Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Ponsiano Ocama
ID: UNCST-2019-R000440
Clinical and immunological impact of Schistosoma mansoni infection and treatment on the course of chronic hepatitis B virus (HBV) infection in HIVuninfected patients in Uganda
REFNo: HS1002ES

To determine Clinical and immunological impact of Schistosoma mansoni (Sm) infection and treatment on the course of chronic hepatitis B virus (HBV) infection in Uganda. This will be done through the following aims: Aim 1: To define and quantify Sm infection, treatment response, and reinfection rates within a cohort of chronic HBV patients Aim 2: To determine the impact of Sm infection and treatment on HBV virological markers, disease stage, and longer-term progression among urban Ugandans Aim3: To determine if HBV-specific immunological responses in the periphery and within the liver are altered in response to Sm infection and treatment

Uganda 2021-01-27 2024-01-27 Medical and Health Sciences Non-degree Award
Miriam Nakalembe
ID: UNCST-2021-R014040
Understanding CIN2+ among HIV infected women after LEEP: An epidemiological and immunohistochemical study
REFNo: HS1154ES

1. To assess the incidence and risk factors for “recurrent” CIN2/3 after LEEP among HIV- infected women.
2. To determine baseline HR-HPV types (in tissue) among HIV-infected women with CIN2/3 undergoing LEEP compared to the HR-HPV types with “recurrent” cervical lesions after a second LEEP.
3. To determine the immunohistochemical differences between the initial and repeat LEEP specimens among HIV-infected women with “recurrent” CIN2/3

Uganda 2021-01-27 2024-01-27 Medical and Health Sciences Non-degree Award
Edward Nsubuga
ID:
Work place violence and interventions used at mental health units in uganda
REFNo: HS435ES

Identifying the patterns of workplace violence,contributing factors ,and remedial interventions available in place for such victims.
Uganda 2021-01-25 2024-01-25 Medical and Health Sciences Non-degree Award
Joseph Kagaayi
ID: UNCST-2024-R015946
Hard to reach populations in Uganda; An observational cohort study
REFNo: HS607ES

Aim 1-We will first determine CHP coverage and HIV incidence among hard-to-reach persons using enhanced surveillance techniques.

Aim 2-We will then characterize ongoing sources of incident HIV infection through partner tracing of newly HIV-infected participants and matched HIV-negative controls, viral phylogenetics, and sexual network analyses.

Aim 3-Finally, we will determine if state-of-the-art CHP can engage hard-to-reach populations and reduce population-level HIV incidence to a level sufficient for HIV elimination by 2030.



Uganda 2021-01-25 2024-01-25 Medical and Health Sciences Non-degree Award
Pauline Byakika-Kibwika
ID: UNCST-2019-R001206
Evaluation of impact of National Research Information Management System on the research regulatory process in Uganda
REFNo: HS906ES

The general objective of this proposal is to determine the usage of NRIMS as well as evaluate the experiences and attitudes of users of the systems at Makerere University, Mulago Hospital and UCI RECs.
2.1.1 Primary Objective
1. To determine the turnaround time between submission of protocols to review and approval, and time to receipt of feedback from REC for one year before and one year after roll out of NRIMS for RECs in Makerere Hospital Complex and UCI
2.1.2 Secondary Objectives
1. To qualitatively document and compare stakeholders’ experiences regarding use of the paper based and the NRIMS for research protocol review and approval in Makerere University, Mulago Hospital complex and UCI at start of roll out and one year after of roll out.
Uganda 2021-01-25 2024-01-25 Medical and Health Sciences Non-degree Award
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