Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
Sherifah Nabikande
ID: UNCST-2022-R009631
 Uptake of HIV prevention interventions among adolescent girls and young women in slum settings in Kampala district, Uganda
REFNo: HS4015ES

3) To explore the barriers and facilitators of condom use, HIV testing and Pre-exposure prophylaxis as HIV prevention interventions among AGYW in slum settings in Kampala district, Uganda,2) To determine the factors associated with condom use, HIV testing and Pre-exposure prophylaxis as HIV prevention interventions among AGYW in slum settings in Kampala district, Uganda,1) To determine the proportion of AGYW who use condoms, HIV testing and Pre-exposure prophylaxis as HIV prevention interventions in slum settings in Kampala district, Uganda,To determine the uptake of condoms, HIV testing and Pre-exposure prophylaxis as HIV prevention interventions and factors associated among AGYW in slum settings in Kampala district, Uganda ,
 Uganda 2024-05-29 9:40:25 2027-05-29 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Adoke Yeka
ID: UNCST-2021-R004300
 A randomized, open-label, multicenter study to compare efficacy, safety and tolerability of KLU156 with Coartem® in the treatment of uncomplicated Plasmodium falciparum malaria in adults and children ≥ 5 kg body weight followed by an Extension phase with repeated KLU156 treatment.
REFNo: HS3732ES

This study aims to confirm the efficacy, safety and tolerability of KLU156, a fixed dose combination of ganaplacide (KAF156) and a solid dispersion formulation of lumefantrine (lumefantrine-SDF), when administered once daily for three days in adults and children ≥ 5 kg body weight and ≥ 2 months of age suffering from uncomplicated P.Falciparum malaria (with or without other plasmodium spp. co-infection). In the Extension phase, the safety, tolerability and efficacy of repeated treatment with KLU156 will be assessed for a maximum of two years in patients who did not experience early treatment failure(ETF), who did not experience any study treatment-related SAE (Serious Adverse Event) previously and who gave informed consent to participate in the Extension phase.
 Uganda 2024-05-29 9:37:35 2027-05-29 Medical and Health Sciences Clinical Trial Non-degree Award
Christine kisubi Esther
ID:
ENVIRONMENTAL JUSTICE IN UGANDA’S OIL AND GAS UPSTREAM SUB-SECTOR DECISION-MAKING
REFNo: SS2634ES

To critically examine the legal frameworks and their implementation concerning environmental justice and community participation in decision-making processes within Uganda\'s oil and gas upstream sub-sector.,
 Uganda 2024-05-27 9:01:35 2027-05-27 Social Science and Humanities Non-Clinical Trial Degree Award
Nakacwa Patricia Florence
ID: UNCST-2024-R004518
 Student\'s Academic Resilience and Competence Based Curriculum: A case study of Secondary Schools in Mukono and Kayunga District.
REFNo: SS2605ES

iv. To evaluate the moderating influence of emotional intelligence on the relationship between academic resilience and competency-based learning in secondary schools in Mukono and Kayunga districts.,iii. To analyze the effect of academic coordination on competency-based learning in secondary schools in Mukono and Kayunga districts.,ii.To examine the relationship between academic confidence and competency-based learning in secondary schools in Mukono and Kayunga districts.,i.To assess the relationship between academic commitment and competency-based learning in secondary schools in Mukono and Kayunga districts.,The study intends to examine the relationship between academic resilience and competency-based learning to develop a model to support quality education in secondary schools in Uganda.,
 Uganda 2024-05-27 9:00:16 2027-05-27 Social Science and Humanities Non-Clinical Trial Degree Award
HELLEN NAIGAGA
ID:
PHENOLOGY MONITORING AND SEASONAL WEATHER FORECASTING IN RELATION TO FARM MANAGEMENT IN UGANDA
REFNo: NS770ES

• To establish local knowledge on abrupt changes in plant phenological patterns • To assess how the use of phenological changes by farmers in weather forecasting impacts on farming activities and farm productivity • To examine the plant compounds and weather parameters which trigger Plant phenological changes • To develop strategies for linking local knowledge and scientific knowledge for future weather forecasting • To predict future weather changes based on plant phenological changes
Uganda 2024-05-27 8:58:04 2027-05-27 Natural Sciences Non-Clinical Trial Degree Award
FREDRICK MAKUMBI
ID:
Post-Phase II Yellow Fever Preventive Mass Vaccination Campaign Coverage Survey in Uganda
REFNo: HS4258ES

To explore individual and health system related factors influencing the non-receipt of yellow fever preventive mass vaccination campaign.,To identify the adverse effects following immunization (AEFI) during the yellow fever preventive mass vaccination campaign.,To assess factors associated with yellow fever preventive mass vaccination campaign uptake.,To determine the reach of the vaccination program and for each of the interventions like IEC, by age, residence (rural/urban), education, wealth, disability status and refugee status.,To measure post-campaign immunization coverage of yellow fever for persons aged 1 to 60 years old within the 6 phase II regions.,The main objective of this survey is to evaluate program performance by coverage, the reach of the program interventions of the yellow fever, and assess the equity of the program to ensure no one is left behind, and validate administrative data coverage at different levels; to further inform the implementation of the vaccination campaign, and provide evidence in each of the 6 phase-II regions (sub-national levels) in Uganda about population vaccination against yellow fever for persons aged 1 to 60 years.,
 Uganda 2024-05-27 8:56:24 2027-05-27 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Jacqueline Kyosiimire-Lugemwa
ID: UNCST-2022-R005393
 Epigenetic modifications in HIV-1 accessory and regulatory genes, Host genes and differential protein expression among LTNP and Rapid progressors from a Ugandan Cohort
REFNo: HS4047ES

Aim 1. Identify the differential expression of Epigenetic signatures of HIV-1 accessory and regulatory genes DNA methylation among African pediatric LTNP and Rapid progressors Aim 2. Identify the differential expression of Epigenetic signatures of the host genome DNA methylation among African pediatric LTNP and Rapid progressors. Aim 3. Identify the differential expression of plasma proteomic signatures among African pediatric LTNP and Rapid progressors. Aim 4. Establish protein-protein interactions and metabolite interaction networks among African pediatric LTNP and Rapid progressors.
 Uganda 2024-05-23 14:57:54 2027-05-23 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Jane Achan Edwin
ID: UNCST-2023-R005498
 Evaluation of the protective efficacy of a spatial repellent to reduce malaria prevalence in Uganda: Study protocol for a cluster-randomized double-blinded control trial: The Mossie-GO trial
REFNo: HS4196ES

The study’s primary objective is to demonstrate and quantify the protective efficacy (PE) of Mossie-GO, an active spatial repellent system disseminating transfluthrin, in reducing the prevalence of malaria infection in children ≤ 5 years of age.

The study’s secondary objective is to measure the impact of the intervention on entomological correlates of transmission including vector densities and host seeking behaviour. Insecticide resistance in the local mosquito population will also be explored.

Uganda 2024-05-23 14:23:11 2027-05-23 Medical and Health Sciences Clinical Trial Non-degree Award
Tonny Oyana Justus
ID:
A HOLISTIC APPROACH IN MANAGEMENT AND SURVEILLANCE OF LOWER RESPIRATORY TRACT INFECTIONS (LRTIS) THROUGH CONVERGENCE OF DIAGNOSTIC TECHNOLOGIES, CAPACITY BUILDING AND STAKEHOLDER ENGAGEMENT (HOLICARE)
REFNo: SIR330ES

1. To survey and describe the existing diagnostics approaches/ technologies applied in Uganda’s health System specifically for lower respiratory tract infections.
2. To develop an ICT-based medical data flow network
3. To validate the framework using diagnostic mobile API’s
 Uganda 2024-05-23 14:00:03 2027-05-23 Engineering and Technology Non-Clinical Trial Non-degree Award
Enerst Edozie
ID: UNCST-2023-R005516
 DEVELOPMENT OF A MONITORING AND DETECTION PIPELINE FOR HUMAN ACTIVITIES AROUND TELECOMMUNICATIONS INFRASTRUCTURE USING ARTIFICIAL INTELLIGENCE - KIU-2023-280
REFNo: SIR337ES

4. To validate the developed system using publicly available human activity datasets. ,3. To design and implement an embedded sensor and alarm systems to curb theft and vandalism of optical fiber cable., 2. To develop a real-time artificial intelligent system based on YOLO Deep Learning for monitoring and detection of activity around an optical fiber cable. ,1. To develop anomaly activities datasets of pedestrians activity around telecoms infrastructure. ,This study aims to implement an efficient monitoring and detection of abnormal activities around telecommunications infrastructure using artificial intelligence based approach. ,
 Nigeria 2024-05-23 13:58:11 2027-05-23 Engineering and Technology Non-Clinical Trial Degree Award
Godfrey Ejuu
ID: UNCST-2021-R013978
 Scaling Inclusive Home-based Early Learning Initiative (SIHELI): Lessons from Uganda, Ghana and Liberia
REFNo: SS2607ES

3. Mobilize the knowledge and evidence on the scaled inclusive early learning play approaches to improve policy and practice in education systems.,2. Strengthen the capacities of parents, teachers, education officials and community members to support and sustain the use of play pedagogy in the established home based early learning centres. ,1. Generate knowledge and evidence on how to scale the impact of inclusive home based early learning approaches to promote inclusive early learning and school readiness. ,The project’s general objective is to generate evidence to contextualize and scale the impact of inclusive home-based early learning play approach to promote smooth transition from ECCE to primary school.,
 Uganda 2024-05-23 13:56:14 2027-05-23 Social Science and Humanities Non-Clinical Trial Non-degree Award
SYLVESTER MUBIRU
ID:
SUPPORTIVE AND NURTURING PARENTING DURING CLIMATE STRESS PROGRAM IMPACT EVALUATION
REFNo: SS2645ES

The main goal of this research proposal is to provide rigorous evidence that will allow the team to respond the following research questions: 1. Is there a relation between caregiver-child interactions and reductions in violence against children? 2. Is there an association between caregivers’ mental health and emotional wellbeing and caregiver-child interactions? 3. Is there a correlation between caregiver behaviors and indirect improvements in children’s behaviors and development? 4. What potential mechanisms (e.g., household dynamics, parental self-efficacy, networks, economic deprivation) are associated with variations in caregiver-child interactions and children\'s development? 5. Are variations in caregiver-child interactions and children\'s development correlated with parents’ initial mental health status, parenting skills, and climate stress incidence?,
 Uganda 2024-05-23 13:54:32 2027-05-23 Social Science and Humanities Non-Clinical Trial Non-degree Award
David Musoke
ID:
Assessment of leadership and management competencies among health managers in Wakiso District, Uganda
REFNo: HS4164ES

To assess the leadership and management competencies among health managers in Wakiso District Local Government, Uganda. Specifically, the study will: (1) determine the leadership and management competencies among the health managers; (2) identify the leadership and management practices among the health managers; and (3) explore the barriers and facilitators to effective leadership and management among the health managers.
Uganda 2024-05-23 13:50:34 2027-05-23 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Phiona Bukirwa
ID: UNCST-2022-R009880
 Stage, therapy and outcome in adult cancer patients in selected African countries: a population-based registry study
REFNo: HS4279ES

1. To obtain information on stage at diagnosis for selected adult cancers ,3. To obtain information on therapy and patient journey how these factors varied according to year of diagnosis in the period 2017-2021,2. To obtain vital status through (active and passive) follow-up for 19 cancers. ,1. To determine cancer survival for 19 selected cancers and factors affecting cancer survival.,
 Uganda 2024-05-23 13:47:29 2027-05-23 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Rhoda Wanyenze
ID: UNCST-2021-R013352
 ACCESS AND USAGE OF DIGITAL HEALTH TOOLS. OPPORTUNITIES AND CHALLENGES TO SUPPORT GENDER EQUALITY AND UNIVERSAL HEALTH COVERAGE IN UGANDA
REFNo: HS4295ES

Explore the strengths and weaknesses of existing digital health policies and structures in addressing gender inequalities and enhancing Universal Health Coverage for women and girls.,Explore the opportunities and challenges for increasing universal health coverage among women and girls using digital health tools. ,Explore gender inequalities associated with digital health tools among women and girls in Uganda.,Analyze the strengths and weaknesses of current digital health tools for women and girls in Uganda.,This study explores digital health tools\' influence on gender equality and Universal health coverage in Uganda. This work will also help identify digital health tools that can be utilized to address gender inequalities and increase access to health care.,
 Uganda 2024-05-23 13:45:18 2027-05-23 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Betty Mwesigwa
ID: UNCST-2020-R014667
 Multinational Observational Cohort of HIV and other Infections (MOCHI)
REFNo: HS2362ES

To determine the HIV incidence rate in a cohort of individuals who are vulnerable to HIV across multiple sites.
Uganda 2024-05-23 13:43:27 2027-05-23 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Duke Fan-Chiang
ID: UNCST-2023-R001922
 THE IMPACT OF CROSS-SECTOR INTERVENTION ON CONFLICT-AFFECTED CHILDREN’S MENTAL HEALTH IN PROTRACTED HUMANITARIAN SETTINGS. THE CASE OF CHILDREN ON REFUGEE SETTLEMENTS IN UGANDA
REFNo: SS2118ES

Explore the impact on the mental health well-being of conflicted-affected children by integrating MHPSS interventions into the existing child protection activities in the Bidibidi settlement by

1. Learning about the extent that MHPSS interventions be effective in a protracted humanitarian setting?

2. Identifying the relationships between mental health and child protection indicators in a protracted humanitarian setting such as the Bidibidi settlement?

3. Identifying the influential factors to promote a positive impact during the implementation process?

Taiwan 2024-05-23 13:35:15 2027-05-23 Social Science and Humanities Non-Clinical Trial Degree Award
Lydia Nakiyingi
ID: UNCST-2022-R010102
 Multi-pathogen wastewater surveillance in Uganda with CRISPR Cas 12/13 assay: A pilot study
REFNo: HS4139ES

The proposed research will test the overarching hypothesis that wastewater pathogen burden measured by SHINE and CARMEN CRISPR-based platforms will positively correlate with the prevalence (for routine pathogens) and incidence (for outbreak pathogens) within our catchment areas,Our second objective involves leveraging the massive multiplex CARMEN assay to broadly survey for high-priority outbreak pathogens such as Ebola, yellow fever, Vibrio cholera and Mycobacterium tuberculosis in regional Kampala wastewater sources (East Bugolobi treatment plant and Nakivubo channels). As an advantage, CARMEN reactions have already been developed for all of these pathogens, which are also shed in human excrement,As our first objective, we propose to assess the performance of the field-deployable SHINE CRISPR assay (benchmarked against CARMEN) in estimating the prevalence of diverse respiratory and food-borne pathogens such as Mycobacterium tuberculosis, common respiratory viruses, and antimicrobial-resistance genes (e.g. Carbapenem-resistant Enterobacteriaceae [CRE], vancomycin-resistant enterococci [VRE]) using wastewater samples from a local sewage line (Mulago Hospital). ,
 Uganda 2024-05-23 13:32:28 2027-05-23 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Namujulirwa Carolyn
ID:
PASTORAL CARE AND HOLISTIC EDUCATION IN CATHOLIC SECONDARY SCHOOLS: A CASE OF THE COMBONI MISIONARIES IN KAMPALA ARCH DIOCESE AND LIRA DIOCESE
REFNo: SS2550ES

iii. What are the legacies of Comboni missionary pastoral care models applied in secondary schools in Kampala arch diocese and Lira diocese and how can they be applied in other catholic dioceses in Ugandan catholic secondary schools?,ii. To what extent do pastoral care structures and strategies influence the promotion of holistic education in the Comboni Missionaries secondary schools in Lira and Kampala arch diocese and Lira diocese?,i. What are the unique characteristics of pastoral care employed in the promotion of holistic education in Comboni missionary secondary schools in Kampala arch diocese and Lira Diocese? ,The purpose of the study is to investigate the role Comboni missionaries played in the promotion of holistic education through pastoral care in Catholic secondary schools in Kampala Arch diocese and Lira diocese,
 Uganda 2024-05-23 13:14:19 2027-05-23 Social Science and Humanities Non-Clinical Trial Non-degree Award
Christine  Wiltshire Sekaggya
ID: UNCST-2019-R000578
 Therapeutic Drug Monitoring for Antimicrobial Agents for People Living with HIV (TAP trial)
REFNo: HS3909ES

1.To determine the concentrations of selected antimicrobial agents in people living with HIV requiring antimicrobial therapy. 2. To assess the utility of therapeutic drug monitoring in achieving therapeutic targets for people living with HIV receiving rifampicin and isoniazid for treatment of tuberculosis. 3. To develop and validate a population pharmacokinetic-pharmacodynamic model for use during therapeutic drug monitoring for selected antibiotics used among PLWH
 Uganda 2024-05-23 13:12:37 2027-05-23 Medical and Health Sciences Non-Clinical Trial Non-degree Award
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