Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Lydia Nakiyingi
ID:
Development of large-scale panel of TB patient urine and serum samples to serve as standards for detection of TB LAM in HIV-positive and negative presumptive TB patients
REFNo: HS1006ES

Primary:
•Estimate the sensitivity of the investigational urine LAM test for detection of culture-confirmed Mycobacterium tuberculosis infection among individuals with clinical signs and/or symptoms of TB.
•Examine the effect of HIV infection and CD4 cell level on sensitivity of these assays
•Compare the sensitivity of the existing FujiLAM and AlereLAM assays with new investigational LAM tests

Secondary:
•Use large-scale samples to compare the immunological properties of urinary LAM in different patients, and to perform structural analyses of the urinary LAM antigens
• Develop and distribute aliquots of characterized large-scale urine samples for standardization and optimization of a point-of-care format of the investigational urine LAM assay.


Uganda 2020-12-18 2023-12-18 Medical and Health Sciences Non-degree Award
Janet Nakigudde
ID: UNCST-2019-R000444
 Effectiveness and Implementation of an Early Childhood School-Based Mental Health Intervention in Low-Resourced Communities in Hoima and Kampala districts-Uganda
REFNo: HS1057ES

1. To evaluate the short and long term effectiveness of Professional Development (PD alone) and Professional Development plus wellness Training (PDT)
2. To examine the effectiveness mechanisms and theory of change underlying the EBIs
3. To examine implementation contextual factors and mechanisms that contribute to teachers' uptake and sustainment of EBI strategies within PD and PDT schools.
Uganda 2020-12-18 2023-12-18 Medical and Health Sciences Non-degree Award
Carolyne Onyango
ID:
Re-Calibration of Quantitative and Contextual Factors to Predict Child Cognitive Deficits in HIV-Exposed Children in the PROMISE/PROMOTE Study Cohorts (CD PROMOTE Study) Version 2.0, dated 08 March 2020
REFNo: HS795ES

1. To identify clinical, maternal, home-environment factors that are associated with the risk of CD among HIV exposed but uninfected children.
2. To develop a CD risk prediction tool for HIV exposed uninfected children informed by identified risk factors observed in Aim 1 and existing literature

 Uganda 2020-12-18 2023-12-18 Medical and Health Sciences Non-degree Award
Bruce Twinamasiko
ID:
FEASIBILITY OF A COMMUNITY HEALTH WORKER-LED INTERVENTION TO CONTROL HIGH BLOOD PRESSURE IN SOUTHWESTERN UGANDA: A PILOT PRAGMATIC CLUSTER RANDOMIZED TRIAL (CHIP TRIAL)
REFNo: HS881ES

1.To test whether a multifaceted intervention program will lead to blood pressure control among patients with uncontrolled blood pressure over a 12-month period compared to usual care.
2.To evaluate whether a multifaceted intervention program will improve hypertension control among hypertensive patients over a 12-month period, compared to usual care.

 Uganda 2020-12-18 2023-12-18 Medical and Health Sciences Non-degree Award
Grace Ndeezi
ID: UNCST-2019-R001802
 Effect of Vitamin D supplementation on Sickle cell disease hospitalisation and related complications among Children in Mulago Hospital: A randomised clinical trial
REFNo: HS985ES

Objectives
The overarching goal for this study is to evaluate whether vitamin D supplementation can decrease the need for hospitalisations in Ugandan children with SCD
Primary objectives:
1. To determine the frequency of hospitalisation among children with SCD supplemented with vitamin D versus placebo.
2. To determine the effect of vitamin supplementation on serum levels of 25 Hydroxyvitamin D levels in children with SCD

Secondary objectives:
To determine the:
1. Incidence of vaso-occlusive crises (VOC)
2. Incidence of acute severe respiratory illnesses
3. Severe adverse events
4. Requirements for blood transfusion among children supplemented with vitamin D versus Placebo in children with sickle cell anaemia

 Uganda 2020-12-18 2023-12-18 Medical and Health Sciences Non-degree Award
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