Henry Mugerwa
ID: UNCST-2019-R000420
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A Phase 1b, Age De-Escalation/Dose Escalation Trial to Evaluate Safety, Tolerability, and Pharmacokinetics of MAM01 in an African Population of Adults and Children in a Setting of Perennial Malaria Transmission
REFNo: HS5298ES
Primary Objective.
To assess the safety and tolerability of MAM01.
Secondary Objectives.
To assess the safety of MAM01.
To characterize the PK of MAM01 following SC, IV, and IM administration of MAM01.
To assess the formation of anti-drug antibodies (ADAs) to MAM01.
Exploratory Objectives.
To assess the protective efficacy of a single dose of MAM01 over 182 days against Pf infection, as detected by blood smear microscopy compared to a placebo.
To assess the protective efficacy of a single dose of MAM01 over 182 days against Pf infection, as detected by blood smear microscopy compared to placebo.
To assess the protection of MAM01 against events of malaria illness (first/only and all episodes).
To correlate MAM01 concentration with Pf infection risk.
To assess the complexity of Pf infection following administration of MAM01 or placebo.
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Uganda |
2024-12-23 12:23:27 |
2027-12-23 |
Medical and Health Sciences |
Clinical Trial |
Non-degree Award |
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Eleanor Namusoke Magongo
ID: UNCST-2021-R013199
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Outcome Evaluation of the Young People and Adolescent Peer Support (YAPS) program Implementation in Uganda
REFNo: HS4809ES
1. To assess fidelity of the YAPS program implementation by different stakeholders (MoH, Implementing Partners, Districts, Facilities, and YAPS personnel)
2. To establish the effect of the YAPS program on the clinical cascade for Adolescents and Young People Living with HIV.
3. To explore perspectives of YAPS and other stakeholders on the effectiveness of the YAPS program.
4. To estimate the incremental costs of implementing the YAPS model at the different levels of implementation (National, District and health facility)
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Uganda |
2024-12-23 12:17:40 |
2027-12-23 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
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DANLADI MAKERI
ID: UNCST-2024-R005300
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Characterization of Staphylococcus aureus Isolated from Foot Ulcers of Diabetic Patients Attending Kampala International University Teaching Hospital, Bushenyi District, Uganda
REFNo: HS4836ES
v. To determine the molecular phylogeny of Staphylococcus aureus isolated from foot ulcers of Diabetic patients attending Kampala International University Teaching Hospital Bushenyi district, Uganda,iv. To determine the antibiogram profile of Staphylococcus aureus isolated from foot ulcers of Diabetic patients attending Kampala International University Teaching Hospital Bushenyi district, Uganda,iii. To assess the phenotypic distribution of Staphylococcus aureus in foot ulcers of Diabetic patients attending Kampala International University Teaching Hospital Bushenyi district, Uganda.,ii. To determine factors associated with diabetic foot infections among Diabetic patients with foot ulcers attending Kampala International University Teaching Hospital Bushenyi district, Uganda ,i. To determine the prevalence of diabetic foot infection among Diabetic patients with foot ulcers attending Kampala International University Teaching Hospital Bushenyi district, Uganda,To characterize Staphylococcus aureus isolated from foot ulcers of Diabetic patients attending Kampala International University Teaching Hospital Bushenyi district, Uganda ,
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Nigeria |
2024-12-23 12:15:59 |
2027-12-23 |
Medical and Health Sciences |
Non-Clinical Trial |
Degree Award |
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Francis Omujal
ID: UNCST-2019-R000428
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DOCUMENTATION OF BATWA INDIGENOUS PEOPLE AND LOCAL COMMUNITIES’ KNOWLEDGE FOR BIO-PROSPECTING FOR THERAPEUTICS PRODUCTS
REFNo: NS658ES
c) To identify priority natural medicinal resources that can be used by BIP for development of therapeutic products for specific diseases ,b) To assess the availability status of medicinal resources used for TMK by the BIP,a) To document the traditional medicine practices of the BIP,To document TMK of the Batwa indigenous people for the development of therapeutic products.,
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Uganda |
2024-12-23 12:14:59 |
2027-12-23 |
Natural Sciences |
Non-Clinical Trial |
Non-degree Award |
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Edgar Mulogo Mugema
ID: UNCST-2023-R008170
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Epidemiology of pediatric severe malaria in the Kasese District of western Uganda
REFNo: HS5367ES
Study Objectives
The overarching goal of this proposed project is to describe the epidemiology of severe malaria among children in the Kasese District of western Uganda. Our scientific objective is to determine if the demographic, clinical, and laboratory characteristics of children admitted to a more urban level IV health center are different from our previous findings at a rural level III health center. To test this hypothesis, we propose to:
AIM 1: Describe the demographic characteristics of children admitted to SPHC with a diagnosis of malaria. We will conduct a prospective, observational study, enrolling children admitted to the IPD. Participating caregivers will complete a questionnaire documenting basic demographic factors as well as information about the household (e.g., location, LLIN access and use). We hypothesize that most children will be (i) <12 years of age, (ii) from areas within 20km of SPHC, and (iii) have previously sought care at lower-level facilities.
AIM 2: Document the clinical and laboratory characteristics of children admitted to SPHC with a diagnosis of malaria: We will elicit a history of illness from the caregiver and record relevant information including vital signs, results of laboratory testing (e.g., malaria RDT, hemoglobin, etc.), along with treatments administered during the hospitalization. We hypothesize that nearly all children will receive ≥24 hours of intravenous artesunate, but there may be substantial variation in dosing.
AIM 3: Estimate measures of severe malaria incidence and associated morbidity and mortality among children presenting to SPHC with malaria. We will record the results of laboratory testing for malaria in the OPD to determine the malaria positivity rate and incidence of SM (i.e., proportion with a positive RDT who are admitted). Among those who are admitted, we will document disposition (e.g., discharge, transfer, death) and complete follow up at 14, 30, 45, and 60 days post-discharge. We hypothesize that mortality will be greatest among children referred from lower-level facilities and those with delayed presentations
|
Uganda |
2024-12-23 12:12:56 |
2027-12-23 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
|
Justus Asasira
ID: UNCST-2021-R012092
|
Socioeconomic and Environmental Impacts of Biomass Briquettes and Solar Cooking Technologies Acceptance by Households in Southwestern Uganda
REFNo: SS2319ES
1. To explore the stakeholders’ perceptions about adopting biomass briquettes for cooking in Southwestern Uganda.
2. To assess the influence of business models on the acceptance and economic feasibility of biomass briquettes and solar technologies for cooking in Southwestern Uganda.
3. To compare the environmental impacts and benefits of producing and using solar technologies with non-renewable sources of energy for cooking in Southwestern Uganda.
4. To identify the design attributes that make biomass briquettes and solar cooking technologies socially acceptable by households in Southwestern Uganda.
|
Uganda |
2024-12-23 12:11:58 |
2027-12-23 |
Social Science and Humanities |
Non-Clinical Trial |
Degree Award |
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OSCAR AYUYA INGASIA
ID: UNCST-2024-R002553
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Gender Analysis; Address gendered aspects of awareness of lower-risk plant protection products/technologies in Uganda
REFNo: A534ES
To explore the roles men and women play in pest management and the products used for pest management in potato farming,To assess the differences between men, women, and young people\'s, values, power dynamics and behaviors which shape their access to and use of digital tools.,To examine the traditional pest prevention technologies, and the gendered obstacles faced by men women and young people,To respond to the needs of farmers and the systems that support them, by helping countries predict, prevent, and prepare for plant health threats, thereby reducing crop losses. ,
|
Kenya |
2024-12-23 12:09:26 |
2027-12-23 |
Agricultural Sciences |
Non-Clinical Trial |
Non-degree Award |
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Isaac Kitone
ID: UNCST-2024-R002847
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Kabale University (KAB) Sustainable Energy Generation System (KSEG) Project
REFNo: SIR421ES
To test the automated non-fossil fuel driven power generator,To construct an automated non-fossil fuel driven power generator ,To design an automated non-fossil fuel driven power generator ,To collect data on existing generator power needs in three western Ugandan districts, Kabale, Mbarara and Ntungamo,To design and construct an automated non-fossil fuel driven power generator ,
|
Uganda |
2024-12-23 12:07:01 |
2027-12-23 |
Engineering and Technology |
Non-Clinical Trial |
Non-degree Award |
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Andrew Mujugira
ID: UNCST-2019-R000871
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UNMET ORAL HEALTH NEEDS AND BARRIERS TO ORAL HEALTH AND SEXUAL HEALTH
SERVICE UTILISATION AMONG MEN WHO HAVE SEX WITH MEN AND
TRANSGENDER PEOPLE IN UGANDA: A MIXED METHODS PILOT STUDY
REFNo: HS5226ES
Objective 1: Estimate the prevalence of oral diseases, HIV, OHPV,
and self-reported STIs and their impact on oral health conditions in
MSM/TGP.
Objective 2: Identify the key barriers to health service utilization
experienced by MSM/TGP.
|
Uganda |
2024-12-23 12:05:34 |
2027-12-23 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
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JOYCE NAMWASE
ID: UNCST-2024-R005002
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FEASIBILITY AND EFFECTIVENESS OF A TRAINING INTERVENTION FOR INFORMAL CAREGIVERS OF PEOPLE LIVING WITH DEMENTIA IN RURAL UGANDA (FETIC-DU)
REFNo: HS5165ES
3. To evaluate the feasibility and effectiveness of the training program in improving knowledge and skills of informal care givers for persons with dementia in rural Uganda. 1.4 Research questions
|
Uganda |
2024-12-23 12:04:08 |
2027-12-23 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
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