Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
NAKAJUBI SHAMUSI
ID: UNCST-2024-R003579
“BLOCKCHAIN-BASED FRAMEWORK FOR INTRA-DATA SHARING IN SAVINGS AND CREDIT COOPERATIVE SOCIETIES (SACCOS)” A CASE OF WAZALENDO SACCO - UGANDA
REFNo: SIR412ES

To Evaluate the framework for intra-data sharing in SACCOS.,To develop a Blockchain-based Framework for intra-data sharing in SACCOS.,To examine the challenges faced in the current intra-data sharing processes in SACCOS,To establish the current state of the art and Intra-data sharing practices in SACCOS,The general objective of this study will be to develop a Blockchain-based Framework for intra-data sharing in SACCOS. ,
Uganda 2024-11-19 7:28:29 2027-11-19 Engineering and Technology Non-Clinical Trial Degree Award
EBENEZER DEBRAH LARTEY
ID: UNCST-2023-R007570
Artificial Intelligence-Based Enhancement of Mammography Interpretation for Early Breast Cancer Diagnosis
REFNo: SIR368ES

d. To evaluate the acceptability and usability of the developed model.,c. To test and validate the developed algorithms for accurate and timely diagnosis and classification of breast cancer from x-ray mammograms.,b. To develop AI-based algorithms for accurate and timely diagnosis and classification of breast cancer from x-ray mammograms.,a. To establish the extent to which artificial intelligence has been adopted in breast cancer diagnosis and classification from x-ray mammograms.,The main objective is to improve the accuracy and timely diagnosis of breast cancer from X-ray mammograms in resource-constrained areas.,
Ghana 2024-11-19 7:25:26 2027-11-19 Engineering and Technology Non-Clinical Trial Degree Award
Sam Ononge
ID: UNCST-2020-R000328
Evaluating utilization of VAYU Bubble Continuous Positive Airway Pressure (CPAP) device piloted among health facilities participating in Saving Women and Preterm Babies (SWAP) Project in Uganda: Ref UNHL-2024-91
REFNo: HS5148ES

To determine the acceptability, feasibility, and sustainability of the Vayu bCPAP among healthcare providers in the five SWAP project-supported facilities as part of the routine care for newborns with respiratory distress, primarily preterm newborns. ,4. To draw recommendations for the scale-up to other facilities in Uganda, 3. To explore the sustainability of Vayu bCPAP in health facilities in Uganda ,2. To determine the key factors that facilitate or hinder the successful implementation of Vayu bCPAP,1. To assess health providers\' acceptability and feasibility of Vayu bCPAP in selected health facilities in Uganda ,To determine the acceptability, feasibility, and sustainability of the Vayu bCPAP among healthcare providers in the five SWAP project-supported facilities as part of the routine care for newborns with respiratory distress, primarily preterm newborns. ,
Uganda 2024-11-19 7:24:21 2027-11-19 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Isaac Ssinabulya
ID: UNCST-2021-R004352
ImpleMEntation of a Digital-first care deLiverY model for heart failure in Uganda (MEDLY Uganda)
REFNo: HS4581ES

In this study, we will implement a digital-first, multi-component strategy for HF (Medly Uganda) and evaluate both implementation and clinical outcomes. The primary objective is to assess the implementation and clinical effectiveness of a digital-first implementation strategy to improve HF self-care in Uganda. We will conduct a stepped-wedge, cluster randomized trial in outpatient departments at 6 Ugandan RRH. The co-primary outcomes will be the Self-Care of HF Index (implementation) and the composite of mortality and HF hospitalization (clinical effectiveness). The secondary objectives will include the following. Conduct a mixed method process evaluation to inform iterative adjustments to the implementation process. We will use a community-engaged approach to systematically collect qualitative and quantitative process data at pre-determined time points based on the Learn-As-You-Go design and make contextually appropriate implementation adaptations. Prior to recruitment, we will also explore patients’ journeys to heart failure diagnosis in Uganda through a qualitative component by conducting in-depth interviews. The aims of this work will be to explore factors associated with patient’s journeys to heart failure diagnosis, including descriptions of initial symptoms, progression, health care referral journey, barriers and facilitators to care, and role of health education and self-care awareness. We will assess the implementation fidelity and sustainability of Medly Uganda with a focus on reach, adoption, and maintenance. Using Medly Uganda meta data from patients (app) and providers (dashboard), we will identify patterns and predictors of usage. We will interview patients and providers to explore these findings, and ensure implementation fidelity. We will also explore patient and provider perspectives on the sustainability of Medly Uganda, using semi-structured interviews to explore patient and provider barriers and facilitators of long-term use, to surface strategies that would optimize Medly Uganda implementation over time. We shall explore cost, cost effectiveness, and sustainability factors for Medly Uganda. We will collect and examine cost data from patients and facilities examining the unit cost (cost per HF patient treated and per HF patient controlled) of control and Medly Uganda scenarios both from a financial and societal perspective. Primary outcomes for cost effectiveness analysis will be the Incremental Cost-Effectiveness Ratio per patient treated and per death averted.
Uganda 2024-11-18 22:56:37 2027-11-18 Medical and Health Sciences Clinical Trial Non-degree Award
MUTEEBWA LABAN
ID: UNCST-2022-R010550
Barriers and facilitators of the intention to use, and the preferred model for HIV Self-Testing among young women in the Kampala Metropolitan Area
REFNo: HS5167ES

4. To assess factors associated with the intention to use HIVST services among AGYW in KMA.,3. To determine the preferred model for delivering HIVST services among AGYW in KMA.,2. To explore the barriers and facilitators influencing the use of HIVST services among AGYW in KMA,1. To determine the level of intention to use HIVST services among AGYW in KMA ,To determine the level of intention to use HIVST services, the influencing barriers and facilitators, associated factors and the preferred model for delivering HIVST services among AGYW in the KMA, Uganda.,
Uganda 2024-11-18 22:50:43 2027-11-18 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Hannah Kibuuka
ID: UNCST-2020-R014355
Secondary Analysis Protocol entitled “Biomarker-guided patient stratification for diagnosis, prognosis, and monitoring of severe infectious disease at the point of need"
REFNo: HS5187ES

Transition existing host-based biomarker classifiers to protein and nucleic acid based fieldable detection devices to validate and optimize performance
Uganda 2024-11-18 22:47:28 2027-11-18 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Edgar Mulogo Mugema
ID: UNCST-2023-R008170
Getting Malaria “off the backs” of women and children in western Uganda
REFNo: HS4758ES

The scientific objective is to demonstrate the protective effect of permethrin-treated lesus against P. falciparum malaria in infants and young children.,
Uganda 2024-11-18 13:40:11 2027-11-18 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Catherine Nabbumba
ID: UNCST-2024-R002912
Genome wide association studies and polygenic prediction of major depressive disorder in samples of African ancestry from Uganda
REFNo: HS5159ES

1) investigate the prevalence and sociodemographic and clinical correlates of MDD among general outpatients attending care at 5 hospitals in Uganda
2) undertake a systematic review on common genetic variants associated with MDD among respondents of non-European ancestry using different datasets from PGC
3) explore common genetic variants associated with MDD in 2 African samples (ED6 study (n=150 cases, 150 controls) (A) and NeuroGAP study (n=324 cases, 876 controls) (B))
4) optimise a PRS for MDD initially developed from MDD-PGC datasets for use in the African setting of Uganda

Uganda 2024-11-18 13:36:01 2027-11-18 Medical and Health Sciences Non-Clinical Trial Degree Award
THOMSON LAKWO LURONI
ID: UNCST-2023-R007843
Evaluating the specificity and cross-reactivity of Mansonella perstans sera against biomarkers for Onchocerca volvulus and Wuchereria bancrofti
REFNo: HS4889ES

To evaluate the specificity and cross-reactivity of M. perstans sera against biomarkers of O. volvulus and W. bancrofti.
Uganda 2024-11-18 13:34:32 2027-11-18 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Rogers Kalyetsi
ID: UNCST-2024-R004177
GENETIC DIVERSITY OF PLASMODIUM FALCIPARUM AND VECTOR SPOROZOITE INFECTIVITY RATES IN SELECTED FLOOD PRONE VILLAGES IN KASESE DISTRICT, WESTERN UGANDA
REFNo: HS4978ES

d. Generate maps for the spatial distribution of infected Anopheles mosquitoes and identify the hot spots in the flood-prone selected villages in Kasese district.,C. To determine vector species composition and sporozoite effectivity rates in selected flood-prone villages in Kasese district,b. Describe the genetic diversity of P. falciparum species responsible for malaria epidemics in selected flood-prone villages in Kasese district.,a. To establish the positivity rates of P. falciparum among children ≤ 12 years in selected flood-prone villages in Kasese district ,To determine the genetic diversity of Human Plasmodium falciparum species and vector sporozoite effectivity in selected flood-prone villages in Kasese district, western Uganda,
Uganda 2024-11-18 13:24:42 2027-11-18 Medical and Health Sciences Non-Clinical Trial Degree Award
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