LOIS BAYIGGA
ID: UNCST-2024-R004310
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PRE-CLINICAL TESTING OF FORWARD-ORIENTED GLOBIN-EXPRESSING LENTIVIRAL VECTOR
REFNo: HS5513ES
e) To determine the efficiency of magnetically assisted transduction in gene modified CD34+ cells, isolated from individuals with sickle cell disease or trait, using flow cytometry and real-time polymerase chain reaction (RT-PCR),d) To compare the efficiency of standard transduction to magnetically assisted transduction in CD34+ cells, isolated from individuals with sickle cell disease or trait, using a forward-oriented globin-expressing lentiviral vector using flow cytometry and real-time polymerase chain reaction (RT-PCR),c) To determine the presence of HbS mutation in the CD34 negative cells isolated from cord blood and red blood cell exchange products using hemoglobin electrophoresis.,b) To determine the yield, purity, and viability of CD34+ cells isolated from cord blood and red blood cell exchange products using multicolor flow cytometry ,a) To isolate hematopoietic stem and progenitor cells (CD34+) from cord blood and red blood cell exchange products using immunomagnetic-based method,To determine the efficacy of the forward-oriented globin-expressing lentiviral vector in HSPCs isolated from individuals with sickle cell disease or trait in Uganda,
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Uganda |
2025-02-20 18:26:20 |
2028-02-20 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
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Stella Muyanja Zawedde
ID: UNCST-2021-R014037
|
Effect of non-communicable disease multimorbidity on TB treatment outcomes amogn TBHIV co-infected patients in Uganda
REFNo: HS5506ES
a) To determine the prevalence of, and factors associated with multimorbidity among people with TB and HIV
b) To determine the effect of NCD Multimorbidity on TB treatment outcomes among persons co-infected with HIV.
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Uganda |
2025-02-20 17:58:06 |
2028-02-20 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
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Brenda Okech Apio
ID: UNCST-2022-R011031
|
Epidemiology of Malaria
Infection in Sub-Saharan
African Countries
REFNo: HS5543ES
Primary Objective
1.To estimate the site-specific IR of
P. falciparum infection by rapid
diagnostic test (RDT) testing,
overall and by age group (5-11
years, 12-17 years, 18-60 years)
during the active detection of
infection period.
Secondary objectives
1.To evaluate the agreement
between RDT and thick blood
smear (TBS), and to evaluate the
sensitivity and specificity of RDT
and TBS using quantitative
polymerase chain reaction (qPCR)
as the gold standard for the
identification of P. falciparum
infection, at baseline and at two
and six months after enrolment.
2.To estimate the site-specific IR of
P. falciparum infections detected
by both active and passive
surveillance over the complete follow-up period (0-6 months),
overall and by age group (5-11
years, 12-17 years, 18-60 years).
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Uganda |
2025-02-20 17:55:11 |
2028-02-20 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
|
RITAH KICONCO
ID: UNCST-2021-R013263
|
MOLECULAR CHARACTERIZATION OF ANGIOTENSIN CONVERTING
ENZYME GENE POLYMORPHISMS AMONG TYPE 2 DIABETES MELLITUS NEPHROPATHY IN
SOUTHWESTERN UGANDA
REFNo: HS5520ES
Objectives:
Main Objective
1. To characterize angiotensin-converting enzyme gene polymorphisms and determine their relationship with the biomarkers of nephropathy and metabolic indicators as well as explore the barriers and motivators to screening for nephropathy among individuals with type 2 diabetes mellitus living in southwestern Uganda.
Specific Objectives
1. To conduct a systematic review on the ACE I/D polymorphisms and the urine albumin-to-creatinine ratio as predictive markers of nephropathy among adult type 2 diabetes mellitus patients.
2. To establish the ACE alleles and genotypes present in the genome of patients with T2D at the MRRH in SW in Uganda.
3. To determine the association between ACE gene polymorphisms and nephropathy biomarkers among T2D patients at the MRRH in SW Uganda.
4. To determine the association between ACE gene polymorphisms and metabolic indicators among T2D patients at the MRRH in SW Uganda.
5. To explore the barriers and motivators to screening for nephropathy as a health-seeking behavior among T2D patients receiving healthcare at the DM clinic in MRRH in SW Uganda.
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Uganda |
2025-02-20 17:50:43 |
2028-02-20 |
Medical and Health Sciences |
Non-Clinical Trial |
Degree Award |
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VINCENT MUBANGIZI
ID: UNCST-2024-R004232
|
RAMPS: REDUCING ALCOHOL PROBLEM DRINKING AND MALNUTRITION THROUGH INCOME-GENERATING PEER SUPPORT GROUPS
REFNo: HS5394ES
To document and evaluate the first peer support groups for men with alcohol problem drinking in Isingiro district
|
Uganda |
2025-02-20 17:49:15 |
2028-02-20 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
|
Eva Laker Odongpiny Agnes
ID: UNCST-2024-R004807
|
Lived Experiences of Mixed Groups of Patients on Dolutegravir after Gaining Clinically Significant Weight.
REFNo: HS5195ES
A) Primary objective (Objective 1)
To explore the lived experiences of PLWH who gained weight after starting dolutegravir and whether these experiences vary among different subgroups.
B) Secondary objective (Objective 2)
To examine the sources of information PLWH have on weight gain and how that shapes their
perceptions.
C) Secondary objective (Objective 3)
To explore how the knowledge of the health risks of excessive weight gain and the willingness of patients to take measures to lose weigh
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Uganda |
2025-02-20 17:47:39 |
2028-02-20 |
Medical and Health Sciences |
Non-Clinical Trial |
Degree Award |
|
Katie Slocombe
ID: UNCST-2024-R016225
|
Development of cognition and communication from infancy to late childhood across different societies
REFNo: SS3663ES
The overall objective of this project is to understand the impact of the socio-cultural environment on the development of communication and social cognition and the developmental processes that lead to similarities and differences in adult human behaviour across the globe.
The specific objectives are to address the three research questions below with the Ugandan sample:
1. To understand how aspects of physical, emotional and social cognition, and communication develop from infancy through childhood into adult-like forms within in a rural population of Uganda
2. To understand the socio-cultural context that the participants are developing in.
3. Does individual variation in socio-cultural environmental factors predict individual variation in performance in social cognition tasks?
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UK |
2025-02-20 17:46:27 |
2028-02-20 |
Social Science and Humanities |
Non-Clinical Trial |
Non-degree Award |
|
Ombeva Malande Oliver
ID: UNCST-2024-R004335
|
Understanding barriers and Strengthening Services for HPV vaccination among adolescents living with HIV in Kampala Metropolitan.
REFNo: HS5254ES
4. To document lessons and experiences drawn from piloting outreach HPV vaccine services at Joint Clinical Research Centre (JCRC) and Mildmay Uganda (MUg). ,3. To pilot HPV vaccination outreach service and education for adolescents living with HIV and attending HIV care and treatment at the Joint Clinical Research Centre (JCRC) and Mildmay Uganda (MUg). ,2. To determine the knowledge, attitude and practices that influence HPV vaccine uptake among adolescents living with HIV and attending HIV care at Joint Clinical Research Centre (JCRC) and Mildmay Uganda (MUg). ,1. To estimate the HPV vaccine coverage among adolescents living with HIV attending Joint Clinical Research Centre (JCRC) and Mildmay Uganda (MUg).,
|
Kenya |
2025-02-20 17:45:09 |
2028-02-20 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
|
Baker Lukwago
ID: UNCST-2021-R013259
|
Implementation Study: Introducing a Point of Care Ultrasound (POCUS) Device (Baby Checker), Supported by Artificial Intelligence (AI), in peri-urban Uganda. An Acceptability Study with Providers, Consumers, and Decision Makers September 2024_Version
REFNo: SS3496ES
1.2 Main objective of the research
This research aims to understand the feasibility of implementation of the BabyChecker Ultrasound scan in private health facilities in Uganda. The research will assess the BabyChecker pilot from the perspective of providers, pregnant women, and key decision makers. Among providers, the study will investigate providers’ behaviors and challenges during 1st month of using the tool and shift or maintenance of these behaviors, practices, and challenges after 5 months of implementation attributed to the project interventions. The study will explore pregnant women’s experiences with the BABYCHECKER & preferences for the BabyChecker features. Among decision-makers, the study will explore potential use cases for BabyChecker in Uganda, including the potential for public sector expansion, public private partnership, and private sector referral mechanisms.
The specific aims are as follows:
A: What are experiences, perceptions, barriers and attitudes towards BabyChecker Scan among providers using it?
1. What are the providers' practices on how they conduct the BabyChecker scans and how the tool is positioned to the consumer?
2. How are providers integrating BabyChecker into ANC service provision?
3. What are the motivators & barriers providers are experiencing with the BabyChecker tool and implementation?
4. How much are the providers willing to pay to purchase the BabyChecker scan, and what payment modalities are acceptable?
B: What are the pregnant womens experiences and acceptability of the BABYCHECKER scans among pregnant women receiving them?
1. How was Babychecker introducted to pregnant women offered the service? (What did pregnant women understand regarding the purpose of BabyChecker? Did providers respond to questions raised during the introduction of BabyChecker?)
2. What is the experience of pregnant women during the administration and in the reception of results ofthe BabyChecker scan after 24 hours?
3. What are pregnant women’s stated preferences regarding BabyChecker product attributes?
4. What is pregnant women’s willingness to pay for BabyChecker services?
5. What are pregnant women’s willing to pay for preferred BabyChecker features?
C: What is the acceptability of the BabyChecker technology among Decision makers in Uganda?
1. What are the perceptions of key stakeholders about the BabyChecker Scan and recommended use cases for Uganda? What are their barriers and motivators to scaling BabyCheckers further in Uganda?
|
Uganda |
2025-02-20 17:43:29 |
2028-02-20 |
Social Science and Humanities |
Non-Clinical Trial |
Non-degree Award |
|
Twalib Aliku Olega
ID: UNCST-2019-R000474
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LEVERAGING RHEUMATIC HEART DISEASE SCREENING PROGRAMS TO IMPROVE OUTCOMES FOR CONGENITAL HEART DISEASE IN NORTHERN UGANDA
REFNo: HS5492ES
1) To improve the quality of life for families living with CHD in Uganda. Our overarching hypothesis is that building a system centered on the needs of patients and providers at the community level will improve care and quality of life for many while simultaneously building the case to invest in more resource intensive tertiary infrastructure.
Our project leverages our team’s expertise and established government and community collaborations to improve CHD care by accomplishing following specific aim as the first step to delivering and testing an evidence-based primary Health Center (HC) driven program - Congenital Heart Interventions for Primary care Systems (CHIPS) - to care for children with CHD incidentally identified through RHD screening.
2) Identify needs, gaps, and capacities in CHD care to co-design the CHIPS technical package with end-users (patients, caregivers and community providers) by collecting quantitative and qualitative data on current care, care needs, access, and affordability and perspectives on proposed components of CHIPS to co-design content and delivery.
|
Uganda |
2025-02-20 17:26:59 |
2028-02-20 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
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