Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Noah Nyende Robert
ID: UNCST-2024-R003575
Health-Seeking Behaviour and Utilization of Sexual and Reproductive Health Services by Adolescents in Uganda: An Analysis of Attitudes, Perceptions and Preferences in The Busoga Region.
REFNo: SS3374ES

4. To assess how personal factors moderate the effect of health-seeking behaviours and the utilization of SRH services by adolescents in the Busoga region of Uganda,3. To examine the relationship between health-seeking preferences and the utilization of sexual and reproductive health (SRH) services by adolescents in the Busoga region of Uganda.,2. To explore the influence of health-seeking perceptions on the utilization of sexual and reproductive health (SRH) services by adolescents in the Busoga region of Uganda.,1. To investigate the effect of health-seeking attitudes on the utilization of sexual and reproductive health (SRH) services by adolescents in the Busoga region of Uganda.,This study aims to investigate the influence of health-seeking behaviours on the utilization of sexual and reproductive health (SRH) services by adolescents in the Busoga region of Uganda. The ultimate objective is to contribute to the creation of an evidence-based model that improves the delivery and acceptance of SRH services among adolescents in Uganda.,
Uganda 2024-11-18 13:22:16 2027-11-18 Social Science and Humanities Non-Clinical Trial Degree Award
LADY MARY KABAPAGASA
ID: UNCST-2024-R002479
DIGITAL LITERACY COMPETENCIES AND SKILLS AMONG INFORMAL SMALL-SCALE WOMEN TRADERS IN THE RWENZORI REGION, UGANDA
REFNo: SS3371ES

5. To develop a policy brief to empower informal women traders with digital literacy skills and competencies in the country.,4. To examine the support systems available to informal small-scale women traders to optimally use digital devices and platforms to enhance their businesses in Rwenzori region,3. To examine the factors that influence the use of digital devices and platforms by informal small-scale women traders to boost trade in Rwenzori region,2. To establish digital literacy competencies and skills among informal small-scale women traders that enhance their use of digital devices and platforms for trade in Rwenzori region,1. To establish the types and application of digital devices and platforms that informal small-scale women traders use to enhance performance of their trade in Rwenzori region.,To examine the digital literacy competencies and skills among informal small-scale women traders in Rwenzori region, Uganda aiming to develop a national policy brief for empowering them with relevant digital literacy competencies and skills.,
Uganda 2024-11-14 9:11:43 2027-11-14 Social Science and Humanities Non-Clinical Trial Degree Award
Deo Wabwire Ogema
ID: UNCST-2021-R013932
A Phase 2 Randomized, Adaptive, Dose-Ranging, Open-Label Trial of Novel Regimens for the Treatment of Pulmonary Tuberculosis (RAD-TB) Version 2.0, Dated 21 Mar 2024
REFNo: HS5088ES

Primary objectives

(i)To compare Mycobacterial Growth in Tube (MGIT) liquid culture Time to Positivity (TTP) slope over the first 6 weeks of treatment for each experimental treatment arm to the standard of care (SOC) arm.

(ii)To compare new Grade 3 or higher adverse events (AEs) (safety) over the first 8weeks of treatment for each experimental treatment arm to the SOC arm.

Secondary Objectives

i)To compare time to stable culture conversion by MGIT liquid culture by week 8
for each experimental treatment arm to the SOC arm.

ii)To compare MGIT liquid culture TTP slope over the first 8 weeks of treatment for
each experimental treatment arm to the SOC arm.

iii) To compare new Grade 3 or higher AEs (safety) over 26 weeks of treatment for
each experimental treatment arm to the SOC arm.

iv) To compare discontinuations of anti-TB drugs for any reason prior to 8 and 26
weeks of treatment for each experimental treatment arm to the SOC arm.

v) To determine the dose- and exposure-response relationships between experimental drug estimated pharmacokinetic (PK) parameters with safety and efficacy.
vi) To compare a composite of efficacy and safety outcomes using a risk-benefit
approach for each experimental treatment arm to the SOC arm.

vii) To compare MGIT liquid culture TTP slope over the first 6 weeks of treatment for Arms 3A-3B and Arms 4A-4B compared to Arm 2.

viii) To compare durable cure by 52 weeks after treatment initiation in each
experimental treatment arm to the SOC arm.

Uganda 2024-11-13 18:02:04 2027-11-13 Medical and Health Sciences Clinical Trial Non-degree Award
JOSAPHAT KAYOGOZA BYAMUGISHA
ID: UNCST-2019-R001680
Heat-stable carbetocin for the treatment of postpartum haemorrhage: a phase III, randomized, double-blind, active controlled, multicountry, multicentre, non-inferiority trial
REFNo: HS5151ES

To evaluate the cost-effectiveness of the PPH treatment with HSC compared to PPH treatment with oxytocin, if HSC is proven non-inferior. ,To evaluate the comparative effects of HSC versus oxytocin on haemodynamic outcomes when used for PPH treatment in women receiving HSC for prophylaxis; ,The primary objective of this trial is to evaluate whether HSC is non-inferior to oxytocin for treatment of PPH in women who receive HSC for PPH prophylaxis, in the prevention of additional blood loss of 500 ml or more at 90 min following randomization. ,
Uganda 2024-11-13 17:36:53 2027-11-13 Medical and Health Sciences Clinical Trial Non-degree Award
Gertrude  Namazzi
ID: UNCST-2024-R002568
Mapping the Bottlenecks and Challenges of the At-Risk Surveillance System for Child Developmental Disabilities in Uganda
REFNo: HS5106ES

To map the bottlenecks and challenges of the At Risk Surveillance system for child developmental conditions and disabilities in order to inform targeted strategies to improve the overall effectiveness of the ARSS system,
Uganda 2024-11-13 17:34:14 2027-11-13 Medical and Health Sciences Non-Clinical Trial Non-degree Award
ANTHONY NUWA
ID: UNCST-2022-R011102
Across Sectional Survey to improve the capacity of the healthcare system to detect, report, and respond to arboviral threats in Uganda.
REFNo: HS5063ES

1. To ascertain the availability and density of mosquito vector species involved in virus
transmission and their bionomics in Uganda.
2. To describe and document the current practices on diagnosis and management of
arboviral diseases in Uganda and provide recommendations for improvement and
strengthening.
3. To describe the current arboviruses data collection, reporting and data use system for
decision making in Uganda.
4. To evaluate current arboviral outbreak detection and response mechanisms in Uganda
To evaluate outbreak hotspots and human/animal cluster susceptibilities to identify
appropriate target sentinel sites.
6. To determine the Yellow Fever, Chikungunya, O’nyong nyong epidemic potential based
on findings from the entomological and historical data collected during the study.
7. To assess knowledge, attitudes and practice among target communities regarding
arbovirus awareness and risk behavior.
Uganda 2024-11-13 17:30:13 2027-11-13 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Moses Joloba Lutaakome
ID: UNCST-2022-R011558
Clinical Performance Evaluation of POC BVBLUE Test for Diagnosis of Bacterial Vaginosis in Uganda
REFNo: HS5231ES

To evaluate the performance of the BVBlue test, a point-of-care test, compared to Amsel, Nugent and Allplex Bacterial Vaginosis plus Assay. ,
Uganda 2024-11-13 17:27:22 2027-11-13 Medical and Health Sciences Non-Clinical Trial Non-degree Award
RUKUNDO  LYDIA LYDIA
ID: UNCST-2023-R005547
PSYCHOSOCIAL CHALLENGES AND COPING STRATEGIES OF CARE - GIVERS OF CHILDREN WITH SICKLE CELL DISEASE AGED 0-9, ATTENDING MULAGO SICKLE CELL CLINIC
REFNo: HS4975ES

To document the coping strategies adopted by care-givers of children with sickle cell disease, attending MSCC. ,To explore the psychosocial challenges experienced by care-givers of children with sickle cell disease, attending MSCC. ,To explore the psychosocial challenges and coping strategies of care-givers of children with sickle cell disease, attending MSCC. ,
Uganda 2024-11-13 17:19:00 2027-11-13 Medical and Health Sciences Non-Clinical Trial Non-degree Award
JOSELYN RWEBEMBERA
ID: UNCST-2021-R013915
Rapid AI-assisted Echocardiography Detection and Analysis of Rheumatic Heart Disease (RADAR) Tool – Evaluation of Acceptability and Feasibility for Field Deployment
REFNo: HS4948ES

Specific Objective 1: To assess the acceptability of this AI tool by the team members (echo nurses) in the echo screening environment.

Specific Objective 2: To evaluate the feasibility of this tool in the echo screening setting. These measures include evaluating time from screening to results, reliability of real-time image transfer from
the echo device to the RADAR tool, and functionality of the device in this environment (i.e. battery life, heat tolerance).
Uganda 2024-11-13 17:17:03 2027-11-13 Medical and Health Sciences Non-Clinical Trial Non-degree Award
STELLA KIZANYE
ID: UNCST-2024-R003321
Design and Fabrication of a Plastic Processing Machine for Recycling High-Density Polyethylene and Polypropylene Plastic Waste- A Means of Environment Reclamation.
REFNo: SIR399ES

1. To collect data about plastic waste collected daily by Kampala waste management centres so as to inform the extent of plastic waste accumulation and show the need for collection of this problem. 2. To determine the design parameters of the components of the plastic processing/recycling machine in relation to the industry standards and need requirements. 3. To fabricate the plastic processing machine so that the recycling process can be initiated. 4. To test the machine by processing a sample of HDPE and PP plastic waste into plastic products.
Uganda 2024-11-13 17:08:35 2027-11-13 Engineering and Technology Non-Clinical Trial Non-degree Award
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