Nathan Tumwesigye
ID:
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Quality Improvement Approaches to Enhance Iron-Folic Acid Supplementation in Antenatal Care Clinics in Iganga and Buyende Districts, Uganda
REFNo: HS396ES
Goal: To develop QI-enhanced process and assess its effects on the IFAS program, including the delivery of services, the availability of supplies and the adherence of pregnant women attending ANC to IFAS.
Aim 1 (QI implementation): The first aim is to examine the state of the health education about IFAS during ANC visits and the supply system, and to investigate the implementation of a QI-enhanced process for IFAS intervention to address the bottlenecks identified regarding a) health education; b) essential drugs quantification.
Aim 2 (QI effectiveness): The second aim is to assess the effectiveness of the QI-enhanced process for IFAS intervention on a) the quality of health education; b) women’ knowledge and motivation to use IFA tablets; c) the tracking procedures and availability of IFA tablets at health facilities providing ANC
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Uganda |
2019-07-10 |
2022-07-10 |
Medical and Health Sciences |
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Non-degree Award |
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Adelline Twimukye
ID: UNCST-2019-R000117
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FACTORS INFLUENCING PATIENT’S DECISION MAKING PROCESS ON SUBSTITUTING FROM EFAVIRENZ (EFV) TO DOLUTEGRAVIR (DTG) AT INFECTIOUS DISEASES INSTITUTE (IDI), KAMPALA- UGANDA.
REFNo: SS314ES
The overall objective of this study is to understand the factors influencing Patient’s decision-making Process on substituting from Efavirenz (EFV) to Dolutegravir (DTG) at Infectious Diseases (IDI), Kampala- Uganda.
Specific objectives
Qualitative
AIM 1. To evaluate the mechanism of the decision-making process and support required among HIV positive patients substituting from EFV to DTG at IDI in Uganda
AIM 2. To explore decision-making process of women in reproductive age (18-55 years) and explore how decisions about substitution from EFV to DTG substitution evolve over time.
AIM 5. Describe experiences around adherence among key populations taking DTG
AIM 9. To evaluate the DTG therapy implementation process among health care providers involved in the substitution from EFV to DTG.
Quantitative
AIM 3. To determine the proportion of stable Patient’s on their previous ART regimens switched to DTG.
AIM 4. To asses factors associated toxicities or adverse effects on patients switched from EFV or DTG.
AIM 6. To determine the proportion and characteristics of patients who have substituted from Efavirenz to DTG.
AIM 7. To determine factors associated with substituting from EFV to DTG
AIM 8. To describe quality of life of patients who have substituted from EFV to DTG.
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Uganda |
2019-07-10 |
2022-07-10 |
Social Science and Humanities |
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Non-degree Award |
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Sabine Haller
ID:
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Amikacin Exposure and Toxicity - Pharmacokinetic-Pharmacodynamic Analysis in Patients with Multidrug-Resistant Tuberculosis in Uganda: A Pilot Study
REFNo: HS402ES
To describe the pharmacokinetics of amikacin in patients with multidrug-resistant tuberculosis.
To explore the relationship between exposure to amikacin and the toxicity of this drug using pharmacokinetic-pharmacodynamic modelling.
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Switzerland |
2019-07-10 |
2022-07-10 |
Medical and Health Sciences |
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Non-degree Award |
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STEPHEN LUTOTI
ID:
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Anti-Proliferative Activity screening of bioactive compounds from medicinal plants traditionally used by Breast Cancer patients in Central Uganda
REFNo: HS405ES
The general objective of this study is to discover novel, potent anti-breast cancer compounds from plants used in traditional treatment of breast cancer by in Central Uganda.
Specific Objectives
This study is designed to address four specific objectives, namely:
i. To describe the beliefs and practices of breast cancer patients in Central Uganda towards use of herbal medicines.
ii. To document the medicinal plants used in traditional treatment of breast tumours in Central Uganda.
iii. To establish the anti-proliferative activity of extracts of selected medicinal plants identified from the ethnobotanical survey.
iv. To elucidate the bioactive compounds in the two most efficacious extracts against breast cancer.
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Uganda |
2019-07-10 |
2022-07-10 |
Medical and Health Sciences |
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Degree Award |
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Elliot Howard-Spink Charles
ID:
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Do cultural evolutionary processes shape the long-distance vocalisations of wild chimpanzees (Pan troglodytes)?
REFNo: NS97ES
Overall Objective: To determine the extent to which populations of chimpanzees show differences in their long-distance communication behaviours, and what factors may drive differences in these behaviours between populations. I will do this by completing the following four sub-objectives.
Objective 1 – Create an ethnography for behavioural features of chimpanzee pant-hoot displays. I intend to collect video and audio footage of the pant-hoot displays of chimpanzees in the Bugoma rainforest, which I can then compare to pre-existing video and audio footage of pant-hoots by chimpanzees in other populations across Africa. I will use collected data, and pre-existing data, to create an ethnography of pant-hoot displays in different chimpanzee populations (Whiten et al., 1999). Once a working ethnography of the behavioural features of these displays has been established, I will investigate the biological forces that may be driving inter-population variation in pant-hoot displays.
Objective 2 – Determine the extent to which genetics determines the behavioural features of pant-hoot displays. I will do this by following a method outlined by Lycett et al, 2007, who investigated the genetic influences of chimpanzee tool use behaviours. The ethnography generated in objective 1 will be used to create a maximum-likelihood phylogenetic tree based on the traits of pant-hoot displays. This will then be compared with well-established genetic phylogenies of chimpanzee populations. Increasing similarities between these evolutionary trees would suggest that genetics is increasingly more likely in explaining behavioural differences in pant-hoot calls between chimpanzee populations.
Objective 3 - Determine the extent to which environmental variables determine the behavioural features of pant-hoot displays. This will be done by creating mathematical models which try to explain variation in pant-hoot displays using physical and social environmental variables of the caller’s environment. Physical variables include weather patterns and vegetation density. Social variables include the immediate social party, caller identity, and caller status at the time of vocalization. These models will assess the variation in pant-hooting which can be explained by the caller’s environment, as well as the variation which remains unexplained.
Objective 4 – Assess the likelihood of cultural evolutionary forces driving pant-hoot variation between chimpanzee populations. This will be done by method of exclusion. This would involve taking variation in pant-hooting behaviour which cannot be explained by genetics or the environment and discussing the likelihood of its formation due to vocal learning behaviours in chimpanzees. The existence of these behaviours in chimpanzee populations remains inconclusive, and this project aims to begin to elucidate the extent to which chimpanzees show cultural differences in their communicative behaviours.
Lycett, S. J., Collard, M. and McGrew, W. C. (2007) ‘Phylogenetic analyses of behavior support existence of culture among wild chimpanzees’, Proceedings of the National Academy of Sciences, 104(45), pp. 17588–17592.
Whiten, A. et al. (1999) ‘Cultures in chimpanzees’, Nature, 399(6737), pp. 682–685. doi: 10.1038/21415.
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UK |
2019-07-10 |
2022-07-10 |
Natural Sciences |
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Degree Award |
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