Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Juliet Kyayesimira
ID:
Development of Governor’s Plum (Flacourtia indica) Herbal Formulation for the Management of Microbial Infections in Humans
REFNo: NS661ES

4. To determine the appropriate propagation method and conditions for domestication and conservation of F. indica,3. To evaluate the efficacy of formulated prototypes Flacourtia indica extracts for the management of microbial infections,2. To quantify the major phytochemicals of medicinal value in methanolic extracts of F. indica,1. To assess the indigenous uses, genetic diversity and habitat range of Flacourtia Spp. in Uganda,
Uganda 2024-01-25 18:38:49 2027-01-25 Natural Sciences Non-Clinical Trial Non-degree Award
Nixon Niyonzima
ID: UNCST-2020-R014577
Utility of a Liquid Biopsy in the Detection of Metastatic Breast Cancer in Uganda
REFNo: HS3277ES

To determine whether ctDNA can be used as a sensitive and specific measure of tumor burden and response to therapy among women with breast cancer undergoing treatment at UCI,To evaluate the feasibility, sensitivity, and specificity of the liquid biopsy, via ctDNA, to detect and quantify tumor-specific molecular characteristics in patients with metastatic breast cancer at UCI,
Uganda 2024-01-25 18:37:59 2027-01-25 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Bosco Buruga Apparatus
ID:
Use of information and communication technologies by farmers to enhance the management of agricultural knowledge and information in West Nile Sub-Region of Uganda
REFNo: SS2084ES

Propose an ICT model for enhancing the management of agricultural and knowledge in developing countries using a case of West Nile sub-region, Uganda.,Identify the effects of challenges farmers face in the use of these ICTs for the management of agricultural knowledge.,Determine the challenges faced by farmers in the use of ICT in enhancing the management of agricultural knowledge.,Examine the factors influencing farmers in adopting and using ICTs for enhancing the management of agricultural knowledge in the West Nile sub-region, Uganda.,Find out agricultural stakeholders’ perception of the use of ICT in the management of agricultural knowledge.,Establish the status of managing agricultural knowledge management processes in the West Nile sub-region.,The purpose of the study is to investigate ways in which ICTs can be used to enhance the management of agricultural knowledge in West Nile sub-region of Uganda and to further propose a model to be adopted for enhancing access to agricultural knowledge by stakeholders. ,
Uganda 2024-01-25 18:35:59 2027-01-25 Social Science and Humanities Non-Clinical Trial Degree Award
Agnes Kabajuni
ID:
Researching Green Activism: How to better protect minority and indigenous communities, Civil Society Organisations, Networks, and climate Change Defenders in East Africa
REFNo: SS2032ES

Overall Objective: to create an enabling environment for climate change defenders from the ethnic minorities and indigenous peoples to play their role in pushing for responsive climate actions, hold governments accountable and protection of communities adversely affected by climate change impacts in Kenya, Tanzania and Uganda
Specific Objectives: a) Generate knowledge by collecting evidence that leads to a deeper understanding of key stakeholders of the challenges faced by environmental activists from the ethnic and indigenous minorities and traditional knowledge as climate change mitigation strategies.
b) Equip environmental activists from MIPs with knowledge/ideas on how to develop successful strategies to mitigate the challenges they face as part of their work and how to meaningfully blend gender and social inclusion in their work.
c) Promote greater collaboration, cross exchange and learning between duty bearers, civil society movements for inclusive decision-making processes.

Uganda 2024-01-25 18:32:52 2027-01-25 Social Science and Humanities Non-Clinical Trial Non-degree Award
Susan  Nabadda
ID: UNCST-2020-R014331
Field Pilot Study for Histoplasmosis and Aspergillosis testing among patients with Advanced HIV Disease in Uganda.
REFNo: HS2803ES

To determine the integration needs of the Clarus Histoplasma Galactomannan Enzyme Immuno Assay (HGM201) and Sōna Aspergillus Galactomannan Lateral Flow Assay (AGM LFA) in the routine screening, testing and management processes for AHD patients in Uganda. To assess the operational characteristics such as usability and acceptability of the Sōna Aspergillus Galactomannan Lateral Flow Assay (AGM LFA) in the public health context. To assess the operational characteristics such as usability and acceptability of the Clarus Histoplasma Galactomannan Enzyme Immuno Assay (HGM201) in the public health context. To determine the prevalence of invasive aspergillosis in Advanced HIV Disease patients in Uganda. To determine the prevalence of disseminated histoplasmosis in Advanced HIV Disease patients in Uganda.
Uganda 2024-01-25 18:23:34 2027-01-25 Medical and Health Sciences Non-Clinical Trial Non-degree Award
EDITH  NAKKU-JOLOBA NAKKU
ID: UNCST-2021-R013931
Point of Care (POC) based Interventions to Improve sexual partner testing and tracking for Chlamydia Trachomatis (CT) and Neisseria Gonorrhoea (NG) in Kampala metropolitan STD clinics (POC-PIKAM STUDY)
REFNo: HS1448ES

To estimate the prevalence of commonly occurring causal organisms for genital discharge in men and women (N. gonorrhea and C. trachomatis T. Vaginalis and Gardnerella) infections in men and women attending outpatient clinics in Kampala using molecular diagnostic tests (Xpert) and other point of care tests,To assess the feasibility and reliability of participant self-collection for POC CT/NG tests (Xpert and Binx io CT/NG tests) and evaluate accuracy of the Binx io CT/NG Test against clinician provider and the Laboratory gold standard among persons presenting with genital discharge attending outpatient clinics in Kampala metropolitan .,To describe the perceptions and practices of persons regarding self-collection and self-testing for STD, and STD partner notification among persons with genital discharge attending outpatient STD clinics in Kampala, Uganda.,To evaluate the use of self-collection and self-testing of swabs in increasing the proportion of individuals and partners that get tested and treated for STI among persons presenting with genital discharge attending outpatient clinics in Kampala, Uganda. ,Our overall goal is to evaluate the effect of an intervention that includes; self-collection and partner notification on the proportion of partners of persons with vaginal and urethral discharge who return to the clinic for partner follow up and treatment at outpatient clinics in Kampala district and on management of NG and CT in this population.,
Uganda 2024-01-25 18:21:26 2027-01-25 Medical and Health Sciences Non-Clinical Trial Non-degree Award
HARRIET NABIRYE
ID: UNCST-2023-R006463
Adoption, Compliance and Effectiveness of MOH-Recommended Biosafety Practices and Guidelines at Public Health Laboratories in Central Uganda: A Cross-Sectional Survey.
REFNo: HS3437ES

1. To evaluate the adoption and compliance of MoH recommended biosafety practices and guidelines at PHLs in Central Uganda

2. To evaluate the effectiveness of MoH recommended biosafety practices and guidelines at Public Health Laboratories (PHLs) in Central Uganda

Uganda 2024-01-25 18:19:01 2027-01-25 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Catherine Atuhaire
ID: UNCST-2021-R013090
Perceived Maternal Social Support and Perinatal Depression among women in Public health facilities, Mbarara district, south western Uganda (PEMPED)
REFNo: HS3525ES

Aim 1: To determine the prevalence of antepartum depression and its associated factors among pregnant women in latent labor in Mbarara district, south western Uganda

Aim 2: To determine the prevalence of maternity blues at six hours and six days postpartum and its associated factors among mothers in Mbarara district, south western Uganda

Aim 3: To examine the association between perceived maternal social support and postpartum depression among mothers in Mbarara district, south western Uganda

Aim 4: To explore perceived psychosocial support practices, types and preferences by postpartum mothers in Mbarara district, south western Uganda

Uganda 2024-01-25 18:14:54 2027-01-25 Medical and Health Sciences Non-Clinical Trial Degree Award
Fanny Fauli Laessoee
ID:
Agrarian Change – How traditional agricultural knowledge and narratives of the future influence agricultural adaptation to climate change amongst smallholders in Acholiland, Northern Uganda
REFNo: A383ES

3. To explore how narratives of the future influence changing agricultural practices, 2. To examine the role of Traditional Agricultural Knowledge in agrarian change, 1. To identify how small-scale farming practices have changed over time Overall research objective: How are traditional agricultural knowledge and Narratives of the future influencing agricultural adaptation to climate change amongst smallholders in Acholiland, Northern Uganda? ,
Denmark 2024-01-25 18:13:00 2027-01-25 Agricultural Sciences Non-Clinical Trial Degree Award
Kamada Lwere
ID: UNCST-2022-R009359
THE RECRUITMENT AND RETENTION OF ALZHEIMER’S DISEASE DIVERSITY GENETIC COHORTS IN THE ALZHEIMER’S DISEASE SEQUENCING PROJECT(READD-ADSP)
REFNo: HS3097ES

Perform genomic analyses,Management of all phenotype, genomic and biomarker data. ,Process, store, and assay biomaterials for the genomics resource including DNA isolation, plasma, and RNA for future gene expression studies,Adjudication and Harmonization of clinical and neurocognitive data,Develop a large genomics resource for the study of AD in individuals with AF and HL ancestry,The overall goal of this proposal is to build a resource that greatly expands the presentation of currently underrepresented African ancestry (African American (AA) and Africans (AF)) and Hispanic/Latinx (HL) individuals in AD genetic studies.,
Uganda 2024-01-25 18:00:36 2027-01-25 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Nixon Niyonzima
ID: UNCST-2020-R014577
Feasibility Assessment of a Comprehensive Treatment Approach for Advanced Breast Cancer using Innovative Cancer Medicines in a Low Resource Setting in Uganda.
REFNo: HS3006ES

a. Primary objectives
The primary objectives of the study are to:

I. To measure the number of patients, out of those who are eligible, who are willing to begin immunotherapy within the recruitment period if perceived barriers are removed
II. To determine the proportion of patients who drop out over the duration of the study period

b. Secondary objectives
I. To describe the incidence of adverse events in patients on immunotherapies
II. To elucidate reasons for discontinuation of patients on immunotherapy treatment
III. To determine the factors associated with the acceptability of patients and healthcare workers for immunotherapy
IV. To describe the quality of life of breast cancer patients on immunotherapy

Uganda 2024-01-25 17:55:55 2027-01-25 Medical and Health Sciences Non-Clinical Trial Non-degree Award
JAMES  KAYIMA
ID:
The development and testing of a low-cost mHealth intervention to improve blood pressure control in Uganda
REFNo: HS3060ES

1) To assess the level of BP control among ambulatory patients attending the hypertension clinic at Kiruddu National Referral Hospital.
2) To explore the perspectives of patients and providers on the acceptability of a mHealth (mobile app) and enhanced self-care strategy and elicit preferred features of a mHealth strategy for BP control.
3) To develop a mobile app for low-cost phones applying a user-centered design process among patients and providers at Kiruddu National Referral Hospital for control of blood pressure.
4) To assess the feasibility of using the m-health app among patients, community health care workers, and clinicians in Kiruddu National Referral Hospital, focusing on acceptability, practicality, demand, adaptation, and pilot the efficacy of the intervention on BP control.

Uganda 2024-01-25 17:52:25 2027-01-25 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Edward Mokooza Kibikyo
ID: UNCST-2020-R014923
PREVALENCE AND DETERMINANTS OF SUBSTANCE USE AMONG UNDERGRADUATE STUDENTS AT THE UGANDA CHRISTIAN UNIVERSITY
REFNo: HS3577ES

1. To describe the current model of substance use care and assistance for UCU students.

2. To measure the point prevalence of substance use among undergraduate students at UCU main campus in the January/May semester of 2024.

3. To determine the effect of faith (knowing), religion (doing) and spirituality (Being) on substance use among UCU students

Uganda 2024-01-25 17:43:59 2027-01-25 Medical and Health Sciences Non-Clinical Trial Non-degree Award
AGNES NAGGIRINYA BWANIKA
ID: UNCST-2019-R001126
A CASE STUDY EXPLORING THE VALUE CHAIN, ENABLERS, OBSTACLES, AND BUSINESS MODELS TO SUSTAIN PRIVATE DIGITAL HEALTH BUSINESS ON GLOBAL GOODS IN UGANDA: A MIXED METHODS CONCURRENT TRIANGULATION STUDY DESIGN
REFNo: SS2051ES

To explore parts of the value chain the companies dealing in digital health are active in and global goods worked with.,To assess barriers(obstacles), enablers for running a private business on digital global goods,To explore business models used to sustain digital health business among the two companies.,i. To explore business models used to sustain digital health business, enablers and barriers to running a private business on digital global goods in Uganda..,
Uganda 2024-01-25 17:40:26 2027-01-25 Social Science and Humanities Non-Clinical Trial Non-degree Award
ASIIMIRE  DONATH
ID: UNCST-2021-R013270
Male-Led health Promotion Program
REFNo: SS2254ES

To develop questions to inform the development and implementation of the male-led group health promotion program for African refugee men,To collect data from African refugee men, women, and other stakeholders around their understanding of the health education needs, concerns,To develop a Male-Led health Promotion Program” for African Refugee men living in Nakivale Refugee Settlement Camp ,
Uganda 2024-01-25 17:39:17 2027-01-25 Social Science and Humanities Non-Clinical Trial Non-degree Award
Philippa Musoke
ID: UNCST-2021-R013523
Using Implementation Science To Understand And Design Stakeholder Informed Innovative Interventions To Improve Youth HIV Prevention And Care Continuums In Rural And Urban Uganda
REFNo: HS3625ES

We will use platforms in aims 1 and 2 to strengthen capacity of implementation science and to translate findings into policy and guidelines through clearly defined and established channels. ,To assess the rollout of a culturally acceptable, feasible HIV prevention and care intervention among AYA at high risk, on uptake and persistence to CAB-LA or SEARCH-YOUTH treatment support intervention using implementation effectiveness hybrid designs. Aim 2 will be informed by Aim 1 with regards to specific implementation features. We will recruit AYA (15-24 years) both HIV negative and HIV positive. We will screen them for high risk of seroconversion if negative and for those testing HIV positive unsuppressed or at risk of being unsuppressed. We will assess scale up in real world settings of evidence-based interventions to increase uptake and persistence on CAB-LA (HIV negative) and increase viral suppression (HIV positive) among high risk AYA.,Using the updated CFIR, we will identify determinants (barriers and facilitators) of potential implementation success of two innovations: CAB-LA uptake and persistence and SEARCH-YOUTH (SY) implementation at the community, clinic, organization, provider, and patient levels in five CRPS in urban, semi-urban and rural Uganda. Using CFIR implementation science framework we will conduct in-depth key informant interviews and focus group discussions with five different stakeholder groups:,
Uganda 2024-01-25 17:36:24 2027-01-25 Medical and Health Sciences Non-Clinical Trial Non-degree Award
SCHOLASTICA TIGURYERA
ID:
Instructional leadership and teaching quality of academic staff mediated by self-efficacy in public universities in Uganda
REFNo: SS2245ES

i. Examine the influence of instructional leadership on teaching quality of academic staff in public universities in Uganda.
ii. Assess the influence of instructional leadership on self-efficacy of academic staff in public universities in Uganda.
iii. Examine the influence of self-efficacy of academic staff on teaching quality in public universities in Uganda.
iv. Test the mediating effect of teacher self-efficacy on the influence of instructional leadership on teaching quality of academic staff in public universities in Uganda.

Uganda 2024-01-25 17:34:18 2027-01-25 Social Science and Humanities Non-Clinical Trial Degree Award
Marion Ouma Atieno
ID:
Setting the Research Agenda on Sexual Reproductive Health and Rights (SRHR) and Women’s Economic Security and Inclusion (WESI) in East Africa
REFNo: SS2249ES

• To identify emerging and unresolved research gaps/questions on SRHR as well as women’s economic security and inclusion in East Africa, particularly Kenya and Uganda.,• To synthesize findings of previous research-agenda setting exercises on SRHR and women’s economic empowerment and inclusion in East Africa.,
Kenya 2024-01-25 17:33:20 2027-01-25 Social Science and Humanities Non-Clinical Trial Non-degree Award
KASIRYE ANDREW KATO
ID: UNCST-2023-R008128
The Founder's Charism and child safeguard in selected ARU Member institutions
REFNo: SS2308ES

a. To suggest and recommend to religious institutions the need of designing child safeguard policies by utilizing and basing on their founder’s charism.,
Uganda 2024-01-25 17:31:27 2027-01-25 Social Science and Humanities Non-Clinical Trial Non-degree Award
Primah Namudiba Kwagala
ID:
GENDER AND THE LEGAL HISTORY OF ABORTION: THE LEGACY OF COLONIAL LEGISLATION IN UGANDA
REFNo: SS2247ES

The main objective of this study is to interrogate Uganda’s legal history on abortion and its legacy on contemporary laws regulating access to safe abortion services in Uganda. Specifically, the study has objectives to
1. Analyse gender dynamics that influenced regulation and means of abortion in pre-colonial Uganda
2. Examine the influence of colonialism on regulation of abortion practices for women in Uganda
3. Assess the legacy of colonial legislation on contemporary laws regulating access to safe abortion services in Uganda and;
4. Identify strategies to decolonize abortion laws in Uganda to inform legal and policy interventions on access to safe and legal abortion

Uganda 2024-01-25 17:29:51 2027-01-25 Social Science and Humanities Non-Clinical Trial Degree Award
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