Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
KEVIN ABER
ID: UNCST-2024-R002518
Microservice Framework for Research Data Management: A Case of Interdisciplinary Research Project-UPCHAIN
REFNo: SIR465ES

To validate MF-RDM using the RDMS,To implement the Research Data Management System (RDMS) based on the developed MF-RDM framework.,To design a Microservice Framework for Research Data Management (MF-RDM).,To determine data requirements for RDM based on the work package in the UPCHAIN interdisciplinary research project.,To develop a scalable Microservice Framework for Research Data Management (MF-RDM).,
Uganda 2025-03-10 13:02:30 2028-03-10 Engineering and Technology Non-Clinical Trial Degree Award
Robert Odendi Gideon
ID: UNCST-2024-R002130
ALCOHOL USE, COGNITIVE FUNCTIONS, AND DEMENTIA SUSCEPTIBILITY AMONG ADOLESCENTS IN IBANDA AND LIRA DISTRICTS, UGANDA
REFNo: HS5517ES

4. To explore the proposed approaches to address adolescent alcohol use in Uganda.,3. To explore the perceptions regarding alcohol use among adolescents in Uganda. ,2. To assess the factors associated with cognitive impairment and risky behavioural patterns among adolescents with alcohol use in selected regions of Uganda,1. To determine the prevalence of cognitive impairment and risky behavioural patterns among adolescents who use alcohol in selected regions of Uganda.,To determine the prevalences and factors associated with cognitive impairment and risky behavioral patterns among adolescents who use alcohol, and explore the perceptions of alcohol use among adolescents, and proposed interventions to address adolescent alcohol use in Uganda,
Uganda 2025-03-10 12:54:08 2028-03-10 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Ronald Nkangi
ID: UNCST-2021-R012153
ASSESSMENT OF VACCINE RESPONSES IN 3D TONSIL CULTURES
REFNo: HS5501ES

1. Assess humoral and cellular responses to vaccines and evaluate the vaccine induced metabolic profiles.
2. Modulate vaccine responsiveness using metabolic and immunologic modulatory compounds.
Uganda 2025-03-10 12:47:51 2028-03-10 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Jafesi Pulle
ID: UNCST-2020-R014213
Defining the Risk Factor Cascade in Rheumatic Heart Disease
REFNo: HS5503ES

Aim 1: Identify modifiable risk factors for developing RHD using prospective population case-control methodologies. Aim 2: Determine the independent and joint contributions of multi-level risk factors for RHD among children and adults in Uganda. Aim 3: Establish a biobank of RHD patients' tissue samples for future RHD research studies.
Uganda 2025-03-10 12:29:08 2028-03-10 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Schola  Matovu Nakachwa
ID: UNCST-2022-R011040
Development and Testing of BAJJAJJA: An Intervention to Promote Economic Empowerment and Health of Grandmothers who Provide Primary Care for Grandchildren in Uganda
REFNo: SS3611ES

Main Objective
The study’s objective is to refine and test the feasibility and acceptability of my innovative intervention, BAJJAJJA: Building A Joint Action for JaJJAs which couples an income- generating activity (IGA) with nurse-facilitated group health coaching. This objective is informed by the NIH Stage Model of behavioral intervention development.

Specific Objectives
Aim 1: To refine and adapt the BAJJAJJA intervention through a collaborative and iterative feedback process with a diverse community group of 18 members. In a series of sessions, I will iteratively engage diverse community groups (nurses, local officials, IGA experts, and GMCs) and use cognitive interviewing to gain feedback on the appropriateness of study measures, content, delivery, and intervention format.
Aim 2: To test the feasibility, acceptability, and preliminary efficacy of the BAJJAJJA intervention in improving economic and health outcomes among 24 Ugandan GMCs. Over a 12-month period and at three time points of assessment, I will use a mixed methodology with a quasi-experimental design to collect data that will be examined to assess the feasibility, acceptability, and preliminary efficacy of the intervention on participants’ household income and health outcomes.
Aim 3: To explore the barriers and facilitators to (3a) maintenance of the BAJJAJJA individual intervention benefits (e.g., physical activity level and frequency) and (3b) sustainability of the IGA activities (e.g., grandmothers’ accessing external supports such as community resources) at 6 months post-intervention. Following a mixed methods approach, the 24 GMCs from Aim 2 will be interviewed to further evaluate the long-term maintenance and sustainability of the intervention. Health assessments, interviews, and IGA site visits will be used to explore the intervention outcomes and benefits at 6 months post-intervention.

USA 2025-03-10 12:23:29 2028-03-10 Social Science and Humanities Clinical Trial Non-degree Award
Pauline Byakika-Kibwika
ID: UNCST-2019-R001206
Randomized trial to evaluate the efficacy and safety of select therapeutic agents in the treatment of Ebola Disease (TOKOMEZA - Ebola Disease Therapeutics)
REFNo: HS5686ES

This is an open-label, adaptive, randomised platform clinical trial to evaluate the impact of 278 potential treatments on mortality in patients with Ebola Disease
Uganda 2025-03-07 18:39:19 2028-03-07 Medical and Health Sciences Clinical Trial Non-degree Award
Shillah  Kwikiiriza
ID: UNCST-2021-R012682
Entrepreneurship among rural youth in the Kamuli district, Uganda,
REFNo: A575ES

I. Identify the specific entrepreneurship opportunities available for youth in the Kamuli district
II. Inform YEP of the potential entrepreneurship opportunities for improved and sustained youth livelihoods in Kamuli district.
Uganda 2025-03-07 18:36:02 2028-03-07 Agricultural Sciences Non-Clinical Trial Non-degree Award
Andrew Kanyike Marvin
ID: UNCST-2020-R014554
Exploring Fund-Pooling Peer-led Patient Support Groups among Hypertension and Diabetes Mellitus Patients in Public Health Facilities in Uganda.
REFNo: HS5668ES

1. To map out fund-pooling peer-led patient support groups for hypertension and diabetes patients at public health facilities in Uganda.

2. To explore the operational mechanisms faced by fund-pooling peer-led patient support groups for hypertension and diabetes patients at public health facilities in Uganda.

3. To explore the barriers and facilitators to hypertension and diabetes patient involvement in fund-pooling peer-led patient support groups at public health facilities in Uganda.
Uganda 2025-03-07 18:34:54 2028-03-07 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Shillah  Kwikiiriza
ID: UNCST-2021-R012682
Assessment of Vegetable Seed Production and Management Practices in Uganda
REFNo: A566ES

1. Determine and assess the existing seed production and management practices by local seed business owners and small-holder individual seed producers in Uganda.
2. evaluate opportunities and limitations associated with vegetable seed production, management, and marketing within seed sources that are readily available to smallholder vegetable growers in Uganda.

Uganda 2025-03-07 18:30:46 2028-03-07 Agricultural Sciences Non-Clinical Trial Degree Award
Nixon Niyonzima
ID: UNCST-2020-R014577
A PHASE III, MULTICENTER, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY EVALUATING THE EFFICACY AND SAFETY OF INAVOLISIB IN COMBINATION WITH PHESGO→ VERSUS PLACEBO IN COMBINATION WITH PHESGO→ AS MAINTENANCE THERAPY AFTER FIRST LINE INDUCTION THERAPY IN PARTICIPANTS WITH PIK3CA‑MUTATED HER2‑POSITIVE LOCALLY ADVANCED OR METASTATIC BREAST CANCER (INAVO122)
REFNo: HS5649ES

This study will enrol particpants
Uganda 2025-03-07 18:26:49 2028-03-07 Medical and Health Sciences Clinical Trial Non-degree Award
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