Richard Muwanika
ID:
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DEFINING DIAGNOSTIC PERFORMANCE, ANALYTICAL AND OPERATIONAL SUITABILITY FOR POINT OF CARE DEVICES FOR HEMOGLOBIN ESTIMATION DEVICES IN ROUTINE HIV AND MATERNITY CARE IN UGANDA
REFNo: HS437ES
1) To evaluate the analytical performance (accuracy and precision/repeatability) of the available non-investigational Hb POC devices in use in Uganda
2) To evaluate the diagnostic performance (sensitivity, specificity, Positive and Negative Predictive values) of the available Hb POC devices in Uganda
3) To evaluate the operational suitability of the available Hb POC devices in Uganda using a standardized scorecard
4) To determine the operational cost and cost-effectiveness of the available Hb POC devices in Uganda
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Uganda |
2019-09-10 |
2022-09-10 |
Medical and Health Sciences |
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Non-degree Award |
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Dunstan Kalanzi
ID:
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EXPLORING THE ASSOCIATION BETWEEN PERIODONTAL DISEASE AND THE RISK OF ALZHEIMER’S DISEASE AND RELATED DEMENTIAS: A COMPARATIVE STUDY
REFNo: HS438ES
To determine the periodontal health status of a community-based cohort of elderly persons and factors associated with Alzheimer’s disease and related dementias in Uganda
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Uganda |
2019-09-10 |
2022-09-10 |
Medical and Health Sciences |
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Non-degree Award |
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EDITH NAKKU-JOLOBA NAKKU
ID: UNCST-2021-R013931
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Performance of a novel, rapid Neisseria gonorrhoeae genotypic and phenotypic test and estimation of prevalence of 4 STI in a gonococcal surveillance program in Uganda
REFNo: HS455ES
Primary:
• To determine the accuracy (correlation, sensitivity, specificity) of a new mobile, dual purpose gonorrhea point-of-care (POC) STI test device [the Mobile NAAT (MobiNAAT)] against reference laboratory methods for diagnosis (Gram stain and/or culture).
Secondary:
• To determine agreement between self-collected meatal swabs and urine samples for the diagnosis of STI using a gold standard NAATs in Ugandan men (a population with high NG positivity).
• To assess acceptability of self-collected tests in men with UDS in Uganda.
• To validate MobiNAAT for gonorrhoea ciprofloxacin AMR in symptomatic men compared with gold standard (culture & disk diffusion).
• To estimate the prevalence of the following 4 STIs in a population of men with UDS: Chlamydia trachomatis (CT), Neisseria gonorrhoea (NG), Trichomonas vaginalis (TV), and Mycoplasma genitalium (MG) using NAATs.
• To compare sensitivity and specificity of GC NAAT with microscopy and culture in Ugandan samples.
• To assess the prevalence of HIV, syphilis and viral hepatitis, and compare HIV result to self-reported HIV status.
• To explore socio-demographic, behavioural and clinical factors associated with positive STI diagnosis (including NG NAAT-positive and NG culture-negative status).
• Determine the proportion of non-reportable results (unresolved, indeterminate and incomplete).
• Test other STI diagnostics in future on available samples.
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Uganda |
2019-09-10 |
2022-09-10 |
Medical and Health Sciences |
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Non-degree Award |
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David Meya Bisagaya
ID: UNCST-2019-R000837
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High Dose Oral Rifampicin to Improve Survival from Adult Tuberculous Meningitis: A Double-blinded Randomised Controlled Phase III Trial. HARVEST trial
REFNo: HS428ES
Our primary objective is: To determine if high dose rifampicin, delivered orally at ~35 mg/kg/day for 8 weeks, is safe and improves 6-month survival compared to standard of care (rifampicin 10 mg/kg/day) for patients with TBM.
Secondary objectives are to compare the high dose rifampicin regimen to the standard of care regimen for:
1. 12-month survival
2. Neurological disability and functional outcomes from TBM
3. Safety and tolerability
4. Hospital outcomes related to TBM
5. Subsequent neurologic deterioration
6. Management of drug-induced liver injury
Tertiary objectives are to:
1. To describe the pharmacokinetics (PK) of high dose rifampicin in plasma and CSF, assess predictors of exposure to rifampicin in plasma and CSF, assess PK-PD relationships also considering exposures to the other first-line TB drugs and ART in HIV-infected patients, and determine the minimally desired rifampicin exposure for optimal treatment of TBM.
2. To determine the cost-effectiveness of the intervention.
3. To determine appropriate TBM diagnostic algorithms
|
Uganda |
2019-09-05 |
2022-09-05 |
Medical and Health Sciences |
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Non-degree Award |
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Kevin Hunt Dean
ID:
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DRY HABITAT CHIMPANZEE ECOLOGY: IMPLICATIONS FOR HUMAN
EVOLUTION
REFNo: NS101ES
Document feeding, social and locomotor behavior using 1-minute focal observations. Record food items, ranging behavior, canopy use, feeding rate and habitat use. Collect hairs for trace element analysis. Collect skeletal material from any deceased individuals. Analyze skeletal material for distinctive characteristics. Analyse hormone profiles to determine if lower levels of aggression are due to low T levels. Look for poisons in Muguri River to find source of sex organ abnormalities. Examine dental micro wear and trace elements in hair to determine diet. Look at genetic variations
|
USA |
2019-09-05 |
2022-09-05 |
Natural Sciences |
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Non-degree Award |
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