Kamya Moses
ID: UNCST-2020-R014203
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Integrating management of alcohol use, intimate partner violence, and menopausal transition into HIV care for women living with HIV in Uganda
REFNo: HS5750ES
To explore the unique health challenges faced by women living with HIV in Uganda related to intimate partner violence, menopausal transition, and alcohol use disorder (AUD), focusing on distinct age groups to inform targeted health interventions
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Uganda |
2025-03-19 13:02:04 |
2028-03-19 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
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Abel Kakuru
ID: UNCST-2022-R009193
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Epidemiology of Malaria Infection in Sub-Saharan African Countries
REFNo: HS5638ES
To estimate the site-specific IR of P. falciparum infection by rapid diagnostic test (RDT) testing, overall and by age group (5-11 years, 12-17 years, 18-60 years) during the active detection of infection period.
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Uganda |
2025-03-19 12:57:39 |
2028-03-19 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
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Noeline Nakasujja
ID: UNCST-2019-R001428
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Clonal Hematopoiesis: A Global Perspective on the Impact of CH on Alzheimer’s Disease in Sub-Saharan Africa
REFNo: HS5533ES
Main Objective
1. The aim of this proposed work is to compare the frequency and type of clonal hematopoiesis (CH) mutations in age-matched African American and Ugandan populations. We intend to determine the correlation between specific CH-associated mutations and development of Alzheimer’s Disease in both a Ugandan and African-American population.
Specific Objectives
1. Compare the frequency of CH in an elderly African American versus elderly Ugandan population.
2. Compare the types of CH mutations in an elderly African American versus elderly Ugandan population.
3. Determine the correlation between specific CH-associated mutations and the development of AD in a Ugandan population.
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Uganda |
2025-03-19 12:53:37 |
2028-03-19 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
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STEVEN SEBBALE
ID: UNCST-2023-R006063
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PARTICIPATION OF FEMALE DOCTORATE HOLDERS IN SCIENCE, TECHNOLOGY AND INNOVATION: AN EXAMINATION ON GENDER EQUITY, INCLUSIVITY AND INTERSECTIONALITY IN UGANDA
REFNo: SS3712ES
a) To examine the demographic and professional characteristics of female doctorate holders in Uganda
b) To assess the intersectional challenges faced by female doctorate holders in Uganda
c) To provide data-driven insights for integrating intersectionality into UNCST’s grants system
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Uganda |
2025-03-18 13:09:22 |
2028-03-18 |
Social Science and Humanities |
Non-Clinical Trial |
Non-degree Award |
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Richard Wismayer
ID: UNCST-2019-R000483
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The microbiome as an aetiological factors in colorectal carcinoma in Ugandan patients
REFNo: HS5644ES
1. To investigate the frequency of carriage of faecal P. micra in Ugandan CRC patients and controls by 16S rRNA sequencing and PCR and assess its potential as a non- invasive biomarker compared to other bacteria (Study 1).
2. To explore the associations of P.micra and F.nucleatum, the general tumour microbiome, the intra-tumour immune response and the tumour MSI status within the tumour itself. P.micra and F.nucleatum will be determined by PCR, the tumour microbiome by 16S rRNA sequencing and the tumour immune response both pathologically and by the numbers of infiltrating lymphocytes a key prognostic marker. MSI and MSS status will also be identified (Study 2).
3. To analyse the bacterial content of faeces using 16S rRNA sequencing in relation to the clinical features and MSI/MSS status of CRC in Ugandan patients and controls using network analysis in Ugandan patients. To identify bacteria positively and negatively associated with Ugandan bowel cancer carriage (Study 3).
4. To determine the prevalence of cancer related stool toxins, pks, FadA, and ETBF in Ugandan colorectal cancer patients and controls using quantitative PCR assays on faeces (Study 4).
5. To compare the above findings with those of CRC patients and controls from the international microbiome network in Ghana, India, Vietnam, Argentina and England (Study 5).
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Malta |
2025-03-18 13:03:54 |
2028-03-18 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
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Shahiid Kiyaga
ID: UNCST-2021-R007055
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Genetic Diversity and Transmission Intensity Heterogeneity of Plasmodium falciparum in Malaria Endemic Regions in Uganda
REFNo: HS5697ES
General Objective
To analyze the genetic diversity of P. falciparum and the heterogeneity in malaria transmission intensity in high-endemic areas of Uganda.
Specific Objectives
1. To assess the genetic diversity and population substructure of P. falciparum in high endemic areas of Uganda by quantifying allelic variation and estimating population structure parameters using F_ST (fixation index) and principal component analysis (PCA).
2. To characterize the heterogeneity in transmission intensity in high endemic areas of Uganda using P. falciparum targeted amplicon genomic data and malaria epidemiological parameters.
3. To develop and apply advanced machine learning models to predict geographical origins of P. falciparum parasites in Uganda using whole-genome sequence data.
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Uganda |
2025-03-14 19:14:47 |
2028-03-14 |
Medical and Health Sciences |
Non-Clinical Trial |
Degree Award |
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Racheal Ninsiima
ID: UNCST-2020-R014564
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Effect of blockchain technology on the performance of barley farmers in eastern Uganda
REFNo: A536ES
i) To determine farmers’ behavioural intention to accept BCT in Uganda’s eastern barley producing region.
ii) To examine the factors that influence adoption and extent of use of BCT among barley farmers in eastern Uganda.
iii) To determine the effect of BCT on barley farmers’ productivity and gross margin in eastern Uganda
iv) To develop suitable BCT implementation framework among barley farmers in eastern Uganda.
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Uganda |
2025-03-14 19:13:35 |
2028-03-14 |
Agricultural Sciences |
Non-Clinical Trial |
Degree Award |
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Bruce Kirenga J
ID: UNCST-2019-R001460
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SURVEY, SAFETY AND EFFICACY OF HERBAL PRODUCTS USED FOR MALARIA PROPHYLAXIS AND TREATMENT IN UGANDA.
REFNo: HS5468ES
To conduct a survey of herbal medicinal products used for malaria prophylaxis and treatment, evaluate their safety and prophylactic efficacy among school-age children (8-15yrs) in Kibuku district, Uganda.
1. To identify herbal medicinal products used by communities for malaria prophylaxis and treatment in Uganda.
2. To evaluate the artemisinin content of herbal medicinal products used by communities for malaria prophylaxis and treatment in Uganda.
3. To determine the antiplasmodial activity (IC50) of herbal medicinal products used for malaria prophylaxis and treatment in Uganda.
4. To evaluate the safety of herbal medicinal products used for malaria prophylaxis among school age children (8-15 years) in Kibuku district in eastern Uganda.
5. To determine malaria incidence among school age children (8-15 years) receiving selected herbal medicinal products for malaria prophylaxis compared to monthly Dihydroartemisinin-Piperaquine (DP) in Kibuku district in eastern Uganda.
6. To determine prevalence of parasitaemia among school age children (8-15 years) receiving selected herbal medicinal products for malaria prophylaxis compared to monthly Dihydroartemisinin-Piperaquine (DP) in Kibuku in eastern Uganda.
|
Uganda |
2025-03-14 19:08:33 |
2028-03-14 |
Medical and Health Sciences |
Clinical Trial |
Non-degree Award |
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Irene Vries de
ID: UNCST-2024-R003372
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A pilot Study for introducing a Point of Care Ultrasound (POCUS) device (Baby Checker), supported by Artificial Intelligence (AI), in peri-urban UgandaVersion 1.3 August
REFNo: SS3581ES
Objective and Research Questions
The objective of this research is to assess the technical performance and health outcomes resulting from the introduction of the BabyChecker device in peri-urban Uganda. Specifically, the study aims to evaluate its impact on enhancing timely ANC, including routine care and referrals, thereby potentially reducing maternal and perinatal morbidity and mortality rates. This evaluation will inform developers and implementers on the effective and responsible deployment of the BabyChecker Point-of-Care Ultrasound Scan (POCUS).
2.1 Research Questions per Component
A. Technical Performance
Health Worker performance research questions:
1. What is the initial scanning performance of health workers by cadre on their first day of using BabyChecker?
2. What is the average scanning performance over the study period for health workers by cadre (e.g., certificate, diploma, degree nurses, midwives, clinical officers)?
3. Is there a correlation between the average scanning performance of health workers and their cadre or years of experience?
4. How much time do health workers require to navigate the BabyChecker application and complete a scan on their first day?
5. What is the average time required by health workers to navigate the BabyChecker application and complete a scan over the study period?
6. How well is the BabyChecker equipment maintained throughout the study period?
Artificial Intelligence (AI) research questions:
1. What is the specificity and sensitivity of BabyChecker's AI in estimating gestational age during the first and second trimesters?
2. What is the specificity and sensitivity of BabyChecker's AI in identifying non-cephalic fetal presentation and low placental localization or placenta previa during the third trimester (36+ weeks)?
B. Health Effectiveness
The hypothesis posits that the introduction of BabyChecker will increase ANC attendance during the first trimester and improve access to imaging services, leading to early detection of risk factors and subsequent referrals. The study focuses on observing changes in ANC attendance, risk factor identification, and referral initiation as direct outcomes of the POCUS intervention.
Health Effectiveness of BabyChecker (AI + Remote Read Results) research questions:
1. Does the introduction of the BabyChecker and other VHE community interventions contribute to an increase in pregnant women first attending ANC during the first trimester?
2. Does the introduction of the BabyChecker and mobilization contribute to an increase in pregnant women that come for the 8th ANC visits?
3. Does the introduction of BabyChecker contribute to an increased overall number of ANC visits?
4. Does the introduction of BabyChecker increase the detection rate of pregnancy risk factors such as multiple pregnancies, placenta previa, breech presentation, or non-longitudinal fetal positions?
5. Does the introduction of BabyChecker increase referrals for multiple pregnancies, placenta previa, breech presentation, or non-longitudinal fetal positions?
6. Do women follow through on referrals, and do these referrals lead to improved health outcomes among women in the private sector?
|
Netherlands |
2025-03-14 18:58:29 |
2028-03-14 |
Social Science and Humanities |
Non-Clinical Trial |
Non-degree Award |
|
Isaac Mugwano
ID: UNCST-2024-R002967
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IMMEDIATE AND LONG TERM OUTCOMES OF PATIENTS WITH SEVERE MITRAL STENOSIS UNDERGOING BALLOON MITRAL VALVULOPLASTY (BVM) AT THE UGANDA HEART INSTITUTE.
REFNo: HS5507ES
1. To describe the immediate (post-operative) outcomes of patients who underwent BMV at UHI during the study period.
2. To describe the long term (1 year and 5 year) outcomes of patients with severe mitral stenosis who underwent BMV at Uganda heart institute during the study period.
|
Uganda |
2025-03-14 18:51:15 |
2028-03-14 |
Medical and Health Sciences |
Non-Clinical Trial |
Degree Award |
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