Approved Research This page provides a searchable list of all research protocols that have been reviewed and approved by the Uganda National Council for Science and Technology(UNCST).
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Name Title Nationality Approval Date Expiry Date Field of Science/Classification Trial Type Research Type  
SEDRIC NABAASA NKUBA
ID: UNCST-2024-R016326
 Peer Influence, Alcohol Use and Risky Sexual Behaviors among Adolescent Students in Secondary Schools in Greater Mbarara
REFNo: SS3934ES

1. To explore the gender difference in prevalence of risky sexual behaviors among adolescent students in secondary schools in greater Mbarara.
2. To establish impacts of peer influence on risky sexual behaviors among adolescent students in secondary schools in greater Mbarara.
3. To determine the mediation effects of alcohol us on the relationship between peer influence and risk sexual behaviors among adolescent students in secondary schools in greater Mbarara.
4. To explore the perceptions of adolescent students in controlling risk sexual behaviors in secondary schools in greater Mbarara

 Uganda 2025-06-25 13:34:21 2028-06-25 Social Science and Humanities Non-Clinical Trial Degree Award
Victor Musiime
ID: UNCST-2021-R013794
 Understanding Post-Discharge Mortality in children living with HIV who are hospitalized (SUPPORT1-PDM)
REFNo: HS6005ES

1. To assess the impact of an improved follow-up on reducing PDM in CLHIV 2. To evaluate the performance of disease severity biomarkers in this specific population to predict PDM 3. To analyze changes in serial measurements of CMV and potential association with PDM at day +360 in CLHIV 4. To describe the number of children with persistent detection of a specific respiratory pathogen 5. To describe the number of children with persistent detection of specific gastrointestinal (GI) pathogens 6. To describe the number of cases of histoplasmosis in CLHIV, its clinical characteristics, and outcomes in the identified cases, up to +360 days after discharge 7. To describe the prevalence of MDR colonization at enrollment, the microorganism isolated, and the duration of the colonization 8. To describe the main characteristics of readmissions, deaths and morbidity during 1-year follow-up after enrollment
 Uganda 2025-06-25 13:30:24 2028-06-25 Medical and Health Sciences Non-Clinical Trial Non-degree Award
JULIAN APAKO
ID: UNCST-2024-R004399
 LUNAS as a versatile and simple technique for malaria testing in a high transmission, rural setting
REFNo: HS5918ES

Primary objective - To determine the diagnostic accuracy of LUNAS POCT for malaria compared to common routine malaria testing (RDT and microscopy) during standard patient care in malaria-suspected individuals presenting at Kumi Hospital, Kumi, Uganda. Secondary objectives - To determine the diagnostic accuracy of LUNAS POCT for malaria compared to a commercial LAMP test - To determine the prevalence of malaria infections categorized by Plasmodium species. - To determine the correlation between time to positivity of both LAMP and LUNAS and parasitaemia as assessed by reference microscopy. - To determine the prevalence of P. falciparum harbouring deletions or mutations of the pfhrp2/3 gene in study participants, who have a P. falciparum infection with a parasitaemia as assessed by reference microscopy but a negative Pf HRP2/3 RDT result. - To determine the prevalence of Pf kelch13 (K13) gene mutations, which have been associated with resistance to artemisinin. - To determine the effectiveness of dried blood spots (DBS) for long term storage and transport of patient samples at ambient temperature for PCR testing.
Uganda 2025-06-25 13:26:35 2028-06-25 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Catherine Atuhaire
ID: UNCST-2021-R013090
 MATERNAL INFANT BONDING AND BREAST-FEEDING OUTCOMES IN UGANDAN MOTHERS DIAGNOSED WITH POSTPARTUM DEPRESSION IN PUBLIC HEALTH FACILITIES IN MBARARA DISTRICT, SOUTH WESTERN UGANDA
REFNo: HS5848ES

1. To determine the prevalence of maternal bonding impairment among mothers diagnosed with PPD in a public health facility in Mbarara district, South western Uganda.
2. To determine the breast-feeding outcomes of children born to mothers diagnosed with PPD in a public health facility in Mbarara district, South western Uganda.
3. To explore the lived bonding and breast-feeding experiences of mothers Diagnosed with PPD in a public health facility in Mbarara district, South western Uganda

 Uganda 2025-06-25 13:21:19 2028-06-25 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Eve Wabule
ID: UNCST-2024-R004285
 DRIVERS OF NO-SHOWS FOR AMBULATORY APPENDECTOMY AMONG PATIENTS SCHEDULED FOR AMBULATORY APPENDECTOMY AT KYABIRWA SURGICAL CENTER
REFNo: HS6046ES

To establish the institutional drivers of no-shows for ambulatory appendectomy among patients scheduled for ambulatory appendectomy at Kyabirwa surgical center,To determine the patient-related drivers of no-shows for ambulatory appendectomy among patients scheduled for ambulatory appendectomy at Kyabirwa surgical center,To determine the prevalence of no-shows for ambulatory appendectomy among patients seeking ambulatory surgery at Kyabirwa surgical center,To assess the drivers of no-shows for ambulatory appendectomy among patients scheduled for ambulatory appendectomy at Kyabirwa surgical center,
 Uganda 2025-06-25 13:19:11 2028-06-25 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Atek kagirita
ID: UNCST-2024-R015689
 LABORATORY SYSTEM RESILIENCE TO CORONAVIRUS DISEASE-19 OUTBREAK; ITS PREDICTORS, POLICY, AND PRIVATE SECTOR SUPPORT IN UGANDA
REFNo: HS6101ES

General objective
To assess the level of laboratory system resilience to COVID-19 disease outbreak, its predictors, appropriateness of policies to support it, and capacity of private sector laboratories to impact it in Uganda
4.2.2 Specific objectives
1. To determine the level and characteristics of resilience among licensed / accredited COVID-19 testing laboratories in Uganda.
2. To establish the predictors of resilience among licensed / accredited COVID-19 testing laboratories in Uganda.
3. To describe private sector laboratory capacity to contribute to national laboratory system resilience during the COVID-19 pandemic outbreaks
4. To appraise the appropriateness of current/emerging policies to support laboratory resilience during the COVID-19 pandemic outbreaks
 Uganda 2025-06-23 13:30:18 2028-06-23 Medical and Health Sciences Non-Clinical Trial Degree Award
Abel  Kakuru
ID: UNCST-2022-R009193
 Development of context-appropriate approaches for the recruitment and retention of women of childbearing age and pregnant women in antimalarial clinical trials
REFNo: HS6036ES

1. To understand the context, socio-cultural practices and beliefs around early pregnancy as well as collecting experience with and/or perception of previous clinical trials to inform the development of culturally acceptable and understandable communication materials about the SAFIRE trial, including the information sheets for obtaining consent.
2. To identify factors and individuals that may influence WOCBA and pregnant women’s decision-making around participation and retention in the clinical trial to be addressed as part of project procedures and communications.
3. To explore approaches for facilitating the inclusion of WOCBA and pregnant women (in early pregnancy) in the clinical trial, based on the findings from objective 2.
4. To identify key stakeholders (including household decision-makers, community leaders and opinion shapers, health sector actors), from community to national levels, to be included and involved in the community engagement strategy prior to trial implementation.

 Uganda 2025-06-20 9:25:32 2028-06-20 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Rita Nakalega
ID: UNCST-2019-R000599
 Exploring Neuro-Vascular Biomarkers in Young Adults with lifelong HIV and without HIV in Uganda: Insights from Carotid Ultrasound
REFNo: HS6038ES

Exploratory objectives/aims: To determine the prevalence of and relationships between HIV infection, carotid pathology, neurological and neurocognitive function, and serum markers of cardiovascular health and inflammation in a population of young adults living with HIV in Uganda who acquired the infection perinatally as well as uninfected age-matched controls,Secondary objective (Aim 2): To determine the prevalence of cognitive dysfunction, as determined by a battery of cognitive evaluations, of a population of young adults living with HIV in Uganda who acquired the infection perinatally, relative to uninfected age-matched controls.,Primary objective (Aim 1): To determine the prevalence of carotid pathology, as determined by ultrasound-based measurement of intima-media thickness (IMT), in a population of young adults living with HIV in Uganda who acquired the infection perinatally, relative to uninfected age-matched controls.,
 Uganda 2025-06-20 9:22:24 2028-06-20 Medical and Health Sciences Non-Clinical Trial Non-degree Award
Kiel McGowan
ID: UNCST-2025-R017284
 Prevalence and patterns of coinfection with malaria and soil transmitted helminths among school-aged children in rural Northern Uganda: A cross-sectional study
REFNo: HS6039ES

To measure the prevalence of coinfection with malaria and STH among school-aged children and to identify factors that may be associated with infection.
 USA 2025-06-20 9:16:14 2028-06-20 Medical and Health Sciences Non-Clinical Trial Degree Award
MARY AGUNLOYE OLAOLUWA
ID: UNCST-2024-R003434
 EVALUATION OF THE ACTIVITIES OF LEAF EXTRACTS OF AVOCADO (Persea americana Mill.) IN HIGH-FAT DIET/ LOW- DOSE STREPTOZOTOCIN - INDUCED TYPE 2 DIABETES MELLITUS IN WISTAR RATS
REFNo: HS5401ES

1. To screen aqueous, ethyl acetate, and ethanol leave extracts of p. americana Mill for anti-hyperglycemic activity
2. To assess the anti-diabetic potential of selected extract in high-fat diet/low-dose streptozotocin-induced T2DM in Wistar rats in a dose dependent pattern, and identify it mechanism of action
3. To perform phytochemical screening and metabolite profiling of the selected bioactive extracts through integrated FT-IR, LC-MS and GC-MS
4. To assess the in silico interactions of compounds of avocado leaf with selected drug targets in type II diabetes.
5. To evaluate the biological activities of the in silico hit compounds using in vitro and in vivo analyses

Nigeria 2025-06-20 9:03:03 2028-06-20 Medical and Health Sciences Non-Clinical Trial Degree Award
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