Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Christine  Wiltshire Sekaggya
ID: UNCST-2019-R000578
A phase II trial to describe the pharmacokinetics, safety and efficacy of pharmacogenetics-guided dosing of isoniazid in patients with HIV-associated TB
REFNo: HS1159ES

• To describe the pharmacokinetics of isoniazid, given at a higher dose (10mg/kg) among patients with fast or intermediate NAT2 acetylator status and a standard dose (5mg/kg) among patients with slow NAT2 acetylator status, among patients with HIV and drug sensitive TB.
• To investigate the safety of pharmacogenetically-determined isoniazid dosing among TB-HIV co-infected patients with drug sensitive TB.
• To explore the efficacy of isoniazid among TB-HIV co-infected patients with drug sensitive TB receiving pharmacogenetically-determined dosing, using pharmacokinetic – pharmacodynamic (PK-PD) models.

Uganda 2021-02-24 2024-02-24 Medical and Health Sciences Non-degree Award
Olive Kobusingye Chifefe
ID:
Observational Studies on Helmet Use, Speeding, Seat-Belt and Child Restraint in Kampala, Uganda
REFNo: HS1178ES

Main objective:
To establish the prevalence of road traffic crash severity risk factors in Kampala city namely speed, use of helmet use, seat-belt use, and drink- driving to generate evidence that can be used to inform policy and implementation strategies to promote road safety.

Specific objectives:
1. To assess the prevalence of seat-belt use and child restraint use among car occupants in Kampala.
2. To determine the prevalence of helmet use among motorcyclists in Kampala
3. To establish the prevalence and extent of speeding in Kampala
4. To determine the level of drink-driving in Kampala


Uganda 2021-02-24 2024-02-24 Medical and Health Sciences Non-degree Award
Karugahe Wilber
ID:
Identifying psychosocial impact of COVID-19 and promising practices for meeting the mental health and protection needs to SGBV of vulnerable populations during a protracted crisis in Kampala Slums
REFNo: SS721ES

1. Identification of psychosocial and mental health issues/problems for potential SGBV victims as a result of COVID-19 pandemic.
2. To examine the relationship that exists between psychosocial and mental health issues, Sexual Gender based violence and Coping strategies among potential SGBV victims.
3. Identify the coping strategies to help potential SGBV victims to improve their mental health, avoid prevent its occurrence or re-occurrence.

Uganda 2021-02-24 2024-02-24 Social Science and Humanities Non-degree Award
Mohammed Lamorde
ID: UNCST-2019-R001293
COVID-19 in people living with HIV: Evaluation of risk factors and outcomes in resource-limited settings
REFNo: HS1192ES

To characterize the clinical features and course of symptomatic COVID-19 in PLWH, described overall and by HIV and comorbid disease factors including pregnancy status
Nigeria 2021-02-24 2024-02-24 Medical and Health Sciences Non-degree Award
Dorothy  Nalweyiso Irene
ID:
Enhancing Ugandan undergraduate healthcare students’ application of evidence into practice through the development and evaluation of an Evidence-Based Practice Education Package
REFNo: HS1246ES

The main objective of the study is to determine the impact of an Evidence Based Practice (EBP) educational Package on the knowledge, skills, attitudes and behavior among undergraduate healthcare students in Uganda.
Specific objectives of the study:
i) To assess of the current literature regarding the present approaches for teaching EBP among undergraduate healthcare students.
ii) To explore the views and experiences of lecturers regarding the training and use of EBP in health practice.
iii) To assess the perceived knowledge, skills, attitudes and behaviour of EBP among undergraduate healthcare students before implementation the educational package.
iv) To develop an Evidence Based Practice (EBP) educational package for Ugandan undergraduate health care professionals.
v) To implement an Evidence Based Practice educational package among undergraduate healthcare students at Makerere university college of health sciences
vi) To compare the perceived knowledge, skills, attitudes and behaviour of EBP among undergraduate healthcare professional students before and after implementation of the educational package

Uganda 2021-02-24 2024-02-24 Medical and Health Sciences Degree Award
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