PROSSY SENYANGE
ID: UNCST-2025-R020541
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PREVALENCE AND FACTORS ASSOCIATED WITH HIGH-RISK HPV POSITIVITY FOLLOWING TREATMENT FOR PRECANCEROUS CERVICAL LESIONS AMONG WOMEN LIVING WITH HIV AT MBARARA REGIONAL REFERRAL HOSPITAL.
REFNo: HS7368ES
General objective
To determine the prevalence and factors associated with high risk HPV positivity after treatment for precancerous lesions among women living with HIV at Mbarara Regional Referral Hospital
Specific Objectives
1. To determine the prevalence of high-risk HPV positivity after treatment for precancerous lesions among women living with HIV at Mbarara Regional Referral Hospital.
2. To determine the factors associated with high risk HPV positivity after treatment for precancerous lesions among women living with HIV at MRRH
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Uganda |
2026-04-30 18:41:23 |
2029-04-30 |
Medical and Health Sciences |
Non-Clinical Trial |
Degree Award |
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Mercy chelangat
ID: UNCST-2025-R017873
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PREVALENCE OF HIGH ACUTE GLYCEMIC VARIABILITY, ITS ASSOCIATED FACTORS, AND 14 DAY MORTALITY AMONG PATIENTS ADMITTED WITH SEPSIS AT MBARARA REGIONAL REFERRAL HOSPITAL
REFNo: HS7303ES
General Objective
To determine the prevalence of high acute glycemic variability, its associated factors and 14-day mortality among patients admitted with sepsis at MRRH.
Specific Objectives
1. Determine the prevalence of high acute glycemic variability among patients admitted with sepsis at MRRH
2. To determine the factors associated with high acute glycemic variability among patients admitted with sepsis
3. To compare the 14-day mortality rates between sepsis patients with high versus normal acute glycemic variability
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Uganda |
2026-04-30 18:40:37 |
2029-04-30 |
Medical and Health Sciences |
Non-Clinical Trial |
Degree Award |
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Henry Ochola
ID:
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MATERNAL EARLY WARNING SCORES AT MBARARA REGIONAL REFERRAL HOSPITAL: SCREENING PERFORMANCE VERSUS SHOCK INDEX, RISK FACTORS, AND EARLY OUTCOME INDICATORS
REFNo: HS7372ES
Main Objective
To evaluate the screening performance of Maternal Early Warning Scores compared with the Shock Index, and to identify associated risk factors and early maternal outcome indicators among women receiving obstetric care at Mbarara Regional Referral Hospital
Specific Objectives
1. To compare the proportion of women flagged high-risk by Maternal Early Warning Signs versus the Shock Index among women admitted at the maternity and gynaecology units at Mbarara Regional Referral Hospital.
2. To determine factors associated with being flagged high-risk at the index observation among women admitted at the maternity and gynaecology units at Mbarara Regional Referral Hospital, monitored with the Maternal Early Warning Signs chart.
3. To describe key process indicators (documentation completeness; guideline-timely escalation) and early outcomes (ICU admission; maternal near-miss; in-hospital mortality) among women admitted at the maternity and gynaecology units at Mbarara Regional Referral Hospital, monitored with the Maternal Early Warning Signs chart.
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Uganda |
2026-04-30 18:39:12 |
2029-04-30 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
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Winnie Muyindike R
ID: UNCST-2021-R013558
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Exploring low-level HIV viremia among individuals on dolutegravir in sub-Saharan Africa (Low-V Africa Study).
REFNo: HS7580ES
Aim 2: To elucidate pharmacologic, viral, and host factor determinants of the progression to VF among participants in the Low-V Africa Cohort. In doing so, we will also characterize the prevalence of these factors in the setting of pLLV in the Low-V Africa cohort. We will evaluate viral suppression and long-term persistence of LLV as secondary outcomes. Analyses will employ longitudinal modeling with repeated measures, as well as machine learning techniques. Aim 2a will assess adherence, as measured by TFV-DP levels from DBS, as a predictor of VF after pLLV. Aim 2b will assess HIV drug resistance, defined by GSS, as a predictor of VF after pLLV. Aim 2c will evaluate the impact of a hyperactive HIV-1 viral reservoir, identified with long-range plasma SGS and MIP-Seq, on the risk of VF after pLLV. Aim 2d will estimate the relative contributions of adherence, resistance, and the reservoir to VF after pLLV. ,Aim 1: To determine longitudinal outcomes of individuals with pLLV while on tenofovir/lamivudine/dolutegravir (TLD). We will enroll a cohort of 200 adults in Uganda with pLLV (Low-V Africa Cohort), defined as at least two consecutive VLs ranging 50-1,000 copies/mL while on TLD for at least 12 months. We will follow participants for 96 weeks and will collect plasma, dried blood spots (DBS), and peripheral blood mononuclear cells (PBMCs) at enrollment, as well as 24-, 48-, and 96-week study visits. Aim 1a will estimate the 96-week cumulative incidence of VF and poor clinical outcomes after pLLV. We will perform VL quantification at each study visit to determine whether participants progress to virologic failure (>1,000 copies/mL), achieve viral suppression (<50 copies/mL), or have persistence of LLV. As secondary outcomes, we will also estimate the cumulative incidence of opportunistic infections, hospitalization, and death. Aim 1b will determine the 96-week cumulative incidence of emergent HIV drug resistance and a hyperactive reservoir in PWH with pLLV. We will perform Sager sequencing of plasma specimens with VLs >500 copies/mL and long-range plasma single-genome HIV RNA sequencing (SGS) of plasma specimens with VLs ?500 copies/mL at each time point, with genotyping of the protease/reverse transcriptase and integrase. We will perform matched integration site and proviral sequencing (MIP-Seq) on follow-up specimens with ongoing viremia, evidence of high-level ART adherence (by tenofovir diphosphate [TFV-DP] levels), and an active ART regimen (genotypic susceptibility score [GSS]?2). Results will identify individuals with resistance versus a hyperactive reservoir in the setting of pLLV. ,
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Uganda |
2026-04-30 18:38:20 |
2029-04-30 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
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CHARLES TIONDI
ID: UNCST-2025-R022907
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This research investigates the impact of the outreach programs on TVET training in Uganda
REFNo: SIR655ES
The study looks at the effect of outreach programme strategies and how they influence practical and soft skills development, industry partnerships, and equity-based interventions.
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2026-04-30 18:35:17 |
2029-04-30 |
Engineering and Technology |
Non-Clinical Trial |
Degree Award |
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