Deogratius Ssemwanga
ID: UNCST-2025-R021563
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Performance Evaluation for Diagnostic Tests
REFNo: HS6649ES
Primary Objective
The overall objectives of this performance evaluation are:
• To verify the performance characteristics of new on-the-market NAATs and antigen RDTs.
• To establish well-characterized viral pathogen sera/plasma reference panels to support evaluation efforts and quality assurance.
• To evaluate the performance characteristics of new, on-the-market, EIAs and RDTs (IgA, IgG and IgM).
• To train laboratory and POC staff in biosecurity and the required technical skills to perform diagnostic testing.
Specific Objectives:
• To confirm whether or not a new NAAT complies with the manufacturer’s specifications,
• To determine the performance equivalence of new on-the-market NAATs, including POC devices, using available gold standards (or any other comparatively/equally as good WHO/FDA approved NAAT),
• To determine the performance equivalence of new on-the-market antigen tests against the gold-standard NAAT,
• To determine the sensitivity and specificity of new on-the-market diagnostic EIAs and RDTs against a gold-standard method,
• To evaluate the operational characteristics of new on-the-market immunoassays. Operational utility characteristics that may be considered include;
o ease of performance
o specimen type utility
o inter-reader variability
o reaction endpoint stability
o suitability for use in facilities with limited infrastructure (no/limited electricity, no/limited clean water)
• To document SOPs and train laboratory staff in performing testing using recommended diagnostic tests,
• To establish a repository of well-characterized natural infection and vaccination sera/plasma as well as swabs/extracted RNA to support future evaluation and verification of immunoassays.
• To establish a cohort of natural infection and vaccinated cases in the country whose samples and demographic characteristics will be used to help understand the dynamics of human immunity development to viral infection in order to inform the clinical interpretation of the various diagnostic assays.
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Uganda |
2025-10-24 17:31:36 |
2028-10-24 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
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Grace Muzanyi
ID: UNCST-2021-R013731
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Exploration Of the Correlation Between Active TB Immunological Markers and Sputum Culture: A Cytokine TB (CYTO-TB) Study
REFNo: HS6426ES
Main Objective
1. To explore the correlation of TB immunological markers (IL-2, IL-2Ra, I-P10, MIP-β, MCP-1) and TB sputum cultures at five-time points: before the start of treatment (Month 0), then Months 1, 2, 5, and 6.
Specific Objectives
1. 1. To assess the level of each or a combination of cytokines at the time points of active TB diagnosis, months 1, 2, 5, and 6, and how they relate to sputum culture on liquid (days to positivity) and solid (quantitative colony counts) media
2. 2. 2. To assess the baseline level of each cytokine or a combination and how it correlates with (a) the clinical response to TB treatment at months 1, 2, 5, and 6; (b) the clinical severity, and radiographic extent (severity) of TB disease at diagnosis and end of treatment.
3. 3. To evaluate the differences in the TB cytokine levels between active and latent TB during treatment with ERHZ (for active TB), and 6H (for latent TB), stratified by HIV status
4. 4. To evaluate the TB cytokine levels across three populations of active TB, Latent TB, and TB-exposed healthy volunteers who are TST/IGRA negative
5. 5. To compare the cost-effectiveness of TB immunological markers against sputum culture (standard of care).
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Uganda |
2025-10-24 17:30:54 |
2028-10-24 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
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Wilber Sabiiti
ID: UNCST-2024-R016293
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UNDERSTANDING INFECTIOUS AND NON-INFECTIOUS DISEASE TRENDS IN KANUNGU DISTRICT TO INFORM PUBLIC HEALTH PLANNING AND INTERVENTIONS
REFNo: HS6462ES
1. Determine types and trends of diseases in Kanungu from 2015–2025.
2. Compare quality and quantity of HCF records with MoH’s DHSI data.
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Uganda |
2025-10-24 17:28:54 |
2028-10-24 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
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Agatha Nakibuule Martha
ID: UNCST-2024-R016574
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EXPLORING HIV SELF-TESTING: PERCEPTIONS AND EXPERIENCES OF SEX WORKERS AND MALE CLIENTS ON KOOME ISLAND, UGANDA
REFNo: HS6306ES
1.3 Objectives
1.3.1 General objective
The overall objective of this study is to increase the adoption and use of HIVST kits among sex workers and their clients on Koome Island, by qualitatively exploring their perceptions, preferences and experiences of using HIVST kits for HIV prevention, and assessing how HIVST may influence status disclosure, behaviour change and linkage to care.
1.3.2 Specific objectives
1. To explore the perceptions, preferences and experiences of HIV self-testing among sex workers on Koome Island.
2. To explore the perceptions, preferences and experiences of HIV self-testing among male clients of sex workers on Koome Island.
3. To assess perceptions, practices, and norms of sex worker peers and healthcare providers that may influence HIVST scale-up and implementation for sex workers and their clients in island fishing communities.
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Uganda |
2025-10-24 17:27:53 |
2028-10-24 |
Medical and Health Sciences |
Non-Clinical Trial |
Degree Award |
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MUGISHA BRIAN
ID: UNCST-2025-R017969
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Evaluating Health Workers' Competence in Utilizing Electronic Health Records Systems for Quality Service Delivery in Hospitals:
Greater Bushenyi, Uganda
REFNo: SIR541ES
Major Objective
-The purpose of this study is to Evaluate Health Workers' Competence in Utilizing Electronic Health Records Systems for Quality Service Delivery in Selected Hospitals in Greater Bushenyi, Uganda.
Specific Objective
1.To establish the current state of Electronic Health Records within hospitals in the Greater Bushenyi region, Uganda.
2.To establish essential requirements for the development of a comprehensive framework model, focusing on the evaluation of effective usage of EHRs.
3.To develop a competence-based framework tailored for evaluating the usage of EHRs in hospitals in the Greater Bushenyi region, Uganda.
4.To Evaluate and validate the effectiveness of the developed framework for assessing EHRs within hospitals in the Greater Bushenyi region, Uganda.
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Uganda |
2025-10-24 17:15:31 |
2028-10-24 |
Engineering and Technology |
Non-Clinical Trial |
Degree Award |
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