Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Julian Adong
ID: UNCST-2021-R013487
 Retention through mHealth for adolescents and young adults with HIV in care
REFNo: HS3722ES

Test the acceptability, feasibility, and preliminary impact of the developed adolescent-tailored mHealth intervention for retention in care of AYWH who are new to or newly re-engaging in care,Iteratively develop a social media-based adolescent-tailored mHealth intervention to improve retention in care for AYWH who are new or newly re-engaging in care,Define the cognitive, environmental, and behavioural challenges and their impact on behavioural intention for AYWH who are new or newly re-engaging in HIV care,To develop and test an mHealth intervention for retention in care for adolescents and young adults with HIV,
 Uganda 2024-02-26 13:34:00 2027-02-26 Medical and Health Sciences Clinical Trial Non-degree Award
alfred andama andama
ID: UNCST-2022-R011051
 TONGUE SWAB TUBERCULOSIS DIAGNOSTIC YIELD STUDY
REFNo: HS3761ES

Aim 1. To determine the proportion of people presenting to primary health centers with signs and symptoms of TB who: a. can provide a sample for TB testing (sputum vs. tongue swab) b. have a valid molecular test result (sputum vs. tongue swab) c. are detected as TB-positive (sputum vs. tongue swab) d. prefer providing a sputum vs. tongue swab sample
Uganda 2024-02-26 13:32:44 2027-02-26 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Bruce Kirenga J
ID: UNCST-2019-R001460
 SOLIDARITY TRIAL-A phase I/II Randomized Placebo controlled trial to evaluate the Safety and Immunogenicity of Sudan Ebolavirus in Uganda
REFNo: HS3190ES

Phase I (rVSV-SUDV)
1. To determine the safety of rVSV-SUDV candidate SUDV vaccine among adult healthy volunteers in Uganda.
2. To determine the immunogenicity of rVSV-SUDV candidate SUDV vaccine.

Phase II (ChAdox1, CAd3 and rVSV-SUDV)
Primary objectives
1. To determine the safety of ChAdox1, CAd3 and rVSV-SUDV candidate SUDV vaccines among healthy volunteers and persons with stable comorbidities.
2. To determine the immunogenicity of ChAdox1, CAd3 and rVSV-SUDV candidate SUDV vaccines.
Secondary objectives
1. To determine the durability of SUDV-specific induced immune responses following vaccination.
2. To determine the factors associated with optimal vaccine-induced immune responses.
3. To determine the putative cross reactivity by the SUDV vaccine candidates against other ebolaviruses (e.g. Bundibugyo ebolavirus (BUDV) and EBOV).

Exploratory objectives
1. To determine the effect of SUDV vaccines on host gene expression.
2. To determine the T and B cell specific responses and immune profiling in response to vaccination.
3. To determine the effect of SUDV vaccines on the host metabolome.
4. To determine the effect of SUDV vaccines on host innate immune responses.

 Uganda 2024-02-26 13:31:25 2027-02-26 Medical and Health Sciences Clinical Trial Non-degree Award
Rhona Mijumbi M
ID: UNCST-2023-R006843
 Building a Culture of Evidence-informed Policy-Making in Uganda (B-CuE)
REFNo: SS2257ES

3) To improve collaboration for better coordinated and complementary support to EIDM in Uganda.,2) To design a sustainable and relevant capacity-building program for pre- and in-service training to ensure individuals and institutions acquire relevant and adequate knowledge and skills to support timely EIDM.,1) To scale-up the activities of the Center for Rapid Evidence Synthesis as a knowledge brokerage institution to strengthen support for timely EIDM in Uganda.,
 Uganda 2024-02-26 13:23:45 2027-02-26 Social Science and Humanities Non-Clinical Trial Non-degree Award
Moses Adroma
ID: UNCST-2019-R000360
 Exploring the potential of a lower blood pressure threshold for diagnosing hypertension in pregnancy: Implications for pre-eclampsia and stroke.
REFNo: HS3784ES

1. To compare the incidence rate of preeclampsia between pregnant women with SBP from 130 to 139 mmHg and/or DBP from 80 to 89 mmHg and those with normotensive blood pressure below 130/80 mmHg.

2. To compare the incidence rate of stroke between pregnant women with SBP from 130 to 139 mmHg and/or DBP from 80 to 89 mmHg and those with normotensive blood pressure below 130/80 mmHg.

3. To investigate potential risk factors and biomarkers associated with the development of preeclampsia and stroke in pregnant women with elevated blood pressure within the range of 130/80 to 139/89 mmHg.

4. To compare the maternal and foetal outcomes between pregnant women with SBP from 130 to 139 mmHg and/or DBP from 80 to 89 mmHg and those with blood pressures below 130/80 mmHg.


Uganda 2024-02-26 13:20:46 2027-02-26 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Rawlance  Ndejjo
ID: UNCST-2022-R010993
 Health Systems Resilience in the Face of Climatic Change in Bududa, Kasese and Moroto Districts in Uganda
REFNo: HS3758ES

To explore the barriers and facilitators of building health systems mitigation, adaptation, and resilience mechanisms to deal with the adverse effects of extreme weather events in Bududa, Kasese and Moroto districts in Uganda.,To describe the mitigation and adaptation mechanisms that health systems in Bududa, Kasese and Moroto districts in Uganda employ to deal with the adverse effects of extreme weather events?,To explore how extreme weather events are impacting the disease burden in Bududa, Kasese and Moroto districts in Uganda.,To assess how extreme weather events are impacting disease burden and explore the resilience of health systems in Bududa, Kasese and Moroto districts so as to inform strategies for building resilient and low carbon health systems in the face of climatic changes in sub-Saharan Africa,
 Uganda 2024-02-26 13:19:29 2027-02-26 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Angelica Kiwummulo
ID: UNCST-2023-R005604
 The impact of digital health technologies on the delivery of maternal and child health services; A case study of Uganda
REFNo: HS3804ES

Evaluate the perceptions of community members, healthcare providers, and other stakeholders regarding the FamilyConnect program to inform opportunities for program optimization and expanded uptake in communities,Assess the success factors and barriers associated with the implementation of Family Connect for insights into program effectiveness.,Assess changes in the prevalence of key infectious diseases within communities using Family Connect app,Assess the changes in attendance rates for antenatal care and other essential Maternal and Child Health (MCH) services before and after the implementation of the Family Connect program,The overall objective of this study is to assess the extent to which Family Connect is influencing behavioral change towards improved uptake of Maternal and Child Health (MCH) services, prevention and control of infectious diseases, and the contextual factors contributing to its success,
 Uganda 2024-02-26 13:17:30 2027-02-26 Medical and Health Sciences Non-Clinical Trial Non-degree Award
David Munyua Okumu
ID:
Exploring military role expansion and its implications on civil-military relations.
REFNo: SS2335ES

1. Explore what motivates the government of Uganda to “pull” the UPDF into roles that are traditionally non-military.
2. Gain insights on how the involvement of the UPDF in non-military roles is conceptualised and formalised.
3. Explore the experiences of UPDF personnel deployed to non-military roles.
4. Explore the experiences and stories of civilians working with UPDF officers in non-military roles.
5. Establish how best the UPDF should engage with civil authorities in the event of undertaking non-military roles.
 Uganda 2024-02-26 13:14:39 2027-02-26 Social Science and Humanities Non-Clinical Trial Degree Award
Isaac Ssewanyana
ID: UNCST-2020-R014336
 CLINICAL PERFORMANCE EVALUATION OF THE COBAS HIV -1/HIV-2 QUALITATIVE ASSAY USING THE COBAS 5800
REFNo: HS3802ES

• To describe and assess the operational characteristics and ease of use of the assay under evaluation and its suitability for use in countries with limited infrastructure (no/limited electricity, no/limited clean water, inadequate means of waste disposal);,To assess analytical performance o Precision; o Limitofdetection; o Subtypedetection; o Cross-contamination or carry-over;, To assess sensitivity and specificity using clinical specimens by comparing with a designated reference standard;,The overall objective of the performance evaluation is to evaluate analytical and diagnostic performance of commercially available qualitative HIV molecular assays undergoing prequalification assessment.,
 Uganda 2024-02-26 13:12:03 2027-02-26 Medical and Health Sciences Non-Clinical Trial Non-degree Award
MWEBEMBEZI ATHERIA K
ID:
Management Practices and Financial sustainability of Church of Uganda founded private secondary schools in Greater Ankole Dioceses
REFNo: SS2404ES

To identify the challenges that hinder management practices and financial sustainability and strategies that will enhance financial sustainability in church of Uganda private secondary schools in greater Ankole dioceses. ,To examine the effectiveness of staffing on financial sustainability of Church of Uganda founded private secondary schools in Greater Ankole Dioceses ,To assess the effectiveness of leadership styles on financial sustainability of Church of Uganda founded private secondary schools in Greater Ankole Dioceses ,To analyze the impact of financial management practices on financial sustainability of Church of Uganda founded private secondary schools in Greater Ankole Dioceses,To examine the effect of management practices on financial sustainability of Church of Uganda private secondary schools in Greater Ankole Dioceses. ,
 Uganda 2024-02-26 13:05:57 2027-02-26 Social Science and Humanities Non-Clinical Trial Degree Award
Adele Stock
ID: UNCST-2024-R005015
 The Spiritual Life of Water: Aquatic Sacred Space and Urban Environmental Change in 20th century Johannesburg and Kampala
REFNo: SS2389ES

My dissertation research explores how water-based religious practices have been profoundly transformed amidst the immense environmental and legal changes precipitated during the colonial and postcolonial periods in Africa. I examine both the creativity and the resilience of African religious practitioners in making new meaning amidst the displacement of water-based loci of spirituality. In particular, I focus on the paradox of ritual cleansing and healing in polluted bodies of water, a practice that has its roots in the systems of colonization and racial exclusion that are foundational to histories of urban Africa. Kampala’s Lubigi Wetland has long been a vibrant space where diverse groups of Ugandans sought and still seek healing, both physical (particularly at the advent of the HIV/AIDS epidemic) and spiritual. Their resources are a powerful spirit medium thought to connect to spiritual forces in the wetland’s tranquil waters. Yet today, human settlement, environmental degradation, and violent conflict overshadow the swamp’s long history as a spiritual healing center of the Buganda Kingdom.
USA 2024-02-26 13:02:30 2027-02-26 Social Science and Humanities Non-Clinical Trial Degree Award
Silver Bahendeka Karaireho
ID: UNCST-2019-R000876
 Effectiveness of Integrating Non-Communicable Disease Services in Primary Care of Rural Districts in Uganda
REFNo: HS3820ES

5. To formulate a potential framework of NCD integration at PHC in Uganda.,4. To determine the burden of NCDs among patients presenting at PHC in the three adjacent districts.,3. To assess the level and determinants of hypertension control achieved by patients with systemic hypertension after intervention.,2. To assess the level and determinants of metabolic control achieved in patients with diabetes after intervention.,1. To ascertain extent and effect of integration of NCDs at PHC achieved by the WDF19-1721 project. The WDF19-1721 project aimed to optimize care of NCDs through integrating delivery of NCDs services at outpatient clinics in PHC.,To evaluate the effectiveness of an NCD health service delivery framework (WDF19-1721 Project) for integrated management of NCDs in Primary Health Care in three adjacent districts of Isingiro, Ntungamo and Sheema located in Western Uganda.,
 Uganda 2024-02-26 13:01:49 2027-02-26 Medical and Health Sciences Non-Clinical Trial Non-degree Award
EDGAR GUMA INNOCENT
ID:
Past-year violence exposure and its association with antiretroviral non-adherence among HIV-positive adolescents in Uganda.
REFNo: HS3831ES

To determine the prevalence of violence exposure and its association with antiretroviral non-adherence among HIV positive adolescents attending the Mildmay Uganda Hospital child and adolescent clinic. , To determine the association between exposure to violence and antiretroviral non-adherence among HIV positive adolescents attending the Mildmay Uganda Hospital child and adolescent clinic.,2. To estimate the prevalence of antiretroviral non-adherence among HIV positive adolescents who experience Physical, sexual and emotional violence attending the Mildmay Uganda Hospital child and adolescent clinic. ,1. To estimate the prevalence of violence exposure among HIV positive adolescents attending the Mildmay Uganda Hospital child and adolescent clinic. ,
 Uganda 2024-02-23 12:34:51 2027-02-23 Medical and Health Sciences Non-Clinical Trial Non-degree Award
SHIRAH ZIRABAMUZALE MANSARAY
ID:
Sustainable, Responsible and Inclusive Innovation for Mental Health (SRII4MH): How interactions between the built environment, space and mental health policy influence mental health service delivery in the United Kingdom and Uganda.
REFNo: HS2816ES

To examine how mental health policy, the built environment including architecture, infrastructure and space can be re-engineered to ensure innovative, sustainable and efficient mental health service delivery in the United Kingdom and Uganda.,To examine how the debate on patient-centric/ user-driven innovation has influenced mental health policy and built environment considerations, including architecture and infrastructure considerations in Uganda and UK.,To identify the learning flows regarding the SRII4MH between the global North (UK) and global South (Uganda).,To identify the factors and actors that shape decision making for mental health services in Uganda.,
 UK 2024-02-23 11:46:27 2027-02-23 Medical and Health Sciences Non-Clinical Trial Degree Award
Francis Mutebi
ID: UNCST-2023-R007422
 TUNGIASIS IN EAST-AFRICA – AN INTERDISCIPLINARY APPROACH TO UNDERSTAND THE INTERACTIONS BETWEEN PARASITE AND HOSTS – PROJECT PHASE II PROJECT
REFNo: NS721ES

1.3. To establish the behavioral determinants for the heterogeneous distribution of tungiasis in space and time,1.2.To establish environmental factors which influence the distribution of off host stages in the dry and wet seasons,1. To establish the occurrence patterns of tungiasis among humans in the dry and wet seasons,To improve on the understanding of the ecology of tungiasis, and the developmental biology of Tunga penetrans ,
 Uganda 2024-02-14 12:52:02 2027-02-14 Natural Sciences Non-Clinical Trial Non-degree Award
Joweria Nambooze
ID: UNCST-2019-R001118
 EFFECTIVENESS OF FOOD VOUCHERS & BEHAVIOURAL CHANGE COMMUNICATION INITIATIVES ON THE DIETARY DIVERSITY OF CHILDREN IN AMUDAT DISTRICT, UGANDA
REFNo: HS3748ES

To explore the opportunities and challenges for the sustainability of the intervention in Amudat district.,To establish the determinants of the dietary diversity of children aged 6-23 months in Amudat district.,To assess the association between the intervention and change in dietary diversity of children aged 6-23 months in Amudat district.,To determine the dietary diversity of children aged 6-23 months in Amudat district before and after the intervention.,To evaluate the effectiveness of the food voucher programme combined with a BCC package intervention in improving the dietary diversity of children aged 6-23 months in Amudat district.,
 Uganda 2024-02-13 18:11:51 2027-02-13 Medical and Health Sciences Non-Clinical Trial Non-degree Award
PAUL TURYAHEEBWA
ID:
“Tax Compliance and Revenue Collection Performance in Selected Commercial Enterprises of Greater Mbarara”
REFNo: SS2287ES

3. To explore the effectiveness of self-assessment system and tax compliance on revenue collection performance in the districts of greater Mbarara,4. To examine challenges that hinder tax compliance and revenue collection performance and advance strategies that will enhance revenue collection performance in commercial enterprises of greater Mbarara,3. To explore the effectiveness of self-assessment system and tax compliance on revenue collection performance in the districts of greater Mbarara.,2. To examine the impact of tax compliance by tax reforms on revenue collection performance among commercial enterprises in the districts of greater Mbarara,1. To analyze the levels of tax compliance on revenue collection performance in commercial enterprises in the districts of greater Mbarara.,The main objective of the study is to examine the effectiveness of tax administration and how it affects revenue collection performance among commercial enterprises in greater Mbarara South Western Uganda,
 Uganda 2024-02-13 18:08:21 2027-02-13 Social Science and Humanities Non-Clinical Trial Degree Award
Iga  David
ID:
ENTREPRENEURIAL SUCCESS AMONG MICRO ENTREPRENEURS IN UGANDA
REFNo: SS2258ES

1. To examine the relationship between
psychological capital and entrepreneurial
success.
2. To contrast the relationship between
emotional intelligence and entrepreneurial
success.
3. To relate the relationship between
individual learning behaviors and entrepreneurial success.
4. To explore the relationship between
entrepreneurial bricolage and entrepreneurial success.
5. To test the combined mediation effect of
entrepreneurial bricolage in the
relationship between psychological
capital, emotional intelligence, individual
learning behaviors and entrepreneurial
success.

 Uganda 2024-02-13 18:05:55 2027-02-13 Social Science and Humanities Non-Clinical Trial Degree Award
Derrick Semugenze
ID: UNCST-2023-R007934
 Association of human cytomegalovirus (HCMV) and other viral exposure with susceptibility and progression to tuberculosis disease
REFNo: HS3255ES

Association of HCMV and other viral infections with tuberculosis progression among household and close contacts to tb index cases,Association of human cytomegalovirus (HCMV) exposure with tuberculosis susceptibility in TB presumptive children from Uganda,Association of human cytomegalovirus (HCMV) exposure with tuberculosis susceptibility in TB presumptive adults from Uganda,Association of human cytomegalovirus (HCMV) exposure with tuberculosis susceptibility in TB presumptive adults from South Africa,Association HCMV and other viral infections with susceptibility and progression to tuberculosis disease,
 Uganda 2024-02-13 18:03:22 2027-02-13 Medical and Health Sciences Non-Clinical Trial Degree Award
Tobby Agwe Michael
ID:
Production and Cleansing of Biogas from Bio-degradable Municipal Solid Waste – A Way of Resource Recovery
REFNo: SIR276ES

• To Design and fabricate the system components of the biogas production plant.
• To prepare the organic fraction of the Municipal Solid Wastes.
• To anaerobically digest the Shredded Biodegradable Municipal Solid wastes.
• To cleanse the biogas.

 Uganda 2024-02-13 17:57:42 2027-02-13 Engineering and Technology Non-Clinical Trial Non-degree Award
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