Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Catherine Hobaiter
ID: UNCST-2019-R001480
 Behavioural Syntactics: the emergence of chimpanzee gestural capacities through adaptations for locomotion, sleep, and social co-ordination.
REFNo: NS735ES

Hypothesis 1: climbing and nest building shaped chimpanzees’ bodies and minds in ways that were later exapted for their unique gestural communication.
Prediction 1a) The rapid expansion in the great ape gestural repertoire was founded on a greater range of available movement selected for in climbing/nest building.
a. If so, then we should see the use of specific hand/arm movements in climbing and nest building that are available to great apes, but not small apes and other primates
b. If so, then we should see those movements present in great ape gestures
Prediction 1b) The basic ability to plan a sequence of actions, with hierarchically structured sections, emerged in the (relatively) simple behaviour of climbing and nest building, and was subsequently exapted/refined for food processing and then communication.
a. If so, then nest building and climbing should show sequences of motor actions that are planned from start to finish with recurred/recursive sections within them
b. If so, then we would see flexible programs of motor actions adapted to the task from the outset.

Hypothesis 2: rhythmic patterning and co-ordination of social behaviour provides a mechanism for social cohesion in chimpanzees.
Prediction 2a) The rhythm and patterning of social touch in chimpanzee grooming will show overlap with the stroke patterns that promote oxytocin release in human social touch.
Prediction 2b) Chimpanzees will show increased co-ordination in locomotory activities (e.g., walking and climbing) when engaged in activities where social cohesion is beneficial (e.g., patrolling).
 UK 2024-04-12 7:07:57 2027-04-12 Natural Sciences Non-Clinical Trial Non-degree Award
Gimono Esther Munira Ali
ID:
Assessment of sexual and reproductive health rights of Deaf women and Deaf adolescent girls in Uganda. Mbale district.
REFNo: SS2222ES

1. To establish the lived experiences of Deaf women and deaf adolescent’s girls on sexual reproductive health rights in Mbale District, Uganda.
2. To analyse the challenges facing Deaf women and deaf girls on sexual reproductive health rights in Mbale District, Uganda.
3. To establish the contribution of government and as a duty bearer in terms of implementing sexual reproductive health rights of Deaf women and deaf girls in Mbale District.
 Uganda 2024-04-12 6:58:27 2027-04-12 Social Science and Humanities Non-Clinical Trial Degree Award
Samson kaboko Benon
ID:
Rising through the Poverty Ceiling to Executive Leadership in Central Uganda
REFNo: SS2379ES

1. To find out the dominant themes expressed by those reared in poverty to describe their lived experiences of rising to the upper echelons of executive leadership in Central Uganda.
2. To explore the perceived negative influences of experiencing poverty while growing up on the rise to the upper echelons of executive leadership in Central Uganda.
3. To find out the perceived positive influences of experiencing poverty while growing up on the rise to the upper echelons of executive leadership in Central Uganda.
4. To find out the other lived experiences other than escaping from the effects of poverty that contributed to the rise to executive leadership in Central Uganda.

 Uganda 2024-04-12 6:46:17 2027-04-12 Social Science and Humanities Non-Clinical Trial Degree Award
Waruiru Kolff Kayla Tinie
ID: UNCST-2021-R012291
 Pan prescription: Medical behaviour and cognition
REFNo: NS784ES

Investigate (i) which behaviours of the Ngogo community use to treat wounds and (ii) whether humans and chimpanzees share features of medical cogntion and prosociality.
 Netherlands 2024-04-09 18:44:03 2027-04-09 Natural Sciences Non-Clinical Trial Degree Award
Lawrence  Egulu
ID:
Giving voice to the victims of the insurgency in Eastern Uganda in the late 1980s and early 1990s: A Phenomenological Research Study
REFNo: SS2498ES

• To document the survival, coping and recovery strategies that the victims adopted in regard to the experiences they underwent, • To record the kind of support the victims received from the local, national or international communities, • To document how the victims made meaning of the experiences they underwent, • To explore the lived experiences of the victims of the insurgency,
 Uganda 2024-04-09 18:41:49 2027-04-09 Social Science and Humanities Non-Clinical Trial Degree Award
Veronica Groves Kelly
ID:
The response to predation cues from an invasive predator in fish with different histories of interactions or hypoxia tolerances.
REFNo: NS779ES

To understand how abiotic environmental stressors and invasive predator pressure impact the behaviour and physiology of freshwater fishes.
Canada 2024-04-09 18:39:14 2027-04-09 Natural Sciences Non-Clinical Trial Degree Award
John Barugahare
ID:
ETHICALITY OF PRESUMED CONSENT AND SOCIAL SUPPORT FOR THE CADAVERIC ORGAN DONATION AND TRANSPLANT SYSTEM IN UGANDA: A PILOT STUDY OF KCCA AREA
REFNo: HS3945ES

The goal of the study is ‘to generate evidence that will inform the development of additional ethical and socially appropriate measures in the implementation of Uganda’s Human Organ Donation and Transplant Act, 2022, to build and maintain public trust and support for organ donation and transplant services in Uganda’.
Specific objectives
i. To assess the knowledge of boda boda riders, regular boda boda transport users and their next of kin, in KCCA area about the existing law on consent for cadaveric organ donation in the Uganda Human Organ Donation and Transplant Act 2022.
ii. To examine attitudes (willingness and unwillingness) towards presumed consent for cadaveric organ procurement among boda-boda riders, regular boda boda transport users and their next of kin in Kampala Capital City Authority area.
iii. To analyze public perspectives on strategies for improving public trust in the implementation of the organ donation and Transplant system in Uganda

 Uganda 2024-04-09 18:36:37 2027-04-09 Medical and Health Sciences Non-Clinical Trial Non-degree Award
SAMANYA  BULHAN
ID:
Decentralization and Service Quality in Healthcare sector of Uganda : A Case of Busoga Sub-Region
REFNo: SS2490ES

5.To validate the inter-district healthcare model of Busoga sub-region. ,3.To design an inter-district healthcare model to improve on service quality in Busoga Sub-region . ,2.To examine the differences in service quality provision among the district hospitals in Busoga Sub-region .,1.To investigate the theoretical implication on decentralization and service quality in healthcare sector of Busoga Sub-region. ,The purpose of the study is to evaluate Decentralization and Service Quality in health care sector of Uganda a case of Busoga Sub-Region. ,
 United Kingdom 2024-04-09 18:33:53 2027-04-09 Social Science and Humanities Non-Clinical Trial Degree Award
Eve  Namisango
ID: UNCST-2021-R014038
 Integration of child- and family-centred outcome measurement into routine palliative care to drive person-centredness and quality in Uganda.
REFNo: HS3578ES

1) To develop a child expert group to advise and act as peer promoters.
2) To refine C-POS for implementation across age groups and diagnoses.
3) To develop a quality improvement team within each of our three demonstration sites and
identify site-specific integration plans.
4) To develop a Decision Support Tool (DST) specifying appropriate and feasible clinical
responses to real-time data that are feasible and effective within local resources.
5) To implement C-POS for quality improvement cycles within routine practice in three
demonstration sites.
6) To determine stakeholder views on quality improvement mechanisms and impact.
7) To develop an implementation manual with consortium partners for the region.
Uganda 2024-04-09 18:21:39 2027-04-09 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Christine Ampumuza
ID: UNCST-2023-R007425
 Modelling Domestic Tourism on Demand and Supply Factors in Uganda RefNo:
REFNo: SS2489ES

iv. To examine the impact of demand and supply factors on domestic tourism consumption in Uganda using econometrics models.,iii. To determine the demand factors influencing domestic tourism consumption in Uganda.,ii. To identify the supply factors influencing domestic tourism consumption in Uganda.,i. To assess the current status of domestic tourism in Uganda.,To identify the supply and demand factors that influence domestic tourism and to develop a model for its promotion in Uganda. ,
 Uganda 2024-04-09 18:13:48 2027-04-09 Social Science and Humanities Non-Clinical Trial Non-degree Award
Ismael Ddumba-Nyanzi Elisha
ID: UNCST-2024-R005106
 Evaluation of the Kulea Watoto Project
REFNo: SS2474ES

1. Evaluate the effect of the Kulea Watoto (KW) Project on the following outcomes:
a) Early learning
b) Responsive caregiving knowledge and practices of parents and caregivers.
c) Household economic well-being
d) Child health and development
e) Psychosocial health and well-being of the child and primary caregiver
2. Qualitatively assess the pathways/mechanisms for impact, satisfaction, and the perceived usefulness of the individual components on well-being of children and caregivers. Further, it seeks to understand continuously the implementation feasibility of the intervention components.

Uganda 2024-04-04 8:29:45 2027-04-04 Social Science and Humanities Non-Clinical Trial Non-degree Award
Patricia NAHIRYA Ntege Nahirya
ID: UNCST-2019-R001117
 Long-Term Follow-Up of CAB LA for Participants in HPTN 083 and HPTN 084 CAB PrEP Studies at Risk of HIV Acquisition.
REFNo: HS3876ES

Primary Objective
• To describe new HIV infections in adult and adolescent participants at risk of HIV acquisition included in the HPTN 084 studies and their associated sub-studies.

Secondary Objective
• To describe any serious adverse events (SAEs), Grade 3 and Grade 4 ISRs, and AEs leading to withdrawal in adult and adolescent participants included in the HPTN 084 studies and their associated sub-studies.


 Uganda 2024-04-04 8:20:33 2027-04-04 Medical and Health Sciences Clinical Trial Non-degree Award
Firminus  Mugumya
ID:
FORMATIVE RESEARCH ON EARLY CHILDHOOD DEVELOPMENT IN NAKIVAALE REFUGEE SETTLEMENT
REFNo: SS2041ES

The overall aim of the implementation research study is to co-design, implement and evaluate an innovative integrated ECD intervention that promotes positive outcomes for refugee children in Nakivaale refugee settlement. This study protocol outlines the formative research to support the development of the intervention, The specific objectives of the formative research are as follows:

1. To describe the current developmental status of children (0-5) in Nakivaale refugee settlement
2. To map formal and informal ECD services in the Nakivaale refugee settlement
3. To understand the current caregiving knowledge, attitudes and practices, in the five domains of the nurturing care framework in the refugee and host setting of Nakivaale refugee settlement;
4. The understand the enabling and influencing factors and barriers to ECD service provision and caregiving among service providers and caregivers

 Uganda 2024-04-04 8:07:24 2027-04-04 Social Science and Humanities Non-Clinical Trial Non-degree Award
Joseph Kiva S.
ID:
Exploring the role of participatory communication in the promotion of maternal health care programmes: A case study of 89.2 Central Broadcasting Services FM in Uganda.
REFNo: SS2231ES

4. To find out in what ways has the programme facilitated community dialogue in the promotion of maternal health among pregnant women and mothers.,3. To explore the pregnant women/mothers’ perceptions of the participatorycommunication channels used during the health programme,2. To explore the participatory communication approaches used in the health programme,1. To find out in what ways maternal health communication occurred in radio,The general objective of this study is to explore the role of participatory communication in the promotion of maternal health care programmes,
 Uganda 2024-04-04 22:25:28 2027-04-04 Social Science and Humanities Non-Clinical Trial Degree Award
Simpson Nuwamanya
ID:
Feasibility of setting up solar powered oxygen supply in Rukungiri District, Uganda and in Butembo, DRC
REFNo: HS3587ES

Main Objective
This proposal seeks to demonstrate the feasibility of solar powered oxygen cylinder filling stations to supply medical oxygen to health facilities in Rukungiri District, Uganda and in Butembo, DRC.

Specific Aims
Describe the oxygen needs (survey of oxygen demand) and willingness-to-pay (market survey) at 14 medical facilities in Rukungiri District, Uganda, and 95 facilities in Butembo, DRC.
a. Specific: The aim is narrowly defined to include cylinder demand and price point.
b. Measurable: Survey data will measure cylinder need at each facility and price point (willingness to pay).
c. Achievable: The 14 sites in Uganda and 95 sites in DRC. We anticipate this survey will take approximately 30 minutes to complete, with on-site interview. Thus, the aim is achievable.
d. Relevant: These data are important for understanding the feasibility of supplying cylinders from a solar powered oxygen filling station.
e. Time-bound: Once approved, the study is anticipated to take 3 to 6 months to complete data collection. Data analysis and write-up of results is anticipated to take another 6 months.
2. Evaluate if solar powered cylinder filling is a feasible model to improve oxygen access.
a. Specific: The aim is narrowly defined to test the feasibility of the proposed cylinder filling stations.
b. Measurable: In order to be feasible, the costs and revenues need to be defined. These will be directly measured (recorded) based on the project activities (cylinder sales, equipment procurement).
c. Achievable: With partners (LeanMed), the cylinder filling stations can be implemented. Thereafter, the evaluation will be achievable.
d. Relevant: These data are important for understanding the real-world implementation of solar powered oxygen filling stations.
e. Time-bound: Once the study is approved and equipment is shipped and installed, we will evaluate project costs and revenues over a well-defined 12-month period.

Hypothesis
The working hypothesis is that solar powered oxygen filling stations are feasible and can generate revenue to maintain the ongoing provision of oxygen in areas where access is limited.

Uganda 2024-03-29 9:38:07 2027-03-29 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Richard Idro
ID: UNCST-2021-R013599
 Etiological role of parasitic exposure and familial susceptibility in nodding syndrome- related epilepsies
REFNo: HS3940ES

The central aim of this study is to investigate if families with nodding syndrome (NS) share common electrophysiological and clinical features forming a distinct familial epilepsy syndrome and if this phenotype is conferred by parasite, Onchocerca volvulus (OV)-associated hu-Leiomodin-1 antibodies in genetically susceptible individuals. This project provides a unique opportunity to mechanistically understand how the onchocerca parasite exposure modifies the risk for epilepsy among susceptible individuals.
Aim1: Characterize the epilepsy sub-phenotypes that aggregate within the NS-affected families. We hypothesize that a common electroclinical feature forms a distinct NS-associated familial syndrome.
Aim 2: Determine if distinct genetic polymorphism in the human host is associated with the pathogenesis of NS-and related epilepsies. Whole-exome/genome sequencing will be performed to test whether a genetic variant of major effect size co-segregates with NS and related epilepsies.
Aim 3: Evaluate the relationship between exposure to OV-associated Hu-leiomodin-1 antibody and host susceptibility that jointly confers risk for NS-and related epilepsies. We will test the hypothesis that OV -associated Hu-Leiomodin-1 antibodies in genetically susceptible individuals cause NS- related epilepsies.
 Uganda 2024-03-28 19:51:45 2027-03-28 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Felix Oyania
ID: UNCST-2021-R013492
 Understanding the Current Pediatric Radiology Imaging and Interpretation Capacity and Need In Mbarara, Uganda - A Survey
REFNo: HS3922ES

Objective 1: Needs assessment survey-To conduct a survey assessing the radiology imaging interpretation capacity and needs among medical providers involved with pediatric care in Mbarara Uganda.

Objective 2: Course Evaluation-To conduct a holistic evaluation of our future free remote pediatric surgical radiology course after at least 6 months of instruction.
Specific objectives:
 Uganda 2024-03-28 19:31:48 2027-03-28 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Namaganda Rehema Rehema
ID: UNCST-2024-R005390
 AGING WITH HIV IN UGANDA: Intersectional stigma, Ageism and adherence to ARVs among older persons in Uganda
REFNo: SS2484ES

The overall objective of this study is to investigate the experiences of living with HIV and accessing ART among older persons in Uganda. ,3. To examine experiences of intersectional stigma among older persons living with HIV ,2. To explore the intersection between Ageism and HIV stigma and how this might affect adherence and experiences of living with HIV among older persons ,1. To establish levels of adherence on ART among older persons living with HIV,
 Uganda 2024-03-28 19:29:32 2027-03-28 Social Science and Humanities Non-Clinical Trial Degree Award
Nishai Moodley
ID:
Global-to-local alignment mechanisms in governing large-scale irrigation schemes in Uganda: Trade-offs and synergies in the water-energy-food nexus
REFNo: SS2481ES

The main objective of this study analyses the alignment mechanisms between international and national development actors in large-scale irrigation schemes, and how this impacts WEF access of local households in Uganda. Put simply, this study aims to analyse the alignment between donors on the global level and departments on the national level, and the influence on households on the local level.
South Africa 2024-03-28 19:22:41 2027-03-28 Social Science and Humanities Non-Clinical Trial Degree Award
Veronica Nyakato
ID: UNCST-2022-R010786
 Improving the diagnosis and prognosis monitoring of children with leukemia at the Uganda Cancer Institute (UCI) by developing and implementing an algorithm for diagnosis and monitoring prognosis.
REFNo: HS3828ES

Aim 1: To understand the baseline practice of laboratory diagnosis and monitoring prognosis of patients with leukemia at the Peadiatric Oncology Unit of Uganda Cancer Institute (UCI), Kampala - Uganda. Objectives of Aim 1: 1) To describe the laboratory diagnostic pathway for children receiving care for leukemia at the Uganda Cancer Institute (UCI), Kampala, Uganda. 2) To explore the experiences of healthcare workers with the laboratory diagnosis and monitoring of prognosis of children receiving care for leukemia at the Uganda Cancer Institute (UCI), Kampala, Uganda. Aim 2: To develop an evidence-based algorithm for laboratory investigation, diagnosis, and monitoring treatment response for leukemia in children at the UCI. Objectives of aim 2: 1) To develop an evidence-based algorithm for laboratory investigation and diagnosis of children with suspected leukemia at the UCI. 2) To develop an evidence-based algorithm for laboratory monitoring of treatment response in children diagnosed with leukemia at the UCI. 3) To train healthcare workers at the UCI Peadiatric oncology Unit on the newly developed algorithms for laboratory diagnosis and treatment monitoring for children receiving care for leukemia at the UCI
 Uganda 2024-03-28 18:56:10 2027-03-28 Medical and Health Sciences Non-Clinical Trial Non-degree Award
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