Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Esau Tugume
ID: UNCST-2019-R000622
Improving the Measurement of Productivity Dispersion and Misallocation in Developing Countries
REFNo: SS1698ES

6. Generate information and knowledge required to make informed policy decisions particularly in raising the productivity of small firms. ,Determine the role of firm-to-firm interactions, either as catalysts or hindrances to growth. ,Quantify the extent of resource misallocation across firms and the role of frictions in constraining firm growth.,Evaluate the strengths and weaknesses of existing empirical approaches to measuring misallocation. ,Verify whether existing estimates of productivity and marginal product dispersion are robust to improved measurement and the accounting of firm-to-firm interactions. If not, our data will identify the source of bias,Quantify three margins of allocative efficiency of firms: (i) the within-firm allocation of inputs across products, (ii) the allocation of resources across firms located in geographical proximity to each other, i.e., that operate within informal “clusters,” as widely documented in low-income country settings, and (iii) the sector-level allocation of resources across different geographic areas (or clusters).,The primary objective of this research project is to shed light on the organization of production in low-income countries and estimate firm-product level production functions. ,
Uganda 2023-05-02 22:16:11 2026-05-02 Social Science and Humanities Non-Clinical Trial Non-degree Award
John Kellett Gale
ID:
Can continuous non-invasive monitoring of movement predict and detect clinical deterioration of hospital patients earlier and more efficiently than traditional intermittent observations?
REFNo: HS2765ES

To determine if continuously collected accelerometer data can indicate and identify clinical deterioration of acutely ill hospitalised patients before intermittently collected vital signs.
Ireland 2023-05-02 22:11:25 2026-05-02 Medical and Health Sciences Clinical Trial Non-degree Award
Stephen Pande Legesi
ID:
Sentinel Surveillance for Adverse Events of Special Interest after Vaccination with COVID-19 Vaccines-Uganda
REFNo: HS2370ES

Primary Objectives The overall aim of this surveillance protocol is to monitor the safety of COVID-19 vaccines in UGANDA in near real-time for pre-specified AESI conditions and evaluation to inform decision making to maintain public confidence in the vaccination program Specific Objective The specific objective of this evaluation is to assess the risk of pre-defined AESI following vaccination with a COVID-19 vaccine by brand. Secondary objectives 1.To strengthen Uganda’s active AEFI Surveillance system 2.To describe lessons learned from implementing active surveillance for various COVID 19 vaccine products.
Uganda 2023-05-02 22:08:38 2026-05-02 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Dorcas Mandera Agatha
ID:
Accelerating Impact for Young Women in Africa (AIM) Project Process Evaluation
REFNo: SS1644ES

- To identify contextual factors and success drivers that influence the program reach and quality,- To ascertain the effectiveness of the project from the perspective of its beneficiaries.,- To assess the viability of the intervention strategy and its feasibility as assumed in the theory of change (ToC).,This process evaluation intends to assess the implementation of the AIM project to ascertain whether it works, why it works, how it works, and its potential replicability. ,
Uganda 2023-04-28 23:54:42 2026-04-28 Social Science and Humanities Non-Clinical Trial Non-degree Award
Lawrence Osuwat Obado
ID: UNCST-2023-R008389
Assessing the Health Risk of Arsenic Burden in Human Beings and its Levels in Natural Water Sources Providing Domestic Water in Amuria District
REFNo: HS2770ES

To determine the arsenic concentration in hair samples taken from residents using water from sampled sources for domestic purposes,To determine the concentration of arsenic in the nails of residents using water from sampled sources for domestic purposes,To profile the arsenic levels of water from natural sources in areas of Amuria district in Eastern Uganda, and test for potential bioaccumulation of arsenic among the residents that use the water for domestic purposes,To determine the amount of arsenic in water collected from underground wells in Amuria District.
Uganda 2023-04-26 11:43:03 2026-04-26 Medical and Health Sciences Non-Clinical Trial Non-degree Award
SSEDYABANE FRANK
ID: UNCST-2022-R011175
ASSOCIATION OF FOXP3, P16INK4A, CMYC AND SELECTED MICRO RNA SERUM EXPRESSION WITH GRADES, TREATMENT STRATEGIES AND OUTCOMES FOR CERVICAL SQUAMOUS INTRAEPITHELIAL LESIONS
REFNo: HS2722ES

1. To determine the prevalence of Cervical Intraepithelial Neoplasia among women attending the cervical cancer clinic at Mbarara Regional Referral Hospital.
2. To establish the individual and combined accuracy of FOXP3, P16ink4a, cMYC, and selected micro RNAs (miR-205, miR-9, miR-192 and miR-21) in detection of cervical squamous intraepithelial lesions among women attending the cervical cancer clinic at Mbarara Regional Referral Hospital.
3. To determine the association between serum levels of FOXP3, P16ink4a, cMYC, and selected micro RNAs (miR-205, miR-9, miR-192 and miR-21) with grades of cervical squamous intraepithelial lesions among women attending the cervical cancer clinic at Mbarara Regional Referral Hospital.
4. To determine the relationship between follow-up serum levels of FOXP3, P16ink4a, cMYC, and selected micro RNAs (miR-205, miR-9, miR-192 and miR-21) and treatment strategies as well as outcomes (clearance, persistence or progression) of cervical squamous intraepithelial lesions among women attending the cervical cancer clinic at Mbarara Regional Referral Hospital.

Uganda 2023-04-26 11:42:24 2026-04-26 Medical and Health Sciences Non-Clinical Trial Degree Award
Ronald Moses Galiwango
ID: UNCST-2024-R015239
Assessing dynamics of heterosexual transmission of genital bacteria and coital impact on microbiome composition/stability in the female and male genital tracts in South-central Uganda
REFNo: HS2696ES

Primary objective
To elucidate the sexual transmission of genital bacteria and the determinants of the penile microbiome after sex.

Secondary objectives
A. To assess the strain variations of the triad and to characterize the different strains’ acquisition and carriage peri-coitus.
B. To identify abiotic and biotic factors from host (penile) and partner (vaginal) micro-environment that have a consistent and significant impact on penile microbiome composition.
C. To assess the short-term impact of standard anti-bacterial vaginosis (BV) treatment on the composition of the genital microbiome within heterosexual couples

Uganda 2023-04-26 11:38:48 2026-04-26 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Andrew Ssemata
ID: UNCST-2023-R008259
Transitioning from pediatric to HIV adult care services and its impact on mental health and wellbeing for young people in Kampala: A scoping review and qualitative study
REFNo: SS1687ES

i.) To identify facilitators and barriers to successful transition process (socio-cultural, behavioural and health system factors) and how this influence adherence and virologic suppression among patients on ART.
ii.) To understand the experiences of healthcare providers and caregivers in providing care and supporting retention of young people on treatment during transition from paediatric to adult clinics.

Uganda 2023-04-26 11:36:57 2026-04-26 Social Science and Humanities Non-Clinical Trial Non-degree Award
Grace Ndeezi
ID: UNCST-2019-R001802
Nutritional management of growth faltering in infants aged under six months. Study protocol for an individually randomised trial
REFNo: HS2766ES

To determine the effect of nutritional supplementation plus intensive breastfeeding support compared with intensive breastfeeding support alone on mortality, morbidity and growth in infants aged 0-6 months with growth faltering in low resource settings in South Asia and Sub-Saharan Africa.
Uganda 2023-04-26 11:15:23 2026-04-26 Medical and Health Sciences Clinical Trial Non-degree Award
Mnason Tweheyo
ID:
Baseline Study for the proposed Conservation and Rural Enterprise (CARE) Project in Bwindi Impenetrable National Park and Budongo Central Forest Reserve
REFNo: SS1703ES

The key objectives of the baseline survey include:

a) Identifying and tracking indicators that enable the assessment of a potential relationship between:
 The proposed interventions of the CARE project, namely the development and launch of a luxury eco lodge and establishment of supporting small to medium enterprises in the Bwindi and Budongo areas and;
 The status of social and economic wellbeing and environmental conservation in this region.
b) Tracking changes to social and economic wellbeing over the 18-month grant period.
c) Tracking the CARE project’s interventions in economic opportunities, such as the creation of small to medium enterprises, trainings offered, employees hired, wages and income earned.
d) Tracking the CARE project’s interventions in environmental sustainability and conservation, such as alternative fuel provision, replantings, environmental education and conservation training courses, and wildlife corridor development.
e) Comparing economic and environmental interventions to changes in social and economic wellbeing, as well as changes in the region’s environment.
f) Collecting baseline data on the identified indicators through surveys and earth observation imagery. This indicator data will be able to be collected again at the culmination of the research collaborative analysis period in 18 months, and indicators should be capable of being tracked again, in the future, in the possible eventuality of a longer-term research project.
g) Using the indicator data to develop a generalizable toolkit for the joint improvement of social and economic wellbeing and environmental conservation, which can be adapted to other rural contexts.


Uganda 2023-04-26 11:13:44 2026-04-26 Social Science and Humanities Non-Clinical Trial Non-degree Award
Rhoda Wanyenze
ID: UNCST-2021-R013352
GENDER EQUALITY AND WOMEN LEADERSHIP IN HIGHER EDUCATION IN EAST AFRICA.
REFNo: SS1672ES

General objective: To establish the prevailing landscape of gender equality in universities in East Africa. Specific objectives: (1) To assess entry and completion rates of women in selected academic programs in universities in East Africa for the period 2012-2022. (2) To establish the status of female academic staff engagement in academia and research (e.g., publishing rates) and leadership in universities in East Africa for the period 2012-2022. (3) To examine existing mechanisms for promoting gender equity and women leadership (e.g., university-wide policies, practices, services) as well as success factors, challenges and barriers to gender equality in universities in East Africa.
Uganda 2023-04-26 11:12:07 2026-04-26 Social Science and Humanities Non-Clinical Trial Non-degree Award
Abel  Kakuru
ID: UNCST-2022-R009193
The immune response to malaria within the germinal center
REFNo: HS2717ES

Comprehensively map the germinal center immune landscape during malaria infection.

Identify key cells and processes required for and/or disrupting the induction of malaria germinal center and antibody responses.

Identify key cells and processes required for germinal center and antibody induction to vaccines that are disrupted by malaria.

Identify and test drugs that can boost germinal center responses appropriate for use in malaria exposed children.

Uganda 2023-04-26 11:08:15 2026-04-26 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Michael Galvin
ID:
Improving HIV Outcomes through Collaborative Mental Health Interventions
REFNo: SS1642ES

To assess the perspectives of traditional and faith healers and biomedical mental health professionals on mental health treatment for people living with HIV/AIDS who have mental illness using a qualitative approach. We will interview 5-10 traditional healers and 5-10 faith healers over 2-4 months in early 2023. They will be recruited from the local area based on their experience working with people with HIV/AIDS and mental illness. These interviews will aid in characterizing the different conceptions of mental illness etiology and treatment strategies among both traditional healers in the African tradition and faith healers/pastors in the Christian tradition, and examine if collaboration between traditional and faith healers, and biomedical service providers can be developed to best serve people living with HIV/AIDS and improve health outcomes.,Objective 1b - To determine the characteristics of people living with HIV/AIDS and mental illness using a quantitative approach. We will collect cross sectional data on this population regarding of mental illness and HIV disease severity and duration, sociodemographics, and traditional and biomedical care history.,Objective 1a – To examine the experiences of people living with HIV/AIDS with mental illness in the Psychiatric Unit at Mbarara Hospital and traditional healer clinics using a qualitative approach. We will interview 15-25 patients living with HIV/AIDS and mental illness over 2-4 months in early 2023. They will be recruited from the psychiatric unit at Mbarara hospital. By interviewing mental health patients living with HIV, we can better understand how they view their illness, how local beliefs inform mental health care utilization, as well as their pathway to care and ultimately treatment outcomes.,To develop an intervention in which biomedical professionals collaborate with local traditional and faith healers to provide mental health services which will ultimately improve viral suppression, increase longevity, and reduce preventable morbidity and mortality.
USA 2023-04-26 11:03:04 2026-04-26 Social Science and Humanities Non-Clinical Trial Degree Award
Julian Adong
ID: UNCST-2021-R013487
An mHealth intervention to address the burden of depression and anxiety among perinatally-infected adolescents and young adults with HIV in Uganda.
REFNo: HS2691ES

Pilot U-SMART Voices among PAYWH with symptoms of anxiety and/or depression ,Adapt the group-based psychosocial mental health intervention, Sauti Ya Vijana (SYV; voice of the youth), to create the Uganda Social Media intervention to improve ART and Treatment outcomes (U-SMART)-Voices,Characterize the symptoms of depression and anxiety among PAYWH and correlation with quality of life.
Uganda 2023-04-26 10:51:31 2026-04-26 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Phiona Bukirwa
ID: UNCST-2022-R009880
Self-reported knowledge about palliative care offers and access to morphine by patients with cancer in Kyadondo County, Uganda
REFNo: HS2738ES

1. To assess patient knowledge of palliative care services. 2. To assess patient access to morphine and investigate the reasons for poor access 3. To describe the barriers to the intake of morphine,
Uganda 2023-04-26 10:44:36 2026-04-26 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Eriab Kapuru Asinja
ID: UNCST-2022-R011430
Title: Uptake of modern contraceptive methods and birth outcomes among women with caesarian sections in Kasese district, Uganda: leveraging innovative digital technology for empowering community health workers in delivering family planning services
REFNo: HS2639ES

4- To investigate the feasibility of using mobile phone health text messaging to women through CHWs and estimate the effect on contraception uptake among women in Kagando (sub-study IV),3- To explore women’s knowledge, attitudes and practices with various methods of contraception and evaluate the perceived benefits and satisfaction with contraception services, comparing those who had CS births and those who never had CS births (sub-study III),2- To estimate the frequency of repeat caesarian sections and factors associated with birth outcomes (sub-study –II).,1- To determine if CHWs can accurately document and follow households in defined geographical areas assigned to them (demographic surveillance area) using mobile phones and the feasibility of linking these data with hospital records (sub-study I).,The main objective of this study is to build the capacity of community health workers to accurately register households, including pregnant mothers and follow them with targeted health messages to improve birth outcomes,
Uganda 2023-04-26 10:40:21 2026-04-26 Medical and Health Sciences Non-Clinical Trial Degree Award
Simon Walusimbi
ID:
Impact of Tuberculosis Preventive Treatment (TPT) on Tuberculosis incidence and all-cause mortality among People Living with HIV (PLHIV) Receiving Anti-Retroviral Treatment (ART) in Uganda
REFNo: HS2772ES

To determine how long after TPT completion does TB incidence begin to rise again in patients who have completed TPT,To compare TB incidence and all-cause mortality among PLHIV who received TPT as 6-month INH versus 3HP regimen,To establish the risk factors for developing TB among PLHIV who have completed TPT,To compare TB incidence and mortality among PLHIV in Uganda who have completed TPT with PLHIV who have not completed TPT,To determine the incidence of all-cause mortality among PLHIV in Uganda who have completed TPT, at 12, 24, and 36 months of TPT completion.,To determine the incidence of newly diagnosed TB disease among PLHIV in Uganda who have completed TPT, at 12, 24, and 36 months after TPT completion,To evaluate the impact of TPT on TB incidence and all-cause mortality among PLHIV in Uganda,
Uganda 2023-04-26 10:39:06 2026-04-26 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Charles  Kajubi
ID: UNCST-2022-R008989
Baseline Study for Safe and Inclusive Cities Project -Uganda.MAKSHSREC-2022-420
REFNo: SS1582ES

To measure the long-term impact of the intervetions on the project participants and formulate recommendations for Plan International Uganda to further strengthen research.,To determine the baseline values for outcome indicators from the onset of the project.,
Uganda 2023-04-26 10:37:49 2026-04-26 Social Science and Humanities Non-Clinical Trial Non-degree Award
Patrick Muinda Emmanuel
ID:
An Information Technology Governance Framework for Improved Success of Digital Transformation Projects for Technical, Vocational Education and Training (TVET)
REFNo: SIR180ES

To test and evaluate the designed ITG Framework for Improved Success of Digital Transformation Projects in TVET institutions,To design and develop an ITG Framework for Improved Success of Digital Transformation Projects in TVET institutions,To determine the factors for improved success of Digital Transformation Projects in TVET institutions,To establish the effectiveness of Information Technology Governance applied in TVET institutions,The General Objective of this study is to develop an Information Technology Governance (ITG) framework for improved success of Digital Transformation Projects in the TVET subsector,
Uganda 2023-04-26 10:31:45 2026-04-26 Engineering and Technology Non-Clinical Trial Degree Award
ELIZABETH ASIGE
ID:
THE IMPACT AND COST-EFFECTIVENESS OF A COMMUNITY-BASED PROGRAM FOR CHILDREN WITH CEREBRAL PALSY AND THEIR CAREGIVERS AND THE STAKEHOLDERS IN UGANDA.
REFNo: HS1979ES

1. To examine the impact of a community-based program on children with CP reported frequency of participation in the home, school, and community activities. 2. To assess the impact of a community-based training program on improving caregiver knowledge regarding CP and reducing caregiver stress. 3. To determine the impact of a communication and advocacy program in broadening stakeholders’ knowledge, attitude and practices regarding childhood disability and inclusion. 4. To determine the cost-effectiveness of a community-based program on children with CP, their caregivers, and the stakeholders in relation to costs and benefits.
Uganda 2023-04-20 21:15:22 2026-04-20 Medical and Health Sciences Clinical Trial Degree Award
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