Philippa Musoke
ID: UNCST-2021-R013523
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Manifestations and Outcomes of Hospitalized African children and Adolescents with SARS-CoV-2 Infection: Insights from the Democratic Republic of the Congo, Ghana, Kenya, Nigeria, South Africa and Uganda (AFRE-Ped-CoV-19) protocol Version November 06 2020. Grant No. 1R25TW011217-01
REFNo: HS1168ES
Study Aims
a) To describe the socio-demographic features; clinical WHO COVID-19 staging at admission, clinical characteristics, laboratory features including inflammatory and
cardiac markers; imaging investigations and associated abnormalities, treatments applied; and comparisons within and across participating African countries.
b) To estimate the prevalence of comorbidities at presentation and recent/current treatment with immunosuppressive drugs and comparisons within and across
participating African countries.
c) To estimate the prevalence of associated tuberculosis (past, current), HIV status (HIV-exposed uninfected or HIV-infected, and type of treatment if HIV-infected), malaria, bacterial infections influenza and other viral infections and comparisons within and
across participating African countries.
d) To assess overall mortality and independent factors associated with mortality and comparisons within and across participating African countries.
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Uganda |
2021-01-21 |
2024-01-21 |
Medical and Health Sciences |
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Non-degree Award |
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Grace Ndeezi
ID: UNCST-2019-R001802
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A Phase 2b Study to Evaluate the Safety and Efficacy of IMR-687 in Subjects with Sickle Cell Disease
IMR-SCD-301
REFNo: HS1130ES
Primary Objectives
To evaluate the HbF response to IMR-687 versus placebo
To evaluate the safety of IMR-687 versus placebo
Secondary Efficacy Objectives
To evaluate the effect of IMR-687 versus placebo on HbF-associated biomarkers
To evaluate the effect of IMR-687 versus placebo on indices of red cell hemolysis
To evaluate the effect of IMR-687 versus placebo on indices of WBC adhesion
To evaluate the effect of IMR-687 versus placebo on the incidence of VOCs
To evaluate the effect of IMR-687 versus placebo on quality of life (QoL) measures
Pharmacokinetic Objectives
To evaluate the PK of IMR-687 and any major circulating metabolites
Exploratory Efficacy Objectives
To evaluate the effect of IMR-687 versus placebo on changes in RBC characteristics and total Hb
To evaluate the effect of IMR-687 versus placebo on renal function
To evaluate the effect of IMR-687 versus placebo on indices associated with cardiovascular pathophysiology and ischemic stroke risk
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Uganda |
2021-01-21 |
2024-01-21 |
Medical and Health Sciences |
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Non-degree Award |
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FRED SEMITALA COLLINS
ID: UNCST-2020-R014096
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Strengthening Integrated Screening for TB and COVID19 in Kampala, Uganda
REFNo: HS1152ES
The overall goal is to establish the acceptability, feasibility and potential for scaling up the use of COVID19-TB Screening algorithm at Kiruddu National Referral Hospital.
Specific objectives
(1) To explore the perspectives of healthcare providers on the integration of COVID19 and TB screening at Kiruddu National referral Hospital.
(2) To determine the effect of the COVID19-TB algorithm on the proportion of patients screened for TB at Kiruddu National Referral Hospital over a 4-month period.
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Uganda |
2021-01-21 |
2024-01-21 |
Medical and Health Sciences |
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Non-degree Award |
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Kirsten Beyer M
ID: UNCST-2021-R013472
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Assessing Health Professionals’ Knowledge, Perspectives and Practices Regarding HPV and Cervical Cancer Prevention and Control among Women Living with Human Immunodeficiency Virus Infection in Uganda
REFNo: HS782ES
General Objective
The proposed study seeks to examine the role that health professionals play in influencing WHIVs’ perceptions of HPV and cervical cancer and their associated health behaviors in Uganda.
Specific Objective
Interview public health and health care professionals (including clinicians, nurses, counselors, other/public health professionals, and community health workers/village health teams) to examine the following:
1. Knowledge regarding how HPV or cervical cancer impacts WHIV, which populations are impacted most, and frequency of HPV vaccination, screening and treatment.
2. Perspectives regarding barriers/facilitators of cervical cancer and HPV prevention and treatment among WHIV.
3. Practices regarding HIV professionals’ work in cervical cancer and HPV.
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USA |
2021-01-20 |
2024-01-20 |
Medical and Health Sciences |
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Non-degree Award |
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Emmanuel Sendaula
ID: UNCST-2020-R014767
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Clinical profile of HIV-infected patients receiving a holistic approach of care model attending Reach Out Mbuya facilities in Kampala district
REFNo: HS903ES
Main Objective
To describe the clinical profile and the factors associated with viral suppression status among HIV-infected patients receiving a holistic approach of care model in Kampala District.
Specific objectives
1. To describe the clinical profile of HIV-infected patients receiving a holistic model of care in Kampala District.
2. To determine the socio-demographic factors associated with viral suppression status among HIV-infected patients receiving a holistic model of care in Kampala District.
3. To determine the clinical factors associated with viral suppression status among HIV-infected patients receiving a holistic model of care in Kampala District.
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Uganda |
2021-01-20 |
2024-01-20 |
Medical and Health Sciences |
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Non-degree Award |
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