Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Pontiano Kaleebu
ID: UNCST-2021-R013577
 A Phase 1 Trial of ChAdOx1- and MVA-vectored Conserved Mosaic HIV-1 Vaccines in Healthy, Adult HIV-1-negative Volunteers in Eastern and Southern Africa
REFNo: HS844ES

Safety
 To evaluate the safety and tolerability of a prime boost vaccine regimen utilizing non-replicating simian adenovirus (ChAdOx1) followed by non-replicating poxvirus modified vaccinia virus Ankara (MVA) in adults in Eastern and Southern Africa
Immunogenicity
 To evaluate the specific T-cell immune responses induced by the ChAdOx1.tHIVconsv1 followed by MVA.tHIVconsv3&4 vaccines in vaccine recipients.
SECONDARY
 To assess tHIVconsvX-specific T-cell responses of for their frequency, breadth and duration in vaccine recipients.
 To assess functional T-cell responses in vaccine recipients that inhibit replication in vitro of viruses of major HIV-1 clades A, B, C and D.
EXPLORATORY
 To assess induction of plurifunctional tHIVconsvX-specific memory T cells in the vaccine recipients.
 Characterization of the gut microbiome composition and richness.
 Uganda 2021-03-05 2024-03-05 Medical and Health Sciences Non-degree Award
Esther Buregyeya
ID: UNCST-2020-R014116
 USING SHORT MESSAGE SERVICE REMINDERS AND MOBILE MONEY INCENTIVES TO ENHANCE LINKAGE TO CARE OF PRESUMPTIVE TUBERCULOSIS PATIENTS IN UGANDA: A RANDOMISED CONTROLLED TRIAL
REFNo: HS993ES

To evaluate the TB diagnostic process and linkage to care by doing cohort analysis.

2. Develop and adapt an SMS reminders and MM incentives to improve linkage to care among TB patients.

3. Conduct a randomized controlled trial of SMS reminders and MM incentives sent to presumptive and confirmed TB patients to improve linkage to care and treatment.

4. To build sustainable capacity in TB research clinical trials in Uganda.

Uganda 2021-03-05 2024-03-05 Medical and Health Sciences Non-degree Award
Jude Onyango Tadeo
ID:
FAMILY SUPPORT, DIABETES SELF-MANAGEMENT, AND GLYCEMIC CONTROL AMONG PATIENTS ATTENDING DIABETIC CLINICS OF REGIONAL REFERRAL HOSPITALS IN EASTERN UGANDA (FS-DSM-GC STUDY)
REFNo: HS1040ES

Research Study objectives:
General objective:
To examine the association between perceived family support, diabetes self-management behavior and glycemic control among patients attending Regional Referral hospitals in the eastern region of Uganda.
Specific objectives:
1. To determine the association between perceived family support and diabetes self-management behavior among patients attending outpatient clinics of Regional Referral Hospitals in the eastern region of Uganda.
2. To determine association between perceived family support and glycemic control among patients attending outpatient clinics of Regional Referral Hospitals in the eastern region of Uganda.

 Uganda 2021-03-05 2024-03-05 Medical and Health Sciences Non-degree Award
Jonathan Mayito
ID:
Utility of the monocyte to lymphocyte ratio in diagnosing latent tuberculosis among HIV-infected individuals with a negative tuberculosis symptom screen.
REFNo: HS1066ES

1. To determine the diagnostic performance of the monocyte to lymphocyte ratio against IGRA in diagnosing latent TB among HIV-infected individuals with a negative tuberculosis symptom screen.
2. To determine the change in the monocytes to lymphocytes ratio measured at baseline, and three months among HIV-infected individuals during tuberculosis preventive therapy.

 Uganda 2021-03-05 2024-03-05 Medical and Health Sciences Non-degree Award
Namulema Edith
ID:
Evaluation of the Safety and Tolerability of the ‘LeVe CPAP Flow Generator’ in Healthy Volunteers at Mengo Hospital in Kampala Uganda
REFNo: HS1250ES

To determine the safety, tolerability and acceptability of the LeVe CPAP Flow Generator’ among healthy volunteers at Mengo Hospital and to ensure they do not cause harm.
 Uganda 2021-03-05 2024-03-05 Medical and Health Sciences Non-degree Award
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