Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Walter Akwat
ID: UNCST-2024-R003452
 Uganda Multi-Sectoral Needs Assessment (MSNA) 2024
REFNo: SS3727ES

• Conduct a thorough inter-sectoral analysis to assess the magnitude and
severity of humanitarian needs and conditions among refugee and host
community households across all 13 formal refugee settlements across
the country and refugee concentrations in Kampala.
• Identify variations in humanitarian needs across different areas of study,
population groups, and household vulnerability profiles.
• Compare key findings of the 2024 MSNA with the Vulnerability and
Essential Needs Assessment (VENA) (2019) and 2018 MSNA.
• Offer insights into inter-sectoral needs to inform prioritization of refugee
response efforts and strategic planning.
Uganda 2025-04-02 9:20:09 2028-04-02 Social Science and Humanities Non-Clinical Trial Non-degree Award
Agrace Atwikirize
ID: UNCST-2024-R002716
 Stressors, Coping Strategies, Hope and Academic Perfomance of Teacher-Trainees in Universities in Central Region, Uganda
REFNo: SS3485ES

i. To find out the variations of stressors with biodata among teacher-trainees in universities in Central Region, Uganda.
ii. To investigate the relationship between stressors and coping strategies among teacher-trainees in universities in Central Region, Uganda.
iii. To establish the relationship between coping strategies and academic performance among teacher-trainees in universities in Central Region, Uganda.
iv. To assess if the relationship between stress and academic performance is mediated by coping strategies among teacher-trainees in universities in Central Region, Uganda.
v. To determine the mediating effect of coping strategies and hope on the relationship between stressors and academic performance among teacher-trainees in universities in Central Region, Uganda.

Uganda 2025-04-02 9:18:20 2028-04-02 Social Science and Humanities Non-Clinical Trial Degree Award
Mohamed  Ali Bashir
ID: UNCST-2024-R002641
 PREVALANCE AND FACTORS ASSOCIATED WITH IMMEDIATE ADVERSE PERINATAL OUTCOMES AMONG WOMEN WITH UNINTENDED PREGNANCIES DELIVERING AT MBARARA REGIONAL REFERRAL HOSPITAL
REFNo: HS5383ES

General Objectives
To determine prevalence and factors associated with immediate adverse perinatal outcome among women with unintended pregnancies delivering at Mbarara Regional Referral Hospital.
Specific Objectives
1. To determine prevalence of immediate adverse perinatal outcomes among women with unintended pregnancies delivering at Mbarara Regional Referral Hospital.
2. To determine factors associated with immediate adverse perinatal outcome among women with unintended pregnancies delivering at Mbarara Regional Referral Hospital.

 Somalia 2025-04-02 9:16:24 2028-04-02 Medical and Health Sciences Non-Clinical Trial Degree Award
Cecilia Akatukwasa
ID: UNCST-2024-R002112
 Feasibility and acceptability of the Vxnaid-Immunization Information System (Vxnaid-IIS) for improved Immunization Monitoring and Data Management through Digitization in Wakiso district.
REFNo: SS3734ES

4. To explore stakeholder’s insights and perspectives into future use of Vxnaid-Immunization Information System including sustainability,3. To assess the barriers and enablers to implementation of the Vxnaid-Immunization Information System across four HSDs and four Municipal councils in Wakiso district.,2. To explore key stakeholders’ perceptions, attitudes and acceptance of the Vxnaid-Immunization Information System,1. Explore key stakeholders’ perspectives on practicality, ease of use and overall experience with integrating Vxnaid into current Immunization Information systems across four HSDs and four Municipal councils in Wakiso district.,
 Uganda 2025-04-02 9:08:21 2028-04-02 Social Science and Humanities Non-Clinical Trial Non-degree Award
William Blackmon
ID: UNCST-2025-R017006
 Consumer Protection Surveys - Uganda
REFNo: SS3650ES

The project aims to:
• Measure consumer protection risks associated with digital financial services (DFS) usage in Uganda
• Track consumer protection risks across two survey rounds
• Create a comparable cross-country analysis (the survey is also carried out in 10 other countries)

 USA 2025-04-02 9:06:12 2028-04-02 Social Science and Humanities Non-Clinical Trial Non-degree Award
Maxensia owor
ID: UNCST-2021-R014003
 An open-label randomised controlled trial comparing novel combination and currently used antibiotic regimens for the empiric treatment of neonatal sepsis with a run-in confirmatory pharmacokinetic phase: NeoSep1
REFNo: HS5639ES

In Part 2, a secondary objective is to provide a ranking of clinically relevant antibiotic regimens based on other efficacy and safety secondary outcomes, as well as on health economic measures and the potential selection of resistance. The trial data will provide data to inform the balance between efficacy, safety, costs (and cost-effectiveness and equity, using health economic analysis) and propensity for resistance selection (based on microbiology tests) that will influence facility-level and national decision-making about adoption of studied regimens, and potential future inclusion in WHO guidelines.,In Part 2, the primary objective is to provide a ranking of eight different clinically relevant antibiotic regimens for first-line empiric and second-line (after lack of response/deterioration) treatment in terms of 28-day mortality as the primary outcome measure. It will flexibly compare these multiple different relevant treatment regimens to enable the trial to be run in sites worldwide with very different background rates of different pathogens, of resistance and patterns of routine clinical care by randomising each participant to locally relevant antibiotic regimens agreed prior to site initiation. The trial will ensure generalisability by focusing inclusion based on clinical symptoms associated with high mortality risk in the NeoOBS study, which have been developed into a novel neonatal sepsis severity score – the NeoSep Severity Score.,
 Uganda 2025-04-02 9:04:16 2028-04-02 Medical and Health Sciences Clinical Trial Non-degree Award
Gloria Lubega
ID: UNCST-2025-R017180
 A retrospective review of patients admitted with SARS-COV-2 at Entebbe regional referral hospital in Uganda across multiple waves.
REFNo: HS5695ES

I. To evaluate the mortality rate, risk factors associated with mortality and prolonged hospital admission among patients admitted with severe COVID-19 disease at ERRH.
II. To determine the time to discharge of patients admitted with severe COVID-19 disease at ERRH.
III. To describe the characteristics of patients across different age groups admitted with severe COVID-19 at Entebbe Regional Referral Hospital
IV. To describe treatment options offered to patients admitted with severe COVID-19 disease with reference to Uganda MoH and WHO recommended treatment options.
V. To compare characteristics of patients who were vaccinated against COVID-19 admitted with severe disease and unvaccinated patients admitted with severe COVID-19 disease.

 Uganda 2025-04-02 9:01:54 2028-04-02 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Mark Kaddumukasa
ID: UNCST-2020-R001798
 Building a Collaborative Research and Training Platform for HIV and Rheumatic and Musculoskeletal Diseases in Uganda
REFNo: HS5606ES

Objective 1. Establish the Ugandan Registry of RMDs in HIV (GEMINI), to create a foundation for future prospective studies on HIV and RMDs.
Objective 2. In a pilot study, among a subset of participants from GEMINI with both RA and HIV, compared to participants with HIV only and RA only, explore the impact of co-morbid disease status on markers of bone metabolism, bone mineral density, as well as quality of life and functional disability.
Uganda 2025-04-02 9:00:14 2028-04-02 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Sylvia Kusemererwa
ID: UNCST-2019-R001717
 A phase III, multi-center, randomized, placebo-controlled, double-blind study to assess efficacy and safety of crizanlizumab (5 mg/kg) versus placebo, with or without hydroxyurea/hydroxycarbamide therapy, in adolescent and adult Sickle Cell Disease patients with frequent vaso-occlusive crises
REFNo: HS5607ES

To assess the efficacy and safety of crizanlizumab (5 mg/kg) versus placebo, with or without
hydroxyurea (HU)/hydroxycarbamide (HC) , on VOC rate in Sickle Cell Disease (SCD) patients aged 12 years and older who experience frequent vaso-occlusive crises (VOCs)
Primary Objective
1. To compare the efficacy of 5 mg/kg of crizanlizumab versus placebo, with or without hydroxyurea/hydroxycarbamide, on the annualized rate of VOCs* that are HCP managed (including VOCs leading to management at a health care facility or those via remote consultation) over the planned 52-week treatment period in SCD patients aged 12 years and older with a history of frequent VOCs (4-12 events in 12 months prior to the screening visit).
Secondary Objectives
1. To compare the efficacy of 5 mg/kg of crizanlizumab versus placebo, with or without
hydroxyurea/hydroxycarbamide, on the annualized rate of all VOCs including VOCs that are HCP-managed (including VOCs leading to management at a health care facility or those managed via remote consultation) and VOCs that are self-managed without recommendations from HCP during the event over the planned 52-week treatment period in SCD patients aged 12 years and older with a history of frequent VOCs (4-12 events in the 12 months prior to the screening visit).
2. To evaluate the annualized rate of VOCs by type of management between treatment arms over the planned 52-week treatment period:
 VOCs that are HCP-managed at a health care facility
 VOCs that are HCP-managed via remote consultation
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 VOCs that are self-managed without recommendations from HCP during the event
 VOCs that are HCP-managed via remote consultation or self-managed without recommendations from HCP during the event
 Uganda 2025-04-02 8:58:47 2028-04-02 Medical and Health Sciences Clinical Trial Non-degree Award
Aloysious Ssemaganda
ID: UNCST-2023-R008046
 Clinical Performance of i.Mune CD4 diagnostic assay amongst people living with Human immunodeficiency virus (HIV) in Uganda (CPHL-CPSP_001)
REFNo: HS5680ES

The primary objective of this study is to evaluate the clinical performance and validity of the i.Mune CD4 diagnostic assay compared to WHO pre-qualified and CE-marked Abbott PIMA CD4 test using matched liquid and dried venous blood as well as capillary dried blood specimen
collected from people living with HIV in Uganda.

Secondary objectives of this study are:
-To validate the i.Mune CD4 diagnostic assay using the Applied Biosystems™ QuantStudio 5 PCR System in Uganda to support WHO pre-qualification.
-To establish trueness of measurement of the i.Mune CD4 diagnostic assay using the LightCycler 480 Instrument II and the LightCycler PRO in comparison to the reference method (Abbott CD4 PIMA) to support CE-marking of the assay.
 Uganda 2025-04-02 8:53:21 2028-04-02 Medical and Health Sciences Non-Clinical Trial Non-degree Award
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