Grace Turyasingura
ID:
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RNAseq, secretome and HIV infection analyses of foreskin epithelial cells upon exposure to cervicovaginal fluid from healthy vs. women with bacterial vaginosis.
REFNo: HS426ES
Primary Objective (Aim 1): Compare the gene expression and secretome profile of primary foreskin epithelial cells following exposure to CVF from normal vs. BV women.
Hypothesis: BV CVF will induce an elevated pro-inflammatory and pro-chemotactic response in foreskin epithelia compared to normal CVF.
 Endpoints: Global gene expression by RNAseq
Secretome profiling by Luminex
Secondary Objective (Aim 2): Assess whether HIV-1 can directly infect primary foreskin epithelial cells following exposure to CVF from women with or without BV.
Hypothesis: HIV will infect foreskin epithelial cells in the presence of HIV- enhancing seminal amyloids, in a manner enhanced by BV CVF.
Endpoints: Assess CCR5/CD4 expression in foreskin epithelial cells, and their susceptibility to productive infection by HIV-1, following exposure to BV-CVF vs. normal CVF.
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Uganda |
2019-10-31 |
2022-10-31 |
Medical and Health Sciences |
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Non-degree Award |
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FLORENCE ANOBE KOMAKECH ANOBE
ID:
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Sustainable WASH systems Concept One Uganda.
REFNo: SS341ES
1.To investigate factors leading to success or failure of PAYF tariff collection to incentivize preventive maintenance arrangements for sustaining hand pumps.
2.To assess the possible mechanisms of exclusion from water services that exist in communities where PAYF is implemented, and how PAYF either causes or addresses these exclusion mechanisms.
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Uganda |
2019-10-31 |
2022-10-31 |
Social Science and Humanities |
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Non-degree Award |
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Emmanuel Mande
ID: UNCST-2023-R007045
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TESTING MEDICINAL PLANTS IN UGANDA FOR LATENCY REVERSING ACTIVITY
REFNo: HS436ES
Primary objective: To prepare soluble extracts in water and hexane from 100 different recognized medicinal plant species growing in Mabira Forest of Central Uganda.
Secondary objectives: To test these extracts for HIV latency reversing activity
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Uganda |
2019-10-31 |
2022-10-31 |
Medical and Health Sciences |
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Non-degree Award |
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Barbara Castelnuovo
ID: UNCST-2019-R000802
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Diagnosis and treatment of non-communicable diseases and geriatric syndromes in the HIV aging population in sub-Saharan Africa.
REFNo: HS454ES
General objective.
The overall goal of the proposal is to improve capacity for detection and management of non-communicable diseases and geriatric syndromes in the aging HIV population in SSA.
Specific primary objectives
Specific Aim 1. To capture NCD endpoints and their risk factors: hypertension, cardio vascular disease (annual ECG screening), respiratory disease (peak flow meter screening and spirometry), renal disease (proteinuria and creatinine clearance), cancers (complete skin evaluation, pap smear, faecal occult blood, breast exam).
Specific Aim 2. To measure physical function using the Short Performance Physical Battery, muscle strength, (Gait speed and assessment of grip strength with handheld dynamometry), frailty phenotype, and history of falls.
Secondary objectives:
o To assess quality of life at baseline and year 1 and 2. To asses Quality of life we will use the WHOQOL-OLD (https://www.who.int/mental_health/publications/whoqol/en/). This module was developed after identifying gaps in the coverage of the standard WHOQOL-100 on aspects of QoL in older patients (29).
o To monitor medication regimens in all older patients, particularly medications that can contribute to inactivity, (e.g. sedatives), medications that cause electrolyte imbalances, and medications that slow reaction time or can interfere with balance and coordination. Polypharmacy will be defined as 5 or more drugs, beyond antiretroviral drugs, used in the same individuals for more than 4 weeks.
o To measure other geriatric syndromes (nutritional status, https://www.mna-elderly.com/; falls history https://www.sralab.org/rehabilitation-measures/history-falls-questionnaire?ID=1131) and urinary incontinence https://sagelink.ca/iciq-ui_short_form_giic) using standardized questionnaires
o To screen for depression using the People Health Questionnaires, PHQ-2 and PHQ-9, (which have been validated in our settings in HIV positive patients (30)), and treated accordingly.
o To assess disability using an HIV specific Instrumental Activities of Daily Living (IADL) tool which will be adapted from the one developed from the University of Toronto.
o To screen for dementia using the Montreal Cognitive Assessment (MoCA) https://www.mocatest.org/wp-content/uploads/2017/05/MoCA-8.3-English-Test-2018-04.pdf. As suggested by a validation study conducted in South Africa, mild cognitive impairment cut off will be lowered from 26 to 24 to take in account cultural differences [36]
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Uganda |
2019-10-31 |
2022-10-31 |
Medical and Health Sciences |
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Non-degree Award |
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Andrew Gidudu
ID:
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Mapping where women in Uganda go to access post- abortion care
REFNo: SS355ES
The overall aim is to gather vital information and map the existing safe, less safe and unsafe post abortion access points and the quality of validated providers who provide services within the law, and PAC service access points in the market, what they offer and where we can fill a service delivery gap. The specific objectives are;
i. To map the location of PAC providers in districts of Uganda where MSI operates centres and social franchisees;
ii. To understand the price of PAC and LAPM services provided in districts of Uganda where MSUG operates centres and social franchises
iii. To understand the safety and quality of PAC services provided in districts of Uganda where MSUG operates centres and social franchisees according to WHO’s safety standards categorize facilities as providing safe, less safe and least safe post-abortion services including mapping and collecting LA/PM pricing from post-abortion providers
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Uganda |
2019-10-31 |
2022-10-31 |
Social Science and Humanities |
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Non-degree Award |
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