
|
Uganda |
2023-04-19 12:41:29 |
2026-04-19 |
Social Science and Humanities |
Non-Clinical Trial |
Degree Award |
|
Violet Gwokyalya
ID: UNCST-2022-R010490
|
An Evaluation Study of Oral PrEP Delivery Models in Uganda
REFNo: HS2734ES
Primary Objectives
1. To document Oral PrEP delivery models currently in use in Uganda.
2. To establish the contribution of the various Oral PrEP delivery models to uptake of PrEP.
3. To establish the contribution of the various Oral PrEP delivery models to continuity of PrEP.
4. To establish the costs involved in implementing different PrEP delivery models in Uganda.
5. To document the best practices from the different PrEP Delivery models and the recommendations for promoting efficient and sustainable PrEP services.
Secondary objective.
To establish the feasibility of injectable PrEP delivery in Uganda
|
Uganda |
2023-04-19 12:27:39 |
2026-04-19 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
|
Rosalind Parkes-Ratanshi Parkes
ID: UNCST-2019-R000717
|
A pilot etiological study of genital ulcer disease in Uganda, including the burden of macrolide resistant T pallidum
REFNo: HS2728ES
-To determine the proportion of genital ulcers caused by syphilis compared with other causes of genital ulcer disease in a contemporary Ugandan setting.
-To determine the proportion of T pal isolates with evidence of macrolide resistance markers.
-To determine agreement between clinical diagnosis and treatment compared with laboratory diagnosis of GUD.
-To determine agreement between GUD PCR result and serological markers of infection including POCT and lab-based assays.
-To develop a library of GUD pictures stratified by microbiological diagnosis.
|
UK |
2023-04-19 12:17:44 |
2026-04-19 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
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GODFREY TUMUHAISE
ID:
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Rapid Assessment of Avoidable blindness /Disability in the Northern, Eastern and Western Regions of Uganda in people aged 50 Years and above
REFNo: SS1695ES
• To determine the causes of blindness and VI.,• To explore the relationship between disability and socio-economic status and eye health,To determine the prevalence of disability among the study population. ,• To assess factors affecting access to cataract surgical services by determining cataract surgical coverage.,• To determine the prevalence and distribution of blindness and VI in the study population.,To estimate the prevalence and causes of blindness and visual impairment among people aged ≥50 years in Uganda.,
|
Uganda |
2023-04-19 12:14:06 |
2026-04-19 |
Social Science and Humanities |
|
Non-degree Award |
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Carolyne Akello Agwau
ID: UNCST-2021-R013375
|
The CATALYST Study: Catalyzing access to new prevention products to stop HIV
REFNo: HS2801ES
The overall goal of the study is to characterize and assess the implementation of an enhanced service delivery package providing choice of PrEP products among women at PEPFAR/USAID delivery sites in Kenya, Lesotho, South Africa, Uganda, and Zimbabwe.
The study has three primary objectives:
Objective 1: Characterize the implementation of the enhanced service delivery package for informed PrEP choice for women in PEPFAR/USAID public health service delivery sites and assess individual-, provider-, facility-, community-, and health system-level facilitators of and barriers to the implementation process. (Achieved through process evaluation, and nested costing and community acceptance studies)
Objective 2: Describe patterns of PrEP use and use effectiveness in the context of informed PrEP choice and assess sociodemographic and contraceptive use correlates of PrEP use patterns. (Achieved through cohort and nested PEU study)
Objective 3: Describe clinically relevant indicators among PrEP users, including rates of HIV infection and drug resistance among PrEP users who acquire HIV following PrEP initiation or had undetected HIV prior to PrEP initiation. (Achieved through cohort, including CAB HIV testing algorithm nested study)
|
Uganda |
2023-04-13 16:51:59 |
2026-04-13 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
|
Pontiano Kaleebu
ID: UNCST-2020-R019901
|
Field Evaluation of National HIV Testing Services Algorithm
REFNo: HS2701ES
Main Objective
To determine the appropriate HIV rapid test algorithm to be used in Uganda considering the new kits on the market.
Specific objectives
1. To assess specificity, sensitivity, negative predictive value (NPV), positive predictive value (PPV) of the rapid HIV tests on the market in Uganda and come up with best RDT algorithm.
2. To identify an algorithm that will best identify acute HIV infections
3. To determine the inter-observer and inter-lab agreement in HIV diagnosis using evaluated RDTs.
|
Uganda |
2023-04-12 15:44:58 |
2026-04-12 |
Medical and Health Sciences |
Clinical Trial |
Non-degree Award |
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STUART TURANZOMWE
ID:
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PREVALENCE, SEVERITY AND FACTORS ASSOCIATED WITH ANAEMIA AMONG WOMEN WITH CERVICAL CANCER AT MBARARA REGIONAL REFERRAL HOSPITAL
REFNo: HS2749ES
To determine the factors associated with anaemia among women with cervical cancer at Mbarara Regional Referral Hospital,To describe the severity of anaemia among women with cervical cancer at Mbarara Regional Referral Hospital,To determine the prevalence of anaemia among women with cervical cancer at Mbarara Regional Referral Hospital,To determine the prevalence, severity and factors associated with anaemia among women with cervical cancer at Mbarara Regional Referral Hospital,
|
Uganda |
2023-04-12 14:46:12 |
2026-04-12 |
Medical and Health Sciences |
Non-Clinical Trial |
Degree Award |
|
Samuel Kawuma
ID:
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Facilitators and barriers to retention on Pre-exposure prophylaxis (PrEP) among Female Sex Workers attending Kiruddu National Referral Hospital.
REFNo: HS2771ES
1. To identify the implementation gaps along the Pre-Exposure Prophylaxis continuum of care and assess the factors associated factors with retention on PrEP among FSWs at Kiruddu National referral Hospital.,To design a stakeholder informed evidence-based intervention to improve retention on PrEP among FSWs at Kiruddu National Referral Hospital ,2. To determine the facilitators and barriers of retention on PrEP among FSWs in care at Kiruddu National referral Hospital.,
|
Uganda |
2023-04-12 14:43:04 |
2026-04-12 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
|
Francis Ssali
ID: UNCST-2021-R012134
|
Protocol A5394: “Safety, Tolerability, and Impact of Oral TLR8 Agonist Selgantolimod on HBsAg in Participants with both Chronic Hepatitis B and HIV” Version 1.0, May 27, 2022
REFNo: HS2647ES
1.2 Primary Objectives
1.2.1 To assess the safety and tolerability of treatment with SLGN administered once weekly by mouth for 24 weeks.
1.2.2 To determine the proportion of participants with ≥1 log10 IU/mL decline in quantitative HBsAg (qHBsAg) after SLGN treatment at Week 24.
1.3 Secondary Objectives
1.3.1 To determine the proportion of participants with ≥1 log10 IU/mL decline in qHBsAg at any time during the study after SLGN treatment initiation.
1.3.2 To determine the proportion of participants with ≥0.5 log10 IU/mL decline in qHBsAg after SLGN treatment at Week 24.
1.3.3 To determine the proportion of participants with ≥0.5 log10 IU/mL decline in qHBsAg at any time during the study after SLGN treatment initiation.
1.3.4 To evaluate the proportion of participants who achieve HBsAg loss after SLGN initiation and who sustain HBsAg loss during follow-up.
1.3.5 To evaluate changes in qHBsAg levels at Weeks 4, 12, 24, 36, and 48 after SLGN initiation and, separately, among the placebo recipients.
1.3.6 To determine the proportion of HBeAg positive participants at baseline who lose HBeAg at any time during the study, by study arm.
1.3.7 To determine the proportion of anti-HBe negative participants at baseline who develop anti-HBe at any time during the study, by study arm.
1.3.8 To determine the proportion of hepatitis B surface antibody (anti-HBs) negative participants at baseline who develop anti-HBs at any time during the study, by study arm.
1.3.9 To evaluate levels of circulating cytokines, including IFN-gamma, IL-12p40, IL-1RA, and CD163 at entry, 24 hours post-first study drug dose, Weeks 4, 12, 24, 36, and 48, by study arm.
1.3.10 To determine whether administration of SLGN will perturb HIV latency as measured by an increase in HIV transcription.
1.3.11 To determine whether administration of SLGN will decrease the size of the latent reservoir, as measured by the change in amount of cell-associated unspliced HIV RNA, HIV DNA, replication-competent and/or intact virus at Weeks 2, 4, 24, and 48.
1.4 Exploratory Objectives
1.4.1 To define the pharmacokinetic (PK) profile and PK-pharmacodynamic (PD) associations of SLGN in people with both HIV and CHB taking suppressive antiviral therapy for both viruses.
1.4.2 To explore if SLGN and antiretroviral (ARV) PK are altered when administered together.
1.4.3 To evaluate participants’ adherence by using several tools, including self-report, directly observed therapy (DOT), and drug concentrations.
1.4.4 To compare quantitative changes in experimental measures of HBV antiviral efficacy (including HBV RNA, hepatitis B core related antigen [HBcrAg], qHBeAg, and low positive HBsAg measured with a high sensitivity qHBsAg assay [LLOQ of 0.05 IU/mL]) and measure changes in large, medium, and small HBsAg isoforms from baseline during and after treatment.
1.4.5 To determine the immunological effects of SLGN on circulating immune signaling by performing single cell RNA sequencing using peripheral blood mononuclear cells (PBMCs) and evaluating HIV-specific T-cell responses.
1.4.6 To determine the effects on circulating immune cells, including cellular phenotypes and T and B-cell responses.
1.4.7 To determine whether administration of SLGN will affect levels of circulating cytokines, including TNF-alpha, IL-12, IL18, IP-10, ISG15, IL-21, Fas Ligand, and TRAIL.
|
Uganda |
2023-04-12 14:38:49 |
2026-04-12 |
Medical and Health Sciences |
Clinical Trial |
Non-degree Award |
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Alex Mwesigwa
ID:
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P. falciparum genetic diversity, multiplicity of infection, gametocytaemia and recrudescence in areas of varied malaria transmission intensity in Uganda.
REFNo: HS2744ES
1. To compare the genetic diversity and multiplicity of P. falciparum infections in areas of varied malaria transmission intensity in Uganda.
2. To evaluate the relationship between malaria severity and P. falciparum genetic diversity, multiplicity of infection among patients living in areas of varied malaria transmission intensity in Uganda.
3. To investigate the temporal and seasonality changes in P. falciparum genetic diversity and multiplicity of infection among patients with malaria infection living in areas of varied malaria transmission intensity in Uganda.
4. To evaluate the performance of microsatellites in differentiating P. falciparum recrudescence from new infections.
|
Uganda |
2023-04-12 14:27:32 |
2026-04-12 |
Medical and Health Sciences |
Non-Clinical Trial |
Degree Award |
|
Jane Frances Zalwango
ID:
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Etiopathogenesis of Blackwater Fever in Budaka District, Uganda: a pilot study
REFNo: HS2752ES
a)To explore the aetiology of BWF in Budaka District
b)To identify therapeutic interventions for the treatment of BWF
|
Uganda |
2023-04-12 14:23:40 |
2026-04-12 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
|
Elizeus Rutebemberwa
ID: UNCST-2022-R009070
|
Evaluation of a Community Health Entrepreneur model in rural Uganda
REFNo: HS2196ES
4.3 General objective
To explore the role, reach, and scalability of CHE programme as a social franchise approach to address the issue of access to healthcare and potential embedment of the programme in the larger health system.
4.4 Specific objectives
1. To investigate health care seeking behaviour of residents in rural communities in Uganda, in order to assess community access, choice and use of health (care) services, service availability and quality, and experience of health care of households in villages in Uganda
2. To investigate the strengths and weaknesses of a CHE programme in communities which already have adopted this programme and the potential added value of a strengthened community health system by a CHE programme in communities without this programme
3. To investigate multi-stakeholder perceptions on the functioning, potential scale-up, and the possibility of integration of a social franchise approach in the larger health system in Uganda
|
Uganda |
2023-04-12 14:20:54 |
2026-04-12 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
|
Isaac Ssewanyana
ID: UNCST-2020-R014336
|
Protocol for the establishment of clinical specimen panel for WHO Prequalification performance evaluation of HIV serology assays
REFNo: HS2786ES
To establish an HIV specimen repository at ITM.,To register the specimens into a Biobank at ITM; ,To characterize the specimens for HIV and syphilis serostatus using standardized reference assays and algorithms at ITM;,To collect biological specimens from patients with known HIV serostatus or blood donors from different regions of the world to establish a WHO HIV specimen evaluation panel that will be used for the laboratory performance evaluation of HIV serology assays undergoing WHO prequalification assessment; ,The overall objective is to assemble a new WHO HIV specimen evaluation panel in collaboration with PELs and collaborating centers, which will be made accessible on demand to all the PELs conducting HIV or dual HIV-syphilis serology test evaluations for WHO prequalification.,
|
Uganda |
2023-04-12 12:56:08 |
2026-04-12 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
|
Edgar Mulogo Mugema
ID: UNCST-2023-R008170
|
Environmental Drivers of Pediatric Postinfectious Hydrocephalus in Western Uganda: Case-Control Study
REFNo: HS2699ES
The overarching objective of the study is to elucidate potential factors that underlie the ecological correlation between precipitation and PIH. Identification of these environmental intermediaries may elucidate potential targets for intervention to reduce the incidence of PIH.,
|
Uganda |
2023-04-11 15:42:30 |
2026-04-11 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
|
Bruce Kirenga J
ID: UNCST-2019-R001460
|
A multiple arm, multiple stage (MAMS), phase 2B/C, open label, randomized, controlled platform trial to evaluate experimental arms including an increased dose of rifampicin, an optimized dose of pyrazinamide, moxifloxacin and sutezolid, in adult subjects with newly diagnosed, smear-positive pulmonary tuberculosis
REFNo: HS2644ES
Primary Efficacy Objective:
Rifampicin- containing experimental arms (arms 1,2)
To evaluate whether one or more of two experimental regimens based on
optimized dose rifampicin, optimized dose of pyrazinamide, and moxifloxacin
given for 12, respectively 17 weeks, are superior to standard treatment given for
26 weeks, as assessed by time to sputum culture conversion to negative in liquid
media.
Sutezolid-containing experimental arm (arm 4)
To evaluate whether the efficacy of an experimental regimen composed of
sutezolid, delamanid, bedaquiline, and moxifloxacin given for 17 weeks is
superior to standard treatment given for 26 weeks, as assessed by time to
sputum culture conversion to negative in liquid media.
Secondary Objectives This study’s secondary objectives are:
Efficacy
To assess treatment efficacy based on proportion of patients with relapse
free outcome at 12 months after randomization.
To assess treatment efficacy based on the rate of decline of bacterial load
measured by the Molecular Bacterial Load Assay
To rank the relative efficacy of the experimental four-drug combinations
for the treatment of pulmonary tuberculosis within the first twelve weeks
of treatment, and select the most efficient experimental treatment
regimen or regimens for further development.
Safety and Tolerability
To assess the frequency, severity, and type of adverse events (AEs), and AErelated
treatment discontinuations.
Pharmacokinetics
To describe the pharmacokinetics of the drugs and doses used, and to assess
possible relationships between pharmacokinetic parameters of the various drugs and between pharmacokinetic parameters and participant characteristics.
Pharmacodynamics To describe relationships between pharmacokinetic parameters on the one hand and efficacy and safety endpoints on the other hand.
|
Uganda |
2023-04-11 15:27:11 |
2026-04-11 |
Medical and Health Sciences |
Clinical Trial |
Non-degree Award |
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Andrew Muhumuza
ID: UNCST-2022-R009010
|
Incidence and predictors of castration resistance among patients with prostate cancer on androgen deprivation therapy at two referral hospitals in Uganda
REFNo: HS2759ES
To identify the predictors of castration resistance among prostate cancer patients on ADT at Mbarara Referral Hospital oncology unit and Uganda cancer Institute, Mulago National Referral Hospital. ,To determine the incidence of castration resistance among patients with prostate cancer on ADT at Mbarara Referral Hospital oncology unit and Uganda cancer Institute, Mulago National Referral Hospital.,To determine the incidence and predictors of castration resistance among prostate cancer patients on ADT at Mbarara Referral Hospital oncology unit and Uganda cancer Institute, Mulago National Referral Hospital.,
|
Uganda |
2023-04-11 14:20:29 |
2026-04-11 |
Medical and Health Sciences |
Non-Clinical Trial |
Degree Award |
|
SAM ALI
ID: UNCST-2020-R014824
|
Stillbirth in High Burden Settings: Ample Room for Improvement using Biomarkers and Ultrasound Technologies (iTECH)
REFNo: HS2762ES
1. To evaluate the relation between placental histopathological lesions and biomarkers, placenta ultrasound and hemodynamic changes after stillbirth and near miss stillbirth in order to understand the underlying mechanisms and specify the prediction model.
2. To engage with important stakeholders on the value of these diagnostic technologies in the community, co-creating the project design, implementation and eventual uptake into practice guidelines.
3. To establish the predictive performance of maternal characteristics and markers emerging from this project for stillbirth and other related endpoints in non-anomalous fetuses and assess the feasibility of integrating relevant markers into clinical decision support tools.
4. To prospectively evaluate patterns of (bio)markers, maternal cardiovascular function and contemporary ultrasound markers in pregnancy, to understand their role in the chain of events and pathophysiology of stillbirth in a resource poor setting.
5. To develop and validate a prediction model for use at the point of care in low-and middle-incomes countries (LMICs) to quantify a woman’s individual risk of antepartum stillbirth based on a set of easily measurable, accessible, highly predictive and cost-effective markers, and make it freely available for healthcare providers in low-resource settings.
|
Uganda |
2023-04-06 8:06:27 |
2026-04-06 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
|
Juliana Namutundu
ID:
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IMPROVING CERVICAL CANCER SCREENING LITERACY AMONG HIV-INFECTED WOMEN IN CARE AT RURAL PUBLIC HEALTH FACILITIES IN EAST CENTRAL UGANDA
REFNo: HS2753ES
3) To assess the feasibility, acceptability and preliminary effectiveness of a cervical cancer screening literacy improvement implementation strategy for Women living with HIV in care at rural public health facilities in East Central Uganda.,2) To design a cervical cancer screening literacy improvement implementation strategy for Women living with HIV in care at rural public health facilities in East Central Uganda.,1) To conduct a multi-level assessment of barriers and facilitators of cervical cancer screening literacy among HIV-infected women in care at rural public health facilities in East Central Uganda.,
|
Uganda |
2023-04-05 17:05:10 |
2026-04-05 |
Medical and Health Sciences |
Non-Clinical Trial |
Degree Award |
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