Hussein Kafeero Mukasa
ID:
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HEPATITIS B GENOTYPES AND IL-2, 4, 10, INF-γ, TNF-α, PROMOTER GENE POLYMORPHISMS IN A HIGH AND LOW ENDEMIC REGION OF UGANDA
REFNo: HS575ES
1. To determine the circulating hepatitis B virus genotypes in regions of high and low endemicity in Uganda.
2. To characterize Th1/Th2 cytokine gene promoter polymorphisms among HBV unexposed and exposed individuals in low and high endemicity regions.
3. To investigate the relationship between hepatitis B virus genotype and the observed Th1/Th2 cytokine gene promoter polymorphisms
4. To determine the expression levels of the cytokines and correlate them with the infecting genotypes and the single nucleotide polymorphisms in the Th1/Th2 cytokine gene promoter.
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Uganda |
2020-04-30 |
2023-04-30 |
Medical and Health Sciences |
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Degree Award |
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ERIC WOBUDEYA
ID: UNCST-2019-R001047
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A randomised trial of 6 months intensified anti-tuberculosis and 2 months anti-inflammatory treatment for HIV-infected and HIV-uninfected African and Asian children with tuberculous meningitis
REFNo: HS593ES
Main objectives of the SURE trial
a) To determine whether the standard 12 month ATT regimen for treating paediatric TBM can be reduced to 6 months with similar efficacy and safety, with an intensified regimen of anti-TB drugs in children aged under 15 years with TBM AND b) To determine whether adjunctive aspirin for the first 60 days of treatment reduces TBM-related neuro-disability with minimal or no toxicity in children with TBM.
Other objectives
(a) To determine whether the doses of anti-TB drugs, prescribed according to weight bands, result in appropriate drug exposures when compared with historical paediatric and adult PK data.
(b) To further understand the pathophysiology of TBM in children and the effects of intensified antibacterial and anti-inflammatory treatment on intra-cerebral inflammation and the macroscopic complications of TBM (infarcts, tuberculomas, hydrocephalus).
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Uganda |
2020-04-30 |
2023-04-30 |
Medical and Health Sciences |
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Non-degree Award |
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Annette Schuh Hildegard
ID: UNCST-2024-R003745
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Evaluation and Transfer of mobile whole slide tissue scanners and liquid biopsies to deliver fast and precise diagnosis for improved outcomes of children and young adults with EBV-driven lymphoma: a joint Tanzanian and Ugandan Paediatric Oncology Network Initiative
REFNo: HS529ES
We have four objectives: to
1. Assess the diagnostic accuracy of liquid biopsy testing
2. Asses the diagnostic accuracy of digital pathology
3. Development of a digital pathology machine learning algorithm
4. Transfer of above novel tests and associated expertise to local laboratories
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UK |
2020-04-24 |
2023-04-24 |
Medical and Health Sciences |
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Non-degree Award |
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Peter Nkurunziza Munya
ID:
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'Evaluation of The Bio-Rad Geenius HIV-1/2 Confirmatory Assay as Part of Confirmatory and Differentiation of HIV infection at Uganda Virus Research Institute-HIV Reference Laboratory'
REFNo: HS612ES
Primary objective
• To conduct an in-country evaluation of the performance of Geenius™ HIV-1/2 Confirmatory Assay for confirmation of HIV infection using DBS and Plasma specimens, as compared to Murex HIV Ag/Ab Combination and/or Genscreen Ultra HIV Ag/Ab Combo.
Specific objectives
• To determine the sensitivity of Geenius™ HIV-1/2 Confirmatory Assay as compared to Murex HIV Ag/Ab Combination and/or Genscreen Ultra HIV Ag/Ab Combo
• To determine the specificity of the Geenius™ HIV-1/2 Confirmatory Assay as compared to Murex HIV Ag/Ab Combination and/or Genscreen Ultra HIV Ag/Ab Combo
• To determine the positive predictive value and negative predictive value of Geenius™ HIV-1/2 Confirmatory Assay as compared to Murex HIV Ag/Ab Combination and/or Genscreen Ultra HIV Ag/Ab Combo.
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Uganda |
2020-04-24 |
2023-04-24 |
Medical and Health Sciences |
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Non-degree Award |
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PROSPER BEHUMBIIZE
ID:
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Implementation Research on Education Management Information Systems (EMIS) Data Use Innovations in Uganda
REFNo: SIR33ES
1. To assess the existing management information systems for the Education Sector
2. To understand how innovations including DHIS2 can be used to improve EMIS data quality, management and use at all levels of the education sector
3. To ascertain the best practices that will inform scale up of Dhis2-for Education within and across countries
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Uganda |
2020-04-17 |
2023-04-17 |
Engineering and Technology |
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Non-degree Award |
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