Andrew Kambugu
ID: UNCST-2019-R000823
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A randomised controlled trial of darunavir versus dolutegravir and tenofovir versus zidovudine in second-line antiretroviral therapy regimens for the public health approach in sub-Saharan Africa, THE NADIA Trial
REFNo: HS333ES
The aims of this trial are: To determine whether a regimen of DTG with two NRTIs is non-inferior to a regimen of DRV/r with two NRTIs as second-line therapy in patients failing on an NNRTI-based first-line regimen in the setting of the public health approach in sub-Saharan Africa, with substantial NRTI cross-resistance.
To determine whether continuing tenofovir and lamivudine is non-inferior to switching to zidovudine and lamivudine in a second-line therapy regimen in patients failing on an NNRTI-based first-line regimen in the setting of the public health approach.
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Uganda |
2019-03-19 |
2022-03-19 |
Medical and Health Sciences |
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Non-degree Award |
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PAUL KATO KALYEBARA KALYEBARA
ID:
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FACTORS HINDERING ACCESS TO ELECTIVE REPEAT CAESAREAN SECTION AT MBARARA REGIONAL REFERRAL HOSPITAL
REFNo: HS259ES
General objective
To determine factors hindering access to elective repeat Caesarean section and compare the immediate maternal and neonatal outcomes among elective repeat Caesarean section and mismatch emergency Caesarean deliveries at MRRH.
Specific objectives
1.To determine the proportion of women with indications for elective repeat Caesarean section that deliver by a scheduled Caesarean section at Mbarara Regional Referral Hospital.
2.To determine the factors hindering access to elective repeat Caesarean section at Mbarara Regional Referral Hospital.
3.To compare the immediate maternal and neonatal outcomes among elective repeat Caesarean section and mismatch emergency Caesarean deliveries at Mbarara Regional Referral Hospital.
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Uganda |
2019-03-14 |
2022-03-14 |
Medical and Health Sciences |
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Degree Award |
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Joseph Ochieng
ID:
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Genetics and genomics research in Uganda: Towards context-specific ethics guidelines
REFNo: SS268ES
1. Assess stakeholder awareness of GGR, and the nature of ethical and social concerns associated with GGR in Uganda, to better understand local needs and issues and provide robust data for later guideline development
2. Evaluate existing guidance and guidelines on the ethics and oversight of GGR for applicability to the Ugandan setting, with a particular emphasis on guidance and guidelines developed by and for Africa.
3. Develop and disseminate a model guideline for the ethics of GGR in Uganda.
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Uganda |
2019-03-14 |
2022-03-14 |
Social Science and Humanities |
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Non-degree Award |
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Hellen Opolot
ID: UNCST-2019-R001724
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A BASELINE ASSESSMENT OF THE ETHICS AND REGULATORY REVIEW PROCESSES FOR CLINICAL TRIALS REGISTERED IN UGANDA BETWEEN JANUARY 2016 AND JULY 2017
REFNo: SS276ES
1. To establish the turnaround times for clinical trial applications reviewed by the Research Ethics Committees and the NRAs in Uganda between January 2016 and July 2017.
2. To document the challenges faced by each stakeholder group along the regulatory review pathway during the study period.
3. To document possible solutions to identified challenges and make some best-practice recommendations that could potentially improve efficiency in the ethics and regulatory review process for clinical trials in Uganda.
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Uganda |
2019-03-14 |
2022-03-14 |
Social Science and Humanities |
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Non-degree Award |
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Elizabeth Namukwaya
ID:
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“Understanding data and information needs for palliative care to target mobile –phone based intervention development in Uganda and Zimbabweâ€
REFNo: HS325ES
1. Establish a consortium of academic researchers (from Uganda, the UK and Zimbabwe) including our research team, non-governmental organisations, palliative care providers, policymakers and mHealth development and implementation expertise, to catalyse mHealth research and generate evidence that can guide palliative cancer care development across sub-Saharan Africa
2. Understand the acceptability and optimal implementation of patient-level data collection (e.g. patient-reported outcome measures and patient-reported experience measures) using mHealth approaches in Uganda and Zimbabwe through patient and caregiver engagement
3. Determine information needs and pathways for leveraging evidence generated from mHealth approaches in service development in Uganda and Zimbabwe through health professional and service manager engagement
4. Determine information needs and pathways for leveraging evidence generated from mHealth approaches in policymaking in Uganda and Zimbabwe through policymaker engagement
5. Define the mechanisms for implementation of mHealth approaches to support development of palliative cancer care in sub-Saharan Africa
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Uganda |
2019-03-14 |
2022-03-14 |
Medical and Health Sciences |
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Non-degree Award |
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