Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Cara Ebert
ID:
Impact evaluation of two youth skill development interventions as part of the Employment for Development (E4D) program of the German Corporation for International Cooperation (GIZ)
REFNo: SS397ES

The objective of the investigation is to identify interventions implemented by the German Development Corporation program E4D/SOGA that work and have the potential to be scaled up. The E4D/SOGA funds and implements a large portfolio of interventions in Uganda – comprising a total budget of EUR 10,700,000. In this light, we intend to evaluate the effectiveness of two E4D/SOGA programs. The investigation will give guidance on policy decisions by highlighting the relevance of short-course technical skills trainings, work readiness skills and labor market attachment via internship placement.
Germany 2019-12-27 2022-12-27 Social Science and Humanities Non-degree Award
Shevin  Jacob Thomas
ID:
THE AFRICAN RESEARCH COLLABORATION ON SEPSIS IN UGANDA (ARCS-UGANDA) COHORT STUDY: AN OBSERVATIONAL STUDY TO IMPROVE UNDERSTANDING OF SEPSIS EPIDEMIOLOGY, DEFINITIONS, HOST IMMUNE RESPONSE AND COSTS OF HOSPITAL CARE IN UGANDAN ADULTS
REFNo: HS511ES

General Objective:
To describe adult sepsis prevalence and incidence, validate sepsis definitions, characterize AMR, describe short- and long- term morbidity and mortality, identify host response to sepsis and quantify hospital costs using a cohort of adult patients with suspected sepsis admitted to hospitals in Uganda

Specific objectives:
1. Determine the epidemiologic characteristics, AMR characteristics, clinical outcomes (including morbidity, mortality and frequency of readmission after discharge from the hospital) and attributable costs from suspected sepsis in Ugandan hospitals
2. Evaluate performance characteristics of extant sepsis definitions/criteria when applied to a cohort of adult patients who fulfil study eligibility criteria for sepsis in Uganda
3. Characterize pathways of sepsis pathogenesis through exemplar pro-inflammatory (through neutrophil respiratory burst activity) and immunosuppressive (through HLA-DR) markers and agnostic transcriptomic analysis in a Ugandan sepsis cohort with a high prevalence of HIV infection.

USA 2019-12-27 2022-12-27 Medical and Health Sciences Non-degree Award
Lydia Nakiyingi
ID:
Prospective Multicentre Evaluation of the Accuracy and Diagnostic Yield of the Fujifilm SILVAMP TB LAM Test for the Diagnosis of Tuberculosis in People Living with HIV
REFNo: HS513ES

ï‚· To determine the diagnostic accuracy of FujiLAM for TB detection among PLHIV using an eMRS
ï‚· To determine the diagnostic accuracy of FujiLAM for TB detection among PLHIV using a CRS ï‚· To determine the diagnostic yield of FujiLAM among all patients identified as having TB by
eMRS and compare to AlereLAM, Smear and Xpert/Ultra (sputum, urine) as comparators
(on Day 1 specimens).

Secondary,
ï‚· To determine the diagnostic accuracy of FujiLAM for TB detection among PLHIV using a MRS.
ï‚· To determine the diagnostic yield of FujiLAM among all patients identified by MRS and compare to AlereLAM, Smear and Xpert/Ultra (sputum, urine) as comparators (on Day 1 specimens).
ï‚· To determine the diagnostic accuracy of FujiLAM across predefined subgroups using a MRS, eMRS and CRS separately.
ï‚· To determine the diagnostic accuracy of FujiLAM of Day 2 early morning urine using a MRS, eMRS and CRS separately.
ï‚· To determine the diagnostic accuracy of FujiLAM of Day 2 early morning urine across subgroups using a MRS, eMRS and CRS separately.
ï‚· To determine the diagnostic accuracy of AlereLAM in the same way as described in objectives 1.1, 1.2 and 2.1, 2.3 and compare it to that of FujiLAM.
ï‚· To determine the yield of FujiLAM over (incremental yield) or in combination with (combined yield) Smear and Xpert/Ultra (sputum) among eMRS-positive patients.
 To determine the diagnostic accuracy of Omega VISITECT® CD4 test for detection of a CD4 count ≤200 cells/µl, using WHO pre-qualified cytometers as the reference standard.  To collect and store high quality and well-characterized urine specimen from PLHIV
Uganda 2019-12-27 2022-12-27 Medical and Health Sciences Non-degree Award
Joseph Baluku B
ID: UNCST-2019-R000612
Prevalence of Sputum Positive Tuberculosis and associated Factors among Individuals found at Bars in Kampala Slums
REFNo: HS459ES

Primary Objective: To determine the prevalence of sputum positive TB among individuals found at bars in Kampala slums
Secondary Objectives:
1. To evaluate factors associated with sputum positive TB individuals found at bars in Kampala slums.
2. To determine the prevalence of HIV infection among individuals found at bars in Kampala slums
3. To determine the prevalence of TB/HIV co-infection among individuals at bars in Kampala Slums

Uganda 2019-12-13 2022-12-13 Medical and Health Sciences Non-degree Award
Jayne Webster
ID:
Process Evaluation of Integrated Immunisation & Family Planning Projects in Benin, Kenya, Malawi and Uganda
REFNo: SS367ES

1. Assess FP method acceptance and continuation in women who access immunisation and/or family planning services 2. Test associations between FP method acceptance and continuation and integration attributes 3. Assess the quality and responsiveness of integrated immunisation and FP delivery 4. Determine implementation fidelity, causal mechanisms and context in integrated immunisation and family planning 5. Develop an overall programme theory of what works, for who, how and in what circumstances the integrated delivery of immunisation and family planning
UK 2019-12-13 2022-12-13 Social Science and Humanities Non-degree Award
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