Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Nazarius Tumwesigye Mbona
ID: UNCST-2019-R000664
 Regulating alcohol packaging and supply to protect health in Sub-Saharan Africa: evidence from policy systems in Malawi and Uganda (RAPSSA study)
REFNo: HS3130ES

General objective
1. To identify how regulatory controls on alcohol production and distribution can be improved and effectively implemented in Sub-Saharan Africa to reduce the availability of cheap, single-use products and related harms
2. To explore contextual factors important for the transferability of findings to other Sub-Saharan countries, to inform alcohol policy development and implementation across the region.


Specific objectives

1. To identify the adoption and formulation of the bans, what mechanisms for implementation were proposed and put in place, how the bans were enforced in practice, as well as stakeholder and public perceptions of, and explanations for, intended and unintended consequences of the bans.
2. To explore contextual factors important for the transferability of findings to other Sub-Saharan countries, to inform alcohol policy development and implementation across the region.

 Uganda 2024-01-11 12:40:52 2027-01-11 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Daniel Kibuuka Musoke
ID: UNCST-2021-R011749
 Evaluation of the impact of the Public Justice System strengthening program on violence against women and children in Uganda
REFNo: SS1980ES

d) To measure change in the status of empowerment and protection of women and children against sexual and intimate partner violence including establishing the prevalence of violence against women and children. ,c) To assess change in the performance of the justice system in prevention and response to violence against women and children in Uganda, with a focus on the ability of the criminal justice processes to secure justice for victims of intimate partner violence and sexual violence against children, b) To explore changes in stakeholder confidence in the criminal justice system and the reliance of victims / survivors of intimate partner violence and child sexual violence on the criminal justice system for redress. ,a) To assess the coherence and relevance of IJM’s VAWC program including profiling changes in the legal landscape, framework and processes for handling cases of violence against women and children in Uganda,The general aim of the study is to evaluate how strengthening the public justice system to enforce law (supply side) and empowerment of sexual and intimate partner violence survivors to undertake justice (demand side) contribute towards the protection of children and women from sexual and intimate partner violence. The evaluation will be guided by the Organization for Economic Co-operation and Development (OECD) Development Assistance Committee (DAC) evaluation criteria of Relevance, Coherence, Effectiveness, Efficiency, Impact, and Sustainability to measure impact,
 Uganda 2024-01-11 12:39:14 2027-01-11 Social Science and Humanities Non-Clinical Trial Non-degree Award
DENIS OKELLO
ID: UNCST-2023-R007227
 Profiling Medicinal Plants and the Corresponding Community Conservation Practices within Kigezi Region
REFNo: NS667ES

Assess the community conservation strategies for priority medicinal plants in Kanungu, Kisoro and Rubanda districts.,To assess the cultural practices in Kanungu, Kisoro and Rubanda districts to ensure sustainable utilization and knowledge transfer of the medicinal values of these plants.,To assess traditional knowledge practices regarding medicinal plants used by communities in Kanungu, Kisoro and Rubanda districts.,To identify and document medicinal plants used by communities in Kanungu, Kisoro and Rubanda districts.,To profile medicinal plants in Kanungu, Kisoro and Rubanda districts in Kigezi region and assess local community conservation practices,
 Uganda 2024-01-11 12:35:14 2027-01-11 Natural Sciences Non-Clinical Trial Non-degree Award
Richard Mayanja
ID: UNCST-2022-R009948
 Genetic Determinants of Kidney Function in Sub-Saharan Africa
REFNo: HS3372ES

The overall aim of this project is to identify the genetic determinants of chronic kidney disease in sub-Saharan Africa
 Uganda 2024-01-11 12:32:07 2027-01-11 Medical and Health Sciences Non-Clinical Trial Degree Award
John Mark Bwanika
ID:
BUILDING MACHINE LEARNING ALGORITHMS FOR PREDICTIVE MODELLING OF THE ABILITY TO PAY FOR PRE-EXPOSURE (PREP) SERVICES, A PILOT STUDY IN KAMPALA, UGANDA.
REFNo: HS3474ES

Primary objective:
To develop and deploy an artificial intelligence (AI) modelling technique for PrEP services market segmentation.
Secondary objectives:
(i) To use machine learning and artificial intelligence modelling to analyze, and profile sub-populations that are able to pay for PrEP in Kampala.
(ii) To identify the most likely favorable pricing for PrEP
(iii) To validate the variables identified as predictors for PrEP payment from dataset analyses through focus group discussions.
(iv) To test the validity and reciprocity of the developed AI model with similar datasets from other settings.

 Uganda 2024-01-11 12:31:29 2027-01-11 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Isaac Ssewanyana
ID: UNCST-2020-R014336
 Evaluation of Clinical Performance and Usability of the KHB HIV I/II Ab Rapid Test (Self-Test) in the hands of untrained users. "Clinical Performance Study Plan - CPSP nr. KHB-CPH 23-039"
REFNo: HS3531ES

The objective of this laymen study is to establish and to qualify the usability of the KHB HIV Self-Test for self-testing in a low and a high prevalence HIV setting in Uganda as described in TSS-1 part 3. In addition, the layperson’s interaction with the device in terms of effectiveness and efficiency, i.e. successful/unsuccessful completion and difficulty of the critical steps as per Instructions for Use will be assessed. ,
 Uganda 2024-01-11 12:30:09 2027-01-11 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Zubair Lukyamuzi
ID: UNCST-2021-R013107
 Feasibility and Acceptability of a Barbershop Based HIV Prevention Initiative Among Heterosexual Men in Kalangala Islands, Uganda: A Cluster Randomized Trial
REFNo: HS3430ES

1. To compare completion of self-initiated HIV testing between intervention and control groups
2. To evaluate the preliminary effectiveness of the intervention on change in behaviors associated with HIV acquisition
3. To compare interest in or use of HIV prevention services between intervention and control groups
4. To evaluate the preliminary effectiveness of the intervention on incident STIs
Uganda 2024-01-08 13:20:21 2027-01-08 Medical and Health Sciences Clinical Trial Non-degree Award
Tumuhimbise Jasper Mpiriirwe
ID:
HEAD TEACHERS’ LEADERSHIP PRACTICES AND FINANCIAL PERFORMANCE IN CHURCH OF UGANDA FOUNDED SECONDARY SCHOOLS IN NAMIREMBE DIOCESE
REFNo: SS2126ES

4. To explore the influence of head teachers’ stakeholder collaboration on financial performance in the Church of Uganda Founded Secondary Schools in Namirembe Diocese. ,3. To analyze the influence head teacher’s team leadership practices on financial performance in Church of Uganda Founded Secondary Schools in Namirembe Diocese in Namirembe Diocese.,2. To assess the influence of head teachers’ values on financial performance in Church of Uganda Founded Secondary Schools in Namirembe Diocese. ,1. To examine the influence of head teachers’ vision on financial performance of Church of Uganda Founded Secondary Schools in Namirembe Diocese.,The general objective of the study is to examine the influence of head teachers’ leadership practices on financial performance of Church of Uganda Founded Secondary Schools (CFSs) in Namirembe Diocese. ,
 Uganda 2024-01-08 13:18:02 2027-01-08 Social Science and Humanities Non-Clinical Trial Degree Award
Joyce Kambugu Balagadde
ID: UNCST-2020-R014996
 Feasibility of Nanopore Sequencing for Classification of Pediatric Malignancies in Low Resource Settings
REFNo: HS3397ES

Expand upon our adapted unbiased Nanopore sequencing classification platform while verifying the feasibility of classification of pediatric solid tumors using GEP. Hypothesis: Unbiased Nanopore sequencing can be implemented and can accurately classify pediatric cancer in low and middle income countries,Establish technical and human resources needed to carry out local, real-time sequencing on Nanopore platforms through optimizing existing supply chains in collaboration with Nanopore and establishing standardized virtual and in-person training of local research, laboratory, and information technology support.,Optimize and validate, within the context of use in low and middle income countries, the efficacy unbiased Nanopore sequencing platform for pediatric cancer classification after integrating a Cloud-based computational analysis pipeline. Hypothesis: Using a Cloud-based unbiased Nanopore sequencing approach, clinical laboratories in LMIC can perform sequencing with Cloud based analytical support, accurately classify pediatric cancer diagnosis and genomic subtypes.,To determine the feasibility of implementing and utilizing Nanopore sequencing for classification of pediatric malignancies, as determined by technical quality, data management, and classification accuracy.,
 Uganda 2024-01-08 13:16:49 2027-01-08 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Tonny Ssekamatte
ID: UNCST-2022-R010961
 Climate change health vulnerability and adaptation assessment (VAA) for sound management of climate change-related health risks in Uganda
REFNo: HS3168ES

6. To use evidence from objectives 1-5 to inform the development of a National Health Adaptation Plan (H-NAP) for effective mitigation, adaptation and response to climate change in the health sector.,5. To understand how monitoring and evaluation of mitigation, adaptation and response measures to climate-change related risks and impacts on the health sector in Uganda should be done,4. To explore what should be done to effectively mitigate, adapt and respond to climate change-related risks and impacts in the health sector in Uganda,3. To identify policies, programmes and adaptation mechanisms that should be prioritized to address current and projected health risks in the health sector in Uganda,2. To describe and quantify the potential impacts (present and future) of climate change on the health sector in Uganda,1. To describe and quantify climate-change related risks (present and future risks) on the health sector in Uganda,To conduct a national health climate change vulnerability and adaptation assessment to identify health risk factors and gaps for sound management of climate change-related health risks in Uganda,
 Uganda 2024-01-08 13:15:39 2027-01-08 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Richard Sanya Edwin
ID: UNCST-2023-R006836
 The Next Generation Vaccine Card: Innovative Technology to Improve Vaccine Equity in Kagando, a Rural Setting in Uganda
REFNo: HS3515ES

To implement and evaluate using cluster-randomised and pre/post intervention approaches, the ‘next generation digital vaccine card’ in Kagando Uganda I. Implement the digital vaccine card intervention in rural Uganda II. Evaluate the implementation process and effectiveness of the intervention III. Evaluate the impact of the intervention on equity at the individual and village levels. IV. Conduct an economic evaluation of the intervention.,To co-design and develop a ‘next generation digital vaccine card’ for childhood vaccinations I. Design and build a prototype digital vaccine card and registry II. Use iterative feedback to refine the digital vaccine card and registry III. Develop a Minimum Viable Product (MVP) that meets the desired stakeholder specifications,To evaluate the current routine childhood vaccination landscape in Kagando Uganda I. Assess baseline routine childhood immunisation data quality at the facility level using WHO standard indicators II. Assess equity in routine childhood immunisation coverage and timeliness using household survey data III. Collect and analyse qualitative data to understand current knowledge, attitudes, and practices of vulnerable populations from patient and provider perspectives.,To develop and evaluate a ‘digital vaccine card’ and registry that will facilitate the electronic collection of individual data at health facilities to allow improved monitoring of vaccine coverage and timeliness by both healthcare providers and parents/caregivers, in turn improving vaccine equity in rural Uganda. ,
 Uganda 2024-01-08 13:14:20 2027-01-08 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Hakim Sendagire
ID:
Clinical, Hematological and Biochemical predictors of outcome in patients admitted with Sudan Ebola virus disease during the 2022 Uganda Ebola Outbreak (CHEBE Study)
REFNo: HS2961ES

General Objective
To evaluate the clinical presentation, treatment, clinical chemistry, immune chemistry, hematology and other laboratory predictors of clinical outcome in patients admitted with Sudan Ebola virus disease during the 2022 Uganda Ebola Outbreak
Specific Objectives
1. To evaluate the clinical presentation of patients at the time of admission in the ETU and treatment offered during admission as predictors of outcome among Sudan EVD patients admitted in hospital during the 2022 Ugandan Ebola Outbreak (CHEBE Study).
2. To describe the clinical chemistry, immune chemistry, hematology and other laboratory predictors of outcome in patients admitted with Sudan Ebola virus disease during the 2022 Uganda Ebola Outbreak (CHEBE Study).
3. To determine the association between laboratory profiles, comorbidities and clinical outcomes among patients admitted with Sudan Ebola virus disease during the 2022 Uganda Ebola Outbreak (CHEBE Study).

 Uganda 2024-01-08 13:13:08 2027-01-08 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Elisa van Dongen Maria Angela
ID:
Belief-based poverty traps and the effects of material and psychological interventions: Evidence from a lab-in-the-field experiment in rural Uganda
REFNo: SS2137ES

This research aims to empirically study the effects of aid on beneficiaries' and non-beneficiaries' agency beliefs and effort decisions.
 Netherlands 2024-01-08 13:12:25 2027-01-08 Social Science and Humanities Non-Clinical Trial Non-degree Award
JOSELYN RWEBEMBERA
ID: UNCST-2021-R013915
 Building the Foundation for Effective Sore Throat Treatment in Uganda.
REFNo: HS3473ES

Objective 1: Co-design a sore throat treatment program model using a community based participatory research approach to ensure a culturally and contextually appropriate and effective strategy for primary prevention of RHD.

Objective 2: Describe the current health seeking behavior of children who have a sore throat, including barriers and facilitators to seeking care within the formal healthcare system.

Objective 3: Describe the current approach by health care workers to a child presenting with sore throat, including barriers and facilitators to guideline-based care for children with sore throats.
 Uganda 2024-01-08 13:11:15 2027-01-08 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Daudi Jjingo
ID:
AI for Health Equity: Transforming Pandemic Preparedness in Uganda (HEAL)
REFNo: HS3524ES

Primary objective: To leverage advanced Large Language Models (LLMs) like GPT-4 to convert the Uganda Ministry of Health pandemic preparedness guidelines and the National Action Plan for Health Security (NAPHS) into an interactive, conversation-based tool, accessible in a native African language. Secondary objective: To validate the effectiveness of the dynamic AI platform encompassing language adaptation, user satisfaction and perception, seamless implementation in clinical settings, and tangible impact on clinical decision-making by conducting focused field testing involving a group of 60 healthcare professionals.
Uganda 2024-01-08 13:08:26 2027-01-08 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Joseph Kirabira
ID: UNCST-2019-R001427
 ADAPTATION, FEASIBILITY AND ACCEPTABILITY OF CAREGIVER PEER-SUPPORTER FACILITATED HIV STATUS DISCLOSURE INTEVERNTION FOR CHILDREN IN EASTERN UGANDA – A TASK SHIFTING MODEL
REFNo: HS3547ES

To assess the feasibility and acceptability of the CPS facilitated disclosure intervention ,1. To culturally adapt a clinic-based pediatric HIV status disclosure intervention into CPS facilitated HIV status disclosure intervention among CLHIV and their caregivers in Uganda,To culturally adapt and assess the feasibility and acceptability of a CPS-facilitated HIV status disclosure intervention among caregivers of CLHIV at Jinja Regional Referral Hospital in Eastern Uganda. ,
 Uganda 2024-01-08 13:07:36 2027-01-08 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Timothy  Muwonge Ronald
ID: UNCST-2020-R014680
 Achieving HIV viral suppression in refugee settlements in Uganda with Head StART: a cluster randomized trial evaluating the effectiveness of community ART delivery for people newly diagnosed with HIV
REFNo: HS2935ES

To estimate the programmatic cost and budget impact of implementing the Head StART intervention in refugee settlements in Uganda. ,To assess Head StART implementation across refugee settlement sites to understand the impact of contextual factors on study outcomes. ,To evaluate the effectiveness of “Head StART,” the expansion of community ART delivery to people newly diagnosed with HIV, in achieving HIV viral suppression in refugee settlements in Uganda. ,The primary objective of this research is to evaluate the effectiveness of expanding community ART delivery to clients newly diagnosed with HIV.,
 Uganda 2024-01-05 9:11:58 2027-01-05 Medical and Health Sciences Clinical Trial Non-degree Award
Kiggundu Nicholas
ID: UNCST-2023-R006508
 Hyperlocal Elicitation and Understanding of Risks to Stability in Complex Systems
REFNo: A369ES

Develop more effective models to predict agro-pastoralist and pastoralist livelihood behaviors,- Expanded use of machine learning and internet-based texts to make predictions and using those in conjunction with field data from surveys and interviews.,Understand the impact of mining on food security and local food systems in Karamoja Sub region.,
 Uganda 2024-01-05 9:09:35 2027-01-05 Agricultural Sciences Non-Clinical Trial Non-degree Award
Bob Denis Odongo
ID:
Access to livelihood assets, adaptive strategies and livelihood outcomes among refugees in Bidibidi settlement-Uganda.
REFNo: SS2114ES

Objectives of the study The main object of this study is to investigate factors that influence refugees’ access to sustainable livelihoods in Bidibidi settlement in Uganda. Specific Objective Stemming from the aim of the study as outlined above, this study sought to achieve the following specific and subsidiary objectives. 1) To explore factors that influence access and utilisation of livelihood assets among refugees in Uganda 2) To assess livelihood barriers and enablers for refugees in achieving sustainable livelihoods outcomes. 3) To examine the key adaptation and coping strategies that facilitates refugees’ achievement of livelihood outcomes. 4) To develop a modal on sustainable livelihood by the end of the study that will guide refugee programming.
Uganda 2024-01-05 9:07:36 2027-01-05 Social Science and Humanities Non-Clinical Trial Degree Award
Michael OCAIDO
ID:
Optimisation of integrated control of ticks and tsetse flies in mixed game and livestock interfaces in Uganda
REFNo: A365ES

The aim of the project is to introduce and demonstrate the profitability of community participation in strategic control of tsetse flies and ticks by restrictive spraying of vector predilection sites on cattle using dual purpose deltamethrin products in Mixed Game Livestock Interfaces
 Uganda 2024-01-05 9:04:52 2027-01-05 Agricultural Sciences Non-Clinical Trial Non-degree Award
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