William NESBITT Alexander
ID:
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Causes and implications of the depletion of effective calcium concentrations in Lake Nabugabo, Uganda, East Africa
REFNo: NS53ES
To re-evaluate the work of Beadle (1981) and accurately measure the calcium and other major ion concentration of Lake Nabugabo and the surrounding wetlands.
To identify the sink of calcium in the system to see why the concentration is so low compared to other lakes in the LVB.
To explore the implications of low calcium by investigating the Ca/P ratio in Nile perch and mukene in both Lake Nabugabo and Lake Victoria to determine the effects on its bone strength, density and growth.
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Canada |
2018-05-22 |
2021-05-22 |
Natural Sciences |
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Degree Award |
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Joel HARTTER Nathan
ID:
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Population, Environment, and Climate in the Albertine Rift
REFNo: NS37ES
To Determine how coupled climate and anthropogenic landscape change impacts the dynamics and resilience of a protected areas and the surrounding human population, including impacts to human and wildlife health, food security, and governance.
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USA |
2018-05-18 |
2021-05-18 |
Natural Sciences |
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Non-degree Award |
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Fiona Cresswell
ID:
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High dose oral and intravenous rifampicin for adult tuberculous meningitis: an open-label phase II randomised controlled trial
REFNo: HS136ES
1. To determine whether higher-dose rifampicin, delivered orally at 35mg/kg/day or delivered intravenously at 20 mg/kg/day (for 2-weeks, followed by orally at 35 mg/kg/day for 6-weeks) provide equivalent plasma and CSF exposures, and whether the exposure profiles are favourable compared to the standard dose oral rifampicin. The pharmacokinetically optimal dose and route of administration of rifampicin can then be taken forward into a phase III clinical trial.
2. To observe whether greater rifampicin exposure in CSF is associated with any clinical benefit including more rapid resolution of coma, reduced neurocognitive deficit or reduced mortality.
3. To determine the diagnostic accuracy of Xpert MTB/Rif Ultra for TBM (ancillary study 1)
4. To describe the concentration of rifampicin in brain tissue in each treatment arm (ancillary study 2)
5. To explore the use of bedside ultrasound as a monitoring tool to improve supportive care for people with TBM (ancillary study 3)
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UK |
2018-05-15 |
2021-05-15 |
Medical and Health Sciences |
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Degree Award |
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Moses Ocan
ID: UNCST-2020-R014731
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Antimalarial resistance in Sub-Saharan Africa: Assessing spread of artemisinin resistance and chloroquine resistance reversal among Plasmodium falciparum parasites
REFNo: HS168ES
1) To determine through a systematic review, the extent of chloroquine resistance reversal among Plasmodium falciparum parasites in malaria endemic countries since the change in policy
2) To determine the association between four (4) most reported K13 gene polymorphisms in Sub-Saharan Africa and artemisinin susceptibility among Plasmodium parasites
3) To predict using a model the spread to Sub-Sahara African (Uganda) Plasmodium falciparum parasite population of the K13 propeller gene polymorphisms detected in Southeast Asia and associated with artemisinin resistance
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Uganda |
2018-05-15 |
2021-05-15 |
Medical and Health Sciences |
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Degree Award |
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Kirsten Ward
ID:
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Evaluation of delivery practices for multiple vaccines at a single immunization visit in low- and middle-income countries Uganda
REFNo: HS170ES
Aim: This evaluation aims to describe current preparation, administration and communication practices in the delivery of more than one vaccine to a single child at a single immunization visit in Uganda.
Objectives: 1. To document the processes and techniques used to prepare and administer more than one vaccine, primarily injectable vaccines, to children in Uganda;
2. To understand the timing, content, and extent of communication messages about co-administration of one or more vaccines and post-vaccination care delivered by providers to caregivers in Uganda; and
3. To use results from 1 & 2 to develop recommendations about best practices for: a) the preparation and delivery of multiple vaccines with a focus on injectable vaccines, and b) provider communication to the caregiver about delivery of multiple vaccines and post-vaccination care.
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Australia |
2018-05-15 |
2021-05-15 |
Medical and Health Sciences |
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Non-degree Award |
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