Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Joseph Baluku B
ID: UNCST-2019-R000612
The effect of previous active tuberculosis on cardiometabolic profiles of people with HIV at an urban HIV clinic in Uganda
REFNo: HS2991ES

1. To determine the association between previous active TB and each of hypertension, dyslipidemia, elevated FBG, central obesity, and high BMI among PLHIV in Uganda, 2. To compare the frequency of each of hypertension, dyslipidemia, elevated FBG, central obesity, and high BMI among PLHIV with and without previous active TB in Uganda.,
Uganda 2023-08-25 8:21:00 2026-08-25 Medical and Health Sciences Non-Clinical Trial Non-degree Award
James Ajal
ID: UNCST-2023-R008516
Network for building resilience and sustainability among smallholder vegetable farmers in East Africa
REFNo: A329ES

Development of capacity for indigenous vegetables research.,Development of IPM packages for sustainability of small-holder vegetable farmers.,Identification of causal agents for key biotic constraints in African indigenous vegetables.,The main research objective is to generate eco-friendly solutions to pest and disease constraints for sustainable production of indigenous vegetables in East Africa,
Uganda 2023-08-25 8:19:01 2026-08-25 Agricultural Sciences Non-Clinical Trial Non-degree Award
Sarah Kiguli
ID: UNCST-2021-R013020
SickleInAfrica Protocol for Clinical and Implementation Research in Newborn Screening for Sickle Cell Disease Using Dried Blood Spots for Point of Care Tests.
REFNo: HS2951ES

1. To evaluate the performance characteristics of DBS POCT against IEF/HPLC.
1b. To evaluate the cost of DBS POCT against IEF/HPLC.
2. To determine the knowledge of the availability of POCTs and acceptability of the use of DBS POCT to health-care workers and parents versus standard POCT for screening in Lira Regional Referral Hospital.
3. To determine the cost of DBS POCT for NBS and confirmatory testing using POCT versus conventional NBS and confirmatory testing with IEF/HPLC: i. Apply DBS POCT in NBS versus Early Infant Diagnosis and compare the number of babies identified in each platform who enroll in comprehensive care.
ii. Train study SPARCO Lira Regional Referral Hospital health care workers on the use of DBS for POCT in newborn screening and follow up of babies identified in the programme using standardised guidelines.
iii. Screen 1000 babies in Ghana, Tanzania, Mali, Lira Regional Hospital, Uganda, Zambia and Zimbabwe while -Nigeria which has 25 subsites will screen 2,500 babies using DBS POCT and enter the identified babies into REDCap using SPARCO CRF.
` iv. Assess the implementation outcomes using CFIR
a. Assess the adoption of DBS for NBS using the three technologies POCT, IEF, HPLC among providers (i.e. midwives, physicians, nurses, councillors) in Lira Regional Referral Hospital.
b. Evaluate the appropriateness of the 3 technologies implemented at Lira Regional Referral Hospital across implementing sites and assess the barriers and facilitators guided by CFIR, inner and outer settings.
c. Assess the technology and implementation costs and sustainability of the three technologies in the various healthcare centres among the six countries.



Uganda 2023-08-25 8:13:57 2026-08-25 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Mark Kaddumukasa
ID: UNCST-2020-R001798
SELF MANAGEMENT INTERVENTION FOR REDUCING EPILEPSY BURDEN AMONG UGANDANS WITH EPILEPSY
REFNo: HS2944ES

1. To assess the efficacy of SMART- U vs. eTAU via an RCT.
H1: Individuals randomized to SMART-U will have significantly improved QOL and fewer seizures compared to eTAU.
H2: Individuals randomized to SMART-U will have greater improvement in depression and functional status compared to eTAU.
2. To use short message service (SMS) delivered via mobile phone text to validate patient self-reported seizure occurrence and push epilepsy self-management messaging in a practical/accessible format.
3. To obtain input from stakeholders (patients, family and clinicians) guided by an Integrated Promotion Action on Research Implementation in Health Services (i-PARIHS) framework to help establish sustainable infrastructure that will facilitate future scale up of SMART in Uganda with epilepsy partners

Uganda 2023-08-25 8:11:10 2026-08-25 Medical and Health Sciences Clinical Trial Non-degree Award
Sharon Pang Sze Lu
ID:
Transform Randomised Controlled Trial in Uganda
REFNo: SS1823ES

To evaluate the impact of the Transform program on the key indicators in values, health and livelihood in Uganda
Hong Kong 2023-08-25 8:07:30 2026-08-25 Social Science and Humanities Clinical Trial Non-degree Award
Sulaiman Bbosa
ID:
MONITORING AND EVALUATION SYSTEMS AND PERFORMANCE OF HUMANITARIAN ORGANIZATIONS IN UGANDA: A CASE OF UGANDA RED CROSS SOCIETY IN EASTERN REGION
REFNo: SS1251ES

To examine how data quality influences the performance of monitoring and evaluation systems of Uganda Red Cross Society in Eastern Uganda,To analyse how structure of monitoring and evaluation influences the performance of Uganda Red Cross Society in Eastern Uganda,To assess how human resource capacity influences the performance of Uganda Red Cross Society in Eastern Uganda,To establish how the Monitoring and evaluation methods influences the performance of Uganda Red Cross Society in Eastern Uganda,The purpose of the study is to examine the contribution of the monitoring and evaluation systems and the performance of humanitarian organizations,
Uganda 2023-08-25 8:05:14 2026-08-25 Social Science and Humanities Non-Clinical Trial Degree Award
APON ISMENE LINDA
ID:
CASH MANAGEMENT, SELF-ORGANIZATION, INTERNAL AUDITING AND SUSTAINABILITY OF SMALL AND MEDIUM ENTERPRISES IN UGANDA
REFNo: SS1658ES

1. The study intends to examine the nature of sustainability of small and medium enterprises (SMEs) in Northern Uganda. 2. To examine the relationship between cash management and sustainability of small and medium enterprises 3. To examine the relationship between cash management and internal auditing of small and medium enterprises 4. To examine the relationship between internal auditing and sustainability of small and medium enterprises 5. To examine the relationship between cash management and self-organisation of small and medium enterprises 6. To examine the relationship between self-organisation and sustainability of small and medium enterprises 7. To examine the mediating role of internal auditing on the relationship between cash management and sustainability 8. To examine the mediating role of self-organisation on the relationship between cash management and sustainability
Uganda 2023-08-25 8:03:10 2026-08-25 Social Science and Humanities Non-Clinical Trial Degree Award
Fabien Schultz
ID: UNCST-2023-R008622
Between Emerald Worlds: Analyzing the Spiritual, Ritual, and Pharmacological Facets of Neuroactive Natural Materials in Rural Uganda
REFNo: SS1894ES

Research questions to be addressed by this project: 1) How do various indigenous communities in Uganda understand, use, and prepare neuroactive plants, fungi, and other natural materials for spiritual, ritual, and ceremonial purposes and within their healthcare systems; 2) can the pharmacological targets of these materials be identified, and what active ingredients are causing the claimed effects; 3) can animal self-medication evidence for the use of neuroactive materials by the apes be generated for the first time; and 4)how to develop and to distinguish best-practice models for the implementation of the Nagoya Protocol for both non-financial and financial benefit-sharing when the intellectual property holders are either a) members of local human populations or b) apes (an unprecedented case)?

Main objective: To help fill gaps in social and natural scientific research on neuroactive natural remedies in a region of the world about which very few ethnopharmacological studies on the use of neuroactive natural remedies exist.

Specific objectives: 1) The first-time documentation of the cultural, spiritual, and ritual use of neuroactive natural remedies in rural Uganda, including methods of preparation and administration in a cultural, potentially ceremonial, setting; 2) the identification of new bioactive substance leads on the basis of the archiving of the chemical biodiversity of the collected samples; 3) the generation of new knowledge on how different populations interpret the spiritual/ritual settings of various neuroactive natural materials; 4) the contribution of new insights into the benefits of neuroactive natural remedies with respect to mental health and societal well-being; 5) a deeper understanding of the importance/intentions of various neuroactive substances for spiritual and ritual purposes within cultural worldviews; 6) the investigation of potential overlap in the use of neuroactives between humans and non-human primates at the study sites; 7) the shifting of negative Western views on neuroactive substances as stimulants/sedatives and rightfully DEA Schedule I substances.
Germany 2023-08-18 9:46:36 2026-08-18 Social Science and Humanities Non-Clinical Trial Degree Award
REBECCA NANTANDA
ID: UNCST-2019-R001533
Assessment of feasibility, acceptability, hesitancy, safety, effectiveness and immunogenicity of COVID-19 vaccines among children in Uganda
REFNo: HS2910ES

1. To assess the feasibility and acceptability of COVID-19 vaccination of children in Uganda.
2. a) To determine the prevalence of hesitancy to COVID-19 vaccination for children in
Uganda.
b) To describe the drivers of hesitancy for vaccination of children against COVID-19 in
Uganda.
3. To assess the safety of COVID-19 vaccines among children aged 12-17 years in Uganda.
4. To determine immunogenicity the BioNTecg/Pfizer of among children aged 12-17 years in Uganda.
5. To determine the effectiveness of COVID-19 vaccines among children aged 12-17 years in Uganda.

Uganda 2023-08-18 9:40:38 2026-08-18 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Adoke Yeka
ID: UNCST-2021-R004300
A pilot study evaluating the feasibility, acceptability and impact of use of highly sensitive malaria RDTs (NxTek™) vs ordinary malaria RDTs on malaria incidence in Uganda: a cluster-randomised trial
REFNo: HS2988ES

1. To determine the impact of detecting and treating additional malaria cases on malaria morbidity, 2 years following introduction of HS-RDTs for diagnosis of malaria in Uganda.
2. To assess feasibility of use (ease of test interpretation, delivery, restocking, storage, invalid tests, and reporting rates) of HS-RDTs among implementers in Uganda.
3. To compare clinical care outcomes for malaria cases diagnosed with HS-RDTs and cRDTs in Uganda.
4. To estimate the cost-effectiveness of delivering HS-RDTs, as compared to cRDTs.

Uganda 2023-08-18 9:13:55 2026-08-18 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Adoke Yeka
ID: UNCST-2021-R004300
An adaptive, randomized, active-controlled, open-label, sequential cohort, multicenter study to evaluate the efficacy, safety, tolerability and pharmacokinetics of intravenous cipargamin (KAE609) in adult and pediatric participants with severe Plasmodium falciparum malaria (KARISMA – KAE609’s Role In Severe Malaria)
REFNo: HS1980ES

Primary objective
To assess the efficacy of different doses of
intravenous cipargamin vs artesunate by evaluating the proportion of
participants with ? 90% reduction of parasitemia at 12 hours post
administration of the first dose.

Secondary Objectives
1. To assess the presence/absence of severe malaria related individual
signs over time
2. To evaluate parasite clearance dynamics and proportion of participants
with recrudescence and reinfection
3. To assess recovery of participants as measured by time (days and hours)
to discharge from hospital or recovery from prostration
4. To evaluate the safety and tolerability of IV cipargamin
5. To assess the risk of long term neurological sequelae for participants at
Day 29
6. The assess the risk of hemolysis (early and delayed) during the study
duration
7. To characterize the plasma pharmacokinetics of IV cipargamin

Uganda 2023-08-18 9:05:14 2026-08-18 Medical and Health Sciences Clinical Trial Non-degree Award
Juliane Etima
ID: UNCST-2022-R008983
Young Generation Alive Survey: Determining Knowledge, Aspirations, and Behaviors of Ugandan Adolescents and Young People Living with HIV.
REFNo: SS1910ES

To understand the HIV knowledge and behaviors among HIV+ and perinatally exposed adolescents and young people in Uganda with respect to achieving career aspirations, financial security, and safe intimate relationships.,
Uganda 2023-08-15 15:43:39 2026-08-15 Social Science and Humanities Non-Clinical Trial Non-degree Award
Fiona Ssozi Catherine
ID:
PATHWAYS TO CHANGE: TOWARDS GENDER JUSTICE IN SCIENCE, ENGINEERING, TECHNOLOGY AND MATHEMATICS (STEM) RESEARCH IN AFRICA (GEJUSTA)
REFNo: SIR240ES

Primary objective: Examine causes of under-representation and reframe Gender Analysis in STEM in Africa
Secondary objectives: Map under-representation, barriers and support mechanisms; explore STEA+M approaches; Develop Gender-aware design methodologies; Develop a support network for mentoring early-career female researchers

Uganda 2023-08-15 15:42:06 2026-08-15 Engineering and Technology Non-Clinical Trial Non-degree Award
Jesca Nantume
ID: UNCST-2021-R013984
EVALUATING EQUITABLE ACCESS TO HEALTH SERVICES FOR SCHISTOSOMIASIS IN COMMUNITY-BASED HEALTH CENTERS; A MIXED METHODS CROSSECTIONAL STUDY IN MAYUGE AND KALUNGU DISTRICT IN UGANDA
REFNo: SS1887ES

3. To identify and understand the barriers that hinder equitable access to health services for schistosomiasis, including socio-economic factors such as income, education level, and employment status, as well as cultural beliefs, attitudes, and practices that affect healthcare-seeking behaviors.,2. To evaluate the accessibility of health services for schistosomiasis in terms of geographical proximity, transportation, cost, and waiting times for individuals seeking diagnosis, treatment, and follow-up care.,1. To assess the availability of health services for schistosomiasis in community-based health centers in Mayuge and Kalungu Districts, Uganda, including the availability of diagnostic tools, treatment options, and healthcare professionals trained in schistosomiasis management.,The main aim of the study is to assess and evaluate the level of equitable access to health services for schistosomiasis in community-based health centers in Mayuge and Kalungu Districts, Uganda, by considering various factors such as availability, accessibility, utilization, and quality of services. The objective is to gain a comprehensive understanding of the barriers and facilitators that impact equitable access to schistosomiasis healthcare services, including the influence of socio-economic factors, cultural beliefs, knowledge and awareness levels, and gender dynamics.,
Uganda 2023-08-15 15:40:28 2026-08-15 Social Science and Humanities Non-Clinical Trial Non-degree Award
Alison Elliott
ID: UNCST-2023-R006524
Understanding the role of, and relationship between, structural, social and biological determinants of vaccine response to improve vaccine impact in Kenya and Uganda: a formative study.
REFNo: HS2901ES

1. To conduct a scoping review exploring how social, structural and biological drivers interact to influence vaccine response. 2. To undertake formative ethnographic case studies to investigate these interactions in two communities where biological factors are known to influence vaccine response. 3. To map stakeholders and influencers critical to vaccine impact in Uganda and Kenya. 4. To work with stakeholders and communities to co-design the VAnguard community surveys to be conducted in year 2 of the programme
UK 2023-08-10 15:46:52 2026-08-10 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Sylivia Namwano
ID: UNCST-2023-R008071
A pragmatic early detection and warning model for reduction of landslide effects for communities at risk
REFNo: SIR243ES

To evaluate the efficiency, reliability, effectiveness and usability of the designed pragmatic early detection and warning model for reduction of landslide effects for communities at risk,To establish ideal characteristic of an effective and efficient landslide early detection and warning systems for communities at risk,To design a pragmatic early detection and warning model for reduction of landslide effects for communities at risk,
Uganda 2023-08-10 15:22:18 2026-08-10 Engineering and Technology Non-Clinical Trial Degree Award
Brian Mikka
ID:
Prevalence and factors associated with low-level viremia in HIV patients on NNRTIs substituted to dolutegravir-based regimen at Kitebi health center
REFNo: NS627ES

To determine the factors associated with LLV among PLHIV who were substituted to DTG-based regimens at Kitebi health centre.,To determine the prevalence of LLV among PLHIV substituted to DTG-based regimen at Kitebi health centre.,To determine the prevalence and factors associated with low-level viremia among patients substituted from NNRTIs to dolutegravir- based first-line regimen at Kitebi health centre.,
Uganda 2023-08-10 15:19:55 2026-08-10 Natural Sciences Non-Clinical Trial Degree Award
Ruth Namazzi
ID: UNCST-2020-R014305
Full Assessment of Clinical Transfusion Support (FACTS): An assessment of hematologic diseases among blood transfusion recipients and donated units at a pediatric regional referral hospital in Uganda
REFNo: HS2908ES

To determine the prevalence of SCA among children requiring blood transfusions at the children’s ward of the Jinja Regional Referral Hospital (JRRH) • To determine the prevalence of malaria parasitemia among children requiring blood transfusions at the children’s ward of the Jinja Regional Referral Hospital • To determine the prevalence of malaria parasitemia among donated, transfused blood units • To determine the incidence of iron deficiency among transfusion recipients donated, transfused blood units • To determine the RBC RhCE and Kell antigen profile on donated units and transfusion recipients
Uganda 2023-08-10 13:53:54 2026-08-10 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Henry Mugerwa
ID: UNCST-2019-R000420
PLATINUM: A multi-part, multi-center PLATform study to assess the efficacy, safety, tolerability and pharmacokinetics of anti-malarial agents administered as monotherapy at multiple dose levels and/or combination therapy IN patients with Uncomplicated Plasmodium falciparum Malaria
REFNo: HS2748ES

Main Objectives:
1. Part A: To assess the parasite clearance time (PCT) of oral doses of an anti- malarial agent administered as monotherapy in patients with uncomplicated P. falciparum malaria
2. Part B: To assess the effect on adjusted 28-day cure rate of an anti-malarial agent administered orally as combination therapy versus the standard of care (SoC) in patients with uncomplicated P. falciparum malaria

Secondary Objectives
1. Part A: To assess the effect on adjusted 28-day cure rate of an anti-malarial agent administered orally as monotherapy in patients with uncomplicated P. falciparum malaria
2. Part B: To assess the parasite clearance time (PCT) of oral combinations of anti-malarial agents versus SoC in patients with uncomplicated P. falciparum malaria
3. To characterize PK of each anti-malarial agent administered orally as monotherapy [Part A] and/or as combination therapy [Part B] in patients with uncomplicated P. falciparum malaria
4. To assess the safety and tolerability of each anti-malarial agent administered orally as monotherapy [Part A] and/or as combination therapy versus SoC [Part B] in patients with uncomplicated P. falciparum malaria
Uganda 2023-08-10 13:49:44 2026-08-10 Medical and Health Sciences Clinical Trial Non-degree Award
ANITA MUHAIRWE
ID:
CORPORATE GOVERNANCE ROLES AND EMPLOYEE SATISFACTION IN HIGHER EDUCATION INSTITUTIONS: A CASE OF SELECTED PRIVATE UNIVERSITIES IN UGANDA
REFNo: NS618ES

iii. To assess the effect of corporate governance roles on employee satisfaction in selected private universities in Uganda ,ii. To analyze the contribution of work environment to employee satisfaction in selected private universities in Uganda.,i. To assess the relationship of corporate governance roles and work environment in selected private universities in Uganda. ,
Uganda 2023-08-08 15:05:06 2026-08-08 Natural Sciences Non-Clinical Trial Degree Award
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