Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
LILLIAN MBABAZI
ID:
Storytelling Among the Bakiga of Uganda: Changing Form, Character and Performance Contexts Between 1930 – 2009
REFNo: SS2359ES

To examine the changing form, character, and performance contexts in storytelling among the Bakiga between 1930 and 2009.
To explore the function of storytelling among the Bakiga.
To assess the changing themes, structure, and settings for storytelling among the Bakiga in times of Christianity and formal schooling.
To examine how migration shaped the content, processes and form(s) of storytelling among the Bakiga.
To analyse how commercialisation influenced the composition and performance of storytelling among the Bakiga.
Uganda 2024-02-26 13:49:42 2027-02-26 Social Science and Humanities Non-Clinical Trial Degree Award
Winfred  Tugumisirize
ID:
Participatory Budgeting and Financial Sustainability in the Local Government in Uganda: A Case Study of Kabale District
REFNo: SS2353ES

4. To establish the relationship between participatory budgeting and financial sustainability in Kabale District Local Government.,3. To assess the relationship between budget implementation and financial sustainability in Kabale District Local Government.,2. To analyze the impact of budget approval on financial sustainability in Kabale District Local Government.,1. To examine the influence of budget formulation on financial sustainability in Kabale District Local Government . ,The main objective of the study is to examine the relationship between participatory budgeting and financial sustainability of Local Governments in Uganda.,
 Uganda 2024-02-26 13:47:53 2027-02-26 Social Science and Humanities Non-Clinical Trial Degree Award
LILLIAN BYERETA HAPPY
ID: UNCST-2021-R012144
 To utilize simplified instruments for geriatric assessment for specialized routine care of Old People Living with HIV (HIV –OLD, HOPE)
REFNo: HS3704ES

2. To evaluate the feasibility of self-collection (with the support of a research assistant) through tablets of simplified validated tools for Quality of life, Instrumental activities of daily living (IADL), history of falls, screening for depression, and incontinence. 1. To utilize simplified instruments for geriatric assessment of OPLWH which can be potentially scaled up in routine care, particularly for the assessment of frailty, sarcopenia , physical and cognitive function. ,The overall goal of the proposal is to validate simplified tools for specialized routine care of OPLWH. ,
 Uganda 2024-02-26 13:45:25 2027-02-26 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Kamoga Ronald
ID: UNCST-2019-R001524
 VAGUS NERVE STIMULATION IN A RAT MODEL OF ALZHEIMER’S DISEASE-LIKE SYMPTOMS: MORPHOLOGICAL, IMMUNOHISTOCHEMICAL, MOLECULAR AND BEHAVIORAL CHANGES
REFNo: HS3781ES

1. To conduct a scoping review of literature on vagus nerve stimulation in Alzheimer's-disease and related dementias.
2. To determine behavioral changes associated with vagus nerve stimulation in a rat model of Alzheimer-like symptoms.
3. To evaluate the morphological, Immunohistochemical and molecular changes in the Hippocampus, prefrontal cortex and medial temporal cortex associated with chronic stimulation of the vagus nerve in a rat model of Alzheimer’s-like disease.

 Uganda 2024-02-26 13:43:22 2027-02-26 Medical and Health Sciences Clinical Trial Degree Award
Mallory Holding Anne
ID:
Play Our Part (PoP) project primary data collection on effective engagement strategies with policymakers to support Learning through Play (LtP) in Early Childhood Education (ECE)
REFNo: SS2399ES

To gather data to help answer the PoP CoP learning question 3A: Which Engagement Strategies with Policymakers lead to the creation of enabling environments for LtP in Centre-based systems. ,Identify which advocacy approaches policymakers have found most effective.,Determine the way in which partners are currently engaging in national level advocacy activities and their definition of effectiveness.,Identify effective strategies for engaging policymakers on LtP in ECCE systems. ,
 USA 2024-02-26 13:42:34 2027-02-26 Social Science and Humanities Non-Clinical Trial Non-degree Award
Sarah Lofgren
ID: UNCST-2019-R001647
 Supervised Treadmill intervention to Reduce Inflammation and Depression through Exercise in HIV: The STRIDE Pilot Study
REFNo: HS3358ES

The objective of this study is to determine the feasibility and acceptability of an aerobic intervention via a treadmill among individuals with HIV and depression in Uganda.
3.1 Primary Endpoint: Feasibility and acceptability of Exercise as a treatment for depression in Ugandans with HIV. This will be measured by:
-Percent completion of the prescribed aerobic exercise intervention, as assessed by research staff logging participation.

3.2 Secondary Endpoint(s)/ Outcome(s):
- acceptability of the intervention assessed via a post intervention survey
-feasibility and acceptability of using a wearable exercise tracker to assess the volume of exercise, based on calories burned and steps achieved, during the intervention period among Ugandans with HIV and depression.
- measure the mean and standard deviation of baseline and 8-week serum BDNF and IL-6 level to estimate an effect size and power a future study.
- measure the mean and standard deviation of baseline and 8-week depression score via PHQ-9 to estimate an effect size and power a future study.
- measure the mean and standard deviation in aerobic fitness baseline and at 8 weeks measured via METS/watts achieved and total time/distance to estimate the effect size for a future intervention.
USA 2024-02-26 13:41:23 2027-02-26 Medical and Health Sciences Clinical Trial Non-degree Award
Waiswa Peter
ID: UNCST-2020-R014921
 Intervention Study on Unintended Pregnancy among Teenagers in Busoga
REFNo: SS2284ES

The implementation objective is to evaluate intervention acceptability and scalability in Uganda,The intervention objective is to evaluate a novel model to reach unmarried teenagers and assess its effectiveness in reducing unmet needs for modern contraceptives among the target population,
 Uganda 2024-02-26 13:39:25 2027-02-26 Social Science and Humanities Non-Clinical Trial Non-degree Award
Miriam Nakalembe
ID: UNCST-2021-R014040
 Cervical Cancer Screening Utilizing Image Capture and Machine Learning to Identify Precancerous Cervical Lesions
REFNo: HS3743ES

Using pathological confirmation of CIN 2/3+ as the reference standard for pre-cancer, determine if the sensitivity and specificity of image capture of the cervix and artificial intelligence/deep machine learning/interpretation is superior to VIA, the current standard of care for cervical cancer screening in sub-Saharan Africa. ,Evaluate the quality of the cervical images captured in the clinics for use in artificial intelligence/deep machine learning.,Establish an informatics and data management infrastructure for cervical cancer that utilizes the IeDEA data platform and will allow for images and biologic data to be stored and characterized with the AIDS and Cancer Specimen Resource (ACSR) and the National Library of Medicine (NLOM). ,
 Uganda 2024-02-26 13:37:44 2027-02-26 Medical and Health Sciences Non-Clinical Trial Non-degree Award
NELSON NSEREKO
ID:
FROM STANDARD SWAHILI TO THE SWAHILI VARIETY SPOKEN IN UGANDA: EVOLUTION AND MORPHOSYNTACTIC VARIATIONS
REFNo: SS2348ES

i) Describe the morphosyntax of the Kiswahili variety spoken in Uganda
ii) Compare and contrast the morphosyntax of Standard Kiswahili with that of the
Kiswahili spoken in Uganda
iii) Account for the emergence of the Kiswahili variety spoken in Uganda

 Uganda 2024-02-26 13:35:31 2027-02-26 Social Science and Humanities Non-Clinical Trial Degree Award
Julian Adong
ID: UNCST-2021-R013487
 Retention through mHealth for adolescents and young adults with HIV in care
REFNo: HS3722ES

Test the acceptability, feasibility, and preliminary impact of the developed adolescent-tailored mHealth intervention for retention in care of AYWH who are new to or newly re-engaging in care,Iteratively develop a social media-based adolescent-tailored mHealth intervention to improve retention in care for AYWH who are new or newly re-engaging in care,Define the cognitive, environmental, and behavioural challenges and their impact on behavioural intention for AYWH who are new or newly re-engaging in HIV care,To develop and test an mHealth intervention for retention in care for adolescents and young adults with HIV,
 Uganda 2024-02-26 13:34:00 2027-02-26 Medical and Health Sciences Clinical Trial Non-degree Award
alfred andama andama
ID: UNCST-2022-R011051
 TONGUE SWAB TUBERCULOSIS DIAGNOSTIC YIELD STUDY
REFNo: HS3761ES

Aim 1. To determine the proportion of people presenting to primary health centers with signs and symptoms of TB who: a. can provide a sample for TB testing (sputum vs. tongue swab) b. have a valid molecular test result (sputum vs. tongue swab) c. are detected as TB-positive (sputum vs. tongue swab) d. prefer providing a sputum vs. tongue swab sample
Uganda 2024-02-26 13:32:44 2027-02-26 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Bruce Kirenga J
ID: UNCST-2019-R001460
 SOLIDARITY TRIAL-A phase I/II Randomized Placebo controlled trial to evaluate the Safety and Immunogenicity of Sudan Ebolavirus in Uganda
REFNo: HS3190ES

Phase I (rVSV-SUDV)
1. To determine the safety of rVSV-SUDV candidate SUDV vaccine among adult healthy volunteers in Uganda.
2. To determine the immunogenicity of rVSV-SUDV candidate SUDV vaccine.

Phase II (ChAdox1, CAd3 and rVSV-SUDV)
Primary objectives
1. To determine the safety of ChAdox1, CAd3 and rVSV-SUDV candidate SUDV vaccines among healthy volunteers and persons with stable comorbidities.
2. To determine the immunogenicity of ChAdox1, CAd3 and rVSV-SUDV candidate SUDV vaccines.
Secondary objectives
1. To determine the durability of SUDV-specific induced immune responses following vaccination.
2. To determine the factors associated with optimal vaccine-induced immune responses.
3. To determine the putative cross reactivity by the SUDV vaccine candidates against other ebolaviruses (e.g. Bundibugyo ebolavirus (BUDV) and EBOV).

Exploratory objectives
1. To determine the effect of SUDV vaccines on host gene expression.
2. To determine the T and B cell specific responses and immune profiling in response to vaccination.
3. To determine the effect of SUDV vaccines on the host metabolome.
4. To determine the effect of SUDV vaccines on host innate immune responses.

 Uganda 2024-02-26 13:31:25 2027-02-26 Medical and Health Sciences Clinical Trial Non-degree Award
Rhona Mijumbi M
ID: UNCST-2023-R006843
 Building a Culture of Evidence-informed Policy-Making in Uganda (B-CuE)
REFNo: SS2257ES

3) To improve collaboration for better coordinated and complementary support to EIDM in Uganda.,2) To design a sustainable and relevant capacity-building program for pre- and in-service training to ensure individuals and institutions acquire relevant and adequate knowledge and skills to support timely EIDM.,1) To scale-up the activities of the Center for Rapid Evidence Synthesis as a knowledge brokerage institution to strengthen support for timely EIDM in Uganda.,
 Uganda 2024-02-26 13:23:45 2027-02-26 Social Science and Humanities Non-Clinical Trial Non-degree Award
Moses Adroma
ID: UNCST-2019-R000360
 Exploring the potential of a lower blood pressure threshold for diagnosing hypertension in pregnancy: Implications for pre-eclampsia and stroke.
REFNo: HS3784ES

1. To compare the incidence rate of preeclampsia between pregnant women with SBP from 130 to 139 mmHg and/or DBP from 80 to 89 mmHg and those with normotensive blood pressure below 130/80 mmHg.

2. To compare the incidence rate of stroke between pregnant women with SBP from 130 to 139 mmHg and/or DBP from 80 to 89 mmHg and those with normotensive blood pressure below 130/80 mmHg.

3. To investigate potential risk factors and biomarkers associated with the development of preeclampsia and stroke in pregnant women with elevated blood pressure within the range of 130/80 to 139/89 mmHg.

4. To compare the maternal and foetal outcomes between pregnant women with SBP from 130 to 139 mmHg and/or DBP from 80 to 89 mmHg and those with blood pressures below 130/80 mmHg.


Uganda 2024-02-26 13:20:46 2027-02-26 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Rawlance  Ndejjo
ID: UNCST-2022-R010993
 Health Systems Resilience in the Face of Climatic Change in Bududa, Kasese and Moroto Districts in Uganda
REFNo: HS3758ES

To explore the barriers and facilitators of building health systems mitigation, adaptation, and resilience mechanisms to deal with the adverse effects of extreme weather events in Bududa, Kasese and Moroto districts in Uganda.,To describe the mitigation and adaptation mechanisms that health systems in Bududa, Kasese and Moroto districts in Uganda employ to deal with the adverse effects of extreme weather events?,To explore how extreme weather events are impacting the disease burden in Bududa, Kasese and Moroto districts in Uganda.,To assess how extreme weather events are impacting disease burden and explore the resilience of health systems in Bududa, Kasese and Moroto districts so as to inform strategies for building resilient and low carbon health systems in the face of climatic changes in sub-Saharan Africa,
 Uganda 2024-02-26 13:19:29 2027-02-26 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Angelica Kiwummulo
ID: UNCST-2023-R005604
 The impact of digital health technologies on the delivery of maternal and child health services; A case study of Uganda
REFNo: HS3804ES

Evaluate the perceptions of community members, healthcare providers, and other stakeholders regarding the FamilyConnect program to inform opportunities for program optimization and expanded uptake in communities,Assess the success factors and barriers associated with the implementation of Family Connect for insights into program effectiveness.,Assess changes in the prevalence of key infectious diseases within communities using Family Connect app,Assess the changes in attendance rates for antenatal care and other essential Maternal and Child Health (MCH) services before and after the implementation of the Family Connect program,The overall objective of this study is to assess the extent to which Family Connect is influencing behavioral change towards improved uptake of Maternal and Child Health (MCH) services, prevention and control of infectious diseases, and the contextual factors contributing to its success,
 Uganda 2024-02-26 13:17:30 2027-02-26 Medical and Health Sciences Non-Clinical Trial Non-degree Award
David Munyua Okumu
ID:
Exploring military role expansion and its implications on civil-military relations.
REFNo: SS2335ES

1. Explore what motivates the government of Uganda to “pull” the UPDF into roles that are traditionally non-military.
2. Gain insights on how the involvement of the UPDF in non-military roles is conceptualised and formalised.
3. Explore the experiences of UPDF personnel deployed to non-military roles.
4. Explore the experiences and stories of civilians working with UPDF officers in non-military roles.
5. Establish how best the UPDF should engage with civil authorities in the event of undertaking non-military roles.
 Uganda 2024-02-26 13:14:39 2027-02-26 Social Science and Humanities Non-Clinical Trial Degree Award
Isaac Ssewanyana
ID: UNCST-2020-R014336
 CLINICAL PERFORMANCE EVALUATION OF THE COBAS HIV -1/HIV-2 QUALITATIVE ASSAY USING THE COBAS 5800
REFNo: HS3802ES

• To describe and assess the operational characteristics and ease of use of the assay under evaluation and its suitability for use in countries with limited infrastructure (no/limited electricity, no/limited clean water, inadequate means of waste disposal);,To assess analytical performance o Precision; o Limitofdetection; o Subtypedetection; o Cross-contamination or carry-over;, To assess sensitivity and specificity using clinical specimens by comparing with a designated reference standard;,The overall objective of the performance evaluation is to evaluate analytical and diagnostic performance of commercially available qualitative HIV molecular assays undergoing prequalification assessment.,
 Uganda 2024-02-26 13:12:03 2027-02-26 Medical and Health Sciences Non-Clinical Trial Non-degree Award
MWEBEMBEZI ATHERIA K
ID:
Management Practices and Financial sustainability of Church of Uganda founded private secondary schools in Greater Ankole Dioceses
REFNo: SS2404ES

To identify the challenges that hinder management practices and financial sustainability and strategies that will enhance financial sustainability in church of Uganda private secondary schools in greater Ankole dioceses. ,To examine the effectiveness of staffing on financial sustainability of Church of Uganda founded private secondary schools in Greater Ankole Dioceses ,To assess the effectiveness of leadership styles on financial sustainability of Church of Uganda founded private secondary schools in Greater Ankole Dioceses ,To analyze the impact of financial management practices on financial sustainability of Church of Uganda founded private secondary schools in Greater Ankole Dioceses,To examine the effect of management practices on financial sustainability of Church of Uganda private secondary schools in Greater Ankole Dioceses. ,
 Uganda 2024-02-26 13:05:57 2027-02-26 Social Science and Humanities Non-Clinical Trial Degree Award
Adele Stock
ID: UNCST-2024-R005015
 The Spiritual Life of Water: Aquatic Sacred Space and Urban Environmental Change in 20th century Johannesburg and Kampala
REFNo: SS2389ES

My dissertation research explores how water-based religious practices have been profoundly transformed amidst the immense environmental and legal changes precipitated during the colonial and postcolonial periods in Africa. I examine both the creativity and the resilience of African religious practitioners in making new meaning amidst the displacement of water-based loci of spirituality. In particular, I focus on the paradox of ritual cleansing and healing in polluted bodies of water, a practice that has its roots in the systems of colonization and racial exclusion that are foundational to histories of urban Africa. Kampala’s Lubigi Wetland has long been a vibrant space where diverse groups of Ugandans sought and still seek healing, both physical (particularly at the advent of the HIV/AIDS epidemic) and spiritual. Their resources are a powerful spirit medium thought to connect to spiritual forces in the wetland’s tranquil waters. Yet today, human settlement, environmental degradation, and violent conflict overshadow the swamp’s long history as a spiritual healing center of the Buganda Kingdom.
USA 2024-02-26 13:02:30 2027-02-26 Social Science and Humanities Non-Clinical Trial Degree Award
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