Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Joshua Greenberg
ID:
Governance, Citizenship, and Accountability: Community-Centered Development in the Ugandan Health Sector
REFNo: SS265ES

This study examines the influence of governance structures on health outcomes in Uganda and tests strategies to foster more efficient healthcare delivery in the country. Specifically, the study will use a pilot randomized controlled trial to assess the feasibility and impact of several governance interventions. First, seeking to improve the performance of local leaders in ensuring quality health service delivery, the study will evaluate the following two community-level interventions: (a) quarterly citizen reporting meetings with Local Council III chairpersons on health service delivery and (b) chairperson skills training on monitoring local government health centers. Second, to study the determinants of citizen participation in meetings, the study will evaluate several different household-level encouragement messages within the meetings intervention group. The messages—which will separately emphasize (a) public duty, (b) social aspects, and (c) civic participation—will be aimed at motivating citizens to attend the quarterly reporting meetings. All of the interventions have been developed in collaboration with Progressive Health Partnership (a non-governmental organization) and the Office of the Prime Minister. This pilot study is meant to prepare for a larger study in the future.
USA 2019-02-05 2022-02-05 Social Science and Humanities Degree Award
lydia kapiriri
ID:
Evaluating Priority Setting for Health Research in Uganda
REFNo: HS309ES

1. Synthesize the current published and grey literature on PS for health research at the global level and specifically in Uganda. 2. Describe and evaluate a historical case scenario of PS for health research in Uganda. 3. Identify some of the barriers to effective PS for health research with particular relevance to governance mechanisms in Uganda. 4. Identify best practices that can serve to influence Ugandan PS for research processes and those of other low-income countries
Uganda 2019-01-30 2022-01-30 Medical and Health Sciences Non-degree Award
Emmanuel Kiiza Mwesiga Kiiza
ID: UNCST-2019-R001588
PREVALENCE, CORRELATES AND EXPLANATIONS OF A LONG DURATION OF UNTREATED PSYCHOSIS AMONG ANTIPSYCHOTIC NAÏVE PATIENTS AT BUTABIKA HOSPITAL: A MIXED METHODS STUDY.
REFNo: HS237ES

1. To determine the prevalence and factors associated with a long duration of untreated psychosis among patients with a first episode psychosis at Butabika hospital in Uganda. 2. Achieve a qualitative understanding of influence of prior treatment with alternative and complimentary therapies on duration of untreated psychosis among patients with a first episode of psychosis (FEP) presenting to Butabika hospital in Uganda.
Uganda 2019-01-29 2022-01-29 Medical and Health Sciences Non-degree Award
Samson Okello
ID: UNCST-2019-R001580
Epidemiology of Coronary Artery Disease among People with HIV in Rural sub-Saharan Africa
REFNo: HS267ES

Our over-arching goals are to demonstrate the extent to which coronary artery disease (CAD) burden may be greater among PLWH in rural Uganda, to discern which risk factors are responsible for this greater burden, and to propose a risk score and promising intervention targets to improve the health of this population. Aim 1: Determine whether CAD is more prevalent and severe among PLWH than HIV-uninfected comparators in rural Uganda. We will complete coronary CT angiography in 600 participants and compare the prevalence and severity of CAD between PLWH and HIV uninfected comparators, before and after adjustment for traditional risk factors Aim 2: Determine the extent to which the association between HIV infection and CAD is modified by sex and region. Within our cohort, we will test for effect modification by sex Aim 3: Identify regional correlates of CAD, and develop a risk prediction score for the presence of CAD among PLWH in rural sub-Saharan Africa. We will collect data on traditional (e.g. age, smoking, diabetes), HIV-specific (e.g. macrophage activation, CD4 count, ART history), and region-specific factors (e.g. biomass exposure, K:T ratio, tuberculosis infection). In Aim 3a we will include traditional, HIV-specific and regional risk factors in models to identify correlates of CAD. In Aim 3b, we will propose a simplified risk score to identify PLWH with CAD.
Uganda 2019-01-29 2022-01-29 Medical and Health Sciences Non-degree Award
Rachael MacLeod
ID:
A prospective observational study of intraventricular haemorrhage (IVH) in a neonatal cohort in Uganda: The IVHU Study.
REFNo: HS299ES

Overall objective To study the proportion of low birth weight (LBW) babies affected by IVH and to assess the severity of and risk factors for IVH and outcomes after IVH at Mbale Regional Referral Hospital in eastern Uganda over a 6-month period. Specific objectives In LBW neonates in a Ugandan population: • Describe the proportion of babies affected by IVH. • Describe the timing and severity of IVH. • Describe the incidence of complications including ventriculomegaly and cerebellar involvement, as well as other pathologies such as periventricular white matter changes with and without cystic change (PVL). • Determine the neonatal morbidities and neonatal mortality associated with IVH. • Describe risk factors associated with IVH.
UK 2019-01-22 2022-01-22 Medical and Health Sciences Non-degree Award
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