Lydia Nakiyingi
ID:
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Impact of TB and HIV co-infection on host and microbial gene expression in the upper airway
REFNo: HS502ES
Objectives of the research project: Aim 1: Compare the differences in the microbiota and host gene expression in the upper airway of TB/HIV cases versus HIV only individuals. We will use RNA-seq to profile host gene expression and microbial abundance in TB/HIV and HIV only individuals and identify differences between these two groups.
Aim 2: Develop candidate diagnostic biomarkers for identifying TB/HIV co-infection. We will develop a preliminary nasal biomarker for differentiating TB/HIV from HIV only (controls) using host gene expression, the microbiome, or a combination.
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Uganda |
2019-12-27 |
2022-12-27 |
Medical and Health Sciences |
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Non-degree Award |
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Gorrette Nalwadda Kayondo
ID:
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Analysis of Quality of Child Immunization Delivery in Rural and Urban Health Care Settings in Uganda
REFNo: HS505ES
a) Design short formatted and de-identified video footage for education, communication and research purpose on immunization delivery in low income settings, based on video footage previously collected under the “Child Immunization Delivery Project, Pathway/Landscape Analysis in Rural and Urban Health Care Settings in Uganda” (Protocol 258).
b)Design and develop a website/web portal to make available video, artefacts, field observation notes and other research data (de-identified data) for non-restricted use, and restricted use (raw data) to people working in public health, innovators, programmers, policy makers.
c) Explore and analyze the quality of child immunization service delivery and compliance with immunization guidelines in rural and urban health care settings, and possible solutions
d) Engaging policy makers in the use of the research findings from the child immunization delivery project for sound development of policies and programs
e) Utilize the de-identified ethno videography data for capacity building, communication and charitable global health activities in maternal newborn and child health policy development and program implementation.
|
Uganda |
2019-12-27 |
2022-12-27 |
Medical and Health Sciences |
|
Non-degree Award |
|
Cara Ebert
ID:
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Impact evaluation of two youth skill development interventions as part of the Employment for Development (E4D) program of the German Corporation for International Cooperation (GIZ)
REFNo: SS397ES
The objective of the investigation is to identify interventions implemented by the German Development Corporation program E4D/SOGA that work and have the potential to be scaled up. The E4D/SOGA funds and implements a large portfolio of interventions in Uganda – comprising a total budget of EUR 10,700,000. In this light, we intend to evaluate the effectiveness of two E4D/SOGA programs. The investigation will give guidance on policy decisions by highlighting the relevance of short-course technical skills trainings, work readiness skills and labor market attachment via internship placement.
|
Germany |
2019-12-27 |
2022-12-27 |
Social Science and Humanities |
|
Non-degree Award |
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Shevin Jacob Thomas
ID:
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THE AFRICAN RESEARCH COLLABORATION ON SEPSIS IN UGANDA (ARCS-UGANDA) COHORT STUDY: AN OBSERVATIONAL STUDY TO IMPROVE UNDERSTANDING OF SEPSIS EPIDEMIOLOGY, DEFINITIONS, HOST IMMUNE RESPONSE AND COSTS OF HOSPITAL CARE IN UGANDAN ADULTS
REFNo: HS511ES
General Objective:
To describe adult sepsis prevalence and incidence, validate sepsis definitions, characterize AMR, describe short- and long- term morbidity and mortality, identify host response to sepsis and quantify hospital costs using a cohort of adult patients with suspected sepsis admitted to hospitals in Uganda
Specific objectives:
1. Determine the epidemiologic characteristics, AMR characteristics, clinical outcomes (including morbidity, mortality and frequency of readmission after discharge from the hospital) and attributable costs from suspected sepsis in Ugandan hospitals
2. Evaluate performance characteristics of extant sepsis definitions/criteria when applied to a cohort of adult patients who fulfil study eligibility criteria for sepsis in Uganda
3. Characterize pathways of sepsis pathogenesis through exemplar pro-inflammatory (through neutrophil respiratory burst activity) and immunosuppressive (through HLA-DR) markers and agnostic transcriptomic analysis in a Ugandan sepsis cohort with a high prevalence of HIV infection.
|
USA |
2019-12-27 |
2022-12-27 |
Medical and Health Sciences |
|
Non-degree Award |
|
Lydia Nakiyingi
ID:
|
Prospective Multicentre Evaluation of the Accuracy and Diagnostic Yield of the
Fujifilm SILVAMP TB LAM Test for the Diagnosis of Tuberculosis in People Living with HIV
REFNo: HS513ES
To determine the diagnostic accuracy of FujiLAM for TB detection among PLHIV using an eMRS
To determine the diagnostic accuracy of FujiLAM for TB detection among PLHIV using a CRS To determine the diagnostic yield of FujiLAM among all patients identified as having TB by
eMRS and compare to AlereLAM, Smear and Xpert/Ultra (sputum, urine) as comparators
(on Day 1 specimens).
Secondary,
To determine the diagnostic accuracy of FujiLAM for TB detection among PLHIV using a MRS.
To determine the diagnostic yield of FujiLAM among all patients identified by MRS and compare to AlereLAM, Smear and Xpert/Ultra (sputum, urine) as comparators (on Day 1 specimens).
To determine the diagnostic accuracy of FujiLAM across predefined subgroups using a MRS, eMRS and CRS separately.
To determine the diagnostic accuracy of FujiLAM of Day 2 early morning urine using a MRS, eMRS and CRS separately.
To determine the diagnostic accuracy of FujiLAM of Day 2 early morning urine across subgroups using a MRS, eMRS and CRS separately.
To determine the diagnostic accuracy of AlereLAM in the same way as described in objectives 1.1, 1.2 and 2.1, 2.3 and compare it to that of FujiLAM.
To determine the yield of FujiLAM over (incremental yield) or in combination with (combined yield) Smear and Xpert/Ultra (sputum) among eMRS-positive patients.
To determine the diagnostic accuracy of Omega VISITECT® CD4 test for detection of a CD4 count ≤200 cells/µl, using WHO pre-qualified cytometers as the reference standard. To collect and store high quality and well-characterized urine specimen from PLHIV
|
Uganda |
2019-12-27 |
2022-12-27 |
Medical and Health Sciences |
|
Non-degree Award |
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