Nixon Niyonzima
ID: UNCST-2020-R014577
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Evaluating Tumor Evolution and the Clinical Utility of Circulating Tumor DNA in Patients with Metastatic Breast Cancer Treated with Talazoparib
REFNo: HS1476ES
1. Evaluate mutational changes associated with disease progression in patients with metastatic breast cancer treated with Talazoparib2. Analyse circulating tumor DNA in blood samples collected from metastatic breast cancer patients treated with Talazoparib.3. Determine the association between circulating tumor DNA levels, CA-15-3 levels, and clinical response in patients with metastatic breast cancer treated with Talazoparib.4. Determine the blood-based tumor mutation burden (bTMB) based on WES data generated from samples collected before and after the development of treatment resistance in metastatic breast cancer patients treated with Talazoparib.5. Evaluate the utility of circulating tumor DNA genomic profiling from blood samples collected as dried blood spots from patients with metastatic breast cancer patients and normal age-matched healthy controls.
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Uganda |
2021-06-30 |
2024-06-30 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
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EDITH NAKKU-JOLOBA NAKKU
ID: UNCST-2021-R013931
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Sexual Network Based Tracking and Treatment of Gonorrhea and Chlamydial infections to Improve STD Management in Urban and Rural Uganda: A Pilot Study
REFNo: HS1384ES
Specific Objective 1a; To estimate prevalence of Neisseria gonorheae (NG) in persons attending outpatient clinics in Kampala, Uganda.
Specific Objective 1b; To estimate prevalence of Chlamydia trachomatis (CT) in persons attending outpatient clinics in Kampala, Uganda
Specific Objective 2; To describe the sexual networks of persons diagnosed with Neisseria gonorrhea and Chlamydia trachomatis attending clinics in Kampala, Uganda and the factors influencing these networks.
Specific Objective 3; To describe the bacterial genotypes of infecting Neisseria gonorrhea and Chlamydia trachomatis bacteria identified in these described sexual networks and the related-ness of the bacteria in the identified sexual networks.
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Uganda |
2021-06-29 |
2024-06-29 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
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Susan Nabadda Ndidde
ID: UNCST-2020-R014331
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Diabetes Mellitus Tuberculosis and HIV multimorbidities among adult patients attending Kiruddu National Referral Hospital, Uganda
Version 2 7/26/2020.
REFNo: HS1386ES
General Objective
The overall objective of this project is to determine the prevalence of DM among patients with either TB, HIV, and TB-HIV co morbidity. This will help to assess the prevalence of silent DM in these categories of patients.
Specific objectives
1. To describe the prevalence of DM among either TB patients or HIV patients or patients with both TB and HIV co morbidity attending the Kiruddu hospital outpatient clinics
2. To determine the factors associated with DM in patients with HIV alone, TB alone and HIV – TB co-infection.
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Uganda |
2021-06-29 |
2024-06-29 |
Medical and Health Sciences |
Clinical Trial |
Non-degree Award |
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Richard Ssempala
ID: UNCST-2021-R004837
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Access to Health Care Services in Uganda: The feasible Community health care services delivery model for Uganda.
REFNo: HS1491ES
2. To identify the designs and feasible models for implementing community health care services/ packages in Uganda.,1. To identify the health services/packages provided at community level under the different intervention types.,To review databases of studies that define different delivery mechanisms (models) for the community health services/packages and thereafter recommend a feasible community delivery model(s) for Uganda ,
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Uganda |
2021-06-29 |
2024-06-29 |
Medical and Health Sciences |
Non-Clinical Trial |
Non-degree Award |
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Teesta Dey
ID:
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Systematic development and validation of a Post-Natal Maternal Self-Assessment Tool for predicting post-natal morbidity in the immediate postpartum period following healthcare facility births in Uganda
REFNo: SS876ES
General Objective
To develop a valid, reliable, useful and acceptable post-natal maternal self-assessment tool for predicting post-natal morbidity in health care facilities in Uganda
Specific Objectives
1. To explore immediate postnatal care provision, coverage and utilisation in healthcare facilities in Uganda and elicit opportunities to improve care
2. To establish the core content of the tool
3. To create a tool that is culture and setting specific to postnatal Ugandan women
4. To assess the tool for validity and reliability
5. To evaluate the feasibility, acceptability and usability of the post-natal maternal self-assessment tool
For each specific objective there are sub-objectives listed within the protocol as attached
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UK |
2021-06-28 |
2024-06-28 |
Social Science and Humanities |
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Degree Award |
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