Nixon Niyonzima
ID: UNCST-2020-R014577
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MUTATIONAL PROFILE OF TRIPLE NEGATIVE BREAST CANCER IN WOMEN SEEKING CARE AT THE UGANDA CANCER INSTITUTE
REFNo: HS1264ES
1. To describe the mutational profile of triple negative breast cancer in women seeking care at the Uganda Cancer Institute
2. To describe the relationship between the mutational load and the primary tumor size of triple negative breast cancer in women seeking care at the Uganda Cancer Institute
3. To describe the differences in mutational profile by histological type in patients with triple negative breast cancer in women seeking care at the Uganda Cancer Institute
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Uganda |
2021-03-12 |
2024-03-12 |
Medical and Health Sciences |
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Degree Award |
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Nathan Kenya-Mugisha
ID: UNCST-2021-R013752
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An Evaluation of the Pediatric Care Process in Uganda for Improvement of Quality of Care
REFNo: HS1227ES
The primary objective of this study is to evaluate the typical pediatric care process at a representative sample of hospitals in Uganda
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Uganda |
2021-03-11 |
2024-03-11 |
Medical and Health Sciences |
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Non-degree Award |
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Peter Olupot-Olupot
ID:
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Severe MAlaria A Research and Trials consortium: A protocol for a prospective case control observational study
REFNo: HS1231ES
To characterise the contemporary epidemiology (including features at presentation and the diagnostic and treatment pathway) of severe malaria presenting to hospital for admission in children in Africa, through conducting a prospective multicentre observational study across 7 sites in 6 countries, enrolling two cohorts of hospitalised children (i.e. stratified) with severe and non-severe malaria.
For this study, severe malaria will be defined as children with a positive POC pHRPT2 test (Paracheck) meeting WHO criteria or Teule criteri. For severe malaria, we will characterise the proportions presenting with different severe complications, or combination of any of or all of these, and compare these proportions across sites.
Secondary Objectives
i. To compare baseline characteristics of admitted children with severe and non-severe malaria.
ii. To document time from presentation to the hospital ‘gateway’ (e.g. outpatients or emergency/triage centre) to ward admission and time to first dose of parenteral artesunate to assess whether delays in initiating definitive antimalarial treatment could contribute to malaria severity.
iii. To estimate the incidence of significant post-discharge events to day-180 including readmission (all-cause and for malaria (i.e. relapse)) and all-cause mortality in severe and non-severe malaria.
iv. To develop (year 1) and evaluate (years 2 and 3) a point-of-care quantitative plasma Plasmodium falciparum histidine-rich protein2 (pfHRP2) test for estimating total body parasite burden, which could be used to swiftly identify those at greatest risk of poor outcomes.
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Uganda |
2021-03-11 |
2024-03-11 |
Medical and Health Sciences |
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Non-degree Award |
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Tom Lutalo
ID:
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Measuring adult health and mortality in Low- and Middle-Income Countries
REFNo: HS640ES
1. To evaluate the accuracy of survey data on adolescent and adult mortality collected retrospectively through siblings’ survival histories (SSH), compared to the reference mortality data collected prospectively.
2. To test whether the siblings of respondents can be reached and interviewed via mobile phone, in order to collect data on the risk factor of adult mortality
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Uganda |
2021-03-10 |
2024-03-10 |
Medical and Health Sciences |
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Non-degree Award |
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Levicatus Mugenyi
ID: UNCST-2020-R014759
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Understanding Factors Associated with IPT Completion among Recipients of Care on ART/IPT Aligned Multi-month Refills across the Differentiated Service Delivery Models
REFNo: HS1228ES
The primary objective is to understand factors associated with completion of IPT among clients in MoH’s integrated IPT/ART models.
Specific objectives:
1.To compare IPT completion rates amongst clients across the five DSD models: Facility-Based Individual Management (FBIM), Facility-Based Group (FBG), Fast Track Drug Refill (FTDR), Community Client Led ART Delivery (CDDP), and Community Drug Distribution Points (CCLAD).
2.To understand individual and facility level factors associated with IPT completion across the different DSD models
3.To compare IPT uptake across the different DSD models
4.To compare the frequency of adverse events (AEs) reported by clients on IPT across the different DSD models
5.To document patient and service provider KAP towards the IPT/ART integrated model
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Uganda |
2021-03-10 |
2024-03-10 |
Medical and Health Sciences |
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Non-degree Award |
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