David Meya Bisagaya
ID: UNCST-2019-R000837
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High Dose Oral Rifampicin to Improve Survival from Adult Tuberculous Meningitis: A Double-blinded Randomised Controlled Phase III Trial. HARVEST trial
REFNo: HS428ES
Our primary objective is: To determine if high dose rifampicin, delivered orally at ~35 mg/kg/day for 8 weeks, is safe and improves 6-month survival compared to standard of care (rifampicin 10 mg/kg/day) for patients with TBM.
Secondary objectives are to compare the high dose rifampicin regimen to the standard of care regimen for:
1. 12-month survival
2. Neurological disability and functional outcomes from TBM
3. Safety and tolerability
4. Hospital outcomes related to TBM
5. Subsequent neurologic deterioration
6. Management of drug-induced liver injury
Tertiary objectives are to:
1. To describe the pharmacokinetics (PK) of high dose rifampicin in plasma and CSF, assess predictors of exposure to rifampicin in plasma and CSF, assess PK-PD relationships also considering exposures to the other first-line TB drugs and ART in HIV-infected patients, and determine the minimally desired rifampicin exposure for optimal treatment of TBM.
2. To determine the cost-effectiveness of the intervention.
3. To determine appropriate TBM diagnostic algorithms
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Uganda |
2019-09-05 |
2022-09-05 |
Medical and Health Sciences |
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Non-degree Award |
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Kevin Hunt Dean
ID:
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DRY HABITAT CHIMPANZEE ECOLOGY: IMPLICATIONS FOR HUMAN
EVOLUTION
REFNo: NS101ES
Document feeding, social and locomotor behavior using 1-minute focal observations. Record food items, ranging behavior, canopy use, feeding rate and habitat use. Collect hairs for trace element analysis. Collect skeletal material from any deceased individuals. Analyze skeletal material for distinctive characteristics. Analyse hormone profiles to determine if lower levels of aggression are due to low T levels. Look for poisons in Muguri River to find source of sex organ abnormalities. Examine dental micro wear and trace elements in hair to determine diet. Look at genetic variations
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USA |
2019-09-05 |
2022-09-05 |
Natural Sciences |
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Non-degree Award |
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Sangjin Kang
ID:
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Establishment of libraries of indigenous medicinal plants in Mount Elgon area
REFNo: NS86ES
To conserve knowledge and resources about indigenous medicinal plants in Mt. Elgon area through activities such as;
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Republic of Korea Reunion |
2019-08-27 |
2022-08-27 |
Natural Sciences |
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Non-degree Award |
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Mushagalusa Kasali Félicien Kasali
ID:
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Phytochemical and Pharmacological Study of Chenopodium ambrosioides L. and Physalis peruviana L., herbs used to treat diabetes in Congolese Traditional Medicine
REFNo: HS440ES
1. To test the activity of the bioguided fractions of the extracts obtained in-vivo, on acute, sub-acute and chronic hyperglycemia in experimental rats.
2. To determine the zootechnical, biochemical and histopathological markers of the extracts obtained in experimental rats.
3. To isolate and elucidate the structure of the bioactive components of the extracts obtained.
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Democratic Republic of Congo |
2019-08-27 |
2022-08-27 |
Medical and Health Sciences |
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Degree Award |
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Zubair Lukyamuzi
ID: UNCST-2021-R013107
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THE ROLE OF COMMUNITY HEALTH WORKERS IN FACILITATING DISCLOSURE AMONG HIV AFFECTED COUPLES IN GREATER LUWEERO DISTRICT, UGANDA.
REFNo: HS443ES
1. To determine the predictors of non-disclosure among HIV affected couples
2. To document perceptions of HIV affected couples on using CHWs to facilitate their HIV status disclosure
3. To explore CHW’s general and attitudes about HIV status disclosure among HIV affected couples
4. To explore CHW’s experience in facilitating disclosure among HIV affected couples.
5. To determine the proportion of HIV status disclosure among HIV affected couples that can be achieved using CHWs
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Uganda |
2019-08-26 |
2022-08-26 |
Medical and Health Sciences |
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Degree Award |
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