Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Denish Calmax Angol
ID:
Antibacterial Use and Resistance in Under Five Children in Post Conflict Northern Uganda
REFNo: HS362ES

General study objective
•To assess the burden, drivers of inappropriate antibacterial prescriptions and resistance patterns of the pathogens among under five children attending care in selected public health facilities in Lango sub-region, northern Uganda.
Specific objectives
•To determine microbiologically, the burden and drivers of inappropriate prescription of antibacterials for under 5-year outpatient children presenting with acute diarrhoea at public health facilities in Lango sub-region (Sub-study I)
•To determine microbiologically, the burden and drivers of inappropriate prescription of antibacterials for under 5-year outpatient children presenting with UTRIs at public health facilities in Lango sub-region (Sub-study II)
•To determine the proportion of bacterial species and their resistance among under 5 year inpatient children with systemic infections at Lira Regional Referral Hospital (Sub-study III)
•To determine the prescribers’ knowledge, attitudes and practices regarding antibacterial prescription with respect to the available guidelines for under 5-year outpatient children with acute diarrhoea and URTIs at public health facilities in Lango sub-region (Sub-study IV)
Uganda 2019-11-19 2022-11-19 Medical and Health Sciences Degree Award
Gerald Mboowa
ID:
UNDERSTANDING TRANSMISSION DYNAMICS AND ACQUISITION OF ANTIMICROBIAL RESISTANCE AT REFERRAL HOSPITALS AND COMMUNITY SETTINGS IN EAST AFRICA
REFNo: HS411ES

i. To determine the prevalence, antimicrobial resistance profiles and the common phenotypic mechanisms of resistance in bacteria isolated from study participants from the orthopaedic ward at Mulago hospital, hospital environments and corresponding community settings.
ii. To describe the emergence, transmission networks, and epidemiology of drug resistant bacteria in the orthopaedic ward at Mulago hospital, hospital environments and corresponding community settings.
iii. To investigate behaviors/practices that influence the emergence and spread of drug resistant bacteria in the orthopaedic ward at Mulago hospital, hospital environments and corresponding community settings.

Uganda 2019-11-19 2022-11-19 Medical and Health Sciences Non-degree Award
ERIC WOBUDEYA
ID: UNCST-2019-R001047
DEVELOPMENT OF A DIAGNOSTIC PREDICTION SCORE FOR TUBERCULOSIS IN HOSPITALIZED CHILDREN WITH SEVERE ACUTE MALNUTRITION
REFNo: HS445ES

Primary Objective
To develop a diagnostic prediction score for TB in hospitalized children with SAM
Secondary Objectives
1. To assess the prevalence of TB among hospitalized children with SAM.
2. To describe the symptoms and clinical characteristics of TB disease in hospitalized children with SAM.
3. To develop a first-step screening prediction score to identify children with presumptive TB among hospitalised children with SAM
4. To propose a stepwise diagnostic algorithm based on the score(s) developed
5. To assess the diagnostic performance and the added value in a diagnostic prediction score for TB in hospitalized children with SAM of the following tests:

a. Ultra performed on one NPA and one stool sample
b. Chest radiography features as assessed by the simplified TB-Speed CXR reading tool
c. Abdominal ultrasound
d. QuantiFERON®-TB Gold In-Tube (QFT) IGRA
e. Monocyte-to-lymphocyte ratio (MLR)
f. CRP
6. To assess the feasibility of collecting NPA and stool in children with SAM
7. To assess the safety and tolerability of NPA collection in children with SAM
8. To assess mortality and weight gain at 6 months in children with SAM, with or without anti-TB treatment
9. To assess the effect of bacteriological features (Xpert and/or culture-confirmed TB) and other key patient characteristics (age, HIV status, initial severity markers, percentage weight gain, and CXR features) on TB treatment outcome.

Uganda 2019-11-19 2022-11-19 Medical and Health Sciences Non-degree Award
Wilberforce Tushemereirwe
ID:
Micronutrient Biofortified Cooking Bananas for East Africa
REFNo: A53ES

The goal of the project is to contribute to the alleviation of vitamin A deficiency in Uganda through enhancing the levels of PVA in banana fruit, the major staple food of Uganda.
Uganda 2019-11-19 2022-11-19 Agricultural Sciences Non-degree Award
Denise Ferris Nicole
ID:
Take-up and Impact of Digital Repayment in Microfinance
REFNo: SS369ES

1. To assess the effect of digital repayment on loan performance and the microfinance model.
a. Understand if access to digital repayment methods affects repayment timeliness and default rates.
b. Understand if access to digital repayment affects group cohesion
2. To assess the effects of digital repayment on microfinance clients.
a. Assess if digital repayment is beneficial for microentrepreneurial clients
b. Assess if digital repayments for microfinance loans affect other use of mobile money
3. To assess how digital repayment differentially affects those who would prefer not to take it up.
a. Assess if those forced into digital repayment change their repayment behaviour.

Canada 2019-11-19 2022-11-19 Social Science and Humanities Non-degree Award
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"A prosperous Science and Technology Led Ugandan Society."