Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Bethany WILLIAMS LIN
ID:
Testing the functional significance of divergent reproductive traits in an African cichlid fish (Pseudocrenilabrus multicolor victoriae)
REFNo: NS52ES

The goal of the proposed research is to better understand the influence of environmental stressors (such as turbidity, hypoxia, and increased temperature) on the divergence of reproductive traits in an African cichlid fish (Pseudocrenilabrus multicolor victoriae). My specific objectives will be to (a) determine the functional role of physiological and behavioral trait changes between populations of P. multicolor, and (b) test the adaptive significance of trait changes by assessing performance of lab-reared fish on reproductive tasks. (c) present conservation education materials about the importance of biodiversity to water quality to local schools through The Water Project
USA 2018-05-22 2021-05-22 Natural Sciences Degree Award
William NESBITT Alexander
ID:
Causes and implications of the depletion of effective calcium concentrations in Lake Nabugabo, Uganda, East Africa
REFNo: NS53ES

To re-evaluate the work of Beadle (1981) and accurately measure the calcium and other major ion concentration of Lake Nabugabo and the surrounding wetlands. To identify the sink of calcium in the system to see why the concentration is so low compared to other lakes in the LVB. To explore the implications of low calcium by investigating the Ca/P ratio in Nile perch and mukene in both Lake Nabugabo and Lake Victoria to determine the effects on its bone strength, density and growth.
 Canada 2018-05-22 2021-05-22 Natural Sciences Degree Award
Joel HARTTER Nathan
ID:
Population, Environment, and Climate in the Albertine Rift
REFNo: NS37ES

To Determine how coupled climate and anthropogenic landscape change impacts the dynamics and resilience of a protected areas and the surrounding human population, including impacts to human and wildlife health, food security, and governance.
 USA 2018-05-18 2021-05-18 Natural Sciences Non-degree Award
Fiona Cresswell
ID:
High dose oral and intravenous rifampicin for adult tuberculous meningitis: an open-label phase II randomised controlled trial
REFNo: HS136ES

1. To determine whether higher-dose rifampicin, delivered orally at 35mg/kg/day or delivered intravenously at 20 mg/kg/day (for 2-weeks, followed by orally at 35 mg/kg/day for 6-weeks) provide equivalent plasma and CSF exposures, and whether the exposure profiles are favourable compared to the standard dose oral rifampicin. The pharmacokinetically optimal dose and route of administration of rifampicin can then be taken forward into a phase III clinical trial. 2. To observe whether greater rifampicin exposure in CSF is associated with any clinical benefit including more rapid resolution of coma, reduced neurocognitive deficit or reduced mortality. 3. To determine the diagnostic accuracy of Xpert MTB/Rif Ultra for TBM (ancillary study 1) 4. To describe the concentration of rifampicin in brain tissue in each treatment arm (ancillary study 2) 5. To explore the use of bedside ultrasound as a monitoring tool to improve supportive care for people with TBM (ancillary study 3)
UK 2018-05-15 2021-05-15 Medical and Health Sciences Degree Award
Moses Ocan
ID: UNCST-2020-R014731
 Antimalarial resistance in Sub-Saharan Africa: Assessing spread of artemisinin resistance and chloroquine resistance reversal among Plasmodium falciparum parasites
REFNo: HS168ES

1) To determine through a systematic review, the extent of chloroquine resistance reversal among Plasmodium falciparum parasites in malaria endemic countries since the change in policy 2) To determine the association between four (4) most reported K13 gene polymorphisms in Sub-Saharan Africa and artemisinin susceptibility among Plasmodium parasites 3) To predict using a model the spread to Sub-Sahara African (Uganda) Plasmodium falciparum parasite population of the K13 propeller gene polymorphisms detected in Southeast Asia and associated with artemisinin resistance
 Uganda 2018-05-15 2021-05-15 Medical and Health Sciences Degree Award
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