Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
Search By Approval Date:
Clear Filter Total: 5,795
Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Moses Sembatya Nixon
ID: UNCST-2024-R015771
Baseline Study of Norms and Behavioral Drivers of Child Marriage and Female Genital Mutilation in Uganda
REFNo: SS3765ES

This study aims to provide crucial insights into the prevalence, drivers, and consequences of child marriage (CM) and female genital mutilation (FGM) in Uganda through a comprehensive baseline study. By assessing social norms, knowledge, attitudes, and practices related to CM and FGM, the study seeks to inform targeted interventions and policy decisions.
Uganda 2025-04-02 10:33:36 2028-04-02 Social Science and Humanities Non-Clinical Trial Non-degree Award
Rogers Ssebunya
ID: UNCST-2025-R016712
Supporting Health System Readiness and Quality for Scaled Delivery of Self-Injectable Contraception: The Delivering Innovation in Self-Care (DISC) 2.0 Study Version 1.1
REFNo: HS5767ES

1. To describe health facility readiness to provide voluntary DMPA-SC SI within the existing contraceptive method mix in DISC-supported facilities in Uganda.
2. To describe quality of contraceptive counseling and client experiences among clients receiving injectables at DISC-supported facilities in Uganda.
3. To understand clients’ self-efficacy and confidence around DMPA self-injection immediately post-training and at 4-months follow-up in Uganda.
4. To improve understanding of DMPA-SC ‘take home’ units, including dispensation practices, provider and client preferences, storage, and usage, and disposal at initiation and 4-months follow-up.
Uganda 2025-04-02 10:31:32 2028-04-02 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Susan  Nabadda
ID: UNCST-2020-R014331
Field Performance Evaluation of the Genbody ConfiSign HIV Self-Test in Uganda
REFNo: HS5760ES

To evaluate the field diagnostic performance and operational characteristics; usability, acceptability, and feasibility of the Genbody ConfiSign HIV ST in Uganda.

Specific objectives
a) To determine the field diagnostic accuracy (sensitivity, specificity, positive predictive value, and negative predictive value) of the Genbody ConfiSign HIV Self Test compared with the Wondflo HIV Self test (Guangzhou, China).

b)To evaluate the operational characteristics; feasibility, acceptability, and usability of the Genbody ConfiSign HIV ST in selected health facilities.

Uganda 2025-04-02 10:25:15 2028-04-02 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Robert Odendi Gideon
ID: UNCST-2024-R002130
MENTAL HEALTH CHALLENGES, ADVERSE CHILDHOOD EXPERIENCES AND INTERPERSONAL PSYCHOTHERAPY AMONG ADOLESCENTS AT KAMPIRINGISA NATIONAL REHABILITATION CENTER, CENTRAL UGANDA
REFNo: HS5763ES

1. To determine the prevalence of mental health challenges (Depression, PTSD, and alcohol substance use disorders) and adverse childhood experiences (ACEs) among adolescents at Kampiringisa National Rehabilitation Centre (KNRC).
2. To examine the relationship between ACEs and mental health challenges, with social support as a mediator among adolescents at KNRC.
3. To explore the experiences and perceptions of adolescents regarding the effectiveness of existing counseling practices in reducing depressive symptoms among adolescents at KNRC.
4. To identify the socio-cultural factors, institutional policies, and individual characteristics that influence the feasibility, acceptability, and effectiveness of Group Interpersonal Therapy (Group IPT) in reducing depressive symptoms at KNRC.
5. To evaluate adolescents' experiences and perceptions of the feasibility, acceptability, and effectiveness of Group IPT compared to the existing counseling practices at KNRC.

Uganda 2025-04-02 10:00:01 2028-04-02 Medical and Health Sciences Non-Clinical Trial Degree Award
Felix Bongomin
ID: UNCST-2020-R014224
Chronic Pulmonary Aspergillosis: Optimization of Therapy, Immunogenetic Screening, and Diagnosis in Uganda [CPA_OPTIONS_Phase I: A Prospective Cohort Study]
REFNo: HS5799ES

The primary objective of this study is to establish a longitudinal cohort comprising individuals who have recently been diagnosed with CPA. The main aim is to comprehensively document various aspects of the disease progression and its impact on patients\' health over a span of 12 months.,The primary objective of this study is to establish a longitudinal cohort comprising individuals who have recently been diagnosed with CPA. The main aim is to comprehensively document various aspects of the disease progression and its impact on patients\' health over a span of 12 months.,
Uganda 2025-04-01 17:44:43 2028-04-01 Medical and Health Sciences Non-Clinical Trial Degree Award
Stella Muyanja Zawedde
ID: UNCST-2021-R014037
The Integrated Management of Chronic Lung Illnesses in Uganda
REFNo: HS5728ES

Aim 1: To determine the prevalence of and factors associated with chronic respiratory illnesses e.g., asthma, chronic obstructive pulmonary disease among presumptive TB patients who test negative for TB on GeneXpert testing

Aim 2: (a) To determine the prevalence of, factors associated with post TB lung disease (PTLD) among patients who complete TB treatment (b) To determine the effect of post TB lung care on health related QoL among patients with PTLD

Aim 3: To determine barriers and facilitators for linkage to treatment for patients referred for chronic lung care

Aim 4: To document the cost per asthma/COPD case found during integrated community-based screening.
Uganda 2025-04-01 17:31:43 2028-04-01 Medical and Health Sciences Non-Clinical Trial Non-degree Award
george paasi
ID: UNCST-2020-R014619
THE CLINICAL SPECTRUM, GEOSPATIAL DISTRIBUTION AND GENETIC MODIFIERS OF SEVERE MALARIA AMONG CHILDREN WITH SICKLE CELL DISEASE IN EASTERN UGANDA.
REFNo: HS5714ES

i) To determine the effect of host RBC polymorphisms on the risk and severity of malaria.
ii) To determine the Geospatio-temporal distribution of the malaria-sickle cell disease syndemic in Uganda.
iii) To determine the clinical spectrum of severe malaria among children with SCA in eastern Uganda.

Uganda 2025-04-01 17:21:57 2028-04-01 Medical and Health Sciences Non-Clinical Trial Degree Award
ERICK SSEGUJJA
ID: UNCST-2021-R012964
Partnerships for Stronger Knowledge Systems in Africa (KNOSA): Lessons from Uganda
REFNo: HS5716ES

Specifically, the implementation research has the following objectives;
1. To characterise the nature and functioning of the different components of the current national knowledge system, ??with a focus on the health sector.
2. To explore constraints and challenges affecting the capacity of Uganda’s national knowledge systems.
3. To document and assess the current interventions to strengthen the national knowledge system?
4. To explore opportunities for strengthening the capacity of the national knowledge system to advance evidence-informed decision making in Uganda’s health sector.

Uganda 2025-03-25 11:14:05 2028-03-25 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Ronald Moses Galiwango
ID: UNCST-2024-R015239
INTEGRATED FEMALE SEXUALLY TRANSMITTED INFECTION TESTING FOR HIV EPIDEMIC CONTROL THROUGH PREP (IN-STEP)
REFNo: HS5715ES

a) To conduct an individually randomized effectiveness implementation trial of SRST plus cSTI testing to increase PrEP use among African women at high HIV risk.
b) To perform a mixed-methods, implementation science evaluation of female cSTI testing for improving PrEP use for HIV prevention.
c) To determine the most efficient, population-level female cSTI testing strategies to reduce HIV incidence in African settings.

Uganda 2025-03-25 11:13:20 2028-03-25 Medical and Health Sciences Clinical Trial Non-degree Award
Prudence Beinamaryo
ID: UNCST-2023-R007239
Developing a robust interdisciplinary-informed WASH framework for the prevention and elimination of the wicked public-health problem of schistosomiasis (WickedSchisto)
REFNo: HS5707ES

I. What are the true health, economic and societal impacts of schistosomiasis?
a) Characterise what quality of life means to individuals living in Schistosoma endemic areas in Cameroon and Uganda, and how this is affected by infections, WASH access, environmental, spatial, social and other determinants.
b) Measure the diverse impact of schistosomiasis on individual’s and household’s quality of life.
c) Quantify the economic costs associated with schistosomiasis to individuals and society.
d) Develop and validate a field-suitable morbidity marker for mapping and monitoring disease resolution.
II. What are the most cost-effective combinations of WASH and MDA interventions?
a) Test the hypothesis that MDA refusal, due to fear of side effects, is linked with latrine access.
b) Characterise relative contributions of existing WASH on reducing reinfection post MDA: risk to self.
c) Quantify environmental force-of-infection and the impact of ‘risk to self’ and ‘risk to
Uganda 2025-03-25 11:11:44 2028-03-25 Medical and Health Sciences Non-Clinical Trial Non-degree Award
View Sort By:

"A prosperous Science and Technology Led Ugandan Society."