Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Grace Mirembe
ID: UNCST-2022-R008850
RV 591 entitled “A Phase I, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety, Tolerability, and Immunogenicity of an Ad26.Mos4.HIV and CH505 TF chTrimer (Env) Combination to Mimic Acute HIV Viral Replication Kinetics in Healthy Adults”
REFNo: HS2891ES

To assess the safety, reactogenicity and tolerability of two vaccination regimens: rapid dose-escalation of CH505 TF chTrimer+ALFQ and Ad26.Mos4.HIV or co-administration of CH505 TF chTrimer+ALFQ and Ad26.Mos4.HIV
Uganda 2023-07-14 9:49:16 2026-07-14 Medical and Health Sciences Clinical Trial Non-degree Award
Alma Ionescu Bianca
ID:
An ethnographic study of mental health activism in Uganda
REFNo: SS1741ES

General objective:

To understand how mental health advocacy and activism function as drivers of social change in Uganda, in order to understand and envision grassroots alternatives to create better environments for mental health

Specific objectives:

i. To explore drivers and possibilities of social change for health equity through mental health activism and advocacy in Uganda.

ii. To produce a literature review identifying the mechanisms and strategies of mental health activism and advocacy in LMIC.

iii. To explore the interconnectedness an
Romania 2023-07-14 9:43:55 2026-07-14 Social Science and Humanities Non-Clinical Trial Degree Award
Nadja Peter
ID:
Reactions to Global Inequality
REFNo: SS1710ES

incorporate perspectives from different parts of the world,explore causal attributions people give for global inequality,
Germany 2023-07-14 9:42:00 2026-07-14 Social Science and Humanities Non-Clinical Trial Degree Award
Joy Gumikiriza- Onoria Louise
ID:
Development of a Caregiver Centered Psychotherapy (CCPT) in addressing patient care for older persons with Alzheimer’s Disease and Related Dementias (ADRD) in Uganda.
REFNo: HS2909ES

1. To explore ways in which older people in the community of Wakiso district conceptualize ADRD and what informs their opinions. 2. To assess caregiver distress, non-professional techniques of patient care, quality of life and the associated factors among family caregivers of persons with ADRD in Wakiso district.To adapt and pre-test the WHO-iSupport for family caregivers of persons with ADRD in Wakiso, Uganda4. To determine the effectiveness of A-iSupport in the alleviation of distress among family caregivers of persons with ADRD in Wakiso, Uganda
Uganda 2023-07-14 9:40:03 2026-07-14 Medical and Health Sciences Clinical Trial Degree Award
Turyahebwa Claire
ID:
MECS East Africa Battery-eCooking Field Trial, Uganda
REFNo: SIR105ES

The aims of this study are to examine the technical performance in real-life use and user experience of battery-augmented electric cooking equipment. Specifically, we are aiming to answer the following questions: - How will this technology perform in a real life situation, with real cooks? What technical changes are needed in the future to make this product more attractive to everyday cooks? - How will cooks respond to using the technology? How do they adopt it over time? In addition, we will be studying the following: - Are the devices compatible with traditional cooking practices? Could they encourage households to move towards clean energy stack? How do everyday cooks use the devices? What are their preferences for features of the devices? How can we make the devices more desirable and sustainable? What are gender implications of using the device? - What is the commercial viability of e-cooking (socially, technically, financially viable)? - How do the batteries perform in a real life setting? How much wear does the battery undergo? What are potential impacts on the grid? When, how, and to what extent is the battery power used? - What are health impacts of using the device?
Uganda 2023-07-14 9:36:50 2026-07-14 Engineering and Technology Non-Clinical Trial Non-degree Award
Nixon Niyonzima
ID: UNCST-2020-R014577
A PHASE III, RANDOMIZED, OPEN-LABEL STUDY EVALUATING THE EFFICACY AND SAFETY OF GIREDESTRANT IN COMBINATION WITH PHESGO VERSUS PHESGO AFTER INDUCTION THERAPY WITH PHESGO-TAXANE IN PATIENTS WITH PREVIOUSLY UNTREATED HER2-POSITIVE, ESTROGEN RECEPTOR-POSITIVE LOCALLY-ADVANCED OR METASTATIC BREAST CANCER (HeredERA)
REFNo: HS2968ES

To identify and/or evaluate biomarkers that are predictive of response to Phesgo and giredestrant (i.e., predictive biomarkers), are early surrogates of efficacy, are associated with progression to a more severe disease state (i.e., prognostic biomarkers), are associated with acquired resistance to Phesgo and giredestrant, are associated with susceptibility to developing adverse events or can lead to improved adverse event monitoring or investigation (i.e., safety biomarkers), can provide evidence of Phesgo and giredestrant activity (i.e., pharmacodynamic biomarkers), or can increase the knowledge and understanding of disease biology and drug safety,To evaluate potential effects of ADAs,To evaluate the immune response to pertuzumab, trastuzumab, and rHuPH20,To evaluate the potential relationships between Phesgo and giredestrant exposure and the safety, efficacy, immunogenicity, or biomarker endpoints.,To characterize the giredestrant, pertuzumab, and trastuzumab PK profile when given in combination,To evaluate the safety of Phesgo plus giredestrant compared with Phesgo from the participant's perspective,To evaluate health utility of participants treated with Phesgo plus giredestrant compared with Phesgo to generate utility scores for use in economic models,To evaluate effects of Phesgo plus giredestrant compared with Phesgo on work productivity and activity,To evaluate the safety of Phesgo plus giredestrant compared with Phesgo,To evaluate the efficacy of Phesgo plus giredestrant compared with Phesgo,
Uganda 2023-07-14 12:43:26 2026-07-14 Medical and Health Sciences Clinical Trial Non-degree Award
David Ssejinja Robinson
ID:
SOCIOECONOMIC REINTEGRATION AND LIFE SATISFACTION OF MIGRANT WORKERS: A CASE OF UGANDAN RETURNEES FROM THE MIDDLE EAST
REFNo: SS1817ES

To analyse the influence of social reintegration on life satisfaction among Uganda migrant worker returnees from Middle East

ii.To assess the relationship between economic reintegration and life satisfaction among Uganda migrant worker returnees from Middle East

iii. To examine the fit between socio economic reintegration and migrant worker returnees policy and process in Uganda for returnees from the Middle East.

iv.To investigate the mediating effect of socio economic reintegration on the fit of migrant worker returnees policy and process and life satisfaction of Ugandan migrant worker returnees from Middle East

Uganda 2023-07-14 12:37:54 2026-07-14 Social Science and Humanities Non-Clinical Trial Degree Award
Emma Riley-Green
ID:
The demand for digital identification amongst small enterprise owners in Uganda
REFNo: SS1836ES

Understand how the provision of UGPass affects business owners, including their likelihood of writing contracts with suppliers and customers.,3.Look at whether uptake and usage of UGPass varies depending on whether: a) contracting is highlighted as a potential benefit of UGPass, or b) sign-up assistance is provided to the enterprise owner.,2. Assess whether willingness to pay for the UGPass digital ID varies depending on whether: a) contracting is highlighted as a potential benefit of UGPass, or b) sign-up assistance is provided to the enterprise owner.,1. Gather data on the willingness of micro, small and medium enterprise owners in Kampala to pay for the new UGPass digital ID.,Informality hinders firm profitability and growth in a variety of ways, including limiting firms to suppliers in their social networks due to issues of trust and fraud. Digital IDs offer potential paths to increasing formality, such as by allowing the verification of identities and the authentication of signed contracts, thus helping businesses to sign contracts with new suppliers with lower prices or a better selection of goods. However, there is no research to date examining the demand for a digital ID and verified authentication services among business owners. ,
UK 2023-07-14 12:36:18 2026-07-14 Social Science and Humanities Non-Clinical Trial Non-degree Award
Angella Natukunda
ID:
DETERMINANTS OF NUTRITION STATUS AMONG ADOLESCENTS IN SELECTED SECONDARY SCHOOLS OF KANUNGU DISTRICT SOUTH WEST REGION UGANDA
REFNo: SS1812ES

Broad obective To investigate the determinants of nutrition status among adolescents in selected secondary schools in Kanungu District South West Uganda. Specific objectives To assess the nutrition status of adolescents in the selected secondary schools of Kanungu District South West Region Uganda. To determine the social demographic and economic factors influencing nutrition status of adolescents in the selected secondary schools of Kanungu District South West Region Uganda. To determine the diet-related factors influencing nutrition status of adolescents in the selected secondary schools of Kanungu District South West Region Uganda. To determine the level of adolescent nutrition knowledge associated with nutrition status among adolescents in the selected secondary schools of Kanungu District South West Region Uganda.
Uganda 2023-07-14 12:34:44 2026-07-14 Social Science and Humanities Clinical Trial Degree Award
Moses Mulumba
ID: UNCST-2022-R008759
Litigating Reproductive Justice in Africa: A Ugandan case study
REFNo: SS1714ES

To assess the potential impact of litigation on expanding access to SRHR and achieving reproductive justice in Uganda and Africa in general.,To determine what potential SRHR issues can be litigated in the Uganda through a reproductive jus-tice lens.,To provide an in-depth assessment of the legal, social, political and cultural landscape of SRHR in Uganda and Africa at large.,To contribute to the expansion of access to SRHR through litigating reproductive justice in Africa using Uganda as the case study.,
Uganda 2023-07-14 12:33:09 2026-07-14 Social Science and Humanities Non-Clinical Trial Non-degree Award
David Mukunya
ID: UNCST-2022-R010707
Effect of neonatal sepsis on neurodevelopment of infants at two years in Mbale (ENON): a cohort study nested in the BabyGel Trial.
REFNo: HS2950ES

Main Objective 1. To compare development and growth at two years between 200 infants who were hospitalized for neonatal sepsis and 200 infants who did not suffer from neonatal sepsis. Specific Objectives 1.To compare participant characteristics between infants who were hospitalized for neonatal sepsis and those who did not suffer from neonatal sepsis 2.To compare growth (defined as weight for height z scores and height for age z scores) between infants who were hospitalized for neonatal sepsis and those who did not suffer from neonatal sepsis. 3.To compare neurodevelopment (measured as development for age z scores DAZ) at two years between 200 infants who were hospitalized for neonatal sepsis and 200 infants who did not suffer from neonatal sepsis
Uganda 2023-07-14 10:03:27 2026-07-14 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Elliot Avila Vicente
ID:
Study on the Adoption of Electric Pressure Cookers
REFNo: SS1842ES

1. To quantify the contribution of EPCs to overall household electricity consumption
2. To assess the effects of reducing the price of electricity on the usage of EPCs
3. To assess the effects of increasing households’ access to data about electric cooking costs on
their usage of EPCs
USA 2023-07-14 10:01:09 2026-07-14 Social Science and Humanities Non-Clinical Trial Non-degree Award
Rhoda Wanyenze
ID: UNCST-2021-R013352
A Hybrid Implementation-Effectiveness Trial of Game Changers for Cervical Cancer Prevention (GC-CCP) in Uganda
REFNo: SS1873ES

1. Conduct a multisite RCT of the GC-CCP network-based advocacy strategy to evaluate effects on CC screening uptake, access to early-stage treatment and prevention of advanced disease among unscreened alters across urban/rural and public/private clinics,4. Evaluate the cost-effectiveness of Implementing GC-CCP to increase CC screening and low cost, early-stage treatment, and prevent advanced disease, compared to enhanced usual care.,3. Examine mediators and moderators (among index, alter and network characteristics) of intervention effects on (a) alter CC screening; and (b) engagement in CC prevention advocacy of index and alter (1st and 2nd degree) to better understand its multiplier effect on diffusion of advocacy throughout a network.,2. Use a mixed methods approach (semi-structured interviews and administrative clinic data) to examine clinic-, provider-, and client-level barriers and facilitators of GC-CCP Implementation and Sustainment.,
Uganda 2023-07-13 11:13:19 2026-07-13 Social Science and Humanities Clinical Trial Non-degree Award
Chloé OULD AKLOUCHE Malika
ID:
Punitive innovation and penal control: A comparison of community service orders in Kenya and Uganda
REFNo: SS1852ES

1- By analysing a punitive innovation, to reveal that public policies are always constructed by a multitude of actors and that models are always translated locally.

2- To identify the conditions of possibility and development of rehabilitative sentences that allow the reintegration of offenders and reduce recidivism.

3- To bring an empirical contribution to the functioning of community service orders in Kenya and Uganda by observing the way it is applied to understand its effects.
France 2023-07-13 11:11:18 2026-07-13 Social Science and Humanities Non-Clinical Trial Degree Award
Flavia Matovu Kiweewa
ID: UNCST-2021-R013337
Persistent HPV Infection among African Women: An Observational Cohort Ancillary Study from the ASPIRE Parent Trial
REFNo: HS2916ES

Correlation between persistent HR HPV infection and abnormal cytology, Incidence of persistent HR HPV infections, defined as HR HPV detected at two visits 4.5 months apart
Uganda 2023-07-13 11:09:36 2026-07-13 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Regina Ndagire Nabikindu
ID: UNCST-2021-R012657
KNOWLEDGE, ATTITUDE, AND PRACTICES REGARDING ANTIBIOTIC USE AND ANTIMICROBIAL RESISTANCE: A MIXED METHODS STUDY AMONG URBAN SLUM DWELLERS IN UGANDA
REFNo: HS2941ES

To assess the knowledge of antibiotic use and AMR in households in Bwaise slum, Kawempe division,To explore the barriers and facilitators of antibiotic use in households in Bwaise slum, Kawempe division,To establish the factors associated with knowledge of antibiotic use and AMR in households in Bwaise slum, Kawempe division,To determine the attitude and practices regarding antibiotic use in households in Bwaise slum, Kawempe division,To investigate the knowledge, attitude and practices regarding antibiotic use and AMR among urban slum dwellers in Kampala, Uganda,
Uganda 2023-07-13 11:07:04 2026-07-13 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Justine  Komunyena Tumusiime
ID: UNCST-2023-R008465
Engaging Young Women in Human-Centered Design for the Integration of HIV Prevention with Family Planning Services in Uganda
REFNo: HS2956ES

1. Understand YW’s perspectives on the pain points and opportunities related to uptake, effective use, and continuation of HIV prevention and contraceptive services.
2. Generate concepts for innovative service models for delivering voluntary contraception and HIV prevention services to YW.
3. Assess feasibility, scalability as perceived as perceived by different stakeholders, and acceptability of these models through use of prototypes and
dialogues with YW, public and private health care providers, and policymakers.

Uganda 2023-07-13 10:22:52 2026-07-13 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Raymond Atwebembere
ID:
Prevalence and Factors Associated with Suicide Behavior Amongst Adolescents Living with HIV in ALow Socio-Economic Setting; Masaka District, Central Uganda
REFNo: SS1874ES

1. To assess the prevalence of Suicide Behavior Amongst Adolescents Living with HIV

2. To assess the factors associated with Suicide Behavior Amongst Adolescents Living with HIV
Uganda 2023-07-13 10:15:57 2026-07-13 Social Science and Humanities Non-Clinical Trial Degree Award
Mayanja Kajumba
ID: UNCST-2022-R009050
The Perspectives of Adolescents with Epilepsy: Development of a Patient-driven Intervention to Impact Health Literacy in Uganda
REFNo: HS2955ES

Aim 3: To understand key methods that the target groups use to learn, and to gather specific ideas that AWE have about effective ways to communicate information about epilepsy. That is: 3A) Identify the commonly used media and/or other epilepsy literacy delivery channels; 3B) Determine the effective ways to deliver information about epilepsy; 3C) Determine the level of accessibility to smartphones or computers, and the feasibility of using an APP or Computer Program to track seizures, and medication usage, and to deliver information about epilepsy.,Aim 2: To determine specific social groupings (e.g., school, family, community) that AWE believe most need education to impact epilepsy literacy. That is: 2A) Identify the patient’s perceived priority areas for epilepsy literacy; and 2B) Determine the patient-prioritized target social groupings for epilepsy health literacy.,Aim 1: To understand the experiences of adolescents with epilepsy (AWE) in relation to community stigma and discrimination and its impact. That is; 1A) Determine the patient history of epilepsy: the onset of seizures, and perceptions; 1B) Determine the immediate and long-term reactions/responses to epilepsy among patients, families, and community members; and 1C) Determine the nature and extent of familial, school, and community-based beliefs and misconceptions about epilepsy,The main objective of this study is to explore the relationship between epilepsy and stigma through the experiences of adolescents, who represent a pertinent target audience and are often agents of change in their communities.,
Uganda 2023-07-13 10:13:23 2026-07-13 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Nixon Niyonzima
ID: UNCST-2020-R014577
A Phase III, Randomized, Open-Label, Multicenter Study Evaluating the Efficacy and Safety of Adjuvant Giredestrant Compared with Physician’s Choice of Adjuvant Endocrine Monotherapy in Patients with Estrogen Receptor-Positive, HER2-Negative Early Breast Cancer (Lidera)
REFNo: HS2193ES

Main Objective

1. To demonstrate superiority of giredestrant over the control treatment.
Specific Objectives

1. To evaluate the efficacy of giredestrant compared with Therapy of Physician's Choice
2. To evaluate the safety of giredestrant compared with Therapy of Physician's Choice
3. To characterize giredestrant Pharmacokinetics
4. To evaluate health status utility scores of participants treated with giredestrant compared with Therapy of Physician's Choice
5. To evaluate the tolerability of giredestrant compared with Therapy of Physician's Choice
6. To identify and/or evaluate biomarkers that are predictive of response to giredestrant (i.e., predictive biomarkers), are early surrogates of efficacy, are associated with progression to a more severe disease state (i.e., prognostic biomarkers), are associated with acquired resistance to giredestrant, are associated with susceptibility to developing adverse events or can lead to improved adverse event monitoring or investigation (i.e., safety biomarkers), can provide evidence of giredestrant activity (i.e., pharmacodynamic biomarkers), or can increase the knowledge and understanding of disease biology and drug safety
Uganda 2023-07-13 10:07:44 2026-07-13 Medical and Health Sciences Clinical Trial Non-degree Award
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