Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Allen Kabagenyi
ID: UNCST-2019-R000665
 A Gendered Analysis of Preparedness and Response to Natural Disasters in Kasese District
REFNo: SS4854ES

To examine household-level flood and landslide response strategies in Kasese District, with a focus on the extent of response mechanisms, the socio-economic and cultural factors influencing their effectiveness, and gender-based differences in disaster response approaches.
Uganda 2026-04-24 14:28:53 2029-04-24 Social Science and Humanities Non-Clinical Trial Non-degree Award
Francis Ssali
ID: UNCST-2021-R012134
 A5424 Menopausal Hormone Therapy for Women Living with HIV (HoT)
REFNo: HS7391ES


1.2 Primary Objective

1.2.1 Determine the effects of HT on VMS in WLWH in the late menopausal transition or early postmenopause.

1.3 Secondary Objectives

1.3.1 Evaluate the safety and tolerability of HT as compared to placebo.

1.3.2 Determine the effect of HT on neurocognition.

1.3.3 Determine the effect of HT on mood.

1.3.4 Determine the effect of HT on sleep.

1.3.5 Determine the effect of HT on quality of life.

1.3.6 Determine the effect of HT on sexual function.

1.3.7 Determine the effect of HT on weight, waist circumference, and waist-to-hip ratio.

1.4 Exploratory Objectives

1.4.1 Determine the effect of HT on markers of bone turnover.

1.4.2 Determine the effect of HT on markers of cardiometabolic health.

1.4.3 Determine the effect of HT on systemic markers of inflammation and immune activation.

1.4.4 Determine the effect of HT on HIV reservoir size, clonality, and activity.

1.4.5 Determine the effect of HT on measures of physical function.

1.4.6 Determine the effect of HT on the rectal and vaginal microbiome.

1.4.7 Explore the effect of HT on all primary and secondary outcomes by antiretroviral regimen.

1.4.8 Explore exposure-response relationships between estradiol pharmacokinetics (PK) and study outcomes in those treated with estradiol.

1.4.9 Evaluate acceptability and feasibility of ambulatory monitors for VMS and sleep on a subset of participants.

1.4.10 Explore agreement between subjective VMS frequency with objective VMS frequency in a subset of participants.


 Uganda 2026-04-24 13:20:15 2029-04-24 Medical and Health Sciences Clinical Trial Non-degree Award
Peter Olupot Simon
ID: UNCST-2025-R022744
 Implementation of Sustainable Public Procurement in the Procurement of Works in Uganda’s Central Government Entities
REFNo: SS5085ES

i. To examine the relationship between external pressures and implementation of SPP.
ii. To examine the relationship between resource heterogeneity and implementation of SPP.
iii. To examine the relationship between stakeholder engagement and implementation of SPP.
iv. To examine the mediating role of resource heterogeneity in the relationship between external pressures and implementation of SPP.
v. To examine the mediating role of resource heterogeneity in the relationship between stakeholder engagement and implementation of SPP.
vi. To examine the moderating effect of procurement officers’ attitude in the relationship between resource heterogeneity and implementation of SPP.
vii. To examine how procurement officers’ attitude will moderate the relationship between external pressures and implementation of SPP through resource heterogeneity.
viii. To examine how procurement officers’ attitude moderates the relationship between stakeholder engagement and implementation of SPP through resource heterogeneity.

 Uganda 2026-04-20 9:42:42 2029-04-20 Social Science and Humanities Non-Clinical Trial Degree Award
Robert Mboizi Baldwin
ID: UNCST-2020-R014356
 Optimising Eligibility Criteria for Participant Selection in Maternal Vaccine Trials in Low-Resource Settings (ACCESS).
REFNo: HS7404ES

1. To conduct a systematic review and analyse existing eligibility criteria used in maternal vaccine trials globally, with a focus on their applicability and limitations in low-resource settings.

2. Determine the proportion of women ineligible to participate in maternal vaccine clinical trials at Kawempe National Referral Hospital using an eligibility assessment tool.

3. Determine the pregnancy outcomes in women ineligible for maternal vaccine trials at Kawempe National Referral Hospital using an eligibility assessment tool.

4. Identify factors associated with pregnancy outcomes among pregnant women excluded from trial participation.

Uganda 2026-04-20 16:50:32 2029-04-20 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Yudaya Nakyeyune
ID: UNCST-2026-R024597
 Using Play in Culturally Responsive Ways to Enhance Children’s Numeracy Skills Achievement in Refugee-Hosting ECD Centers in Kampala
REFNo: SS5116ES

1. To analyze children's voices of learning through play in refugee hosting ECD centers in Kampala.
2. To identify the challenges teachers encounter when using play in the teaching of numeracy in refugee hosting ECD centers in Kampala
3 To establish the impact of engagement in Continuing Professional Development (CPD) on teachers' knowledge regarding the use of play-based methods in culturally responsive ways in refugee hosting ECD centers in Kampala
4. To assess the impact of engagement in culturally responsive learning through play activities on children's numeracy achievement in refugee hosting ECD venters in Kampala
Uganda 2026-04-20 16:47:28 2029-04-20 Social Science and Humanities Clinical Trial Degree Award
PIUS OKELLO ROBERT
ID: UNCST-2026-R024675
 School Management Functions and Academic Performance of Students in Government-Aided Secondary Schools A Case of Dokolo District, Uganda
REFNo: SS5162ES

Purpose of Study
To investigate the contribution of School Management Functions and its relationship with academic Performance of Students in Government-aided Secondary Schools in Dokolo District.


Specific Objectives
1. To evaluate the effect of management planning function on academic performance of students in Government-aided Secondary Schools in Dokolo District.

2. To analyze the effect of management organizing function on academic
performance students in Government-aided Secondary Schools in Dokolo District.

3. To assess the role of management controlling function on academic performance of students in Government-aided Secondary Schools in Dokolo District.

4. To investigate the mediating effects of perceived on relationship between school management functions and academic performance of students in government-aided Secondary Schools in Dokolo District.
 Uganda 2026-04-20 16:25:31 2029-04-20 Social Science and Humanities Non-Clinical Trial Degree Award
Clifton IRAHUKA
ID: UNCST-2025-R018482
 Evaluating the Feasibility and Acceptability of an Offline-First AI Health Companion for Frontline Health Workers in Uganda: A Mixed-Methods Concurrent Triangulation Study
REFNo: HS7408ES

General objective To evaluate the feasibility and acceptability of an offline-first AI Health Companion for clinical decision-making among Frontline Health Workers in health facilities in Luweero District, Uganda. Specific objectives To assess the feasibility of the offline-first AI Health Companion application among FHWs in public health facilities in Luweero district. To evaluate the acceptability of the offline-first AI Health Companion among FHW in public health facilities in Luweero district. To determine the individual, technological and organisational factors that influence the adoption and sustained use of AI clinical decision support tools among FHWs in public health facilities in Luweero district. To explore the facilitators of and barriers to scaling offline AI decision support tools among FHWs in Luweero district
Uganda 2026-04-20 16:19:00 2029-04-20 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Madrine Nabukenya Mkisa
ID: UNCST-2026-R024084
 Psychological Resilience among Teachers in Private Secondary Schools in Wakiso District, Uganda.
REFNo: SS5118ES

i) To document factors that influence the psychological resilience of teachers in private secondary schools in Wakiso district ii) To explore the perception of teachers on self-efficacy, affective flexibility, and spiritual well-being in private secondary schools in Wakiso district. iii) To assess the influence of self-efficacy, flexibility, and spiritual well-being on teachers’ ability to adapt to employment terms (remuneration, job security, career growth, workload management, resource management) in a private secondary school in Wakiso district. iv) Examine the relationships that may exist between self-efficacy, flexibility, spiritual well-being, and psychological resilience among teachers in private secondary schools in Wakiso district.
Uganda 2026-04-20 16:16:00 2029-04-20 Social Science and Humanities Non-Clinical Trial Degree Award
David Mafigiri Kaawa
ID: UNCST-2019-R001276
 Testing on the frontline: empowering health engagement through ‘rational use’ of diagnostics for infectious and non-communicable disease (TIYENI Dx)
REFNo: SS5125ES

1. To define ‘rational use’ from the perspective of users, families, communities and frontline health workers and document social and structural drivers of self-testing for self-care under specific external conditions of stigma, emergency disease outbreaks and lifestyle and risk management for chronic disease across mainstream and marginalised groups.

2. To unpack the dynamic between empowerment through self-testing and engagement with public and private health services including the role of frontline health providers influencing self-testing in different contexts and potential for linkage to health and data systems.

3. To explore discourses of uncertainty, trust and risk influencing individual, family, community and frontline health worker decisions, embedded within complex socio-ecological environments and the impact of these on intended and unintended, beneficial and potentially harmful health and social consequences of self-testing.

4. To co-production of toolkits for ‘rational use’ of frontline diagnostics including community review of the UNICEF ‘Lets Test Toolkit’ and co-adaptation of self-testing generic and self-testing specific implementation guidelines and instructions for use.

5. To promote health equity across mainstream and marginalised groups in access to and ‘rational use’ of self-testing and monitoring that appropriately reflects future direct to consumer markets through a) informing country level strategies on frontline diagnostics as part of national health plans and b) developing a theoretical framework for people-centred ‘rational use’.

 Uganda 2026-04-20 16:06:19 2029-04-20 Social Science and Humanities Non-Clinical Trial Non-degree Award
John Mary Kanyamurwa
ID: UNCST-2025-R019398
 Climate Change Threats to Livelihood Resilience and Adaptive Governance in Uganda's Bulambuli District
REFNo: SS5070ES

Major Objective To critically examine the impacts of climate change on livelihood resilience and adaptive governance in Uganda’s Bulambuli District, focusing on identifying targeted strategies to enhance rural communities' adaptive capacity and resilience to climate-induced shocks. Specific Objectives 1. To analyze the impacts of climate change on rural farm livelihoods and socio-economic stability in Bulambuli District. 2. To investigate the mechanisms by which governance system interventions address climate change challenges and enhance livelihood resilience. 3. To evaluate local communities' coping mechanisms in response to climate-induced challenges in Bulambuli District. 4. To identify gaps in governance mechanisms that hinder effective adaptation of rural communities' resilience to climate change impacts in the district.
Uganda 2026-04-20 16:02:15 2029-04-20 Social Science and Humanities Non-Clinical Trial Non-degree Award
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