Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Brian Mikka
ID:
Prevalence and factors associated with low-level viremia in HIV patients on NNRTIs substituted to dolutegravir-based regimen at Kitebi health center
REFNo: NS627ES

To determine the factors associated with LLV among PLHIV who were substituted to DTG-based regimens at Kitebi health centre.,To determine the prevalence of LLV among PLHIV substituted to DTG-based regimen at Kitebi health centre.,To determine the prevalence and factors associated with low-level viremia among patients substituted from NNRTIs to dolutegravir- based first-line regimen at Kitebi health centre.,
Uganda 2023-08-10 15:19:55 2026-08-10 Natural Sciences Non-Clinical Trial Degree Award
Ruth Namazzi
ID: UNCST-2020-R014305
Full Assessment of Clinical Transfusion Support (FACTS): An assessment of hematologic diseases among blood transfusion recipients and donated units at a pediatric regional referral hospital in Uganda
REFNo: HS2908ES

To determine the prevalence of SCA among children requiring blood transfusions at the children’s ward of the Jinja Regional Referral Hospital (JRRH) • To determine the prevalence of malaria parasitemia among children requiring blood transfusions at the children’s ward of the Jinja Regional Referral Hospital • To determine the prevalence of malaria parasitemia among donated, transfused blood units • To determine the incidence of iron deficiency among transfusion recipients donated, transfused blood units • To determine the RBC RhCE and Kell antigen profile on donated units and transfusion recipients
Uganda 2023-08-10 13:53:54 2026-08-10 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Henry Mugerwa
ID: UNCST-2019-R000420
PLATINUM: A multi-part, multi-center PLATform study to assess the efficacy, safety, tolerability and pharmacokinetics of anti-malarial agents administered as monotherapy at multiple dose levels and/or combination therapy IN patients with Uncomplicated Plasmodium falciparum Malaria
REFNo: HS2748ES

Main Objectives:
1. Part A: To assess the parasite clearance time (PCT) of oral doses of an anti- malarial agent administered as monotherapy in patients with uncomplicated P. falciparum malaria
2. Part B: To assess the effect on adjusted 28-day cure rate of an anti-malarial agent administered orally as combination therapy versus the standard of care (SoC) in patients with uncomplicated P. falciparum malaria

Secondary Objectives
1. Part A: To assess the effect on adjusted 28-day cure rate of an anti-malarial agent administered orally as monotherapy in patients with uncomplicated P. falciparum malaria
2. Part B: To assess the parasite clearance time (PCT) of oral combinations of anti-malarial agents versus SoC in patients with uncomplicated P. falciparum malaria
3. To characterize PK of each anti-malarial agent administered orally as monotherapy [Part A] and/or as combination therapy [Part B] in patients with uncomplicated P. falciparum malaria
4. To assess the safety and tolerability of each anti-malarial agent administered orally as monotherapy [Part A] and/or as combination therapy versus SoC [Part B] in patients with uncomplicated P. falciparum malaria
Uganda 2023-08-10 13:49:44 2026-08-10 Medical and Health Sciences Clinical Trial Non-degree Award
ANITA MUHAIRWE
ID:
CORPORATE GOVERNANCE ROLES AND EMPLOYEE SATISFACTION IN HIGHER EDUCATION INSTITUTIONS: A CASE OF SELECTED PRIVATE UNIVERSITIES IN UGANDA
REFNo: NS618ES

iii. To assess the effect of corporate governance roles on employee satisfaction in selected private universities in Uganda ,ii. To analyze the contribution of work environment to employee satisfaction in selected private universities in Uganda.,i. To assess the relationship of corporate governance roles and work environment in selected private universities in Uganda. ,
Uganda 2023-08-08 15:05:06 2026-08-08 Natural Sciences Non-Clinical Trial Degree Award
Ezekiel Mupere
ID: UNCST-2021-R012739
Assessing the effect of mealworm consumption and production on nutrition and health status of children in refugee and host communities in Western Uganda, a Refugee Insect Production For Food and Feed ( RefIPro) Project
REFNo: HS3071ES

D. To assess child anthropometrics/growth and dietary intake over 6 months in preparation for a mealworm-based school meal intervention study,C. To develop a nutritious school meal enhanced with mealworm and with high acceptability among the target group of school children,B. To assess the progress of building the capacity for scaling up mealworm production including identifying local feed substrate and assess the implementation processes in the local context ,A. To assess barriers and drivers among key stakeholders (farmers, farmers associations, school heads/teachers/parents/children) of mealworm consumption and production for sale ,Improving nutrition and health of refugee and host community children through the production of mealworm,
Uganda 2023-08-08 12:45:34 2026-08-08 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Bernard Kikaire
ID:
Effect of an interactive SMS system in improving the reporting of adverse drug reactions among people living with HIV in Tanzania and Uganda: a randomized controlled trial: The REMIND ADR TRIAL
REFNo: HS2922ES


To investigate the effectiveness of SMS reminders on improving ADR reporting compared to no SMS among people living with HIV in Tanzania and Kampala Uganda.
To describe the most commonly reported ADR profiles among people living with HIV in Tanzania and Uganda.
To determine the most common routes/ methods of reporting ADR used by PLHIV.
To explore the causal relationship between the commonly reported ADRs and ART.
To improve treatment options for participants who reported ADR.
To explore the technical feasibility and acceptability of the intervention in reporting ADR among PLHIV.

Uganda 2023-08-08 12:42:32 2026-08-08 Medical and Health Sciences Clinical Trial Non-degree Award
Joseph Lutaakome
ID: UNCST-2020-R008323
Strategies and Treatments for Respiratory Infections & Viral Emergencies (STRIVE)
REFNo: HS2703ES

Strategies and Treatments for Respiratory Infections & Viral Emergencies (STRIVE) is a master protocol being conducted in many countries around the world, and funded by the National Institutes of Health, USA. STRIVE will evaluate the safety and effectiveness of unlicensed and licensed treatments and different combinations of treatments, to improve the health outcomes of adults
hospitalised with acute respiratory infections, like COVID-19 or influenza.
Uganda 2023-08-08 12:39:21 2026-08-08 Medical and Health Sciences Clinical Trial Non-degree Award
Mathias Gerecht
ID:
Colonialism and racism in Uganda : a study of racial speeches and policies in the Western province (1890-1962)
REFNo: SS1854ES

1. Showing which racial theories and stereotypes were developed by which colonial actors and when.
2. Understanding how these racial theories and stereotypes were developed (how was this knowledge constructed ?)
3. Analysing the various ways the Ugandan people reacted to this racism.

France 2023-08-08 12:33:56 2026-08-08 Social Science and Humanities Non-Clinical Trial Degree Award
BARBARA NAGGAYI RITA
ID: UNCST-2019-R000062
Digital Storytelling for Global Health Research and Action
REFNo: SS1603ES

Preparing an evidence-based, practice-informed, GH focused DST package consisting of guidelines, recommendations, and innovation, which can be adapted in Phase 2 into tools and training materials for sharing with others in Canada and beyond.,
Uganda 2023-08-07 16:22:34 2026-08-07 Social Science and Humanities Non-Clinical Trial Non-degree Award
Ronald Nkangi
ID: UNCST-2021-R012153
Role and clinical significance of unconventional gamma delta T cell in cervical cancer and HIV- 1 co-infection
REFNo: HS2832ES

To assess the association of frequency and functions of γδ T cell with clinicopathological characteristics of Cervical cancer among women living with HIV infection ,To assess the cytotoxic effects of γδ T cell among women living with cervical cancer and HIV co-morbidity,To assess the immune phenotypes of the γδ T cells among women living with cervical cancer and HIV co-morbidity.,To assess the frequencies of different subsets of γδ T cells in peripheral blood among women living with cervical cancer and HIV co-infection.,To investigate the role and clinical significance of gamma delta (γδ) T cells among the women with cervical cancer and HIV co-morbidity.,
Uganda 2023-08-07 16:18:49 2026-08-07 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Rapheal Wangalwa
ID: UNCST-2022-R008718
Ecological niche modelling of at-risk medicinal plants in a changing climate in Uganda: A case of Warburgia ugandensis
REFNo: NS466ES

To model the potential distribution area of Warburgia ugandensis under the current environmental conditions and predict its distribution under various future climate change scenarios
Uganda 2023-08-07 16:17:48 2026-08-07 Natural Sciences Non-Clinical Trial Non-degree Award
Yang Jae Lee
ID: UNCST-2021-R012449
Mental Health Stigma in Rural Uganda
REFNo: SS1860ES

D. Radio Drama's Effects on Stigma: Develop a radio drama designed to communicate de-stigmatizing information about mental health and measure differences in stigma and likelihood of seeking treatment among those exposed to radio theater and those not exposed. ,C. Attitudes and Stigma towards Mental Illness in Healthcare Seeking Population: To evaluate both the prevalence of and attitudes and stigma towards mental illness in healthcare seeking population to assess their subjective reasons for seeking healthcare and currently accesible treatment modalities for mental distress. Through illuminating the current definitions and practices for mental illness, future interventions can be targeted to build upon current community definitions and structures for mental illness. ,B. Stigma and Suicidality: Evaluate experience of individuals with history of suicidality and their families to understand current practices and attitudes, as well as stigma experienced from disclosure of suicidality. Stigma of suicidality could impact treatment seeking as well as recurrence of suicidality, and it is critical to understand it.,A. Pathways to Care: To assess mental health attitudes, practice, stigma and the feasibility of collaboration among key individuals on potential pathways to care including traditional healers, families of individuals with mental illness, individuals with mental illness, health workers, and religious leaders through qualitative and quantitative, or mixed, methods. Elucidating pathways to care is critical for finding bottlenecks in obtaining treatment for future interventions. A particular focus will be developing ageement on potential forms of collaboration acceptable to the different parties. ,
USA 2023-08-07 15:23:20 2026-08-07 Social Science and Humanities Non-Clinical Trial Non-degree Award
Simon  Okongo
ID:
PREVALENCE, ASSOCIATED FACTORS, AND CUTANEOUS EFFECTS OF SKIN LIGHTENING AMONG PATIENTS AT MBARARA REGIONAL REFERRAL HOSPITAL SKIN CLINIC. RefNO: SS1867ES
REFNo: SS1867ES

To determine the cutaneous effects of skin lightening among MRRH skin clinic patients. ,To identify the factors associated with skin lightening among MRRH skin clinic patients.,To establish the prevalence of skin lightening among MRRH skin clinic patients.,To establish the prevalence, the associated factors, and cutaneous effects of skin lightening among MRRH skin clinic patients.,
Uganda 2023-08-07 15:22:35 2026-08-07 Social Science and Humanities Non-Clinical Trial Degree Award
Juliet Namukasa
ID:
Low-carbon Mobility in Kampala: User perspectives and practices on walking, cycling and public transport.
REFNo: SS1921ES

The following research questions will be addressed: i. What factors have influenced the adoption and non-adoption of low-carbon mobility transport modes by Kampala’s every day travelers? Who is adopting what (choice of modes), how frequently and why? ii. Is there an enabling environment that supports adoption and implementation of low-carbon mobility modes of transport? How are new infrastructures connected to these mobility modes and domesticated? iii. What strategies should be in place to support more widespread usage of low-carbon mobility modes of transport (including shared solutions) and how can the middle class be encouraged to use mass transportation modes? iv. What is the potential of e-mobility being introduced in Uganda to replace the fossil fuelled vehicles?
Uganda 2023-08-07 15:21:03 2026-08-07 Social Science and Humanities Non-Clinical Trial Degree Award
Harriet Mayanja-Kizza
ID: UNCST-2021-R013074
A phase 2, partially-blinded, randomised trial assessing the safety and efficacy of TBAJ876 or bedaquiline, in combination with pretomanid and linezolid in adult participants with newly diagnosed, drug-sensitive, smear-positive pulmonary tuberculosis
REFNo: HS2928ES

The objectives of the trial are to evaluate the efficacy, safety, and tolerability of TBAJ876 (3 doses) or bedaquiline in combination with pretomanid and linezolid in adult participants with newly diagnosed, smear-positive pulmonary DS-TB in comparison to the SOC
Uganda 2023-08-07 15:20:08 2026-08-07 Medical and Health Sciences Clinical Trial Non-degree Award
Kamada Lwere
ID: UNCST-2022-R009359
GUT MICROBIOME COMPOSITION, IMMUNE RESPONSE, AND GENETIC PREDISPOSITION TO ALZHEIMER’S DISEASE AND RELATED DEMENTIA IN A UGANDAN POPULATION.
REFNo: HS2930ES

1. To conduct a systematic review of the gut microbiome composition of individuals with Alzheimer’s disease and related dementia. 2. To determine the composition of the gut microbiome and compare individuals with ADRD and their controls. 3. To determine the levels of proinflammatory cytokines and compare individuals with ADRD and their controls. 4. To determine the distribution of ApoE (ApoE2, ApoE3 and ApoE4 variants) and ABCA7(Premature termination codon (PTC) mutations) and Presenilin (PSEN 1, 2 mutations) and compare individuals with ADRD and their controls.
Uganda 2023-08-07 15:12:16 2026-08-07 Medical and Health Sciences Non-Clinical Trial Degree Award
Ephraim Kisangala
ID:
Preferences, value and impact of informal caregivers in the management of chronic diseases in sub-Saharan Africa (SSA)
REFNo: SS1846ES

• To examine the health and economic impact of caregiving on informal caregivers (ICGS) of patients with chronic diseases in sub-Saharan Africa • To understand the factors ICGs consider when making a decision to provide care to a person with a chronic disease in SSA. • To explore how providing informal care affects the lives of informal caregivers. • To determine the most important factors in the decision to provide informal care. • To estimate the monetary value of providing informal care to patients with chronic diseases.
Uganda 2023-08-07 15:04:16 2026-08-07 Social Science and Humanities Non-Clinical Trial Degree Award
Shubaya Naggayi Kasule
ID:
Infections, Academic Achievement and Cognitive Functioning among Children with Sickle Cell Anaemia in Uganda.
REFNo: SS1883ES

To synthesize data on academic achievement among children with SCA in LMICs and assess academic achievement, cognitive functioning and infections among Ugandan children with SCA.
Uganda 2023-08-07 14:59:23 2026-08-07 Social Science and Humanities Non-Clinical Trial Degree Award
Alfred Wonyaka
ID:
Eco theology: A strategy for Ecological protection in Mountain Elgon Region Church of Uganda
REFNo: SS1713ES

a). To analyze the current ecological trends in Mountain Elgon region
b.) To access the effects of current ecological trends on ecological health in Mountain Elgon region.
c.) To examine how eco theology could be utilized as a strategy for ecological protection in Mountain Elgon region.

Uganda 2023-08-07 14:56:55 2026-08-07 Social Science and Humanities Non-Clinical Trial Degree Award
Hellen Ndagire
ID:
CHARACTERISATION OF BACTERIAL COMMUNITIES IN BLOODSTREAM AND RECTAL SWABS AMONG GOATS AND CATTLE FROM SELECTED DISTRICTS IN UGANDA
REFNo: A336ES

1. To screen for bacterial communities in the blood stream and rectal swab among cattle and goats free of overt disease from Wakiso, Kampala and Kassanda Districts of Uganda
2. To characterize the bloodstream and rectal swab bacteria from cattle free of overt disease using 16S rRNA typing
3. To characterize the bloodstream and rectal faecal bacteria from goats free of overt disease using 16S rRNA typing

Uganda 2023-08-07 14:55:24 2026-08-07 Agricultural Sciences Non-Clinical Trial Degree Award
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