Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Moses Joloba Lutaakome
ID: UNCST-2022-R011558
Predicting the Future: Incipient Tuberculosis (PreFIT)
REFNo: HS1242ES

1.1 Aim:
To validate the clinical performance, cost, and feasibility of a package of ready-to-use new and existing candidate diagnostic assays for the prediction of the development of active TB.
1.2 Objectives:
1. Establish a multi-country diagnostic evaluation cohort of highly exposed TB contacts free of co-prevalent active TB, followed prospectively for active TB development over a 12-months period, and collect and store biological specimens from these contacts at pre-set time-points for laboratory testing; and
2. Validate a package of candidate assays for their predictive accuracy (sensitivity, specificity, positive and negative predictive values) for incident TB, feasibility, and cost. Based on combining results for the different tests, cost-optimised predictive algorithms will be derived.

Uganda 2021-03-01 2024-03-01 Medical and Health Sciences Non-degree Award
Miriam Nansunga
ID:
ASSESSMENT OF THE SAFETY AND EFFICACY OF COMMON MEDICINAL PLANTS OF CENTRAL UGANDA ON IMPAIRED LEARNING AND MEMORY IN RATS
REFNo: HS648ES

1. To identify medicinal plants of Central Uganda used in the management of memory impairment.
2. To determine the effect of the aqueous extracts of the 5 most commonly mentioned plants on escape latency in the Morris Water Maze and step down latency in Passive Avoidance test.
3. To determine the effect of the total crude extracts of the two most effective plants on: acetylcholine, glutamate; muscarinic receptor M1, M3 and M5; glutamate receptors AMPA and NMDA in the hippocampus and orbital frontal cortex

4. To establish the safety and toxicity profile of the two most active plants extracts on memory and learning enhancement.

Uganda 2021-02-26 2024-02-26 Medical and Health Sciences Degree Award
Leevan Tibaijuka
ID: UNCST-2021-R012986
Predictors for preterm neonatal mortality at Mbarara Regional Referral Hospital
REFNo: HS469ES

General objective
To Describe the Predictors for Preterm Neonatal Mortality among preterm babies delivered at Mbarara Regional Referral Hospital (MRRH).
Specific objectives
1. To describe the neonatal mortality of preterm babies at Mbarara Regional Referral Hospital
2. To describe the association of antenatal care attendance, antenatal corticosteroid use and mode of delivery with preterm neonatal death at Mbarara Regional Referral Hospital

Uganda 2021-02-25 2024-02-25 Medical and Health Sciences Degree Award
Francis Ekadu
ID:
Uganda Bribery Index
REFNo: SS392ES

To increase citizens awareness on the prevalence, gravity and impact of corruption in uganda
Uganda 2021-02-25 2024-02-25 Social Science and Humanities Non-degree Award
Lucrèce Ahovègbé Yémalin Judith
ID:
Evaluation of two medicinal plants on key factors causing treatment failure in Hepatitis C infection
REFNo: HS1004ES

1. Evaluate the antiviral and anti-mutagenic effect of A. nilotica and T. ciliata on HCV in presence and absence of DAA
2. Evaluate the effect of A. nilotica and T. ciliata on induced mutation in HCV infection in presence and absence of DAA
3. Determine effect of A. nilotica and T. ciliata on immunologic parameters involved in body response to HCV in presence and absence of DAA
4. Investigate the genotypes of HCV circulating in African region (Uganda, Benin) and their response in vitro to DAAs

Benin 2021-02-25 2024-02-25 Medical and Health Sciences Degree Award
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