Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Catriona  Waitt John
ID: UNCST-2019-R001068
Pilot feasibility study for uptake and implementation of a clinical algorithm for warfarin dosing in sub-Saharan African patients in the War-PATH Ugandan and South African clinical study sites.
REFNo: HS721ES

To evaluate whether the clinical algorithm improves anticoagulation control compared with local standards of care.
To determine the feasibility and acceptability of implementation of a clinical algorithm developed from the observational phase (phase 2) of the War-PATH study
UK 2021-03-17 2024-03-17 Medical and Health Sciences Non-degree Award
Ben Jones
ID:
Challenging categories: educated unemployed youth as institutional innovators in rural Uganda
REFNo: SS599ES

The objective of the study is to examine participation in local institutions to challenge understandings of youth, education and
unemployment. The outputs involve academic publications and advocacy work. The target population are educated unemployed youth and actors working with local institutions, including churches and courts. By “educated unemployed youth” we mean youth who are educated up to a minimum of S4.
UK 2021-03-17 2024-03-17 Social Science and Humanities Non-degree Award
Cissy  Kityo
ID: UNCST-2021-R013663
Gut Integrity and Metabolic Complications in Youth Living with HIV in Uganda.
REFNo: HS1036ES

The overall objective is to use surrogate markers to investigate the interplay between intestinal integrity, microbial translocation, immune activation, systemic inflammation and metabolic comorbidities in YLPHIV residing in urban and rural settings in Uganda.
Specific Aim 1: Assess differences in gut integrity, microbial and fungal translocation markers, as well as inflammation in YLPHIV compared to HIV-uninfected controls in Kampala (urban), and Gulu (rural), Uganda.
Specific Aim 2: Assess whether markers of gut integrity, translocation and inflammation are associated with adiposity, measured by dual-energy X-ray absorptiometry (DXA) and levels of the homeostatic assessment of insulin resistance (HOMA) in YLPHIV and HIV-uninfected participants in Kampala and Gulu.
Specific Aim 3: Assess the relationship between gut and inflammatory biomarkers and diet, physical activity, socioeconomic status and air pollution.
Uganda 2021-03-17 2024-03-17 Medical and Health Sciences Non-degree Award
Christine Kiconco
ID:
Management of Agricultural Indigenous Knowledge in Agricultural Research Organizations in Uganda.
REFNo: SS739ES

1. To establish the efforts of AR4D organizations towards AIK management
2. To examine how AR4D researchers’ perceptions of AIK influence their attitudes towards AIK management
3. To assess how facilitating conditions influence AIK management efforts in AR4Ds
4. To explore strategies that can enhance AIK management in AR4Ds to prevent continued AIK loss and increase possibilities for its access and utilization in agricultural development.
Uganda 2021-03-17 2024-03-17 Social Science and Humanities Degree Award
Shevin  Jacob Thomas
ID:
Understanding Drivers of Antimicrobial Resistance Among Mothers and Children in Uganda (DRUM+)
REFNo: HS1185ES

Understanding Drivers of Antimicrobial Resistance Among Mothers and Children in Uganda (DRUM+)
Specific Objectives:
Determine the prevalence of ESBL-E and ESBL-K bloodstream infections (BSI) and colonization among peripartum women and neonates/children < 5yo hospitalized with suspected sepsis.
2. Among peripartum women and neonates/children < 5yo hospitalized for suspected sepsis, determine the clinical outcomes, including morbidity (e.g., incidence of chronic kidney disease), mortality percentage (in-hospital and up to 4 months after the date of hospitalization) and frequency of readmission up to 4 months after the date of hospitalization.
3. Determine whether there is a molecular epidemiologic linkage between household carriage (including humans, associated domestic animals, and environment) of ESBL-E and ESBL-K AND patients (peripartum women or neonates/children < 5yo) hospitalized with sepsis who have ESBL-E and ESBL-K BSI or colonization.
4. Among patients (peripartum women or neonates/children < 5yo) hospitalized with sepsis who have ESBL-E and ESBL-K BSI or colonization, evaluate drivers of AMR transmission in Uganda (e.g., directionality of transmission and independent risk factors for transmission) using a dynamic agent-based model incorporating their microbiologic resistance data AND the data from linked households describing microbiological resistance and WASH observations.
USA 2021-03-17 2024-03-17 Medical and Health Sciences Non-degree Award
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