Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Moses Kamya R
ID:
Cohort and entomology studies to estimate longitudinal changes in malaria metrics in Nagongera, Uganda
REFNo: HS119ES

Objectives of epidemiology studies 1. To estimate the incidence of malaria, parasite prevalence, and the molecular force of infection among cohort study participants. 2. To characterize factors determining the malarial force of infection. 3. To determine factors affecting the duration, density, and clinical consequences of blood stage malaria infection. 4. To assess the associations between overnight travel and the risk of malaria infection. 5. To estimate measures of transmission intensity including the human biting rate, sporozoite rate, and the entomological inoculation rate at the household level. 6. To characterize the species composition of mosquito vectors and the host source of mosquito blood meals. Objectives of transmission studies 7. To characterize factors associated with gametocyte production. 8. To evaluate the impacts of human, parasite, and mosquito factors on parasite infectivity to mosquito vectors. 9. To characterize the human infectious reservoir for malaria. Objectives of immunology studies 10. To measure antibody responses to malaria antigens and associations between antibodies responses and protection from /exposure to infection with malaria parasites. 11. To characterize malaria specific cellular immune responses in naturally exposed children and adults. Objectives of resistance studies 12. To assess the impact of genotypic markers of antimalarial drug resistance on malaria transmission. 13. To assess the impact of genotypic markers of insecticide resistance on malaria transmission.
Uganda 2017-09-29 2020-09-29 Medical and Health Sciences Non-degree Award
Irene Andia Biraro Rebecca
ID: UNCST-2019-R001475
The Link Between Tuberculosis Infection and Type-2 Diabetes Mellitus: Contribution of Innate Lymphoid Cells
REFNo: HS66ES

Primary objective: To investigate the exposure prevalence of latent and active tuberculosis among newly diagnosed type 2 diabetes mellitus (T2DM) patients attending the diabetic clinic at Mulago National Referral Hospital (MNRH)-Kiruddu, compared to healthy non diabetic community controls in Kampala, Uganda Nested Secondary objective: To assess the frequency of innate lymphoid cells (ILCs), T-helper (Th)17, Th1 cells, and immune responses among T2DM patients.
Uganda 2017-09-26 2020-09-26 Medical and Health Sciences Non-degree Award
Bruce Kirenga J
ID: UNCST-2019-R001460
Reducing exposure to household air pollution
REFNo: HS71ES

To evaluate the feasibility, acceptability and effectiveness of proven household air pollution reduction interventions in households using traditional way of cooking and heating methods in selected communities in four countries of Uganda, Vietnam, the Kyrgyz Republic and Greece. Research questions will be: 1. What is the feasibility and acceptability of clean cooking and heating interventions compared to traditional cooking and heating? 2. What is the effectiveness of a clean cooking intervention on health outcomes? 3. What is the effectiveness of household air pollution reduction on health outcomes?
Uganda 2017-09-26 2020-09-26 Medical and Health Sciences Non-degree Award
Kelly Sambucci Marie
ID: UNCST-2019-R001513
Parasite occurrence and genetic relatedness in overlapping populations of Mountain Gorilla (Gorilla beringei beringei), livestock, and the Batwa community in Bwindi Impenetrable National Park (BINP), Uganda
REFNo: NS22ES

1. To collect faecal samples for analysis, using light microscopy to identify intestinal helminth eggs and PCR for protozoan diagnosis. 2. Use targeted PCR and amplicon sequencing to confirm parasite identity and genotype those species detected, allowing for investigation into cross-host species transmission. 3. Focus on the occurrence and genetic diversity of Entamoeba species, comparing to existing data which defines the Entamoeba infecting mountain gorilla, livestock and humans in BINP in 2015, exploring changes in prevalence and diversity.
UK 2017-09-26 2020-09-26 Natural Sciences Degree Award
Richard Wamimbi Wotti
ID:
Utilizing Information Communication Technology (ICT) to prevent violence against children in and around schools.
REFNo: SS108ES

The general research purpose is understanding the utilization of ICT in preventing violence against children in and around schools and developing a model that can be applied by agencies to prevent violence against children. Specific objectives: 1.Establish the role of ICT in driving, sustaining and mitigating behavior that contributes to violence against children in and around schools 2.Examine the benefits of ICT use to prevent violence against children specifically for knowledge generation and transfer, capabilities enhancement and social enabler 3.Establish when and how ICT - enabled child sexual violence and exploitation starts, is maintained and perpetuated in and around schools. 4.Examine the inter-related constraints to ICT utilization to prevent violence against specifically social cultural, infrastructural, economic and technological. 5.Find out how ICT (telephone sms, whatsapp, etc.) is promoting values and influencing ICT that can prevent violence against children 6.Suggest the strategies and actions that can be adopted by formal ( law enforcement, teachers, social workers) and non-formal ( children, families, religious, traditional leaders ) actors to better address ICT enabled child sexual abuse and exploitation
Uganda 2017-09-26 2020-09-26 Social Science and Humanities Non-degree Award
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