Kamya Moses
ID: UNCST-2020-R014203
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COVID-19 sydromic and sero-surveillance using established Uganda malaria surveillance sites.
REFNo: HS1125ES
To establish COVID-19 syndromic surveillance through existing Uganda Malaria Surveillance sites by collecting additional data on COVID-19 specific symptoms.
To perform enhanced surveillance for COVID-19 and assess for serological evidence of past infection with SARS-CoV-2 in patients, in order to estimate disease burden and map the geographic spread of the epidemic.
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Uganda |
2021-01-20 |
2024-01-20 |
Medical and Health Sciences |
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Non-degree Award |
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Edgar Agaba
ID:
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One Nutrition in Complex Environments (ONCE), a cluster-randomized trial of nutrition education and access to simple supportive technologies in improving agricultural practices and water quality management
REFNo: HS492ES
Aim 1: Implement and test a social and behavior change (NIPP) program alone (free-standing) and in combination with a “value-added” approach (NIPP+). The latter includes access to innovative low-cost tools and technologies relating to WASH and agriculture.
Aim 2: Identify best-practices emerging from the implementation of both approaches through process and program monitoring for effective integration, implementation, scale-up, and uptake of multi-sectoral and multi-level packages in complex environments to ascertain potential for scale up.
Aim 3: Study the sustained impact of the NIPP approach and the “value added” package (NIPP+) on knowledge and practices by gender within participating households, environmental risk factors, child health and nutritional status through a rigorous impact evaluation and longitudinal monitoring system.
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Uganda |
2021-01-12 |
2024-01-12 |
Medical and Health Sciences |
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Non-degree Award |
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Henry Ddungu
ID: UNCST-2019-R000966
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A Phase 2b Study to Evaluate the Safety and Efficacy of IMR-687 in Subjects with Sickle Cell Disease.
REFNo: HS1078ES
Primary Objectives:
(a)To evaluate the fetal hemoglobin (HbF) response to IMR-687 versus placebo
(b)To evaluate the safety of IMR-687 versus placebo.
Secondary Efficacy Objectives
(a)To evaluate the effect of IMR-687 versus placebo on HbF-associated biomarkers
(b)To evaluate the effect of IMR-687 versus placebo on indices of red cell hemolysis
(c)To evaluate the effect of IMR-687 versus placebo on indices of white blood cell (WBC)
adhesion
(d)To evaluate the effect of IMR-687 versus placebo on the incidence of vaso-occlusive crises(VOCs)
(e)To evaluate the effect of IMR-687 versus placebo on quality of life measures
Pharmacokinetic Objectives
(i)To evaluate the PK of IMR-687 and any major circulating metabolites
Exploratory Efficacy Objectives
(ii)To evaluate the effect of IMR-687 versus placebo on changes in red blood cell (RBC)
characteristics and total Hb
(iii)To evaluate the effect of IMR-687 versus placebo on renal function
(iv)To evaluate the effect of IMR-687 versus placebo on indices associated with
cardiovascular pathophysiology and ischemic stroke risk.
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Uganda |
2021-01-12 |
2024-01-12 |
Medical and Health Sciences |
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Non-degree Award |
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Kamya Moses
ID: UNCST-2020-R014203
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Impact of long-lasting insecticidal nets (LLINs) treated with pyrethroid plus pyriproxyfen vs LLINs treated with pyrethroid plus piperonyl butoxide on malaria incidence in Uganda: a cluster-randomised trial
REFNo: HS1097ES
Primary Objective:
To evaluate the impact of LLINs treated with a pyrethroid insecticide plus pyriproxyfen (PPF LLINs), as compared to LLINs treated with a pyrethroid plus piperonyl butoxide (PBO LLINs), on malaria incidence in Uganda. We will test the hypothesis that malaria incidence will be lower in intervention clusters (randomised to receive PPF LLINs) than in control clusters (randomised to receive PBO LLINs).
Secondary Objectives:
To evaluate the impact of PPF LLINs vs PBO LLINs on parasite prevalence, anaemia, and vector density.
To estimate the cost-effectiveness of delivering PPF LLINs, as compared to PBO LLINs
To assess net durability, survivorship and use of PPF LLINs vs PBO LLINs.
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Uganda |
2021-01-11 |
2024-01-11 |
Medical and Health Sciences |
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Non-degree Award |
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Robert Opika Opoka
ID: UNCST-2021-R014036
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The Influence of Comprehensive Follow-Up in Pediatric Sickle Cell Disease in an African Setting: a retrospective cohort Study
REFNo: HS636ES
General Objectives: To compare a set of sickle cell-related outcomes (mortality, stroke, blood transfusions, and hospitalizations) between children with SCA on a comprehensive follow up schedule under clinical trials setting and that of a cohort of children with SCA receiving routine care at a specialized sickle cell clinic.
Primary Objective: To compare sickle cell-related outcomes in the NOHARM children who were on the placebo arm to those of children of similar age group from the MHSCC who fulfilled the inclusion criteria for the NOHARM study at the time the study was recruiting patients but who were not enrolled.
Secondary Objectives: To assess the added effect of hydroxyurea therapy (in addition to comprehensive follow up schedule) on sickle cell-related outcomes. This shall be done by comparing sickle cell related outcomes in
1) NOHARM children randomized to hydroxyurea arm and that of the cohort of non-study MHSCC children with SCA over the time period of the NOHARM study (calendar years 2015-17).
2) NOHARM children on the MTD dose of hydroxyurea to that of the cohort of non-study MHSCC children with SCA over the time period of the MTD study (calendar years 2018-19).
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Uganda |
2021-01-08 |
2024-01-08 |
Medical and Health Sciences |
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Non-degree Award |
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