Edgar Mulogo Mugema
ID: UNCST-2023-R008170
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HIV-Associated Viral Acute Respiratory Tract Illness (HAVARTI): The burden and severity of vaccine-preventable respiratory infection in people living with HIV in rural Uganda.
REFNo: HS5676ES
Primary Objective
The overarching goal of this study is to define the incidence and relative frequency of, and severity of illness from, influenza and two other vaccine-preventable viral respiratory infections, respiratory syncytial virus (RSV) and SARS-CoV-2, among people living with HIV (PLWH) in rural Uganda.
Specific Aims
1. Determine the incidence of ARI in a cohort of individuals living with HIV in rural Uganda and the proportion and incidence of those ARI episodes caused by vaccine-preventable viral respiratory infections (influenza, RSV, and SARS-CoV-2). We will enroll adolescents and adults infected with HIV who receive care at the Antiretroviral Therapy (ART) clinic at Bugoye Health Centre (BHC), a rural peripheral health facility in western Uganda. Participants will self-collect a mid-turbinate nasal swab at the onset of every episode of ARI during the study follow-up period. Samples will be tested for RSV, influenza, and SARS-CoV-2 within 48 hours of collection using a molecular assay.
2. Estimate the morbidity and mortality from influenza, RSV, and SARS-CoV-2 in this same population of PLWH. Study staff will conduct home visits 14 days after the onset of each episode of ARI to assess outcomes. Specifically, they will record any antibiotic or other treatment taken and its source (e.g., purchased at drug shop or prescribed by a healthcare provider); missed days of work (e.g., in the field for subsistence farmers); care-seeking including outpatient visits and inpatient admissions; and vital status.
3. Explore risk factors for severe disease from influenza, RSV, and SARS-CoV-2 among PLWH. As an exploratory aim, we will collect information on demographics, household and socioeconomic factors, cooking methods, past medical history including presence of underlying lung disease, smoking status, and history of pneumonia or tuberculosis, nadir and last CD4 count, most recent HIV viral load (VL) and VL at diagnosis, and ART history.
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Uganda |
2025-04-11 14:15:22 |
2028-04-11 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
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Ouma Simple
ID: UNCST-2021-R012820
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Harnessing Parental Social Networks to Increase HIV Testing Uptake Among Children of At-Risk Parents in Uganda: A Parallel-Group, Two-Arm Quasi-Experimental Implementation Science Protocol
REFNo: HS5741ES
Objectives:
Main Objective
To Adapt, implement and evaluate maternal SNS to improve access to HIV testing services among children of FSW.
Specific Objectives
1. To adapt SNS that harnesses maternal SN for HIV testing in children of female sex workers
2. To implement the adapted HASHTAG intervention targeting CARP in Gulu City
3. To evaluate the effectiveness and implementation science outcomes of the HASHTAG project
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Uganda |
2025-04-11 14:13:08 |
2028-04-11 |
Medical and Health Sciences |
Clinical Trial |
Non-degree Award |
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Davis Hafashimana Simon
ID: UNCST-2025-R018006
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An investigation into the variability of Hemileia vastatrix on Robusta coffee in Uganda
REFNo: A591ES
Objectives
1. To assess the genetic diversity of Hemileia vastatrix on Robusta coffee in Uganda
2. To make a linkage of any observed diversity to disease distribution in Uganda
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Uganda |
2025-04-11 14:11:00 |
2028-04-11 |
Agricultural Sciences |
Non-Clinical Trial |
Non-degree Award |
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Venantius Bbaale Kirwana Bbaale
ID: UNCST-2024-R002370
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RISKY SEXUAL BEHAVIOUR AMONG YOUNG PEOPLE IN UGANDA’S ISLANDS, AN ANALYSIS OF SEXUALITY INFORMATION SOURCES AND COMPLETENESS.
REFNo: SS3785ES
4-Evaluate the level of completeness of sexuality information from various sources to young people in Uganda\'s island communities,3-Compare current and preferred sources of sexuality information sources among young people in the Uganda Island communities,2-Assess the barriers young people in island communities face in accessing sexuality information from different sources.,1-Explore young people’s perceptions of risky sexual behavior in the Uganda Island communities.,Examine young people’s perceptions of risky sexual behavior and how sexuality information sources and completeness influence sexual behavior, in Uganda Island communities.,
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Uganda |
2025-04-11 14:09:55 |
2028-04-11 |
Social Science and Humanities |
Non-Clinical Trial |
Degree Award |
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Javan Tindyebwa
ID: UNCST-2025-R017192
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ETHICAL LEADERSHIP, LEADER ACCOUNTABILITY, STAKEHOLDER PARTICIPATION, AND EDUCATION SERVICE QUALITY AT MAKERERE UNIVERSITY IN UGANDA
REFNo: SS3802ES
To examine the extent to which Stakeholder Participation mediates the relationship between Ethical Leadership and Education Service Quality in MUK in Uganda.,To establish the effect of Ethical Leadership on Education Service Quality in MUK in Uganda. ,To establish the effect of Stakeholder Participation on Education Service Quality in MUK in Uganda., To establish the effect of Leadership Accountability on Education Service Quality in MUK in Uganda,To examine the relationship between ethical leadership and leader accountability, and service quality and how these relationships are mediated by stakeholders at Makerere University.,
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Uganda |
2025-04-11 14:04:32 |
2028-04-11 |
Social Science and Humanities |
Non-Clinical Trial |
Degree Award |
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EDIMOND SERWANGA
ID: UNCST-2025-R017659
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ASSESSING THE SITUATION OF TEACHERS IN PRIMARY AND SECONDARY SCHOOLS IN UGANDA
REFNo: SS3797ES
General objective
To assess the teaching and learning situation of primary and secondary school teachers in both refugee and non-refugee settings across Uganda's West Nile and Karamoja sub-regions.
1.2.2. Specific objectives
The study aims to address the following specific objectives:
(i) To explore how teachers create, promote and utilise a supportive teaching environment that enhances their professional growth and well-being.
(ii) To establish school and community practices that enhance child protection, well-being, and inclusion.
(iii) To assess teachers’ practices on classroom management, instruction and assessment.
(iv) To establish teachers’ understanding of the curriculum and how it informs teachers’ practices.
(v) To establish language support strategies used by teachers to promote learning in schools.
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Uganda |
2025-04-09 17:19:38 |
2028-04-09 |
Social Science and Humanities |
Non-Clinical Trial |
Non-degree Award |
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Lolem Lucy Chegem
ID: UNCST-2024-R004656
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Nature and Degree of Karamojong Pastoral Community Participation and Integration in Wildlife Conservation Interventions in Kidepo Valley National Park, North Eastern Uganda
REFNo: SS3755ES
1. To conduct a policy review towards the establishment of national (Uganda) wildlife conservation policies and guidelines on community participation and integration of Indigenous peoples' social and cultural practices
2. To examine the Karamojong Indigenous and traditional wildlife conservation values, practices, and livelihood needs associated with KVNP
3. To explore the nature of the Karamojong participation in wildlife conservation practices in the management of KVNP
4. To determine the degree of the Karamojong participation in wildlife conservation activities in KVNP
5. To explore the nature of the Karamojong integration in wildlife conservation practices in the management of KVNP
6. To determine the degree of the Karamojong integration in wildlife conservation activities in KVNP
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Uganda |
2025-04-09 17:01:55 |
2028-04-09 |
Social Science and Humanities |
Non-Clinical Trial |
Degree Award |
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REBECCA NANTANDA
ID: UNCST-2019-R001533
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Optimization and testing of ALRITE, a clinical decision support tool for management of respiratory illnesses in young children in primary care health facilities in Uganda
REFNo: HS5721ES
To pilot test ALRITE in 4 Ugandan health facilities after an optimization phase of iterative testing and ALRITE improvement.
1. To optimize ALRITE for health worker use through multiple cycles of reversal single-case experiments29,30* with 6-8 health workers per cycle.
2. Pilot-test study feasibility and the effectiveness of the optimized ALRITE tool on the diagnosis and management of wheezing illness and pneumonia in young children using interrupted time series (ITS) design.
3. Assess outcomes of implementation following ALRITE deployment and determinants of successful adoption using a sequential quant-> QUAL mixed methods design.
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Uganda |
2025-04-09 16:40:46 |
2028-04-09 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
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Peter Olds
ID: UNCST-2023-R006240
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Evaluation of NT-proBNP in outpatient heart failure care in southwestern Uganda
REFNo: HS5796ES
Main Objective
1. Create and evaluate an algorithm for nurses using a point-of-care biomarker of heart failure (N-terminal-pro hormone B-type natriuretic peptide, NT-proBNP) to support heart failure management in Uganda.
Specific Objectives
1. Identify an average baseline NT-proBNP for patients with HFrEF in the MRRH outpatient cardiology clinic.
2. Develop and compare the use of an algorithm for diuresis based on the NT-proBNP with standard of care diuretic plans for patients with HFrEF in the MRRH outpatient cardiology clinic
3. Evaluate the feasibility and acceptability of implementing an NT-proBNP based algorithm for heart failure care in Uganda
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USA |
2025-04-09 16:31:41 |
2028-04-09 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
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Jennifer Serwanga
ID: UNCST-2024-R002056
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VacICoP: Chimpanzee Adenovirus Type 3-Vectored Marburg Glycoprotein (GP)-Expressing Vaccine
(ChAd3-MARV)-Induced Correlates of Protection
REFNo: HS5469ES
This study aims to identify the immune correlates of protection (ICoPs) against Marburg virus disease (MVD) through comprehensive analyses of humoral and cellular responses in both vaccinated and infected individuals. ICoPs will be identified by studying human and non-human
primates (NHPs) that have either survived infection, succumbed to it, or been successfully immunised. The research aims to expedite regulatory approval and licensure by identifying the most effective and durable ICoPs against MVD.
Key objectives and deliverables include:
1. Identifying the MVD ICoPs
2. Detailed humoral and cellular immune profiles distinguishing protective from nonprotective anti-MARV immunity
3. Reference reagents and scalable high-throughput screening assays
4. Predictive statistical models for forecasting vaccination effectiveness
5. Integrated clinical, immunological, and demographic datasets
6. Regulatory guidance for new vaccines approval
7. Global collaborative data exchange framework
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Uganda |
2025-04-09 16:29:46 |
2028-04-09 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
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