Doreen Nakimuli
ID: UNCST-2021-R013668
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Understanding Self Injection of DMPA-SC: Consumer Insight Research
REFNo: HS767ES
To understand where consumers get their health and family planning information from, where and how they access family planning products, what might motivate them to choose DMPA-SC self-injection, what are the barriers to choosing self-injection, what are consumers’ perceptions and attitudes towards self-injection.
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Uganda |
2020-08-03 |
2023-08-03 |
Medical and Health Sciences |
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Non-degree Award |
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Harriet Mayanja-Kizza
ID: UNCST-2021-R013074
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Evaluation of New Diagnostics and Field evaluation of point-of-care triage tests for Active Tuberculosis.
REFNo: HS688ES
The primary objective of the study is:
1. To finalise a POC-MBT TB triage test suitable for global application and to perform field-testing and validation thereof. The target for each validation process will be the World Health Organisation (WHO) target product profile 90% sensitivity and 70% specificity.
Secondary objectives:
1. To compare the efficacy of the POC-MBT’s TB diagnostic ability between certain sub-classification groups, for example by HIV-status, history of previous TB, extra-pulmonary vs pulmonary TB, and positive vs negative smear/GeneXpert® Ultra/culture.
2. To estimate the efficiency of different TB diagnostic algorithms that include the POC-MBT screening test along with clinical and/or radiological and/or sputa results.
3. To evaluate the POC-MBT as an indicator of treatment response during treatment for active TB.
4. To evaluate a prototype 3-marker gene signature on an Xpert mRNA cartridge using fingerstick blood.
5. To store samples and data to allow the testing or validation of future diagnostic candidates and algorithms, such as automated chest X-ray analysis and transcriptomic bio-signatures.
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Uganda |
2020-07-30 |
2023-07-30 |
Medical and Health Sciences |
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Non-degree Award |
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Gloria Seruwagi Seruwagi
ID:
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Knowledge, adherence and the lived experiences of refugees in COVID-19: A comparative assessment of urban and rural refugee settings in Uganda
REFNo: SS511ES
General objective
We seek to study refugee lived experiences, assess behavioural shifts and determine public compliance and social behaviour in both urban and rural refugee settings
Specific objectives
1. To assess knowledge or awareness of COVID-19 and local perception of risk in urban and rural refugee settings. This will also capture infodemic issues, myths, fears, etc
2. To identify local pre-post COVID attitudes and practices relating to health and social norms. This will include e.g. WASH, healthseeking behaviour, community cohesion practices
3. To explore implementers’ interpretation and enforcement of COVID-19 guidelines.
4. To determine the feasibility of, and adherence to, COVID-19 preventive measures.Will include local interpretations, experiences, innovations, improvisations and explanatory factors
5. To identify community resources, systems and assess their efficacy in the COVID-19 response. E.g. this will cover essential systems and services including health, social care and community leadership
6. To compare urban and rural refugees in line with Objectives 1-5
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Uganda |
2020-07-30 |
2023-07-30 |
Social Science and Humanities |
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Non-degree Award |
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David Meya Bisagaya
ID: UNCST-2019-R000837
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Alternative Meningitis therapies Phase II Trial for Cryptococcal Meningitis (AMPLYX-CM)
REFNo: HS583ES
To determine the safety and efficacy for all drugs for the treatment of cryptococcal meningitis Primary: 1) “Early Fungicidal Activity” (EFA), which is the rate of CSF yeast clearance quantified by the change of log10 Cryptococcus CFU/mL CSF/day as measured by serial quantitative CSF fungal cultures over the first ~2 weeks 2) Incidence of Grade 3-5 laboratory Adverse Events 3) Incidence of Grade 3-5 Clinical Adverse Events or SAEs Secondary: 4) 18-week survival time as time to event analysis a. 2 and 10 week survival time will be presented 5) Among 2-week survivors, 18-week hospital-free survival time 6) Tolerability: all cause drug discontinuation, study withdrawal, or lost-to-follow-up 7) 3-month quantitative neurocognitive performance Z-score 8) Pharmacokinetic studies of APX001A concentrations in blood, CSF, and other bodily fluids/tissues; and with respect to concomitant medicines.
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Uganda |
2020-07-28 |
2023-07-28 |
Medical and Health Sciences |
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Non-degree Award |
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Gertrude Nakigozi
ID:
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Mental Health and Cognition in HIV Infection in Rakai, Uganda
REFNo: HS634ES
Aim 1: Examine separate and interactive effects of HIV and psychosocial determinants on CNS dysfunction in PLWH. Hyp 1. Exposure to sexual/physical trauma or violence will interact with HIV in this population and will be associated with greater impairments/decline in declarative memory, cognitive control, and NVS.
Aim 2: Examine effects of psychosocial determinants on ART adherence in PLWH. Hyp 2. Exposure to sexual/physical trauma or violence will interact with impairments/decline in declarative memory, cognitive control, and NVS will adversely affect ART adherence).
Exploratory Aim 3: Determine biomarkers that relate most strongly and reliably to CNS dysfunction in the context of HIV and/or psychosocial determinants. Hyp 3: Different biomarkers of neuronal damage damage (e.g., neurofilament protein light chain-NFL) and CNS inflammation will relate to patterns of impairment/decline in declarative memory, cognitive control, motor, and NVS in the context of HIV and/or exposure to sexual/physical trauma or violence.
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Uganda |
2020-07-28 |
2023-07-28 |
Medical and Health Sciences |
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Non-degree Award |
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